3 tips on how to be a savvy spender this summer

2023-05-02T15:01:00

(BPT) – Summer is the season of events — from graduations and BBQs to weddings and holiday weekends, these next few months are filled with exciting plans. As commitments add up, so can the prices. This can prevent us from buying that thing we’ve had our eyes on or booking a trip for some well-deserved rest and relaxation.

As summer creeps closer, plan to make the most out of the moments that matter by channeling these tips:

Make a list and earn on every purchase

For those who enjoy hosting, planning the perfect summer party can add up, especially as prices go up. Before heading to the store (or clicking confirm purchase online), create a checklist with everything you need to buy. This way you can avoid over-buying while at the store and remove items that aren’t necessary (maybe even get creative and DIY decorations!).

With all this party prep, make sure you’re using a cash back credit card, like the Chase Freedom Unlimited®, so you’re able to get rewarded on every purchase and earn 1.5% cash back on every $1 spent. Cardmembers can link their card to Amazon to shop and instantly redeem cash back rewards on eligible purchases at checkout, including tax and shipping.

Maximize travel purchases

Thinking about a long weekend getaway or big family vacation this summer? We all know it’s important to research flights or hotel prices ahead of time, but many forget to check the rewards or offers available through their credit card. For example, Chase Freedom Unlimited cardmembers can earn 5% cash back on travel purchases through Chase Ultimate Rewards®, so they’re able to earn rewards toward their next trip.

And when you’re packing, don’t forget to bring your Chase Freedom Unlimited card along for the trip — you’ll earn 3% cash back on dining (including takeout and eligible delivery services) and drugstore purchases (think: sunscreen, snacks and other last-minute needs).

Stay alert for deals and offers

There’s a good chance you’re celebrating someone this summer — whether it’s for Mother’s Day, a graduation or even a wedding — so you’ll also need to budget for a few gifts. Start thinking of ideas early and sign up for emails from popular retailers so you can stay up to date on sales.

If you’re shopping during the month of May, be sure to check out Chase’s Month of More, a month-long promotion where cardmembers can score some of the best offers and earn higher cash back on a variety of popular brands. Cardmembers can save up to 15% on gift cards from Macy’s, Wayfair and Chipotle and earn 5% or more cash back from favorite brands like Sam’s Club, Walmart, Athleta, Neiman Marcus, Sephora, Lowes, Nike and more. Cardmembers can also get 10% more value for their points at Chase Apple Rewards Store.

Start your summer off right by maximizing every purchase and earning rewards. Plus, new Chase Freedom Unlimited cardmembers earn a $200 bonus after spending $500 on purchases in the first three months from account opening.

No matter how you plan to celebrate this summer, make the most of your spending!

Don’t sweat it — how to keep your cool even under heat and stress

2023-05-02T08:01:00

(BPT) – Plenty of things can make you sweat — hot weather on a summer day, strenuous physical activity or feeling stressed out. But why do you smell worse when you’re stressed compared to after a workout or an afternoon in the sun? What you may not know is that there are three different kinds of sweat — stress, heat and activity — and they come from different glands in your body.

“Compared to heat and activity sweat (salt water that comes from eccrine glands), odor from stress sweat from the apocrine glands smells worse because it contains food for the bacteria on our skin,” said Dr. Maiysha D. Jones, Principal Scientist, North America Personal Care at Procter and Gamble. “When bacteria consume the fat and proteins in stress sweat, they produce foul-smelling gases that we perceive as body odor.”

So what can you do to cut down on all three types of sweat, especially the smelliest stress sweat? Here are some tips to help you stay cool in the summer heat and conquer your stress so you can be at your best, no matter what you’re doing:

  • Keep your cool while outside in the summer sun: As the temps start heating up, make sure not to overdo it, especially if you’re outdoors for a long period of time. Remember to stay hydrated and keep water handy. If possible, cool your body down with a dip in the pool — even running cold water on your face can help you feel cooler.
  • Be careful when exercising in the heat: It’s easy to get overheated when you’re working out, playing sports or doing yard work during the warmer months, so it’s important to safeguard your health while doing activities outside. Try to work out in the early morning or late evening to avoid the hottest times of the day and choose moisture-wicking clothing to keep you cool.
  • Protect against sweat and odor: No matter the type of sweat you experience the most, Secret Clinical Antiperspirant/Deodorant has you covered. It’s made with advanced odor fighters, provides 72-hour sweat protection, it’s clinically proven to fight sweat from stress, heat and activity, and it comes in several delightful scents.
  • Take mindful steps to reduce stress: Everyone experiences stress sometimes, whether due to work demands, unexpected events or everyday obligations. Take the time to replenish your energy and try stress-relieving activities such as deep breathing, unplugging from social media or computer screens, listening to music, or spending time outdoors to enjoy nature.

