Category: Brandpoint Health

2026-09-09T15:15:00

(BPT) – Eating delicious food with great company is one of the best parts of attending your favorite fall festivities, whether you’re at a backyard cookout, planning back-to-school dinners, tailgating or hosting a football watch party. However, certain popular foods like spicy wings, pizza and fried favorites are often accompanied by an uninvited guest — heartburn.

If you know certain foods trigger heartburn but still eat them anyway, you’re not alone, as many Americans are willing to make that tradeoff. According to a new PEPCID^® brand survey, almost half of respondents knowingly eat or drink things they expect will cause heartburn. While avoiding these foods could help reduce the likelihood of acid reflux and discomfort after eating, 80% of respondents believe certain foods are “worth the risk.”*

The good news is that you do not have to pass on eating delicious dishes this fall. That is why having a heartburn game plan, including these five simple strategies, can help you manage symptoms and feel more prepared to enjoy the food you love at gatherings.

1. Elevate your upper body or stand up

When you lie down, increased pressure on the lower esophageal sphincter, the muscle that keeps the bottom of the esophagus closed, can worsen heartburn symptoms. Stand up after eating or elevate your upper body and head with a pillow to keep the stomach acid from flowing up into your esophagus.

2. Loosen tight clothing

Clothing that fits tightly around the waist can put pressure on your stomach, pushing its contents backward into the esophagus and causing discomfort. If you feel heartburn coming on, try loosening your belt or, when possible, opting for looser-fitting clothing to give your midsection more room to relax.

3. Chew gum to help reduce acid

Believe it or not, gum can help take the edge off a heartburn-triggering meal. Chewing gum boosts saliva production and makes you swallow more often, which can help clear acid from the mouth and esophagus. The best part? You’ll get the added benefit of fresh breath.

4. Get moving

Did you know that regular exercise can help manage heartburn? Low-intensity aerobic exercises (walking, cycling and yoga) may offer protective benefits against acid reflux. These activities can also support a healthy weight, which is an important part of managing heartburn and acid reflux. However, you should try to avoid eating right after. The next time you eat a meal, invite a friend or family member to take a leisurely stroll around the block.

5. Have an acid reducer on hand

Many people who occasionally experience heartburn take a “wait and see” approach to potential heartburn, even though they know that there are over-the-counter (OTC) acid reducers that can help relieve their symptoms. In fact, according to the survey, 67% said they have experienced heartburn symptoms but chose not to take medication because they expected symptoms would go away on their own. Even among those who experience severe symptoms, 77% reported doing the same.*

Don’t let heartburn interrupt the moment. If you know certain foods can trigger occasional heartburn, consider picking up an OTC acid reducer like PEPCID^® so you can enjoy a Saturday barbecue. By reducing the amount of acid in the stomach, PEPCID^® relieves heartburn and controls acid for up to 12 hours.** It works fast and lasts all day***, so you can enjoy a meal without worrying about discomfort.

Enjoy the season with a heartburn game plan

You don’t have to give up your favorite foods to avoid heartburn. Using these simple tips, you can feel more prepared to enjoy the season’s biggest food moments with the people you love. Before your next backyard cookout, tailgate or fall gathering, visit Pepcid.com to learn more about occasional heartburn, compare product options and find where to buy relief near you.

Use products only as directed.

*PEPCID^® commissioned an online survey with KRC Research of 3,000 U.S. adults aged 18 or over in Spring 2026, reflective of U.S. census demographics.

**Acid control does not imply symptom relief.

***Starts to work in 15-30 minutes. Lasts all day based on 8-hour symptom relief studies during the day.

2026-09-08T08:01:00

(BPT) – Sponsored by Merck

Crohn’s disease (CD) is a chronic condition that affects approximately 1 million people living in the U.S.¹ Research shows that the disease has become increasingly common in the U.S. and other parts of the world, yet experts don’t know why.¹

CD is a type of inflammatory bowel disease (IBD) that causes inflammation (swelling) and ulcers (sores) in the digestive tract.¹ CD accounts for approximately 40% of IBD cases.^2,3

Your digestive tract digests and moves food through your body. It includes your⁴:

• Mouth
• Esophagus (the tube that connects your mouth to your stomach)
• Stomach
• Small intestine
• Large intestine, which includes your colon, rectum and anus

What causes CD?

