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Hope Springs Eternal: An Indiana Mother’s Journey to a Kidney Transplant.

2020-12-14T07:05:00

(BPT) – Kindness spreads kindness. Unexpected kindness, while often surprising, has the potential to heal and change a life.

The trajectory of 38-year-old Rebecca Barcenas’ life has been forever changed by unexpected kindness. A mother of two girls, she was diagnosed with chronic kidney disease during her second pregnancy. Her kidneys failed a year later.

Over the next eight years, Barcenas received life-sustaining dialysis treatment four hours a day, three days per week at DaVita University Dialysis of Indy in Indianapolis, where she was introduced to Toni Brown, licensed clinical social worker, whose role it is to educate dialysis patients on transplants. She also leaned on her faith to help her through the ups and downs of her disease.

“I don’t know where I’d be without my priest,” said Barcenas. “The staff at St. Philip Neri know everything about my family and the challenges I’ve faced. When I missed a few of my daughter’s holiday performances, they reached out to help. They gave me faith to keep going.”

During her dialysis treatments, Brown and Barcenas discussed Barcenas’ future.

A kidney transplant is the best treatment option for eligible patients with end-stage kidney disease. Outside of her kidneys, Barcenas is very healthy. But her immigration status posed some challenges. She provided updated, official documentation of her visa, which was initially denied by her transplant center. When that happened, Brown got to work.

“I just started calling the transplant center, two, three days a week, every week, I wouldn’t take no for an answer,” relayed Brown.

As Brown made her calls, Barcenas’ priest and parish staff did the same. The barrage of communication paid off. Barcenas was officially referred for a kidney transplant evaluation in July 2019. By that December, she had connected and matched with a living donor. Suddenly, after years of waiting, Barcenas had a path forward.

“Advocating for others shouldn’t be unexpected,” said Brown. “They’re sick and going through so much.”

The road to a new kidney was still a little bumpy for Barcenas. Her transplant was postponed twice — first following a bout with anemia and then due to COVID-19 restrictions. Finally, the surgery took place, successfully, on May 14, 2020.

Years of struggle behind her, Barcenas is hopeful of what’s to come. Warm spring days perfect for long bike rides. Spending time with her daughters and watching them perform in their school Christmas plays. Working again. And as the heart of the holiday season approaches, she’s grateful for the unexpected kindness she’s received and plans to return the favor.

According to the United Network for Organ Sharing, 99,316 people in the U.S. are currently waiting for a kidney transplant.1 The average wait time for a kidney from the national deceased donor waiting list is five years.2

Remaining engaged and on-track for a transplant during that waiting period is critical. DaVita, a leader in clinical quality in kidney care for more than 20 years, has designed a comprehensive, multimedia education platform to guide patients through the transplant process. Featuring motivating peer-to-peer videos and animations, Transplant Smart® informs patients and their loved ones about what to expect at every stage of their transplant journey.

To learn more about kidney transplants or giving the gift of life as a living donor, visit DaVita.com/Transplant.

1. United Network for Organ Sharing website. https://www.unos.org/data/transplant-trends/. Based on OPTN data as of Dec. 8, 2020

2. American Kidney Fund website. https://www.kidneyfund.org/kidney-disease/kidney-failure/treatment-of-kidney-failure/kidney-transplant/transplant-waitlist/. Dec. 2020


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Navy Vet is Armed with a Wearable Device during Battle against Cancer

2020-12-14T14:01:01

(BPT) – When Navy vet Terry O’Keefe first started to get sick, he was enjoying his retirement, touring the U.S. in an R.V. with his wife, Diane.

At first, the couple thought that Terry just had allergies, but as Terry’s condition became steadily worse as they drove from state to state, Diane became worried.

“Finally, Diane said, ‘You are going to the hospital and that’s it.’”

The couple would soon learn that Terry had malignant pleural mesothelioma (MPM), a rare but severe form of cancer that affects the linings of the lungs.

Terry’s problems with MPM likely started decades before, during his time with the U.S. Navy in the 1970s. Here, while working in his ship’s boiler room, he had close contact with asbestos.

“It was everywhere. Everything had asbestos on it, in it, around it,” Terry recalled from his home in Pennsylvania. “The dust in the boiler room was like snow — we’d make snowballs and throw it at each other. We were a bunch of dumb kids; we didn’t know.”

Asbestos is now known to be the leading cause of MPM. However, symptoms often don’t appear until decades after exposure, which, along with non-specific symptoms, can often lead to delayed diagnosis.