“While most of us can’t avoid sweating altogether, we can stay protected with products that keep us feeling confident,” added Jones. “Secret Clinical fights sweat from stress, heat and activity so no matter what the day brings, you’ll be ready to take it on.”

Visit Secret.com to find the best product for you or find Secret Clinical at retailers nationwide.

Four Substitute Educators Honored by Kelly Education to Kick Off Teacher Appreciation in May

2023-05-02T08:01:00

(BPT) – As May rolls around each year, we are reminded to show our appreciation for the educators who have dedicated themselves to shaping our future generations. It’s not just the classroom teachers who deserve our gratitude — we should also acknowledge the invaluable contributions of substitute teachers and non-instructional support staff who play a crucial role in student achievement.

Substitute educators aren’t just temporary teachers.

Substitute teachers have a unique opportunity to positively impact the lives of children, and their role is essential for students to succeed academically. When a teacher is absent, a substitute teacher helps to maintain the continuity of learning by teaching lesson plans and curriculum established by the classroom teacher. While quickly adapting to new classroom environments and routines, substitute teachers ensure students receive a quality education with minimal disruptions to the learning environment.

Even before the COVID-19 pandemic, substitute educators have been critical in filling the gap of absent full-time educators, and demand has only increased. According to the Bureau of Labor Statistics, nearly 600,000 substitute teachers cover more than 30 million absent teachers in K-12 schools annually. Findings from a recent National Center for Education Statistics report indicate that “as of October 2022, 6 percent of all public school non-teaching staff positions were vacant. The average public school had one vacant non-teaching staff position.”

In many ways, substitute educators are the unsung heroes of the educational system in our country.

Celebrating substitute educators

To honor the contribution of substitute teachers and non-instructional substitute educators such as paraprofessionals, nurses and food service workers, Kelly Education, the nation’s largest education staffing provider, has had a longstanding tradition of recognizing the achievements of substitute educators with its annual Substitute Educator of the Year Award.

This year, Kelly Education chose four educators for the 2023 Substitute Educator of the Year Award. Criteria included current employment by Kelly Education and a nomination by a school colleague demonstrating how the educator enriched the lives of students and peers in their school community. Each winner receives a $5,000 bonus plus an additional $1,500 to give to the school of their choice.

Check out how the four winners of this year’s award are changing students’ lives one classroom at a time.

Jim Rue retired from teaching full-time in Saint Paul, MN. However, he continues to serve as a substitute educator at Belwin Outdoor Science, where he previously taught. Working as a substitute teacher allowed him to work with students outdoors while maintaining a flexible schedule and his skills as an educator.

“Never underestimate the positive effect you can have on a young person’s life,” said Rue. “Substitute teachers should never lose sight of being able to change a student’s life. That positive influence may not be seen by them until years down the road or ever, but what you do does have an impact.”

Bonnie Weeks graduated from Brigham Young University and immediately began teaching second grade full-time. After several years as an educator, she chose to stay home to raise her children and later cared for her aging parents. After they passed away, she began working as a substitute teacher.

“Throughout the years, I never lost my passion for teaching,” said Weeks. “The best part of each day is positively influencing the students’ lives. When I can help a student, particularly one who struggles, learn and understand a concept, it brings me great satisfaction as it helps build their self-esteem.”

Charles Sheehan is a veteran who retired from the U.S. Army in 2016 and began working with troubled teens in detention. During the pandemic, his family decided to move back home to Florida, where he chose to work as a substitute educator.

“The greatest benefit of working as a substitute teacher with Kelly Education is providing an exceptional education to students in need and having a flexible schedule,” said Sheehan. “Substituting isn’t easy, but it is very rewarding. I enjoy working with and getting to know all the third-grade students and teachers at Belmont Elementary.”