In CD, the body’s immune system overreacts and damages healthy tissues in the digestive tract.⁵ It most often happens in the small intestine and the beginning of the large intestine. However, CD can happen in any part of the digestive tract.¹ Though experts don’t know exactly what triggers CD, research shows that it may be due to a combination of immune system changes, genes and lifestyle factors.⁵

“Researchers are evaluating the safety of an investigational medicine and how well it may work in resolving or improving Crohn’s disease symptoms compared to placebo in a clinical trial happening now,” said Dr. Ahmed Kurdi, gastroenterologist and principal investigator at Sanford Health. “You or a loved one may be eligible to participate based on the inclusion criteria.”

Join a clinical trial for CD

A clinical trial, also called a clinical study, is a type of research designed to learn more about how the body responds to investigational medicines, vaccines, or other treatments.

There is a clinical trial studying an investigational medicine for moderate to severe CD. Moderate to severe CD means symptoms happen more often or are more intense compared to mild CD, often leading to additional complications and greater impact on daily life.⁶

The goal of this trial is to learn if the investigational medicine is safe and works well to improve CD symptoms compared to a placebo.⁷ A placebo looks like the trial medicine but has no medicine in it. Using a placebo helps researchers better understand the effects of the investigational medicine.

This trial is for adults who⁷:

• Are between ages 18 and 80
• Have had CD for at least 2 months and currently have moderate to severely active CD
• Have had at least 1 of the below:
  • Have not responded well or stopped responding to at least 1 CD treatment
  • Have not tolerated their dose of corticosteroids (such as prednisone, budesonide, or beclomethasone) being reduced
  • Have not been able to tolerate taking at least 1 CD treatment

The importance of representation in clinical trials

Representation in clinical trials helps researchers gain a more complete picture of how investigational medicines work across populations. This helps support the development of safe and effective medicines for those who are most affected by the disease or condition being studied. Today, only 24% of clinical trial participants are from communities of color despite making up more than 40% of the U.S. population and facing higher burdens of many diseases.⁸

“Communities of color haven’t always been equally represented or treated in healthcare,” said Dr. Kurdi. “Acknowledging that history can open the door to honest conversations about clinical trial participation and provide access to research that may be relevant to their care.”

More about this trial

There are more eligibility criteria for this trial. There may be risks related to participating in clinical trials. The trial doctor can discuss these with you.

Participation in clinical trials is voluntary, and participants are free to leave at any time, for any reason. Participants may or may not directly benefit from being in the clinical trial, but they will help researchers learn more about the investigational medicine and CD.

You can learn more about this clinical trial at Merck’s clinical trial page.

References

1. National Institute of Diabetes and Digestive and Kidney Diseases. Definition & facts for Crohn’s disease. Updated October 2025. Accessed May 1, 2026. https://www.niddk.nih.gov/health-information/digestive-diseases/crohns-disease/definition-facts
2. Crocetti E, Bergamaschi W, Russo AG. Population-based incidence and prevalence of inflammatory bowel diseases in Milan (Northern Italy), and estimates for Italy. Eur J Gastroenterol Hepatol. 2021;33(1S suppl 1):e383-e389. doi:10.1097/MEG.0000000000002107
3. Lewis JD, Parlett LE, Jonsson Funk ML, et al. Incidence, prevalence, and racial and ethnic distribution of inflammatory bowel disease in the United States. Gastroenterology. 2023;165(5):1197-1205.e2. doi:10.1053/j.gastro.2023.07.003
4. Cleveland Clinic. What is the digestive system? October 25, 2024. Accessed June 16, 2026. https://my.clevelandclinic.org/health/body/7041-digestive-system
5. Cleveland Clinic. Crohn’s disease: What it is, symptoms, causes & treatment. December 4, 2023. Accessed May 1, 2026. https://my.clevelandclinic.org/health/diseases/9357-crohns-disease
6. CrohnsAndColitis.com. Crohn’s disease severity and progression. Accessed July 8, 2026. https://www.crohnsandcolitis.com/crohns/severity-and-progression
7. Merck Clinical Trials. A study to evaluate the efficacy and safety of tulisokibart in participants with moderate to severe Crohn’s disease. Accessed May 7, 2026. https://www.merckclinicaltrials.com/trial/nct06430801/
8. Merck. Let’s Talk Trials. Accessed May 27, 2026. https://www.merckclinicaltrials.com/Lets-Talk-Trials/

2026-08-13T08:01:00

(BPT) – Finding out you have a chronic illness is challenging, but it can be particularly traumatic when it happens far away from home. That’s exactly what happened to Gretchen when she was 23 years old during what was supposed to be a dream international trip.

