Month: February 2020

2020-02-28T07:01:00

(BPT) – The fact is, most people don’t get enough sleep even during the best of times. Daylight Saving Time is around the corner, and the time difference can pack a surprising punch to your internal clock. It can take up to a week to adjust, which can leave you groggy in the daytime and not ready for bed in the nighttime.

While it’s great to have more hours of daylight and to enjoy those light-filled evenings, losing one hour can really throw you off your sleep schedule. One thing people have been increasingly turning to is melatonin — a sleep aid that helps you fall asleep and reset your sleep-wake cycle† — to help in times like these. Read on for five other things you can do to quickly adjust your and your family’s sleep schedule.

1. Wind your body’s clock back

Go to bed a little earlier every night this week: For example, try 15 minutes earlier on Wednesday, 30 on Thursday, and 45 on Friday, so that by Saturday night you are already going to bed an hour early, and you’re ready to spring forward on Daylight Saving.

If your kids or spouse aren’t shifting their sleep schedules, you’ll have a tough time changing yours. So, get the entire family ready for the time change for their benefit and yours, too.

2. Exercise

No matter your age, physical activity has been proven to help you sleep better at night. Exercising in the morning can help reset your body’s clock so you’re sleepier at bedtime.

However, keep in mind that strenuous exercise right before bedtime can make it harder to settle down for a good night’s rest.

3. Wind down early

When your internal clock is thrown off due to the time change, you need to give yourself more time to slow down and get ready for sleep. Limit mentally stimulating activities late in the evening, like television, video games and playing on your smartphone.

Turn off the gadgets an hour or so before bedtime and pick up a book, de-stress with soothing music, meditation, a warm bath, or any other activity you find relaxing. This is especially important for children, who can be easily overstimulated by electronic entertainment, so avoid leaving them in the bedroom.

4. Put a cork in it!

Alcohol makes you drowsy, but it can degrade the quality of your sleep. Skip that glass of wine. Instead try to eat sleep-friendly foods such as sweet potatoes, turkey and broccoli.

5. Create an ideal bedroom environment

For the best night’s sleep, most people need cool, quiet rooms that are as dark as possible. A sound machine can help soothe you to sleep and drown out outside noises. The longer days delay the natural production of melatonin. Blackout shades can help.

6. Consider taking a melatonin supplement

If you’re still not sleepy at your new target bed time or you or your child is having trouble adjusting, consider a low-dose melatonin supplement such as Natrol Melatonin and Kids Melatonin.

Melatonin can help you overcome sleep disruptions like Daylight Saving by resetting your sleep-wake cycle.† It is pediatrician-recommended* and 100% drug-free. To find Natrol Melatonin in a store near you, visit Natrol.com.

Whether you’re coping with Daylight Saving Time, symptoms of jet lag from a trip, or just have occasional difficulty relaxing and getting to sleep, all of these tips can help you get the rest you need to feel and be your best.

*Recommended by The Canadian Paediatric Society

2020-02-27T08:01:00

(BPT) – Sponsored by Takeda Oncology

An avid soccer player his whole life, Hans was used to the physical impact of the game. But at age 40, he slowly started to experience strange symptoms like exhaustion, weight loss and sporadic shakiness that impacted his abilities in the game and at home.

“After my soccer games, I would shake uncontrollably for 10­ to 15 minutes. I would have night sweats. I didn’t realize at the time, but I’d lost about 20 pounds,” Hans said. After getting his blood test results from a routine doctor’s appointment, Hans learned he had chronic myeloid leukemia (CML), a type of rare blood cancer. He was shocked.

“When my doctor diagnosed me with CML, my spleen was about twice the size it was supposed to be, and I was tired all the time,” Hans said. “I didn’t realize at the time that CML is a chronic disease that I could have had for years before I realized I was actually sick. I was scared – at the time I had a two­ year ­old son and my wife was six months pregnant,” he said.

What is CML?

CML is one of four main types of a blood cancer known as leukemia. It is a result of a genetic mutation that takes place in the cells that form red blood cells, platelets and most types of white blood cells, which then turns the damaged cell into a CML cell. Though not always the case, CML can change into a fast-growing acute leukemia that is hard to treat, according to the American Cancer Society.