Patricia Phillips is a school nurse in North Kansas City, MO. She retired from hospital care after more than 20 years and went to work in education. She has worked for Kelly Education for 12 years and recently received a certificate from the state of Missouri honoring her 50 years of nursing service.

“Being the nurse, you have the opportunity to help children and teens in all kinds of situations,” said Phillips. “It might be chronic health issues, emergency situations or emotional issues. You have to have a lot of confidence in your assessment skills because you are working alone most of the time. But you also need to know when to reach out for help.”

Creating a robust academic experience requires the contribution of all school employees, especially substitute teachers. This year, during the month of May, take time to thank the substitute educators in your community.

“One of my greatest joys is celebrating the work of our educators,” said Kelly Education President Nicola Soares. “These four educators are extra special because they were all nominated by school colleagues for the positive impact they have on their school community.”

You can learn more about this year’s winners by reading their full profiles on kellyeducation.com.

These top summer 2023 must-haves are dupes that don’t break the bank

2023-05-01T07:01:00

(BPT) – What are the hottest must-haves of summer 2023? Look at social media and you’ll find influencers touting everything from luxury sunglasses to name-brand emotional support water bottles. These items may be great, but they also can come with a hefty price tag and long waitlists.

Because most people don’t have endless time and money, a new movement is gaining traction: de-influencing. Part of this is avoiding name brands and instead buying affordable dupes that have equal features. Yes, that means it’s now ultra cool to buy duplicates that are comparable to the original product and bask in the savings.

With the rise of the de-influencing trend, Reduce, a reusable drinkware company, is launching in Walmart stores nationwide at the perfect time. The Reduce Cold1 40oz straw tumbler is the ultimate dupe for more expensive, name-branded options. It keeps drinks cold for 40 hours, is cup-holder friendly, has an easy-to-grab handle, includes hydration tracking on the inside and is available for just $19.88.

Think this nice price means skimping on style? Not at all. With two new Walmart-exclusive prints — wave and sunset — as well as popular solid colors, you can choose a style that speaks to you and reflects your personality. Now, no matter what summer adventures await, you have a water bottle that performs and looks great.

Other de-influencing examples for saving and staying cool this summer:

Save by making your own pink drink

Everyone knows that light pink drink that, while delicious, can cost a lot for even a modest cup. Instead, grab a jug of Ocean Spray White Cranberry and coconut milk. You can make more than 40 ounces of your own tasty pink drink to enjoy in your new Cold1 40oz.

Reach for designer sunscreen alternatives

Sun protection is essential, especially when you’re spending time outdoors. Instead of dropping over $30 on designer sunscreen, consider options with rave online reviews that give you the same protection for less. An example: e.l.f.’s Suntouchable! Whoa Glow is half the cost of upscale brands.

Use an affordable, durable sports bottle

No need to spend $50 or more on a sports water bottle. Even the most hardcore outdoor adventurer will love Reduce’s affordable Hydrate Pro sports bottle with an easy-clean silicone straw. It comes in five summery colors and is available at Walmart for less than $20.

Get the look of luxury sunglasses for less

A cool pair of shades enhances your style and protects your peepers from the sun’s harsh rays. Instead of shelling out hundreds on luxury eyewear, you can protect your eyes and your wallet by looking for affordable brands, like Goodr sunglasses that are high-quality and stylish.

Opt for a glass tumbler to get your smoothie and boba fix

Enjoy your favorite summer sips in style with the new Aspen glass tumbler that features borosilicate thermo-shock glass with a vacuum-insulated stainless-steel cover and an extra-large straw perfect for protein shakes, green smoothies, boba tea or milkshakes. The Aspen tumbler keeps drinks cold for up to 12 hours, comes in five colors and is available at Walmart for less than $20.

Looking and feeling great this summer doesn’t mean forking out big money for big brands. Look for dupes like these with quality, function and style that cost much less. Get started at Walmart.com.

How confident are you that you’ll be able to retire?

2023-05-02T05:01:00

(BPT) – More Americans are retiring earlier than previous generations. According to a survey by the Federal Reserve Bank, their odds of retiring before age 62 rose to roughly 50% in July 2021, partly due to the pandemic. For many, moving up their retirement seemed like the right choice kgiven the state of the labor market and economy, but many were not and are still not financially prepared to retire.