A cruise across the Mediterranean took an unexpected turn when Gretchen suddenly became severely ill, experiencing decreased appetite and dehydration. She thought she might have a minor travel-related sickness or infection and visited the ship’s physician for care. After running a battery of tests, the doctor delivered a surprising diagnosis. Gretchen had Type 1 diabetes (T1D) and, at that moment, was experiencing diabetic ketoacidosis (DKA), a life-threatening condition that occurs in people with diabetes when ketone levels are too high. For people living with diabetes, their ketones reach dangerously high levels when their body is not able to use glucose as fuel due to a lack of insulin, so instead, the body breaks down fat too quickly, which in turn produces ketones in the blood stream.¹ A DKA event, like the one Gretchen experienced, is how many people find out they have T1D, which accounts for about 20% to 40% of DKA cases.¹

Ambiguous DKA symptoms can delay treatment

For people with diabetes who use insulin, elevated or high ketone levels can lead to DKA, a serious health condition that is on the rise.¹ A study showed that between 2017 and 2024, DKA prevalence among people with Type 1 diabetes increased approximately 24%,² rising from 50 to 62 cases per 1,000 individuals.² DKA is particularly dangerous because in severe cases it can lead to a coma or death.¹ Unfortunately, many patients don’t detect it early enough, mistaking their symptoms for other, more common illnesses like the flu, dehydration or food poisoning.^4,5,6

According to Eden Miller, DO, a family practitioner and diabetologist, there are clear reasons behind this alarming trend. “Part of the problem lies in how difficult it can be to distinguish DKA symptoms from less serious, run-of-the-mill medical conditions,” said Dr. Miller. “The other part is the underutilization of ketone monitoring methods. While glucose monitoring has advanced, ketones and glucose do not always rise together, and current monitoring tools don’t provide continuous visibility into rising ketones. Together, these issues can delay critical treatment.”

This trend highlights a clear gap for people living with diabetes. Instead of patients feeling equipped with the insights they need to be proactive and prepared, they are left in a reactive state.

“Improving awareness of DKA and helping people understand what to do when ketones are rising are important opportunities to help reduce DKA risk,” said Miller.

Getting treated and gaining confidence

Initially overwhelmed by the diagnosis, once back in the U.S., Gretchen visited an endocrinologist who introduced her to modern diabetes management tools — like Abbott’s FreeStyle Libre 3 Plus sensor which continuously measures her glucose levels — and helped guide her through the initial steps of how to live with diabetes. While learning the basics of living with diabetes, Gretchen also learned about ketones, the importance of recognizing DKA symptoms and how to act quickly during a DKA event.

“My diagnosis was a wake-up call, but it wasn’t a stop sign. Managing a chronic condition like diabetes doesn’t mean shrinking your world; it just means packing a little smarter. By taking control of my health and having a proactive plan, I’ve reclaimed my love for travel. I want other people to know that living with chronic illnesses shouldn’t keep you from making plans, booking trips and living fully.”

Tips to keep diabetes management top of mind for travel

Gretchen’s experience during her European holiday inspired her to create her own diabetes travel guide to help herself and others living with diabetes proactively plan and diligently monitor their condition, so their vacations stay on track. Below are her top tips for traveling safely and confidently with diabetes.

1. Always stay hydrated: Drink plenty of water, especially when traveling in warm weather and during physical activity like walking through new cities.
2. Pack smart and double up: It’s always a good idea to carry extra medications and supplies. This includes insulin, pumps, needles, automated insulin delivery (AID) infusion sets and ketone testing supplies — including blood or urine test strips. Be sure to check the expiration date before packing! Also, bringing a doctor’s note can help too in case you get stopped or questioned while traveling with your supplies.
3. Monitor more, adjust often: Travel means changes to your routine. To make sure you stay on top of your diabetes management, check your glucose monitor, pumps and sensors more frequently.
4. Know the signs, act fast: Signs that you may be experiencing a DKA event include extreme thirst, frequent urination, nausea, abdominal pain or fruity-smelling breath. If you experience any of these symptoms, check your glucose and test for ketones immediately.
5. Seek care: When traveling, find the nearest pharmacy or urgent care in case you need medical attention during your trip.

Don’t let fear of managing diabetes keep you from seeing the world. Using these tips, you can stay prepared to explore new horizons safely and confidently.

If you or someone you know is living with diabetes, work with a healthcare provider to create a proactive DKA plan so you can feel confident in knowing what to do when ketones are rising or you are not feeling well. For more information about DKA, go to RisingKetones.com.

Sources:

The views expressed in this article should not be used for medical diagnosis or treatment or as a substitute for professional medical advice. Individual symptoms, situations and circumstances may vary.

For U.S. residents – Important Safety Information Product for prescription only, for Important Safety Information please visit FreeStyleLibre.us.