Q&A with Dr. James McCloskey

CML is rare and symptoms often are either hard to distinguish or are seemingly unrelated, like in Hans’s case. Because of this, patients are often diagnosed through routine bloodwork during regular doctor’s appointments. Patients with CML face a unique challenge because their treatment often needs to change over time. Roughly 24% of patients become resistant or intolerant to their initial TKI treatment, requiring these individuals to adjust their treatment regimen. While patients can live normal lives with treatment, it can be dangerous if their CML treatment stops working.

Treatment failure can be a challenging hurdle that many people living with CML face, and the cause of treatment failure is variable. This is why it’s crucial to be aware that multiple treatment options are available for CML: if one treatment fails, there may be alternatives available that target patients’ specific needs. It is important for patients to talk with their healthcare teams about the range of treatment options available and how to best manage side effects. Dr. James McCloskey, oncologist and leukemia researcher, answered key questions about CML:

How is CML diagnosed?

“Diagnosing CML can be difficult, especially in its early stages. In some cases, CML is identified by high white blood cell counts found in tests performed for other reasons. Then, we check for something called the Philadelphia chromosome, which is either found by testing the patient’s blood or bone marrow.”

What is the standard of care for CML?

“For first-line treatment, there are four approved treatments called tyrosine kinase inhibitors, or TKIs, which are the backbone for treatment of patients with CML. A TKI is a daily oral pill that is able to identify, attack and block proteins that cause uncontrolled CML growth.”

Is it possible that a TKI treatment can stop working?

“Unfortunately, yes. But it’s important to know that just because one TKI stops working, it does not mean that there aren’t other TKIs that can be tried instead. It’s relatively common for patients to become resistant or intolerant to a certain TKI, meaning that the TKI stops treating the disease or that the patient experiences side effects. Resistance can happen for a number of reasons, including changes to a person’s genetics. We identify this by regular blood tests, and if the patient’s blood counts become elevated, it’s critical to then assess if the treatment plan needs to be adjusted.”

What should a patient do if a TKI treatment stops working?

“If the first, or even second, TKI that we try does not work or stops working, I would partner closely with my patient to understand why – was it because of resistance or intolerance? If it’s because of resistance, there are other factors that we’ll need to consider before choosing the next TKI, like how many treatments have been tried and if the patient has developed any new genetic mutations which would be identified through mutational testing.”

Testing and treatment: Hans’s experience

Treatment resistance and intolerance are pertinent issues in treating CML. Since people can stop responding, or may never respond, to a certain TKI, it is important to consider the multiple options available. So if one treatment fails, there are alternatives available for patients that target their specific needs. Like many patients with CML, Hans’s cancer proved more difficult to manage, and he needed to become his own advocate and work closely with his doctor to explore other treatment options.

“Early on in my treatment journey, we were optimistic because my blood counts returned to normal in 30 days after starting treatment with the first TKI that I tried,” Hans said. “Unfortunately, after six months, I did not have adequate cytogenetic response, which meant the treatment wasn’t working even though I had started feeling better.”

Like Hans, many patients with CML do not experience new or worsening symptoms when their current treatments stop working which is why it’s important to receive blood tests on a regular basis. When Hans did not respond to a second TKI, his doctor conducted mutational testing which showed that Hans had the T315I mutation. While this is the most common genetic mutation in people living with CML, it is also the most difficult to treat.

ICLUSIG^® (ponatinib) is a potent TKI that may be a suitable option for adults living with CML who have experienced prior treatment failure with TKIs. ICLUSIG is also the only approved treatment option that demonstrates activity against the most common genetic mutation, T315I, which can cause resistance to other TKIs. People should always consult with their healthcare team about which treatment is best and how to manage side effects. After discovering he had the T315I mutation, Hans and his doctor determined ICLUSIG to be an appropriate treatment option for him.

“I was thrilled to know that there was another treatment that I could try, even though my first two TKIs stopped working. I started taking ICLUSIG and it has been effective for the management of my CML,” said Hans. “After a year or so, the disease became virtually undetectable. There is no cure for CML, and I know I’m not free from the disease, but I take nothing for granted now.”

Not every patient will have the same experience, and all treatment decisions should be discussed with a doctor.