According to a 2022 retirement confidence survey from the Employee Benefit Research Institute, one in three workers are “not too” or “not at all” confident they will have enough money to live comfortably throughout their retirement. And for those surveyed who say they are confident, retiring “comfortably” only covers the basics like housing, transportation, health care, food and utilities.

Retirement can mean a lot of things, but most people envision it as a time after their working life to enjoy things they may not have had the time to do before. While this looks different from person to person, many look forward to traveling, visiting family and enjoying hobbies.

Are you confident you will be able to retire with your basic expenses covered and enjoy the post-work life you’ve imagined? Check these three things.

1. Define your goals

After decades spent working, the prospect of retirement can feel sudden, and some people may have difficulty envisioning what it will look like. When you picture your retirement, what do you see yourself doing? Traveling abroad and checking cities off your bucket list? Paying for your children’s or grandchildren’s weddings? Setting up a legacy fund for your loved ones?

If you don’t yet know what you want out of retirement, start thinking now. Without clear goals, you won’t know how much money it will take to reach them. Beyond your core living expenses, consider how you would like to spend your time during your “go-go” (the first 10 years of retirement), “slow-go” years (middle retirement), and beyond.

2. See where you stand

Now that you have defined your goals, it’s time to see how your savings, investments, retirement accounts and other assets can support your desired retirement lifestyle. An easy way to check your retirement readiness is to use an online platform like Prudential Stages for Retirement.

This digital tool will take the information you share about your current financial life and retirement goals to determine your personal “confidence score,” which indicates your retirement readiness. In a few steps, you will have a clearer picture of your retirement based on how you are saving and investing today.

3. Speak with an advisor

Once you have a clearer view of the big picture, you can meet with a financial advisor to help map out a step-by-step financial plan. If you do not have a financial advisor, you’re not alone.

Millions of Americans do not have a financial advisor. Some do not because they don’t know how to find someone they trust. Still others may feel an advisor is not for them, mistakenly thinking they need a certain level of wealth to engage a professional’s help. However, establishing a relationship with a financial advisor can help you confidently plan for a better retirement and even give you an edge.

According to the Warrington College of Business, industry data suggests that people who receive professional financial advice can add 1.5%-4% to their portfolio returns over time. Enlisting the help of a financial advisor can make planning for retirement easier and grow your wealth so you can achieve your retirement goals instead of having “just enough,” or even not enough.

Through Prudential Stages for Retirement, you can set up a meeting with a noncommission-based financial advisor who will recommend strategies and products that can help you reach your retirement goals. They will look at your retirement confidence score and establish a personalized plan to help you refine your goals and determine if you’re on track to afford your retirement. You do not have to be an existing Prudential customer; anyone can get started planning a more secure retirement. To learn more and get started, visit Prudential’s Retirement Calculator.

5 tips to find the best deals on gifts for Mom, Dad and your favorite grad

2023-05-01T07:01:00

(BPT) – If it seems like you’re searching for a lot of gifts this time of year, it’s not your imagination. Between Mother’s Day, Father’s Day and graduations, late spring through early summer is filled with celebrations. And as if those occasions weren’t enough, May, June and July are among the most common birthday months, and peak wedding season starts in June.

So if you’re scrambling to find budget-friendly gifts that bring smiles to the faces of your loved ones, here are some tips.

1. Make it personal

Consider ordering a customized item your gift recipient will know is unique. Several sites online can create almost any gift item marked with your friend or family member’s name, a personalized message or even a photo. Even more memorable would be choosing a favorite image with the two of you together, then creating a framed keepsake of that moment labeled with your names and the occasion.

2. Celebrate what makes them unique

Show your support for your loved ones by recognizing and encouraging their talents and passions. If your dad loves gardening, your mom is an avid crafter and your brother is great at drawing, assemble a box or basket filled with supplies they can use to do whatever it is they love most.

3. Find the best deals to stretch your dollar

To gift your friends and family the way you want, it pays to find great deals. Using Microsoft Edge as your web browser can make all the difference — it’s the best browser for shopping, with built-in tools right there in the sidebar like coupons, price comparison, price history and cash back. You don’t have to leave your browser tab or download any extensions. Combined with the new AI-powered Microsoft Bing search engine, you can find what you’re looking for quickly and easily, make smart shopping decisions, and even get inspired with unique and thoughtful gift ideas.