1. Cleveland Clinic. Diabetes-Related Ketoacidosis (DKA). Accessed July 2026 from: https://my.clevelandclinic.org/health/diseases/21945-diabetic-ketoacidosis-dka.
2. SHERR, J., WYSHAM, C., MEHTA, S., & VIRDI, N. (2026). 2977-LB: Trends in the prevalence of Diabetic ketoacidosis and severe hypoglycemia in type 1 diabetes. Diabetes, 75(Supplement_1). https://doi.org/10.2337/db26-2977-lb
3. Umpierrez, G. E. Diabetes Care (2024). https://doi.org/10.2337/dci24-0032
4. Dhatariya, et al. Lancet Diabetes & Endocrinology (2026): https://pubmed.ncbi.nlm.nih.gov/41381175/
5. Virdi, N. Diabetes Technology & Therapeutics (2023). https://doi.org/10.1089/dia.2023.0149
6. Nguyen, K. T. Journal of Diabetes Science and Technology (2022). https://doi.org/10.1177/19322968211042656

2026-08-20T17:01:00

(BPT) – For people living with depression, post-traumatic stress disorder (PTSD) or other mental health conditions, ketamine therapy may offer an option when other therapies haven’t worked. But if you are considering ketamine, either at a clinic or through a prescription obtained via telehealth, it’s important to understand how your treatment is provided and what safeguards are in place to keep you safe.

The $5 billion ketamine therapy market is projected to nearly triple over the next decade, and the American Society of Anesthesiologists (ASA) is calling for stronger patient protections amid concerns that safety standards and oversight are not keeping pace. ASA urges patients to ask how the drug will be prescribed, who will oversee their care, and what safety and monitoring protocols will be in place.

Ketamine is approved by the U.S. Food and Drug Administration (FDA) as an anesthetic, but its use for mental health conditions is off-label. A related drug, esketamine, is FDA-approved for certain forms of depression and must be administered in a certified healthcare setting.

Because ketamine can affect breathing, heart rate and blood pressure and carries a risk of misuse, it should only be prescribed as part of a comprehensive treatment plan with medical supervision. Last year, a 41-year-old New York woman seeking relief from depression died after being prescribed at-home ketamine through a telehealth company — even though she had reported taking Xanax, a combination the FDA warns can dangerously suppress breathing.

“For decades, anesthesiologists have safely administered ketamine in hospitals and other medical settings where patients are carefully monitored, and we have grave concerns about home delivery and unsupervised use of ketamine,” said ASA President Patrick Giam, M.D., FASA. “You can move very quickly from feeling relaxed to becoming deeply sedated, and without proper monitoring and supervision, that can become dangerous.”

What safe ketamine care requires

Ketamine can cause serious side effects requiring prompt medical intervention. That is why it matters where treatment is provided and whether qualified medical professionals are available if something goes wrong. For ketamine given by IV or injection, ASA guidance recommends that treatment should only be provided in a monitored medical setting under the supervision of a physician who is immediately available, familiar with ketamine’s effects and prepared to respond to complications. Appropriate monitoring and emergency equipment should also be readily available.

However, some patients receive prescriptions after virtual visits and take ketamine at home, typically as a tablet or lozenge that dissolves under the tongue, without a trained healthcare professional to monitor their breathing, heart rate or level of consciousness.

“You can go from a short online screening to receiving a powerful anesthetic at home,” said Dr. Giam. “If something goes wrong, there may be no one there trained to respond. In the hospital, we have strict protocols to account for every milligram of ketamine administered, yet ketamine used at home is subject to far less scrutiny. Patients need appropriate safeguards wherever they receive treatment.”

Lawmakers and policymakers in some states, including Texas, are considering stricter regulations, and federal officials have stepped up scrutiny of online ketamine providers and unapproved ketamine products.

What to ask before treatment

Before starting therapy, your healthcare professional should review your medical history, medications and overall health to determine whether ketamine is appropriate for you. Follow-up appointments are also important to monitor your response, adjust care if needed and identify side effects or complications.

If you’re considering ketamine therapy, ask questions before treatment begins so you can make a safer, more informed decision:

• Who will evaluate whether ketamine is appropriate for me?
• Will I have an in-person medical evaluation before treatment begins?
• Who will oversee and monitor me during treatment?
• What safety measures and emergency procedures are in place if I have a serious reaction?
• How could ketamine interact with my current medications or medical conditions?
• How often will I have follow-up appointments, and who should I contact if I experience problems after treatment?