Sponsored by Takeda Oncology

About ICLUSIG (ponatinib) tablets

ICLUSIG is a kinase inhibitor primarily targeting BCR-ABL1, an abnormal tyrosine kinase that is expressed in chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). ICLUSIG is a targeted cancer medicine developed using a computational and structure-based drug-design platform, specifically designed to inhibit the activity of BCR-ABL1 and its mutations. ICLUSIG targets native BCR-ABL1, as well as BCR-ABL1 treatment-resistant mutations, including the most resistant T315I mutation. ICLUSIG is the only approved TKI that demonstrates activity against the T315I gatekeeper mutation of BCR-ABL1. This mutation has been associated with resistance to all other approved TKIs. ICLUSIG received full approval from the FDA in November 2016.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ICLUSIG^® (ponatinib)?

ICLUSIG can cause serious side effects, including:

Blood clots or blockage in your blood vessels (arteries and veins). Blood clots or blockage in your blood vessels may lead to heart attack, stroke, or death. A blood clot or blockage in your blood vessels can prevent proper blood flow to your heart, brain, bowels (intestines), legs, eyes, and other parts of your body. You may need emergency surgery or treatment in a hospital. Get medical help right away if you get any of the following symptoms:

• chest pain or pressure
• pain in your arms, legs, back, neck or jaw
• shortness of breath
• numbness or weakness on one side of your body
• leg swelling
• trouble talking
• headache
• dizziness
• severe stomach area pain
• decreased vision or loss of vision

Blood clots or blockage in your blood vessels can happen in people with or without risk factors for heart and blood vessel disease, including people 50 years of age or younger. The most common risk factors for these problems are a history of high blood pressure (hypertension), high levels of fat in the blood (hyperlipidemia), and heart disease. Blood clots or blockages in your blood vessels happen more often in people as they get older, and in people with a past history of decreased blood flow, high blood pressure, diabetes, or high levels of fats in the blood.

Heart problems. ICLUSIG can cause heart problems, including heart failure which can be serious and may lead to death. Heart failure means your heart does not pump blood well enough. ICLUSIG can also cause irregular slow or fast heartbeats and heart attack. Your healthcare provider will check you for heart problems during your treatment with ICLUSIG. Get medical help right away if you get any of the following symptoms: shortness of breath, chest pain, fast or irregular heartbeats, dizziness, or feel faint.

Liver problems. ICLUSIG can cause liver problems, including liver failure, which can be severe and may lead to death. Your healthcare provider will do blood tests before and during your treatment with ICLUSIG to check for liver problems. Get medical help right away if you get any of these symptoms of liver problems during treatment:

• yellowing of your skin or the white part of your eyes (jaundice)
• dark “tea-colored” urine
• sleepiness
• loss of appetite
• bleeding or bruising

See “What are the possible side effects of ICLUSIG?” for information about side effects.

What is ICLUSIG?

ICLUSIG is a prescription medicine used to treat adults who have:

• chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) who cannot receive any other tyrosine kinase inhibitor (TKI) medicines
• a specific type of abnormal gene (T315I-positive) chronic phase, accelerated phase, or blast phase CML, or T315I-positive Ph+ ALL

ICLUSIG is not for use to treat people with newly diagnosed chronic phase CML.

It is not known if ICLUSIG is safe and effective in children less than 18 years of age.

Before you take ICLUSIG, tell your healthcare provider about all of your medical conditions, including if you:

• have a history of blood clots in your blood vessels (arteries or veins)
• have heart problems, including heart failure, irregular heartbeats, and QT prolongation
• have diabetes
• have a history of high cholesterol
• have liver problems
• have had inflammation of your pancreas (pancreatitis)
• have high blood pressure
• are pregnant or plan to become pregnant. ICLUSIG can harm your unborn baby.
  • Your healthcare provider will do a pregnancy test before you start taking ICLUSIG.
  • You should not become pregnant during treatment with ICLUSIG.
  • For females who can become pregnant:
    • Use an effective form of birth control during treatment and for 3 weeks after your last dose of ICLUSIG.
    • Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with ICLUSIG.
    • ICLUSIG may affect your ability to have children. Tell your healthcare provider if this is a concern for you.
• are breastfeeding or plan to breastfeed. It is not known if ICLUSIG passes into your breast milk. Do not breastfeed during treatment and for 6 days after your last dose of ICLUSIG.
• have bleeding problems
• plan to have surgery or have had a recent surgery. You should stop taking ICLUSIG at least 1 week before planned surgery. See “What are the possible side effects of ICLUSIG?”
• are lactose (milk sugar) intolerant. ICLUSIG tablets contain lactose.
• drink grapefruit juice

Tell your healthcare provider about all the medicines you take, including prescription medicines and over-the-counter medicines, vitamins, and herbal supplements. ICLUSIG and other medicines may affect each other causing side effects.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I take ICLUSIG?