Armed with a diagnosis, Terry next sought treatment, wanting to be ‘as aggressive as I could be.’ Zachary D. Horne, MD, a radiation oncologist at Alleghany Health Network Cancer Institute, recommended a treatment that was approved by the FDA in May 2019 — a wearable device called Optune LuaTM.

“I said, ‘Yes, I’ve got stuff we’re trying to do,’” Terry recalled saying to Dr. Horne. “I’m not ready to give up.”

Optune Lua is a wearable, portable, FDA-approved device developed by Novocure, a global oncology company, and was the first FDA-approved treatment for mesothelioma in 15 years.

According to Horne, “The treatment is non-invasive and delivers treatment directly to the tumor, and most patients experience only minor side effects.”

Optune Lua works by delivering low-intensity, wave-like electric fields via adhesive patches called transducer arrays, placed on a patient’s upper body. These fields, known as Tumor Treating Fields or TTFields are not strong enough to hurt a patient or his or her healthy cells, but are strong enough to slow or stop cancer cells from dividing and may destroy some cancer cells completely. Optune Lua is used together with standard chemotherapy. When used with chemotherapy, skin irritation was the most common side effect.

“Because the electric fields are tuned very specifically to a cell size, they impact the mesothelioma cells, and they leave everything else essentially alone,” Dr. Horne said.

According to Dr. Horne, the more the device is used, the more effective it is.

“When I met Terry I thought to myself, ‘We need to give him the best chance while managing the disease the best we can,’” said Dr. Horne. “The goal with Optune Lua is to slow or stop disease progression for as long as possible.”

Terry and Diane both worked with Dr. Horne and the nCompass team at Novocure, which offers the patient customized support based on their needs. This includes everything from working with a patient’s insurance provider to minimize costs, offering travel assistance and resources, troubleshooting any technical issues 24/7 via phone and more.

“They have helped me with our insurance company, everything,” Diane said.

Part of the nCompass team is a Device Support Specialist (DSS), who not only provides the initial training around using Optune Lua but also conducts monthly check-ins to review treatment usage and offer any tips and resources.

According to Diane, “If we have any questions or anything, she helps us right out.”

While there is an initial adjustment to using the device, Dr. Horne recognizes that it can be a worthwhile treatment for those fighting mesothelioma.

“We look forward to providing Optune Lua as a treatment option for additional patients who may otherwise feel that they have little hope for the future,” Dr. Horne said.

For Terry and Diane, right now they are enjoying their present by hiking, kayaking and going out on nature walks with two dogs. Based on advice from Dr. Horne, Terry is able to wear Optune Lua for all his activities except kayaking.

Terry, whose oldest son tragically died of cancer at the age of 25, hopes that sharing his experiences living with mesothelioma may serve as a motivation to others.

“I have already lived longer than what doctors predicted when I was first diagnosed,” he said. “And I’ve come to the conclusion that my mission in life is to help the next generation … because I’d like to see this — and all these cancers — find a cure.”

Optune Lua for MPM is classified as a Humanitarian Use Device (HUD), approved under the Humanitarian Device Exemption (HDE).

Caution: Federal law restricts this device to sale by or on the order of a physician. Humanitarian Device. Authorized by Federal Law for use in the treatment of adult patients with unresectable, locally advanced or metastatic, malignant pleural mesothelioma concurrently with pemetrexed and platinum-based chemotherapy. The effectiveness of this device for this use has not been demonstrated.

What is Optune Lua™ approved to treat?

Optune Lua is a wearable, portable, FDA-approved device indicated for the treatment of adult patients, with unresectable, locally advanced or metastatic, malignant pleural mesothelioma (MPM) to be used together with standard chemotherapy (pemetrexed and platinum-based chemotherapy).

Who should not use Optune Lua?

Optune Lua is not for everyone. Talk to your doctor if you have:

  • An implanted electronic medical device including a pacemaker, implantable automatic defibrillator, etc. Optune Lua has not been tested in people with implanted electronic devices, which may cause the devices not to work properly
  • A known sensitivity to conductive hydrogels (the gel on the arrays placed on the upper body like the ones used on EKGs). When Optune Lua comes into contact with the skin, it may cause more redness and itching or may rarely cause a life-threatening allergic reaction

Do not use Optune Lua if you are pregnant or are planning to become pregnant. It is not known if Optune Lua is safe or effective during pregnancy.

What should I know before using Optune Lua?

Optune Lua should only be used after receiving training from qualified personnel, such as your doctor, a nurse, or other medical staff who have completed a training course given by Novocure®, the maker of Optune Lua.