Be sure to tell your healthcare professional about all prescription and over-the-counter medications, dietary supplements, alcohol, cannabis and other substances you use. Some combinations can increase the risk of dangerous side effects or make ketamine unsafe.

For more information about ketamine, visit https://madeforthismoment.asahq.org/pain-management/ketamine/.

2026-08-14T10:47:00

(BPT) – The transition from summer days to the back-to-school season is notoriously hectic. Between new routines, extracurriculars and supply shopping, schedules are packed. But there’s one thing that shouldn’t get lost in the shuffle: a back-to-school health checklist.

From updating health forms to stocking up on medicine cabinet essentials, early preparation is key to keeping the household running smoothly. Samantha Picking, PharmD, senior director of immunizations at Walgreens, breaks down the health to-dos to knock out before the school year starts:

1. Get ahead of seasonal and routine vaccines

The start of a new school year is a good time to ensure the whole family is up to date on routine and seasonal vaccinations, such as those protecting against flu, COVID-19, tetanus, diphtheria and whooping cough.

Pro tip: “Keep in mind that many vaccines take about two weeks to provide protection,” Picking said. “That’s why it’s worth scheduling appointments before kids and teens are back in close contact with classmates and respiratory virus season ramps up.”

At Walgreens, patients can schedule vaccination appointments for up to four people in a single visit and book well in advance, giving families more flexibility to plan ahead and save time. myWalgreens^® members can also earn $15 in Walgreens Cash rewards when they spend $5+ on their next eligible in-store purchase, plus 10% back in Walgreens Cash on eligible in-store purchases for 30 days when they get vaccinated.*

2. Coordinate school medications and medical forms

For students with conditions like asthma or severe allergies, early coordination with school staff is essential. Make sure to check the expiration dates on emergency inhalers or epinephrine auto-injectors and verify that the school has updated health forms on file.

Pro tip: “Don’t wait until the first day of school to get those required medical forms filled out,” Picking said. “Local pharmacy teams can also help refill essential emergency medications, so families are prepared before the first bell rings.”

3. Restock the medicine cabinet

Having sick-day supplies on hand is a key part of back-to-school readiness. Take stock of overall household health and wellness needs, including items like daily vitamins, cough drops, antacids, cough medicine, combination flu & COVID-19 tests and other essentials like a first aid kit.

Pro tip: “As a mom of three, I always do a quick check of the medicine cabinet and replace anything that’s expired or running low before the school year starts,” Picking said. “It only takes a few minutes, but it means you’re not caught off guard when someone actually gets sick.”

For families short on time, Walgreens has options to grab what you need with 1-hour Delivery and 30-minute Pickup.**

4. Reset daily wellness habits

Transitioning from relaxed summer schedules to structured school routines can be physically taxing for kids and parents alike. Establish a consistent sleep schedule, prioritize nutritious meals and reinforce healthy habits, like proper handwashing and using hand sanitizer, to form a strong foundation for the year ahead.

Pro tip: “Getting enough sleep and practicing good hygiene are two of the simplest ways to start the school year on the right foot,” Picking said. “It’s easy to let healthy routines slip during the summer, so ease back into them a week or two before school starts.”

Walgreens: A partner in health and back-to-school prep

Walgreens is a one-stop destination for vaccinations, over-the-counter essentials and last-minute school supplies. Vaccination appointments can be scheduled online, through the Walgreens app or by calling 1-800-WALGREENS. For any questions, expert pharmacists are ready to provide trusted guidance and personalized support.

*Must be a myWalgreens^® member. Offer available for a limited time and valid for 14 days from vaccination date. Must scan coupon at checkout to earn rewards/activate. Coupon offer not valid in AR, NJ or NY. Limit three coupons per person. See coupon for terms and restrictions. Vaccines subject to availability. Walgreens administers applicable vaccinations for children ages three and older. State-, age- and health-related restrictions may apply. Additional terms and exclusions apply. Complete details, including Walgreens Cash rewards expiration dates, at Walgreens.com/offerdetails.

$15 Offer

• Earn rewards on qualifying in-store purchases of $5+. Limit one storewide coupon redeemed per transaction, up to three redemptions per offer period. Maximum $45 Walgreens Cash rewards per member.

10% Offer

• Earn rewards on qualifying in-store purchases of $1+. Scan once to activate offer. Limit one offer per myWalgreens^® member. Maximum $100 Walgreens Cash rewards. Offer valid for 30 days following activation.

**Delivery in as little as 1 hour and Pickup in as little as 30 minutes based on national averages, actual times may vary. Pickup is available for eligible items when your order is $10 or more (after promo codes and paperless coupons are applied and before taxes). Exclusions, restrictions, and fees may apply. For details, visit Walgreens.com/same-day-delivery and Walgreens.com/Pickup.