Shoppers can already save up to $400 a year using Microsoft Edge, and during Microsoft Edge Deal Days May 8-14, you can save even more on gifts from some of the most popular retailers with special deals like:

  • Home and decorating essentials with up to 7% cash back on select Walmart purchases and up to 10% cash back on select Ashley Furniture.
  • Laptops designed by Microsoft with up to 11% cash back on Surface Pro 9, up to 8% cash back + $300 off Surface Laptop 5.
  • Upgrade to a new fridge, smartphone or TV with up to 12% cash back on select Samsung products.
  • For a limited time, $10 cash back on one purchase of $100 or more from select retailers like Sephora, Neiman Marcus and Overstock.

4. Gift them an experience

How about gifting your friend or relative a class, a tour or another event you know would interest them? Even better, find something special you can do together, creating a once-in-a-lifetime memory you’ll both cherish forever. Think about an experience you’ve had that you want to share with them, one thing they love to do that you’d also like to explore — or discover a new activity, and join them on the journey.

5. Give them something they’d never treat themselves to

Can you identify an item they’d love, but would never get for themselves? It could be a luxury or treat you know they want, but might feel too self-indulgent to get on their own. This might be a gorgeous gold bracelet or new laptop for Mom, a supply of Dad’s favorite high-end coffee or a superior quality smartphone. If you’re unsure what they’re hankering after, brainstorm with family members to find that special item — and consider chipping in on a luxury item with them so you can aim higher with your gifting goals.

With these tips, you can make this gift-giving season easier, memorable and more affordable. Happy gifting!

How are you planning to cover college costs?

2023-05-01T09:01:00

(BPT) – Your child has applied for schools, and now your mailbox is flooded with financial aid award letters. Do you have a plan for how to cover the rest? Check out the most common options to finance college costs, from CollegeAve.com.

Four tips for small business success

2023-05-01T10:01:00

(BPT) – Sponsored by Office Depot

More women than ever before are using their energy, passion and insights to create new business ventures. What they’ve learned along the way can provide valuable lessons for anyone dreaming of owning their own business or even those who are farther along on their entrepreneurial journeys.

For more than 35 years, Office Depot has offered innovative solutions and support to help business owners achieve success. In 2020, the company became the premier and founding sponsor of Selfmade, Brit + Co’s interactive virtual community and membership program geared towards connecting women with tools, resources, community and coaching to help them start, manage, and grow their own businesses. Through this collaboration, Office Depot has provided hundreds of female entrepreneurs with the opportunity to participate in the program for free via Office Depot OfficeMax-funded scholarships.

In honor of small business week, here are four tips from some of the dynamic small business owners who took part in the Selfmade program. For more stories, studies and strategies for success, visit Office Depot’s content hub, The Stepping Stone.

1. Home in on the big idea

How does someone know their business idea is good? Most importantly, it should address a problem that needs solving. That’s what led Domeanic Carter-Banks to her great idea. Waiting in a car dealership playroom with her three-year-old, who was diagnosed with non-verbal autism, she saw her daughter become frustrated and irritable.

“There were no appropriate sensory toys to hold her focus and attention,” said Carter-Banks. “I wished there was something I could leave behind to help other autistic children and their parents.”

Carter-Banks applied for an Office Depot OfficeMax scholarship to Selfmade to get feedback from others and hone in on her idea for a sensory toy company. After participating in live workshops with business coaches, one-on-one mentoring and group chats with other entrepreneurs like her, she started Masterpiece Kids Box, a curated subscription box for children with autism that encourages sensory and discovery play.

“My advice to busy moms with an idea is to do what you can in small leaps if you can’t make the big one yet,” said Carter-Banks.

2. Build a network and positive mindset

To help prepare for whatever comes next, it helps to learn from others who are on similar paths. “Being an entrepreneur can be a super lonely journey, so having other people there, especially other people who can understand the highs and the lows, is really helpful,” said Karly Hiser of Crann Organic, which sells 100% GOTS certified organic cotton kids’ clothes for the 9.6 million American kids who suffer from eczema, like Hiser’s son.