  • Do not use any parts that did not come with Optune Lua sent to you by Novocure or given to you by your doctor
  • Do not get the device or transducer arrays wet
  • Please be aware that Optune Lua has a cord that may cause tripping when connected to an electric socket
  • If you have an underlying serious skin condition on the upper body, discuss with your doctor whether this may prevent or temporarily interfere with the Optune Lua treatment

What are the possible side effects of Optune Lua?

Most common side effects of Optune Lua when used together with chemotherapy were low red blood cell count, constipation, nausea, tiredness, chest pain, fatigue, skin irritation from device use, itchy skin, and cough.

Other potential adverse effects associated with the use of Optune Lua include: treatment related skin irritation, allergic reaction to the plaster or to the gel, electrode overheating leading to pain and/or local skin burns, infections at sites of electrode contact with the skin, local warmth and tingling sensation beneath the electrodes, muscle twitching, medical device site reaction and skin breakdown/skin ulcer.

Talk to your doctor if you have any of these side effects or questions.

Please click here to see the Optune Lua Instructions For Use (IFU) for complete information regarding the device’s indications, contraindications, warnings and precautions.

© 2020 Novocure GmbH. All rights reserved. Novocure and Optune Lua are trademarks of Novocure GmbH. US-OPT-04167. December 2020


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COVID-19: What is an Emergency Use Authorization?

2020-12-14T08:01:01

(BPT) – Sponsored by Pfizer.

According to the FDA, an Emergency Use Authorization (EUA) is a mechanism to facilitate the availability and use of medical countermeasures, including vaccines, during public health emergencies, such as the current COVID-19 pandemic.1 An EUA allows the use of medical products, not yet approved, when there are no adequate, approved and available alternatives.2

Since the start of the COVID-19 pandemic, the FDA has issued EUAs for select medical products and drugs it believes may help address the impact of the virus on the American public.3

What are the criteria for a COVID-19 vaccine candidate to receive an EUA?

When the Health and Human Services (HHS) Secretary has issued a public health emergency the FDA may issue an EUA after it has determined that the following requirements are met2:

  • Based on available scientific evidence, including data from clinical trials, it is reasonable to believe that the product may be effective to prevent, diagnose or treat serious or life-threatening diseases or conditions that can be caused by SARS-CoV-2 (the virus that causes COVID-19).
  • The identified and potential benefits of the product, when used to diagnose, prevent or treat the identified serious or life-threatening disease or condition, outweigh the identified and potential risks of the product.
  • There is no adequate, approved and available alternative to the product for diagnosing, preventing or treating the disease or condition.

Who will have access to a vaccine that receives an EUA?

In the U.S., the Centers for Disease Control and Prevention (CDC) will recommend the allocation of vaccine doses and who should receive a vaccine first, if there are not enough doses of the vaccine for everyone. On December 1, the CDC’s Advisory Committee on Immunization Practices (ACIP) made initial recommendations on who should be offered COVID-19 vaccination in the initial phase of the U.S. COVID-19 vaccination program, while there is limited vaccine supply, and recommended that healthcare personnel and residents of long-term care facilities should be prioritized first.4

Will an EUA mean that the vaccine has been tested for safety?

Issuance of an EUA for a COVID-19 vaccine requires a determination by the FDA that the vaccine’s known and potential benefits outweigh its known and potential risks based on data from at least one well-designed Phase 3 clinical trial that demonstrates the vaccine’s safety and efficacy in a clear and compelling manner.2 An EUA for COVID-19 vaccines will be assessed by the FDA on on a case-by-case basis considering all available scientific evidence.2

“The FDA’s Emergency Use Authorization process serves an absolutely critical role during public health emergencies. Throughout the COVID-19 global pandemic, we have welcomed the opportunity to work collaboratively with the FDA, CDC and regulatory agencies around the world to help fight the COVID-19 global pandemic,” noted Donna Boyce, vice president of Global Regulatory Affairs for Vaccines at Pfizer.

PP-CVV-USA-0065 © 2020 Pfizer Inc. All rights reserved. December 2020

1 Emergency Use Authorization for Vaccines Explained. U.S. Food and Drug Administration. Accessed December 10, 2020. https://www.fda.gov/vaccines-blood-biologics/vaccines/emergency-use-authorization-vaccines-explained. Published 2020.

2 US Food and Drug Administration. Emergency use authorization for vaccines to prevent COVID-19 – Guidance for industry. Accessed October 2020. https://www.fda.gov/media/142749/download.

3 Emergency Use Authorization. U.S. Food and Drug Administration. Accessed December 4, 2020. https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization. Published 2020.

4 Centers for Disease Control and Prevention. How CDC is making COVID-19 vaccine recommendations. Accessed November 6, 2020. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations-process.html. Published 2020.


