Poison safety tips to keep your family safe this winter

2018-02-21T15:01:00

(BPT) – According to the Centers for Disease Control and Prevention, there are approximately 2 million poisoning incidents per year within the U.S., and more than 90 percent of these occur within the home. This winter, keep your family safe by learning more about the potential for poisoning, how to prevent it and how to get help if an incident occurs, most notably by calling the Poison Help line at 1-800-222-1222.

Follow these tips to have a healthy and safe winter season:

1) Know which winter items are poisonous. There are many household items in use during the winter that may pose a specific poison risk, including antifreeze and snow salt.

Antifreeze is a poisonous liquid used in cars. It has a sweet taste that children and animals like. If even a little is swallowed, it can be harmful and can cause kidney damage and death. Keep antifreeze, household cleaners and all chemicals in the containers they came in with a tight cap and keep away from children and pets. Before throwing away an antifreeze container, be sure to rinse it with water and replace the safety cap.

Salt used on driveways and sidewalks in winter can harm a pet or child if eaten. Store such salt out of reach and in a locked cabinet.

2) Keep your home warm — and safe. Carbon monoxide (CO) is a poisonous gas that has no color, odor or taste. The risk for CO poisoning increases in the winter, as the use of fuel-burning devices increases. Sources of CO include gas furnaces, gas water heaters, gas stoves, gas ovens, kerosene space heaters, wood and gas fireplaces, wood-burning stoves, power generators and car engines. These devices make CO, primarily when they are not working properly or are not used in a properly ventilated space.

Signs of CO poisoning are similar to flu and other cold-weather-virus symptoms, including headaches, nausea, vomiting, dizziness and confusion. To prevent CO poisoning, have at least one CO detector in your home. The best places for a CO detector are near bedrooms and close to furnaces. Have your heating system, vents and chimney checked every year by experts. Always follow product instructions for installing and repairing appliances that burn fuel, and never burn charcoal inside a house or garage. Additionally, do not use a gas oven to heat a house or apartment or use unvented fuel-burning devices indoors. Finally, never run a car in a closed garage.

3) Don’t let winter cold and flu season become more serious. Be sure that all medication, including over-the-counter cold medicine, is kept in locked cabinets, away from children and pets. Also, avoid mercury poisoning by using digital thermometers instead of glass mercury thermometers, which can break in a child’s mouth. Stay with children when taking their temperature. Spilled mercury should be cleaned up properly as it is a hazardous waste.

4) Save the number, save a life. The Poison Help line is your first line of defense against poisoning deaths and injuries. By dialing 1-800-222-1222, you will be connected to a local poison center staffed by trained, professional experts who can help you right away. Save the number in your phone today so you have it if you need it. You can also visit the Poison Help website at www.poisonhelp.hrsa.gov for more information on poison prevention.


Bipolar I Disorder – It’s More Common Than You Think

2018-02-06T09:59:01

(BPT) – Bipolar I disorder is a condition that equally affects men and women, regardless of age, race, or ethnicity.1 Approximately 1.5 million adults in America are living with this disease, yet it’s a condition that’s still chronically misunderstood and often misdiagnosed.2 In fact, people with bipolar disorder may struggle an average of 10 years before they receive an accurate diagnosis.1 That’s why knowing and understanding the symptoms is so important.

“One of the biggest difficulties with diagnosis is the wide variety of ways in which the disorder can manifest itself,” said Gary Sachs, MD, Associate Clinical Professor of Psychiatry at Harvard Medical School. “Although every person with bipolar I disorder can experience it differently, these experiences do include features that fall into specific categories of identifiable symptoms.”

Whether you’re someone who has a history of mental illness or are concerned about a loved one who is struggling with their mental health, Dr. Sachs sheds light on bipolar I disorder and answers some important questions to help you better understand this condition.

What is bipolar I disorder?

Bipolar I disorder is a brain and behavioral disorder that causes unusual changes in mood, activity levels, energy, and judgment, impacting a person’s ability to carry out day-to-day tasks.3 Everyone has typical ups and downs, but in bipolar I disorder these can be more extreme. People diagnosed with bipolar I disorder have periods called “mood episodes,” which can be either manic, hypomanic, depressive, or mixed.3 Every patient experiences episodes differently, but it’s important to note that bipolar I patients have had at least one manic or mixed episode. When managing their condition, patients should keep an open dialogue with their healthcare providers.4

Can you tell me more about what it means to experience mania?