• Take ICLUSIG exactly as your healthcare provider tells you to take it.
• Swallow ICLUSIG tablets whole. Do not crush or dissolve ICLUSIG tablets.
• You may take ICLUSIG with or without food.
• If you miss a dose of ICLUSIG, take your next dose at your regular time. Do not take 2 doses at the same time to make up for a missed dose.
• If you take too much ICLUSIG, call your healthcare provider or go to the nearest hospital emergency room right away.

What are the possible side effects of ICLUSIG?

ICLUSIG may cause serious side effects, including:

• See “What is the most important information I should know about ICLUSIG?”
• High blood pressure. Your blood pressure should be checked regularly and any high blood pressure should be treated while you are taking ICLUSIG. Tell your healthcare provider if you get confusion, headaches, dizziness, chest pain or shortness of breath.
• Inflammation of the pancreas (pancreatitis). Tell your healthcare provider if you get any of the following symptoms: sudden stomach-area pain or discomfort, nausea, and vomiting. Your healthcare provider should do blood tests to check for pancreatitis during treatment with ICLUSIG.
• Neuropathy. ICLUSIG may cause damage to the nerves in your arms, brain, hands, legs, or feet (neuropathy). Tell your healthcare provider if you get any of these symptoms during treatment with ICLUSIG:
  • muscle weakness, tingling, burning, pain, and loss of feeling in your hands and feet
  • double vision and other problems with eyesight, trouble moving the eye, drooping of part of the face, sagging or drooping eyelids, and change in taste
• Effects on the eye. Serious eye problems that can lead to blindness or blurred vision may happen with ICLUSIG. Tell your healthcare provider if you get any of the following symptoms: bleeding in the eye, perceived flashes of light, light sensitivity, floaters, dry inflamed, swollen, or itchy eyes, and eye pain. Your healthcare provider will monitor your vision before and during your treatment with ICLUSIG.
• Severe bleeding. ICLUSIG can cause bleeding which can be serious and may lead to death. Tell your healthcare provider if you get any signs of bleeding during treatment with ICLUSIG including:
  • vomiting blood or if your vomit looks like coffee-grounds
  • pink or brown urine
  • red or black (looks like tar) stools
  • coughing up blood or blood clots
  • unusual bleeding or bruising of your skin
  • menstrual bleeding that is heavier than normal
  • unusual vaginal bleeding
  • nose bleeds that happen often
  • drowsiness or difficulty being awakened
  • confusion
  • headache
  • change in speech
• Fluid retention. Your body may hold too much fluid (fluid retention). Tell your healthcare provider right away if you get any of these symptoms during treatment with ICLUSIG:
  • swelling of your hands, ankles, feet, face, or all over your body
  • weight gain
  • shortness of breath and cough
• Irregular heartbeat. ICLUSIG may cause an irregular heartbeat. Tell your healthcare provider right away if you experience loss of consciousness, fainting, dizziness, chest pain or palpitations.
• Low blood cell counts. ICLUSIG may cause low blood cell counts, which can be severe. Your healthcare provider will check your blood counts regularly during treatment with ICLUSIG. Tell your healthcare provider right away if you have a fever or any signs of an infection while taking ICLUSIG.
• Tumor Lysis Syndrome (TLS). TLS is caused by a fast breakdown of cancer cells. TLS can cause you to have:
  • kidney failure and the need for dialysis treatment
  • an abnormal heartbeat