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Easy ways to make your holiday dishes the star of the show

2020-12-14T06:01:00

(BPT) – The holiday season is upon us, and while it may look and feel a bit different from holidays past, there’s still just as much to do. Even if it’s mostly online, we’re busy searching for the perfect presents, decorations galore, favorite festive movies and so much more. And, as always, joyful moments will be celebrated gathered around the table. With this season seemingly busier than ever, Panera knows that it can be hard to find the time (and energy!) to cook a homemade feast for your holiday celebration. To help, Panera has created a collection of festive, delicious recipes that are easy to make and sure to impress everyone at the table.

Crafted by Panera chefs, these recipes can be made with the brand’s line of cafe-inspired grocery products, which can be found at grocery retailers nationwide. Even better, most can be prepared in advance to accommodate hectic holiday schedules. So, whether you’re looking for a new dish to kick off your meal or a dessert to leave your loved ones feeling wowed, we have tasty ideas for you!

1. Broccoli Cheddar Mac & Cheese Cups

Simply irresistible bites bursting with the flavors of two iconic Panera favorites, our newly launched mash-up of Broccoli Cheddar Soup and classic Mac & Cheese becomes a memorable appetizer.

2. BBQ Chicken Ranch Flatbread Pizza

A simple but absolutely delicious flatbread drizzled with our Creamy Buttermilk Ranch Dressing + Dip turns into a true crowd-pleaser when cut into shareable squares.

3. Broccoli Cheddar Stuffed Mushrooms

Our popular Broccoli Cheddar Soup is the hero in these perfectly poppable and shareable appetizers.

4. Cranberry Apple Brie Bites

Featuring our fan-favorite Fuji Apple Vinaigrette Dressing and delicious cranberry sauce, along with baked brie and almonds, this appetizer is a festive addition to any spread.

5. Citrus Avocado Salad

This beautiful fruit salad is a refreshing option that’s sure to impress. Topped with a drizzle of our Poppyseed Dressing and a sprinkle of mint, this salad brings together fresh citrus, creamy avocado and the tart pop of pomegranate seeds.

6. Primavera Mac & Cheese

Colorful vegetables and our signature creamy Mac & Cheese star in this easy meal that the whole crew will love. Try broccoli florets, red and yellow bell peppers, spinach and grape tomatoes to make it look especially festive.

7. Autumn Squash Bread Pudding

Whether enjoyed as a tasty lunch on its own or a key ingredient in a delectable entrée, our Autumn Squash Soup is a versatile option for any and all courses, especially this seasonal dessert. For a delicious indulgence, we recommend serving warm, topped with a dollop of whipped cream or vanilla ice cream and drizzled with caramel sauce.

To find any of the above cafe-inspired grocery products at a store near you, use Panera’s online Find a Store feature: https://www.paneraathome.com/find-a-store.


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How to help teachers in your area during the pandemic

2020-12-14T15:48:22

(BPT) – Our nation’s teachers are facing unprecedented challenges this year due to the COVID-19 pandemic.

Some teachers are implementing new rules, procedures and classroom configurations to limit the spread of the illness. Others are creating entirely new online curricula for students who are learning from home. Many teachers are tasked with doing both at the same time, often without additional financial resources to make it all happen.

A recent survey of 1,000 U.S. teachers by the education nonprofit DonorsChoose found that 42% of teachers were planning to teach in a hybrid format this fall, with students undergoing a combination of online learning and in-person learning. Thirty-five percent were set to teach entirely remotely, with 8% teaching in person and 14% unsure at survey time. Eighty-six percent of teachers reported feeling uncertain, anxious and overwhelmed as they prepared for the school year, and 81% expect that their schools will be forced to go online only at some point this school year.

“I feel like waiting for answers is the hardest part,” notes one teacher who responded to the survey. “It is a wait-and-see with the health and safety of students, families and staff members always in the forefront.”

In the survey, teachers also revealed the resources they most need.

Teachers in the classroom: Cleaning supplies and PPE

Of those teachers who returned to the classroom, 79% said they need cleaning supplies and personal protective equipment (PPE) to keep their students healthy and safe. In fact, DonorsChoose — which allows teachers to create requests for school resources that the public can help fund — has seen a surge in teacher requests for hand sanitizer, cleaning wipes and air filters. Teachers have also been quick to request basic supplies like glue, scissors, crayons and pencils, since 72% of teachers report their schools are no longer allowing students to share materials.

Teachers online: Instructional technology

Many teachers began teaching online at the end of last school year. As school started this fall, 52% of teachers reported feeling more prepared to teach online than they did last spring, but there are still several challenges. The hardest part of teaching online, teachers report, is keeping students engaged. To do so, their greatest need is for instructional technology: laptops, tablets, document cameras and other technology to help them do demonstrations and keep their students interested in the content. Fifty-three percent of teachers also reported a greater need for technology for their students, so they can follow along at home.