Many people know what it means to be depressed, but fewer understand mania. Someone experiencing manic symptoms of bipolar I disorder may have periods of unusually elevated feelings like extreme happiness, energy, or irritability. Some symptoms of manic episodes may include3:

  • Feeling unusually happy, excited, or energetic
  • Feeling restless, irritable, wired, or overreactive
  • Having racing thoughts, difficulty concentrating
  • Poor judgment with risk taking, indulging in impulsive behaviors, and having a heightened sense of self-importance

What does it mean to experience a mixed episode? Is it common?

Someone with bipolar I disorder can have a mixed episode when experiencing symptoms of mania and depression at the same time. Mixed episodes are more common than you may think. In fact, 40% of people living with bipolar I disorder have experienced a mixed episode, sometimes called a “mixed state.”5 Some of these symptoms include3:

  • Feeling overly energized, while feeling very hopeless
  • Feeling agitated, while having extreme changes in appetite, and having suicidal thoughts
  • Having racing thoughts, while feeling “slowed down” or experiencing a loss of interest in something once enjoyed

Can you treat bipolar I disorder?

There is no known cure for bipolar I disorder, but symptoms may be managed through treatment. It is important for patients to partner with their healthcare providers, so that, together, they can determine an appropriate treatment plan. This may include counseling, support groups, and medicine. In fact, recently approved atypical antipsychotics have provided additional options to help people living with bipolar I disorder.

VRAYLAR® (cariprazine) is a once-a-day prescription medicine that’s FDA-approved in adults for the acute treatment of manic or mixed episodes of bipolar I disorder.6 In clinical studies, VRAYLAR® was proven to help manage manic symptoms in adults with manic or mixed episodes associated with bipolar I disorder. VRAYLAR® showed significant improvement in overall manic symptoms compared to those who took a placebo (sugar pill). VRAYLAR® was not studied to measure symptoms individually, and is not approved to treat hypomania, depression, or depressive symptoms.

Every patient experiences symptoms differently and not all patients respond to treatment in the same way. That’s why it’s important for patients suffering from bipolar I disorder to actively engage with their healthcare provider to determine which treatment path is appropriate for them.

IMPORTANT RISK INFORMATION

What is the most important information I should know about VRAYLAR?

Elderly people with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) taking antipsychotic drugs are at an increased risk of death.

VRAYLAR may cause serious side effects, including:

  • Stroke (which can be fatal) in elderly people with dementia
  • Neuroleptic malignant syndrome (NMS): Call your healthcare provider right away if you have high fever; stiff muscles; confusion; changes in pulse, heart rate, or blood pressure; or sweating. These can be symptoms of a rare but potentially fatal side effect called NMS. VRAYLAR should be stopped if you have NMS
  • Tardive dyskinesia (TD): Tell your healthcare provider if you cannot control the movements of your face, tongue, or other body parts. These could be signs of a serious and sometimes permanent side effect called TD. Risk of developing TD and the chance that it will become permanent are thought to increase the longer a person takes the medicine and the more medicine a person takes over time. TD can develop even after a person has been taking the medicine for a short time at low doses. TD may partially or completely go away if you stop taking VRAYLAR. TD may also start after you stop taking VRAYLAR
  • Late-occurring side effects: VRAYLAR stays in the body for several weeks, even after you stop taking it, which could affect the timing of when you may experience side effects. Tell your healthcare provider if you have side effects (eg, uncontrolled movements of the body and face, muscle stiffness, or feelings of restlessness) as these may occur several weeks after starting or increasing dose of VRAYLAR
  • Problems with your metabolism, such as:
    • High blood sugar and diabetes: If you have diabetes or risk factors for diabetes (eg, being overweight or family history of diabetes), your blood sugar should be tested before you start VRAYLAR and regularly during treatment. Complications of diabetes can be serious and even life threatening. Tell your healthcare provider if you have symptoms such as feeling very thirsty or very hungry, urinating more than usual, or feeling weak
    • Increased blood cholesterol or triglycerides: Your healthcare provider should check your cholesterol and triglyceride levels before and during treatment
    • Weight gain: Weight gain has been reported with VRAYLAR. Your healthcare provider should check your weight before and regularly during treatment
  • Low white blood cell count: Low white blood cell counts have been reported with antipsychotic drugs, including VRAYLAR. This may increase your risk of infection. Very low white blood cell counts, which can be fatal, have been reported with other antipsychotics
  • Decreased blood pressure: You may feel lightheaded or faint when you rise too quickly from a sitting or lying position
  • Falls: VRAYLAR may increase risk of falls, which could cause fractures or other injuries
  • Seizures
  • Impaired judgment, thinking, and motor skills: Do NOT drive or use dangerous machinery until you know how VRAYLAR affects you. VRAYLAR may make you drowsy
  • Increased body temperature: VRAYLAR may make you more sensitive to heat. You may have trouble cooling off. Be careful when exercising or when doing things likely to cause dehydration or make you warm
  • Difficulty swallowing: VRAYLAR and medicines like it have been associated with difficulty swallowing