3. Your healthcare provider may do blood tests to check for TLS.

• Reversible Posterior Leukoencephalopathy Syndrome (RPLS – also known as Posterior Reversible Encephalopathy Syndrome – PRES). ICLUSIG may trigger a condition called RPLS. Call your healthcare provider right away if you get headaches, seizures, confusion, changes in vision or problems thinking.
• Wound healing problems. Wound healing problems have happened in some people who take ICLUSIG. Tell your healthcare provider if you plan to have any surgery before or during treatment with ICLUSIG.
  • You should stop taking ICLUSIG at least 1 week before planned surgery.
  • Your healthcare provider should tell you when you may start taking ICLUSIG again after surgery.
• A tear in your stomach or intestinal wall (perforation). Tell your healthcare provider right away if you get:
  • severe pain in your stomach-area (abdomen)
  • swelling of the abdomen
  • high fever

The most common side effects of ICLUSIG include:

• stomach-area (abdomen) pain
• skin rash
• constipation
• headache
• dry skin
• blood clots or blockage in blood vessels (arteries)
• tiredness
• high blood pressure
• fever
• joint pain
• nausea
• diarrhea
• increase in lipase levels (a blood test done to check your pancreas)
• vomiting
• muscle pain
• pain in arms, hands, legs, and feet

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with ICLUSIG if you have certain side effects.

Talk to your doctor if you have a side effect that bothers you or does not go away. These are not all of the possible side effects of ICLUSIG. For more information, ask your healthcare provider or pharmacist.

To report SUSPECTED ADVERSE REACTIONS, contact Takeda at 1-844-817-6468 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please read the Medication Guide in the full Prescribing Information , including Important Serious Side Effects.

All trademarks are the property of their respective owners. ©2020Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited. All rights reserved

MAT-USO-ICL-19-00064 2/20

2020-02-27T11:07:00

(BPT) – SPONSORED BY NOVO NORDISK – From late nights at the office, to outings with family and friends, sticking to a diet and consistent mealtime can be challenging for many Americans. But if you’re living with diabetes, how much, when and what you eat can have implications for your overall health and even shift blood sugar levels out of target range.

The following tips can help you stay on track with your doctor-approved diabetes management plan — whether you’re grabbing a quick snack or going out to a big dinner with friends.

1. Keep an eye on portions

Reading nutrition labels or using food scales can seem daunting when you’re trying to eat, but it will help you keep to your target calories and carb counts. Oftentimes, there are multiple servings in packaged foods, meaning there’s double or triple the calories, fat and carbohydrates in one bag or box. If you’re dining out, you can measure your meal with your hand. Think about it in these simple terms: Your hand is about a cup, your palm is 3 ounces and your thumb tip (up to the first knuckle) is about 1 teaspoon. It’s not precise, but it can help you estimate appropriate serving size.

2. Map out your plate

Still not sure what to eat? The American Diabetes Association recommends that before you dig in, start by splitting your plate down the middle. Fill half your plate with non-starchy vegetables (think spinach or broccoli). Then, divide the remaining half into two smaller halves. Place starchy foods (like potatoes or rice) in one section and place protein (meat, fish, eggs or tofu) in the final section. By remembering this simple ratio — 50/25/25 — you can make a balanced meal out of any cuisine.¹

3. Create healthy habits and stick to them

Maintaining a balanced diet won’t happen overnight. Start with small adjustments that will slowly become part of your mealtime routine. For example, if you typically have dessert with dinner, try switching from ice cream to a healthier alternative once or twice a week rather than skipping a treat entirely. If you often skip meals and snack instead, try setting one day a week with established mealtimes. Slowly but surely, these adjustments will change the way you approach your diet and meals.

4. Check your blood sugar regularly

If you are living with diabetes, blood sugar monitoring is an essential part of your management plan. It can help you better understand how various factors — including what you eat — affect your blood sugar levels over time. Being in tune with your blood sugar before and after mealtimes can also minimize the risk of unanticipated changes in blood glucose level, and the associated complications. The American Diabetes Association recommends 80 to 130 mg/dL before a meal and 180 mg/dL two hours after the start of the meal.² However, every person’s situation may be different, so you should speak to a doctor about target levels and when to test.

5. Stay on top of your medication

There has been significant progress in diabetes management in recent years. Each person living with diabetes has a unique experience and different treatment needs. For example, some people need to take a rapid-acting insulin at mealtime. One treatment, Fiasp^® (insulin aspart injection), is the first and only fast-acting mealtime insulin injection that does not have a pre-meal dosing recommendation, meaning it can be administered at the beginning of a meal or within 20 minutes after starting a meal, which may help to take the guesswork out of mealtime. Fiasp^® is now available for use in adults and children with diabetes.³ You can learn more about Fiasp^® by visiting myfiasp.com. If your treatment isn’t giving you the blood sugar control you need at mealtime, you should talk to your doctor.