All teachers: Professional development

For experienced teachers, the lessons they’ve built and refined over years are being recreated to work for online or socially distanced learning. In the survey, 41% of teachers said the professional development they need most is for online instruction techniques; 20% were interested in learning more about online tools and technology to help them become stronger at remote teaching.

All of these resource needs can add up quickly for teachers. “There will be a much greater need for classroom supplies as teachers have to change many things in their classrooms to keep materials, belongings and children separated,” said another teacher who responded to the survey. “This expense will fall on the teachers.”

Since July, over 350,000 people have helped fund more than 110,000 teacher requests on DonorsChoose to help teachers to have a strong year, whether they’re teaching at home or in the classroom. Still, there are nearly 50,000 teacher requests awaiting support.

To find a teacher request to support, visit www.donorschoose.org.


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How to Design a Successful Home Office

2020-12-14T13:01:01

(BPT) – Sponsored by Office Depot

With the increasing number of organizations allowing employees teleworking options and today’s growing gig economy, proper home office setup ideas are becoming more relevant. People love the flexibility that working from home provides, saving time spent commuting, allowing flexible arrangements and avoiding office distractions.

That is not to say that working from home doesn’t have its own built-in complications. While you may not be able to control how demanding your work life is, you can design your home office for optimal productivity.

Part of optimizing productivity is designing a home office that is completely separate from the rest of your home in order to set boundaries; mixing the two can blur the line between your personal and work life.

The Right Layout and Organization

Having a place for everything in your office is one way to help stay organized and focused. Many will spend the majority of their time at a desk, so keeping the surface clutter-free by using drawers and filing solutions is always a good idea. Consider the right desk for your space allocation. As for the desk’s surface, there are many options for organizing papers, gathering pens and pencils, and making room for additional office supplies.

Larger storage solutions can include file cabinets, bookcases, cabinets and shelving units, bins and drawers. Not only will these storage spaces help keep your workspace neat, but they will also save you time when trying to locate items.

Think About Ergonomics

For work and health purposes, it is much better for a home office to have an ergonomic office chair which promotes better posture while providing support and comfort. For ease of recline, look for chairs that have a tilt mechanism and tile lock, as well as seat and back height adjustments for optimal positioning.

Other things you can ask yourself when choosing an office chair:

  • Is the seat pan comfortable, and does it fit your shape?
  • Is the chair backrest large enough to provide good support?
  • Is there enough hip room when you sit back against the lumbar support?
  • Do you need armrests?
  • Does the chair provide good lumbar support in reclining positions?

A variety of studies show that good chair ergonomics combined with correct body posture can lead to improved productivity. For example, one study from the Institute for Work & Health provided adjustable chairs and ergonomic training to a group of some 200 office-working tax collectors, then measured their comfort levels and productivity. The new chairs yielded dramatic results as well as productivity increases of almost 18%.

Get the Right Equipment

Older equipment and software eventually require upgrades, or workflow needs may have changed. Choosing an all-in-one printer can combine multiple peripherals into one simple unit, allowing for more desktop space. If printing in high volumes, an upgrade from an inkjet to laser printer just might be the thing.

A new computer with the latest security software can better protect against hacking or malware. And along with a more powerful computer, a faster internet connection can boost speed and productivity, as well as provide alternatives for where you choose to work via wireless connectivity.

Newer equipment tends to be more energy-efficient, helping to save on utility bills, and many come with a smaller footprint to free up valuable home office space. Think about the possibility of trading a cumbersome desktop computer system for a sleek laptop that can be stored safely in a desk drawer.

Mistakes Made in Home Office Design

A healthier work-life balance can be achieved by keeping work equipment, files and other supplies in the office away from living spaces to make a clearer distinction between the two mindsets. So, next time you indulge in a hearty breakfast with a warm cup of coffee, avoid bringing it over to your desk and consume your meal in its proper place, in the kitchen or dining room.

Other challenges to home office setup ideas which can undermine mood and productivity include but are not limited to: a cluttered office space, bad lighting and non-ergonomic office furniture.

At the end of the day, you want to design a home office space that you associate with work but makes you feel comfortable, so you can shift gears immediately and hit the ground running.

To learn more about how Office Depot can help you enhance your home office, visit officedepot.com or business.officedepot.com.