And every entrepreneur can feel a bit of doubt at some point, but letting it overcome them in a way that prevents them from moving forward can hinder their success. “It’s very easy to let your feelings and negative emotions get in the way,” said Hiser. “Starting off your day with a little bit of meditation, breathing, yoga, whatever it is, really helps to calm your nervous system so that you can approach your day with a really positive attitude.”

3. Stay organized to avoid burnout

Disorganization in the workplace can have many negative impacts like leading to lower-quality work, missed deadlines, wasted time on unproductive tasks and even burnout. Kinsey Egan-McGee is the founder of Claim Your Roots, a virtual hair care platform for women with textured hair, and she prioritizes organization to help stay productive.

“Whether it’s inside or outside of the business, I try to weigh the importance, immediacy, and level of detail something should be dealt with, so I don’t burn out. I have pretty extensive to-do lists that I have broken down by months and weeks. I’ve loved crossing things off my agenda since elementary school, but I also realized as an adult that it’s great to have a list of completed items that you can reference. You just have to be honest with yourself, whether a task has actually been completed or not,” McGee said.

“I make sure to record meetings … so I can be present and not fixated on taking notes. I also always write down questions/talking points to prepare for a meeting with someone,” said McGee.

4. Nurture creativity when the going gets tough

Being a business owner can be overwhelming. How can an entrepreneur feed the creative passion that inspired their dream? Stay open to new ideas — especially when external circumstances throw curve balls. Jenifer Shwartz owned a wholesale bakery when the pandemic hit. After losing sales from events, catering and restaurants, she had to think creatively and pivot fast.

“I thought, let’s start making Japanese cheesecake,” Shwartz recalled. She sold through food delivery services, then fell ill. She had to pause her business, so she freeze-dried the cake. “When I came back to work, I opened a bag of freeze-dried cheesecake, it literally had the same flavor as the fresh-baked cheesecake.”

Her next step was learning how to sell packaged products in stores for her new business, Freezcake. That’s when she saw an opportunity to apply for an Office Depot OfficeMax scholarship to Selfmade. Shwartz also turned to Office Depot for a new printer and laminator machine to help her run her business more smoothly.

Shwartz finds time to nurture her creativity every day. “I always thought that, as a pastry chef, I have to constantly be making new things,” said Shwartz. “But there’s so much creativity in the decision making and different parts of running a business.”

And as a mother of five, she finds ways to be creative at home with her kids as well. “We have lots of coloring, painting, clay. It’s a good way for me to get my creative juices out. I was an artist before I was a pastry chef. Now instead of clay, my medium is flour, sugar and butter!”

Small business giveaway — Lessons in Success

The path to success can get a little bumpy, but the lessons learned along the way can help entrepreneurs take the biggest steps forward. Small business owners can share some of the biggest lessons they’ve learned as a business owner and enter the Office Depot Lessons in Success Small Business Giveaway for a chance to win a $250 Office Depot OfficeMax card to help them achieve their business goals. Winners will be selected at random on or about 5/28/23. Complete the form to enter online at officedepot.com/giveaways.

Small business owners can find innovative products and solutions to help them be successful online at officedepot.com and at Office Depot and OfficeMax stores. They can also take advantage of exclusive benefits and everyday savings on products like furniture, paper and cleaning supplies through the Office Depot® OfficeMax® Business Select program. Now through June 3, a first-year Business Select membership is just $49.

What You Need to Know About Endometrial Cancer and a Potential Treatment Option

2023-04-28T00:00:00

(BPT) – Sponsored by GSK — An estimated 948,000 women will be diagnosed with cancer this year.[i] While breast and cervical cancer may come to mind, a lesser-known, but equally important disease is endometrial cancer, which affects the lining of the uterus. Endometrial cancer is the most common gynecologic malignancy in the US.[ii] Approximately 1 out of 4 people with endometrial cancer have either advanced or recurrent cancer.[iii]

Until recently, people with advanced or recurrent endometrial cancer had limited options.[iv] Unlike breast or cervical cancer, there are no standardized screening tests or exams to detect endometrial cancer early.[v] In addition, advancements in treatment have been slower, especially for recurrent or advanced forms of the disease and for those with specific biomarkers.[vi] A biomarker is a biological marker found in blood, tissue, or cells in the body.[vii] Biomarkers can help your doctor diagnose cancer and may help decide which treatment options may be right for you.[viii] For approximately 25% of people with endometrial cancer, one particular biomarker is mismatch repair deficiency, or dMMR.[ix]