2026-08-11T13:01:00

(BPT) – Key takeaways

• Wellness routines have become incredibly complicated, and people are seeking effective solutions to support their daily habits without adding more work.
• Ryde: SLEEP simplifies bedtime routines with a quick 2oz shot designed to help you unwind and get ready for better rest.
• The functional shot is designed for busy people who want to feel more prepared for the next day, whether that means work, workouts, travel or everyday commitments.
• Rob Gronkowski brings the message to life by showing that even a “Full Gas” lifestyle needs smart recovery and simple tools that actually fit into real life.
• Alongside SLEEP, Ryde: FOCUS gives consumers another easy functional dietary supplement shot for moments when you want help tuning out distractions and locking in.

Wellness used to be simple. Somewhere along the way, it turned into a cabinet full of supplements and a bedtime routine too complicated to keep up with. As people look to simplify their daily habits without sacrificing results, easy, effective solutions are having a major comeback.

Enter Ryde:, the globally loved well-being brand known for its pocket-size 2oz functional dietary supplement shots. Challenging the increasingly complicated nature of modern wellness routines, Ryde: is proving that taking care of yourself doesn’t need to be a tedious chore with its newest launch in partnership with Rob Gronkowski, Ryde: SLEEP: a simple, science-backed solution that fits seamlessly into busy lives.

The power of the night before

Whether preparing for an intense workday, an early morning workout, or back-to-back commitments, feeling your best starts hours before the alarm goes off. Ryde:’s SLEEP shot was built specifically for people who know that the night before matters just as much as the morning after.

Formulated with a delicious blackberry flavor, Melatonin, GABA, L-Theanine and Chamomile, SLEEP is designed to support sleep quality and helps you fall asleep faster.

Informed Choice certified and developed with science-backed ingredients, zero calories, zero sugar and no unnecessary extras, Ryde: delivers functional support without the fuss. Every shot also features Ryde: Ryplenish™, a scientifically backed formula that works right when you need it, making it the perfect daily ally for well-being on-the-go.

2026-07-31T08:01:00

(BPT) – As cancer research continues to move forward, scientists are increasingly recognizing that cancer is not the same for everyone. Even people with the same diagnosis can have very different experiences. This realization is shifting thinking away from one-size-fits-all treatment approaches and toward a better understanding of what makes each person’s cancer unique.

By learning more about the genetic makeup of a person’s tumor, researchers can begin to see those differences more clearly and use them to guide future scientific and clinical advances.

A Novel Approach

Merck and Moderna are working together to explore an innovative approach to cancer care — one that seeks to address each individual’s cancer with a “one medicine for one patient” mindset. This research centers on an individualized neoantigen therapy (INT) approach, which is designed with the intent to train and activate a patient’s immune system to specifically identify and then destroy cancer cells.

Every person’s tumor has a distinct “fingerprint” made up of mutated genes resulting in abnormal proteins, called neoantigens. An INT, leveraging mRNA as the body’s instruction-carrying molecule, could help train a patient’s immune cells to recognize these cancer “fingerprints” as foreign and potentially launch an immune response against those cancer cells to help their own body fight back.

“Because the genetic makeup of a patient’s cancer is unique to that person, we believe there is a need for innovative therapies that can be tailored to a patient’s tumor with the potential to enhance immune surveillance for each person’s specific cancer,” said Dr. Vassiliki Karantza, Associate Vice President, Global Clinical Development, Merck Research Laboratories.

Using these insights, researchers identify genetic mutations of a patient’s cancer by performing an analysis of their blood and tumor samples to select which neoantigens may be best suited to activate the patient’s immune cells. An INT is then created with the intent to specifically treat the individual patient’s cancer.

“Our teams are working relentlessly to explore this new approach, which is grounded in the fact that every patient’s cancer has unique features,” said Dr. Michelle Brown, Head of Oncology Portfolio Development at Moderna. “Made possible by mRNA technology, this approach could represent a shift toward more personalized care in cancer, where we design therapies based on each patient’s specific biology — moving us toward creating one medicine for one patient.”

Research Underway

Researchers are currently conducting studies to better understand how INTs may help train the body’s immune system. There are currently no U.S. FDA-approved individualized neoantigen therapies.

For more information about ongoing research in cancer, visit: Merck.com or Moderna.com.

This information is provided by Merck and Moderna.

Copyright © 2026 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved.