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From Cancer to COVID-19, How One Company is Transforming Vaccine Technology

2020-12-14T16:17:01

(BPT) – The race to create and distribute effective COVID-19 vaccines continues. Big pharmaceutical companies are producing promising vaccines and initial distribution is underway, however, this is not without numerous concerns or logistical hurdles. What you don’t hear much about is the smaller biotech companies working hard behind the scenes to develop alternative medicines that have big potential in fighting the novel coronavirus and much more.

Concerns with current big pharma options

The COVID-19 pandemic is rapidly changing vaccine technology, with innovative approaches that are moving away from the use of live viruses towards genetic-based approaches using RNA and DNA vaccines.

Rather than injecting a weakened form of a virus or bacteria into the body, like with the flu vaccine, DNA and RNA vaccines use part of the virus’ own genes to create antigens that stimulate an immune response. So, when someone who was treated with the vaccine gets exposed to the virus later on, their immune system will be able to fight it off more easily and reduce their risk for serious illness.

While it’s critical to produce a safe, effective COVID-19 vaccine, the leading candidates are RNA vaccines, which despite promising results, do have several drawbacks. RNA is very easily destroyed due to the body’s natural enzymes and chemical reactions which will break the RNA apart. As a result, these vaccines need to be manufactured, shipped and stored under very specific and extremely cold conditions in order to try to slow or prevent that breakdown of RNA.

These stability and manufacturing issues can lead to limited production capabilities, leaving governments and communities fighting for available supplies. Distribution and storage is complex, with one option requiring more than -70 degrees Celsius refrigeration. Supply chain issues may be an ongoing issue.

Small biotech with big ideas and the potential to save lives

While leading pharmaceutical companies are spearheading the fight against COVID-19, it’s important to consider the potential technologies that smaller organizations are researching. One of those companies is Orbis Health Solutions, a South Carolina-based biotech using its deep cancer research experience and established vaccine technology to create a new approach to fighting COVID-19 — a DNA vaccine that addresses the shortcomings of the current frontrunners and with the ability to combat future viruses and biological threats.

Based on the research and science of Thomas E. Wagner, Ph.D., the company’s founder and chief scientific officer, the potential COVID-19 vaccine uses a blueprint based on Orbis’ success in treating cancer through personalized vaccines. In addition to positive data from its Phase IIb cancer clinical trial, proof-of-concept studies have demonstrated that Orbis’ vaccine technology platform has a wide range of possibility, from addressing agriculture and veterinary applications to fighting future pandemics and biological threats.

“We have developed a very successful vaccine against cancer, which is the most difficult challenge for the immune system,” says Wagner. “Now we’ve shifted our science and technology to fight the current COVID-19 pandemic and what we’re seeing is incredibly hopeful.”

The science for the new vaccine is based on cancer vaccine technology that delivers foreign substances (antigens) to help the immune system to recognize an invader and trigger an immune response. In cancer therapy, this is created with antigens from a patients’ own tumor. For COVID-19, Orbis scientists have created a synthetic replica of portions of the DNA code of the virus focusing on the spike proteins, which is the external part of the virus that penetrates a healthy cell. The vaccine contains this information in order to trigger a response and help teach the immune system how to fight the foreign invader and eliminate the virus.

Neutralizing antibodies in 100% of trial participants

The good news: Early data shows promise. Results of a clinical trial evaluating 20 healthy volunteers demonstrated that one inoculation with the vaccine led to 100% of participants expressing neutralizing antibodies against the virus, meaning the vaccine is successful in triggering that critical immune response to COVID-19.

The Orbis COVID-19 vaccine doesn’t use any part of the virus itself, only the DNA encoding the spike protein. For this reason, it is believed to be a safe option with few side effects. What’s more, there’s no need for low-temperature storage and it’s highly scalable, so it may be easier to quickly get enough vaccine worldwide, especially to those who need it most.

“We are very encouraged by these Phase I data, which represent a critical milestone for our vaccine technology platform and echo the early success of our personalized cancer vaccine,” said George E. Peoples, M.D., chief medical officer of Orbis Health Solutions. “Following further data analysis and discussion with regulatory authorities, we remain committed to initiating a larger Phase II trial that will move us one step closer to bringing this important treatment to patients as soon as possible so that we can help address this global health emergency.”

These trials are particularly important because if successful, they will provide definitive proof of concept for the platform that could be rapidly applied to future vaccines to help with new viruses and health concerns within a matter of weeks versus months to years. To learn more, visit http://orbishealthsolutions.com/.

“Just as COVID-19 didn’t exist a few years ago, other diseases and viruses will evolve,” Wagner says. “The proprietary delivery platform for the Orbis vaccine provides a blueprint that can be updated quickly with different DNA information, which allows for rapid vaccine development and deployment to address the next viral or biological threat. This platform has the potential to save many lives both now and in the future.”