In normal cells, mismatch repair (MMR) is a process that ensures DNA is copied without errors during natural cell growth and replication.[ix] When a repair mechanism is defective, it is known as mismatch repair deficient (dMMR). A dMMR system results in the accumulation of errors, which may lead to an increased risk of cancer.[ix]

To date, there have been limited Food and Drug Administration (FDA)-approved treatment options for those with dMMR recurrent or advanced endometrial cancer whose disease progresses on or after initial treatment with platinum-based chemotherapy; and the prognosis for these patients is poor.[ix] However, with new cases rising and increased attention given to awareness and research, progress is being made for patients.[x]

In 2021, the FDA approved a treatment option, known as JEMPERLI (dostarlimab-gxly for injection 500 mg), for this population of patients with high unmet need, as well as for those with dMMR recurrent or advanced solid tumors.

JEMPERLI is a prescription medicine used to treat adults with certain cancers that have been shown by a laboratory test to be dMMR, and your cancer has returned, or it has spread (advanced cancer). JEMPERLI may be used when:

  • you have a kind of uterine cancer called endometrial cancer, and you have received chemotherapy that contains platinum and it did not work or is no longer working and your cancer cannot be treated by surgery or radiation.
  • you have a solid tumor that progressed during treatment or after treatment, and you have no satisfactory treatment options. This use is approved based on how many patients responded to treatment and how long they responded. Studies are ongoing to confirm the clinical benefit of JEMPERLI for this use.

JEMPERLI is a medicine that may treat certain cancers by working with your immune system. JEMPERLI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Please see below for additional Important Safety Information and full Prescribing Information.

Endometrial cancer has the highest rate of dMMR across all types of tumors.[xi] Tumors with dMMR have certain properties that may make them more likely to respond to an immunotherapy like JEMPERLI.[xii]

For those with dMMR recurrent or advanced endometrial cancer, this treatment may give them, as well as their providers, more tools in their arsenal to face this disease.

As research continues to progress, awareness of the disease and the patients it affects remains important.

JEMPERLI is being studied in other types of cancers. JEMPERLI was studied in 209 patients with dMMR recurrent or advanced solid tumors who had progressed on or following systemic therapy and had no satisfactory alternative treatment options. Some of the dMMR tumor types studied included the following: colorectal cancer, small intestinal cancer, gastric cancers, pancreatic carcinoma, biliary neoplasm, liver cancer, ovarian cancer, adrenal cortical cancer, breast cancer, esophageal cancer, malignant neoplasm of the female genitals, pleural cancer and renal cell carcinoma. It is a positive step forward to see treatments being developed for eligible patients who need them.

Those impacted by dMMR recurrent or advanced solid tumors, including endometrial cancer, should talk to their doctors about potentially available treatment options, such as JEMPERLI and visit jemperli.com to learn more.

Approved Uses

JEMPERLI is a prescription medicine used to treat adults with certain cancers that have been shown by a laboratory test to be mismatch repair deficient (dMMR), and your cancer has returned, or it has spread (advanced cancer).

JEMPERLI may be used when:

  • you have a kind of uterine cancer called endometrial cancer, and you have received chemotherapy that contains platinum and it did not work or is no longer working and your cancer cannot be treated by surgery or radiation.
  • you have a solid tumor that progressed during treatment or after treatment, and you have no satisfactory treatment options. This use is approved based on how many patients responded to treatment and how long they responded. Studies are ongoing to confirm the clinical benefit of JEMPERLI for this use.

It is not known if JEMPERLI is safe and effective in children.

Important Safety Information

JEMPERLI is a medicine that may treat certain cancers by working with your immune system. JEMPERLI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.

Call or see your healthcare provider (HCP) right away if you develop any new or worsening signs or symptoms, including:

Lung problems. Signs and symptoms may include cough, shortness of breath, or chest pain.

Intestinal problems. Signs and symptoms may include diarrhea or more bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.

Liver problems. Signs and symptoms may include yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), or bleeding or bruising more easily than usual.