2026-07-30T13:01:02

(BPT) – Blood cancers develop when changes in DNA cause blood-forming cells to grow abnormally. Instead of producing healthy blood cells that support the immune system and carry oxygen through the body, these altered cells multiply in an uncontrolled way. Over time, this can weaken the immune system and make it harder for the body to fight infection and perform essential functions.

Types of blood cancer: leukemia, lymphoma and myeloma

The most common types of blood cancer are leukemia, lymphoma and myeloma. Together, they account for the majority of hematologic malignancies, with more than 190,000 new cases projected each year in the U.S.

• Leukemia forms in the blood and bone marrow and is caused by the rapid production of abnormal white blood cells. There are several types of leukemia, which include acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia and chronic myeloid leukemia.
• Lymphoma develops in the lymphatic system, a network of organs, vessels and tissues that helps protect the body from infection. It is often classified as either Hodgkin lymphoma or non-Hodgkin lymphoma, depending on the type of lymphocyte involved and specific cellular features.
• Myeloma, also known as multiple myeloma, forms in plasma cells found in the bone marrow. Unlike cancers that first appear in one location, myeloma can occur in multiple areas of the bone marrow at the same time.

Rare blood cancers: myeloproliferative neoplasms (MPNs) and myelodysplastic syndromes (MDS)

In addition to the previously listed more common blood cancers, there are rarer related blood disorders, such as myeloproliferative neoplasms (MPNs) and myelodysplastic syndromes (MDS). About 20,000 new cases of MPNs and MDS are diagnosed each year in the U.S. MPNs occur when the bone marrow produces too many blood cells, while MDS develops when blood cells do not mature properly and are unable to become healthy cells. The main types of MPNs include essential thrombocythemia, primary myelofibrosis and polycythemia vera.

As the number of people affected by blood cancers and disorders continues to rise, scientists at Merck are exploring innovative strategies aimed at improving outcomes for patients living with these complex and challenging conditions. These approaches focus on enhancing the body’s response to cancer, targeting cancer cells more precisely and addressing pathways that drive cancer growth.

Merck is currently investigating several potential innovative treatment approaches for hematologic malignancies across a broad range of different disease pathways, including:

• Targeting ROR1, a protein that is overexpressed in multiple hematologic malignancies

• Evaluating the role of Bruton’s tyrosine kinase, including common mechanisms of resistance for patients with certain hematologic malignancies

• Targeting lysine-specific demethylase 1 (LSD1), an enzyme that is potentially important for regulating the uncontrolled reproduction of blood stem cells and the maturation of blood cells in the bone marrow

• Evaluating the role of the BCR::ABL novel protein in white blood cell proliferation

• Researching T-cell engagement for certain types of leukemia and lymphoma

“Our team is building on our legacy in oncology to understand how various mechanisms and modalities could address blood cancers in innovative ways,” said Dr. Shweta Jain, vice president, oncology clinical research, Merck Research Laboratories. “By exploring multiple potential novel mechanisms of action across a broad range of blood cancers and disorders, we hope to help address longstanding unmet needs for patients with hematologic malignancies.”

Through ongoing studies and clinical trials, Merck is working to advance clinical research for patients living with blood cancers and disorders. Learn more about Merck’s hematology research and clinical trials.

2026-07-24T12:01:00

(BPT) – Key takeaways

• Habits, routines and environmental cues work together to influence your body’s natural sleep-wake cycle.
• One of the most important players in that ecosystem is melatonin, which helps signal to your brain that it’s time to wind down.
• Better sleep is one of the strongest investments you can make in your health and well-being.

Americans have never been more focused on optimizing their health. They wear devices that measure nearly every aspect of their day — from workouts and steps to heart rate and recovery — and increasingly turn to GLP-1 medications as part of the weight management journey.

Alongside these changes, experts are encouraging people to prioritize another key pillar of health: quality sleep, which plays an important role in overall well-being and can support healthy lifestyle habits.

According to the Centers for Disease Control and Prevention (CDC), more than 30% of U.S. adults regularly get less than the recommended seven to nine hours of sleep each night¹.

Dr. Stephanie Stahl, Medical Director at Indiana University Health, notes that many people still treat sleep as something they’ll fit in if there’s time. Stahl is the Sleep Medicine Fellowship Program Director and Associate Professor at Indiana University School of Medicine as well as Natrol^® Sleep Science Advisory Board member. “Many people think of sleep as the first thing they can sacrifice when life gets busy. But sleep isn’t a luxury. It’s one of the most powerful tools we have to support our health, mental well-being and daily performance.”