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7 signs you might need new water pipes

2020-12-14T18:33:32

(BPT) – While spending more time at home, you’ve probably started noticing repairs you need to make. You may have even tackled a few home improvement projects. However, there are some improvements you might not consider, because they’re hidden until they reach their breaking point — like your home’s plumbing system.

You rely on the pipes to bring safe water into your home for cleaning, laundry and drinking every day. But you can’t usually tell something is wrong until they leak, creating water damage costing thousands of dollars.

There are signs that indicate it’s time to repipe your home. And when you do it right, that one project can save thousands of dollars and lots of future headaches by preventing leaks, water damage and unsafe drinking water.

Here’s what to look for.

1. Is your home over 50 years old?

If the original pipes weren’t replaced, repiping might be a good idea — before large-scale water damage occurs. Older homes typically used galvanized pipes prone to corrosion, leaking and bursting.

If your house was built even earlier — around the 1920s — the pipes were probably made of polybutylene and/or lead. These materials are dangerous and should be replaced immediately. Polybutylene is highly prone to breaking and leaking, so it’s only a matter of time before a serious problem occurs. And lead seeps into drinking water, which can cause serious health problems for your family.

2. Do you have low water pressure?

When pipes contain rust or mineral buildup, it eventually restricts water flow into the house. By the time it affects your water pressure, it’s the result of years of buildup — a clear sign repiping is needed.

3. Have you had leaks?

Bigger problems start small. If you’ve welded or patched leaks in small sections of pipe, this can indicate your entire system is at risk.

4. Do you see a problem?

Stains, flaking, indentations or rust on the pipes signals corrosion. Corroding pipes may leak and should be replaced. Rusty pipes can also turn water reddish or brown, indicating the need to repipe to make your water healthy to drink.

5. Does your water taste or smell bad?

An unappealing smell or taste may also mean your water is unsafe, because of a breakdown of your pipes. It’s best to have them inspected immediately — and drink bottled water in the meantime.

6. Is it making odd noises?

If your plumbing rattles, clanks or bangs, this is a sign of a larger problem. You should have your pipes checked right away.

7. Does it run hot and cold?

If your shower quickly switches from icy cold to burning hot, corroded materials may have broken off inside the pipes and jammed the anti-scald device or valve regulating your water temperature.

The inspection

If any of these signs sound familiar, contact a professional. Each house is different, requiring a unique repiping solution. Professionals like Uponor Pro Squad experts are trained on multiple installation configurations and considerations that can arise in your home.

These experts do a thorough site analysis first, checking your home for signs of leaks, such as moisture, mildew, foundation cracks and a running water meter. They also conduct a water-usage review. Their inspection and recommendations allow you to be proactive and prevent problems before they occur.

The solution

Once the problem is identified, it’s vital to replace pipes with a more durable material. One innovative solution to repiping homes is using Uponor AquaPEX, a flexible polymer piping material that resists corrosion, pitting and scale buildup while also offering greater resiliency in freezing conditions. Flexible crosslinked polyethylene (PEX) pipe lasts longer and also makes repiping less invasive. The pipe can bend around corners and fit into tight spaces without having to cut large holes in drywall.

Its benefits include:

  • Highest industry rating for drinking water safety
  • Faster, safer, easier installation
  • Flexible for fewer fittings and better system performance
  • Resists corrosion, pitting and scale buildup
  • Sustainably produced
  • Expands to minimize damage from frozen water
  • Backed by a 25-year transferable limited warranty

Repiping using PEX can give you peace of mind by protecting your home and family from future water disasters, costly repairs and unsafe drinking water.

For more information, visit ConnectWithUponorProSquad.com.


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The pandemic has increased plastic consumption: How you can help

2020-12-14T18:42:11

(BPT) – The COVID-19 pandemic has increased the consumption of single-use plastic as disposable mask and glove usage has skyrocketed. Additionally, many businesses have eliminated the option to use reusable shopping bags at a store or to bring your own mug to a coffee shop.

These measures are important to help stop the spread of the virus but there are simple steps to take to help reduce your single-use plastic consumption and achieve a more sustainable way of living, even during the coronavirus pandemic. Here are six ideas:

1) Buy local

If possible, get out to your local farmers market or butcher for your grocery shopping. Farmers market vendors often use less packaging and you can ask your butcher to wrap your meat in wax paper instead of plastic. Shopping local is also a great way to support your community.

2) Swap your cleaning tools

The leading spray mop uses single-use plastic pads. One greener choice, the O-Cedar ProMist MAX Microfiber Spray Mop features a reusable, machine washable microfiber pad and a refillable bottle to cut down on plastic waste while removing over 99%of E. coli and Staph. aureus from pre-finished hardwood flooring and ceramic tile using tap water, as tested at an independent accredited lab.