Hormone gland problems. Signs and symptoms may include headaches that will not go away or unusual headaches, eye sensitivity to light, eye problems, rapid heartbeat, increased sweating, extreme tiredness, weight gain or weight loss, feeling more hungry or thirsty than usual, urinating more often than usual, hair loss, feeling cold, constipation, your voice gets deeper, dizziness or fainting, changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness.

Kidney problems. Signs and symptoms may include change in the amount or color of your urine, blood in your urine, swelling in your ankles, or loss of appetite.

Skin problems. Signs and symptoms may include rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms; or swollen lymph nodes.

Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with JEMPERLI. Call or see your HCP right away for any new or worse signs or symptoms. Signs and symptoms may include chest pain, irregular heartbeat, shortness of breath, swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight; persistent or severe muscle pain or weakness, muscle cramps; low red blood cells, bruising.

Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain.

Rejection of a transplanted organ. Your HCP should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.

Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with JEMPERLI. Your HCP will monitor you for these complications.

Getting medical treatment right away may help keep these problems from becoming more serious. Your HCP will check you for these problems during treatment with JEMPERLI and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your HCP may also need to delay or completely stop treatment with JEMPERLI.

Before receiving JEMPERLI, tell your HCP about all of your medical conditions, including immune system problems such as Crohn’s disease, ulcerative colitis, or lupus; received an organ transplant; have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic); have received radiation treatment to your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.

If you are pregnant or plan to become pregnant, tell your HCP. JEMPERLI can harm your unborn baby. If you are able to become pregnant, your HCP will give you a pregnancy test before you start treatment. Use an effective birth control method during treatment and for 4 months after your last dose of JEMPERLI. Tell your HCP right away if you become pregnant or think you may be pregnant during treatment with JEMPERLI.

If you are breastfeeding or plan to breastfeed, tell your HCP. It is not known if JEMPERLI passes into your breast milk. Do not breastfeed during treatment with JEMPERLI and for 4 months after your last dose.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of JEMPERLI include tiredness and weakness, low red blood cell count (anemia), diarrhea, nausea, decreased number of certain white blood cells, decreased albumin in the blood, increase in certain liver blood tests, decreased salt (sodium) in the blood.

These are not all of the possible side effects of JEMPERLI. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA by calling 1-800-FDA-1088 or visiting www.fda.gov/medwatch.

Please see full Prescribing Information, including Medication Guide for patients.

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©2023 GSK or licensor. DSTCOCO230004 March 2023 Produced in USA.

[i] American Cancer Society. Cancer facts & figures 2023. Accessed February 22, 2023. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2023-cancer-facts-figures.html.

[ii] Mahdy H, Casey MJ, Crotzer D. Endometrial Cancer. StatPearls [Internet]. January 2022. [Updated September 26, 2022]. Accessed February 22, 2023. https://www.ncbi.nlm.nih.gov/books/NBK525981/

[iii] CancerMPact® Patient Metric, Cerner Enviza. Accessed February 22, 2023. https://cancermpact.khapps.com/

[iv] Halla K. J Adv Pract Oncol. 2022;13(1):45­59.

[v] National Cancer Institute (NCI). NCI Endometrial Cancer Screening. Bethesda, MD: U.S. National Institutes of Health (NIH); 2021. Accessed February 22, 2023. https://www.cancer.gov/types/uterine/patient/endometrial-screening-pdq

[vi] Brooks RA, et al. CA Cancer J Clin. 2019;69(4):258­279.

[vii] National Cancer Institute (NCI). NCI Dictionary of Cancer Terms. Bethesda, MD: U.S. National Institutes of Health (NIH); 2021. Accessed February 22, 2023. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/biomarker

[viii] National Cancer Institute (NCI). Biomarker Testing for Cancer Treatment. Bethesda, MD: U.S. National Institutes of Health (NIH); 2021. Accessed February 22, 2023. https://www.cancer.gov/about-cancer/treatment/types/biomarker-testing-cancer-treatment

[ix] Lorenzi M, et al. J Oncol. 2020;2020:1­17.

[x] Ferriss JS, et al. Int J Gynecol Cancer. 2021;31:1165­1174.

[xi] Le DT, et al. Science. 2017;357(6349):409­413.

[xii] Le DT, et al. N Engl J Med. 2015;372(26):2509­2520.