That can be difficult in today’s always-on world. Packed schedules, constant notifications and late-night scrolling can all work against the body’s natural sleep-wake cycle. In fact, 38% of adults say using their phone or tablet before bed to read the news or “doomscroll” makes their sleep somewhat or significantly worse².

What sleep myths could be keeping you awake?

“One of the biggest misconceptions I hear is that sleep starts when your head hits the pillow,” said Stahl. “The truth is that your body has been preparing for sleep all day. Your light exposure, activity, meals, stress and evening routine all influence how prepared your brain and body are for sleep.”

She describes this as your sleep ecosystem — the daily habits, routines and environmental cues that work together to influence your body’s natural sleep-wake cycle. One of the most important players in that ecosystem is melatonin, a hormone your body naturally produces in response to darkness. Rather than forcing sleep, melatonin helps signal to your brain that it’s time to wind down.

Stahl is helping to debunk three common sleep myths:

Myth: Better sleep starts at bedtime.

Stahl: “Great sleep starts the moment you wake up. Morning sunlight helps regulate your body’s internal clock and supports natural melatonin production later that evening.”

Myth: I’ll catch up on sleep this weekend.

Stahl: “Consistency matters more than catch-up sleep. Keeping a regular sleep and wake schedule (yes, even on weekends) helps reinforce your body’s natural rhythm.”

Myth: The eight hours you’re asleep are all that matter.

Stahl: “The hour before bed matters, too. A consistent wind-down routine, like dimming the lights and avoiding screen time, helps prepare your brain and body for quality sleep.”

What small habits lead to better sleep?

The good news is that improving sleep doesn’t require overhauling your lifestyle. Stahl recommends focusing on a few consistent habits: Get outside for natural light early in the day, stay physically active, avoid caffeine in the afternoon and evening, maintain a regular sleep schedule and create a cool, dark, quiet sleep environment.

When healthy habits need extra support that is safe

Healthy sleep habits are the foundation of better sleep, but even the best routines can’t account for everything. Travel, shift work, changing schedules, stress and age-related changes can all temporarily disrupt your body’s natural rhythm.

It’s one reason more than 27% of U.S. adults report using melatonin supplements, making it one of the country’s most commonly used sleep supplements³. Melatonin is a well-studied naturally occurring hormone that plays a key role in regulating the sleep-wake cycle. When used as directed, it is widely recognized as a safe, effective and non-habit-forming option for temporary sleep support. Backed by 30 years of scientific research and widespread use, melatonin is the No. 1 doctor recommended ingredient for sleep⁴, recognized by experts as a safe, reliable way to help people fall asleep faster and stay asleep longer*.

“Healthy sleep starts with healthy habits,” says Stahl. “Melatonin is a hormone your body naturally produces to help signal when it’s time to sleep. If travel, changing schedules or other temporary disruptions affect that rhythm, melatonin supplements can help support your body’s natural sleep-wake cycle. The key is to think of it as one part of a broader sleep strategy, not a replacement for healthy habits.”

Because sleep challenges vary from person to person, some people may also benefit from ingredients such as magnesium glycinate, valerian root, GABA or L-theanine depending on their individual needs. Guided by leading sleep experts, including Stahl, Natrol develops science-backed sleep solutions designed to complement healthy sleep habits and support different sleep needs.

The benefits of prioritizing sleep extend well beyond feeling rested — 88% of adults who are satisfied with their sleep, report they are flourishing, compared with just 47% of those who aren’t⁵. Better sleep isn’t just another wellness goal. It’s one of the strongest investments you can make in your overall health and well-being.

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

SOURCES:

1. Centers for Disease Control and Prevention. Short Sleep Duration Among Adults. National Center for Health Statistics, U.S. Department of Health and Human Services, 2025, https://www.cdc.gov/nchs/products/databriefs/db559.htm. Accessed 26 June 2026.
2. American Academy of Sleep Medicine. “Americans Are Doomscrolling at Bedtime, Prioritizing Screen Time Over Sleep.” American Academy of Sleep Medicine, 2025, https://aasm.org/americans-are-doomscrolling-at-bedtime-prioritizing-screen-time-over-sleep/. Accessed 26 June 2026.
3. SleepFoundation.org survey. October 2022. https://www.sleepfoundation.org/sleep-news/how-much-melatonin-do-adults-really-take.
4. Based on a survey of doctors who recommend sleep support products.
5. National Sleep Foundation. Sleep in America^® 2025 Report. National Sleep Foundation, March 2025, https://www.thensf.org/wp-content/uploads/2025/03/NSF_SIA_2025-Report_final.pdf. Accessed 26 June 2026.

2026-07-22T07:01:00

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