Indications and Usage

What is Fiasp^® (insulin aspart injection) 100 U/mL?

Fiasp^® is a man-made insulin used to control high blood sugar in adults and children with diabetes mellitus.

Important Safety Information

Do not share your Fiasp^® with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.

Who should not take Fiasp^®?
Do not take Fiasp^® if:

• your blood sugar is too low (hypoglycemia) or you are allergic to any of its ingredients.

Before taking Fiasp^® tell your health care provider about all your medical conditions, including if you:

• have kidney or liver problems
• are pregnant or breastfeeding or plan to become pregnant or breastfeed. It is not known if Fiasp^® passes into your breast milk.
• are taking new prescription or over-the-counter medicines, including supplements.

Talk to your health care provider about low blood sugar and how to manage it.

How should I take Fiasp^®?

• Read the Instructions for Use and take Fiasp^® exactly as your health care provider tells you to.
• Fiasp^® starts acting fast. You should take your dose of Fiasp^® at the beginning of the meal or within 20 minutes after starting a meal.
• Know the type and strength of your insulin. Do not change your insulin type unless your health care provider tells you to.
• Change (rotate) your injection sites within the area you choose with each injection to reduce your risk of getting pits in skin or thickened skin (lipodystrophy) and skin with lumps (localized cutaneous amyloidosis) at the injection sites.
  • Do not use the exact same spot for each injection.
  • Do not inject where the skin has pits, is thickened, or has lumps.
  • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.
• If you miss a dose of Fiasp^® monitor your blood sugar levels to decide if an insulin dose is needed. Continue with your regular dosing schedule at the next meal.
• Check your blood sugar levels. Ask your health care provider what your blood sugar levels should be and when you should check them.
• Do not reuse or share your needles with other people. You may give other people a serious infection or get a serious infection from them.

What should I avoid while taking Fiasp^®?

• Do not drive or operate heavy machinery, until you know how Fiasp^® affects you.
• Do not drink alcohol or use medicines that contain alcohol.

What are the possible side effects of Fiasp^®?
Serious side effects can lead to death, including:

• Low blood sugar (hypoglycemia). Some signs and symptoms include: anxiety, irritability, mood changes, dizziness or light-headedness, sweating, confusion, and headache.
• low potassium in your blood (hypokalemia).
• serious allergic reactions (whole body reactions). Get emergency medical help right away if you have a rash over your whole body; trouble breathing; a fast heartbeat; swelling of your face, tongue or throat; sweating; extreme drowsiness; dizziness, or confusion.
• heart failure. Taking certain diabetes pills called TZDs (thiazolidinediones) with Fiasp^® may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with Fiasp^®. Your health care provider should monitor you closely while you are taking TZDs with Fiasp^®. Tell your health care provider if you have any new or worse symptoms of heart failure including shortness of breath, swelling of your ankles or feet, or sudden weight gain.

Your insulin dose may need to change because of:

• weight gain or loss, increased stress, illness, or change in diet or level of physical activity

Common side effects of Fiasp^® may include:

• skin problems such as eczema, rash, itching, redness and swelling of your skin (dermatitis), reactions at the injection site such as itching, rash, skin thickening or pits at the injection site (lipodystrophy), or weight gain.

Please see Prescribing Information for Fiasp^® at http://www.novo-pi.com/fiasp.pdf

References

1. American Diabetes Association (ADA). What Can I Eat? https://www.diabetes.org/blog/what-can-i-eat. Accessed November 2019
2. American Diabetes Association (ADA). The Big Picture: Checking Your Blood Glucose. https://www.diabetes.org/diabetes/medication-management/blood-glucose-testing-and-control/checking-your-blood-glucose. Accessed January 2020.
3. Fiasp [package insert]. Plainsboro, NJ: Novo Nordisk, Inc.; December 2019.

Fiasp^® is a registered trademark of Novo Nordisk A/S.

Novo Nordisk is a registered trademark of Novo Nordisk A/S.

© 2020 Novo Nordisk All rights reserved. US19FSP00199 January 2020