3) Plate over bowl, bowl over plate

If you’re doing more cooking at home, you’re likely finding yourself with leftovers. Ditch the plastic wrap and use your dishes as an easy, inexpensive food storage solution. To do this, place a plate or saucer over a bowl to cover its contents or, alternatively, flip any size bowl over leftovers on a plate. It’s a simple solution using what you already have. You’ll be protecting your food from drying out in the fridge while eliminating your plastic waste.

4) DIY cleaning solutions

With all the extra cleaning you’re doing around the house, buying cleaning solutions in disposable bottles for your home can be expensive and result in additional plastic waste. The average household goes through 18 bottles a year of cleaning solution when using the leading disposable spray mop. (Calculated using consumer consumption data found in Linkage Research Report: Spray Mop Habits & Practices Study (March 10, 2020).) Instead use a refillable bottle and make your own cleaning solution using water and your choice of vinegar or castile soap.

5) Wear a cloth mask

Safety guidelines make it difficult to go anywhere without wearing a face covering. But the popularity of disposable face masks has impacted the amount of plastic in the waste stream, according to a report by the LA Times. Do your part by opting to wear reusable, cloth masks – you can find them just about anywhere these days.

6) Avoid plastic where you can

When you’re ordering takeout, be sure to ask the restaurant to leave out any extra disposable materials. For example, let them know you don’t need disposable silverware. And although most coffee shops and cafes aren’t accepting reusable drink containers, you can still bring your own reusable straw.

These tips make it easier to do your part in reducing plastic waste. For more information, visit https://ocedar.com/swap-your-mop/.


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5 ways COVID-19 changed our daily drive

2020-12-14T12:01:00

(BPT) – It is an indisputable fact that the COVID-19 pandemic changed a lot about our daily lives, including our relationships with our vehicles. While Hankook Tire’s latest Gauge Index found that 60% of Americans are driving every day, as opposed to only 19% in April 2020, many of our habits behind the wheel have shifted in light of everything this year put in front of us.

1) We’re spending less money at the gas pump.

The COVID-19 pandemic quickly closed many regular driving destinations, including office buildings, schools, restaurants and retail, which in turn gave drivers fewer places to go. While the amount of driving we’ll be doing over the next few months is still uncertain, the positive impact on wallets is still there: 70% of Americans say that they have spent less money on gas since the start of the pandemic.

And when they do need to fill up the tank, drivers are strategic about it. Since the pandemic, over three-fourths (77%) make a plan to get gas while running errands to limit their time out of the house.

2) There are designated errand runs — and designated runners.

Americans are also strategic with how and when they leave the house for essentials. Many are not comfortable making a quick run to the store to pick up something they forgot for dinner. Nearly two-thirds (64%) say they now save all of their errands for one day or do curbside orders to limit potential exposure to the virus. Another half (53%) have a designated errand runner, so only one person has to leave the house.

3) Rush hour is less rushed.

With more Americans continuing to work from home and students taking classes online, rush hour is proving less intense. Nearly two-thirds (63%) of drivers recognize that normal traffic patterns have shifted since the start of 2020. Another 65% confirm there is less traffic on their regular routes — though that largely depends on where you live. Hankook found that drivers in the Northeast saw the most significant impact on their regular traffic flow, where 71% of drivers say their daily routes have fewer cars on the road.

4) Comfort levels are shifting gears.

As a result of the pandemic, 75% of Americans are not comfortable using public transportation. However, confidence behind the wheel is down, too — just over a third (36%) say they are less confident driving since the start of the pandemic, perhaps because they aren’t doing so as often. Interestingly enough, men are almost twice as likely to say they’re less confident behind the wheel as women … 44% vs. 28%.

Additionally, people are careful about who they drive with. Two-thirds (66%) are not comfortable getting into a car that belongs to someone outside their household. Another two-thirds (63%) are not comfortable having passengers from outside their household in their own vehicle.

5) Face masks are the new sunglasses.

2020 has not just changed when and where we use our cars, it is also changing what we keep in them. Most Americans (81%) keep a face mask in their car, the Gauge found. More than half (55%) have a designated spot for it in their vehicles — be it in the glove compartment, center console, rearview mirror, or the gear shift. And 72% say they have hand sanitizer in their vehicle, too.

We will have to wait and see which of these trends will stick around and which are more temporary reactions to a tumultuous year. However, one thing is for certain: The COVID-19 pandemic significantly impacted how we view, use and depend on our vehicles.