Who should not take VRAYLAR?

Do not take VRAYLAR if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (eg, rash, itching, hives, swelling of the tongue, lip, face or throat).

What should I tell my healthcare provider before taking VRAYLAR?

Tell your healthcare provider about any medical conditions and if you have or have had:

  • Diabetes or high blood sugar in you or your family
  • High levels of total cholesterol, triglycerides, or LDL-cholesterol; or low levels of HDL-cholesterol
  • Seizures or conditions that increase your risk for seizures
  • Low or high blood pressure
  • Low white blood cell count

Tell your healthcare provider if you are pregnant, or if you plan to become pregnant. Using VRAYLAR in the third trimester may cause uncontrolled movements of the body and face, muscle stiffness, or feelings of restlessness and/or withdrawal symptoms in newborn babies. A special program (National Pregnancy Registry for Atypical Antipsychotics) collects information on the safety of antipsychotic drugs, including VRAYLAR, during pregnancy. For information, contact the program at 1-866-961-2388 or visit http://www.womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/.

Tell your healthcare provider about all medicines that you take or have recently taken, including prescriptions, over-the-counter medicines, and supplements. VRAYLAR may affect the way other medicines work, and other medicines may affect how VRAYLAR works.

What are the most common side effects of VRAYLAR?

  • The most common side effects were uncontrolled movements of the body and face, muscle stiffness, vomiting, indigestion, sleepiness, and restlessness.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all possible side effects of VRAYLAR.

Please also see full Prescribing Information, including Boxed Warning, which are also available at www.vraylar.com and https://www.allergan.com/assets/pdf/vraylar_pi.

References

  1. Depression and Bipolar Support Alliance. Bipolar Disorder Statistics. Available at: http://www.dbsalliance.org/site/PageServer?pagename=education_statistics_bipolar_disorder. Accessed January 31, 2018.
  2. National Institute of Mental Health. Bipolar Disorder Among Adults. Available at https://www.nimh.nih.gov/health/statistics/prevalence/bipolar-disorder-among-adults.shtml. Accessed January 31, 2018.
  3. National Institute of Mental Health. Bipolar Disorder. Available at: https://www.nimh.nih.gov/health/topics/bipolar-disorder/index.shtml. Accessed January 31, 2018.
  4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.
  5. Muneer, A. Mixed States in Bipolar Disorder: Etiology, Pathogenesis and Treatment. Chonnam Medical Journal. 2017 Jan; 53(1): 1–13. doi: 10.4068/cmj.2017.53.1.1.
  6. VRAYLAR® (cariprazine) [package insert]. Irvine, CA: Allergan USA, Inc.; 2017.

Allergan® and its design are trademarks of Allergan, Inc.

VRAYLAR® and its design are registered trademarks of Forest Laboratories Holdings Ltd., an Allergan affiliate.

Licensed from Gedeon Richter Plc.

© 2018 Allergan. All rights reserved.

VRA112771_v2 02/18

Low white blood cell count: Low white blood cell counts have been reported with antipsychotic drugs, including VRAYLAR. This may increase your risk of infection. Very low white blood cell counts, which can be fatal, have been reported with other antipsychotics

Decreased blood pressure: You may feel lightheaded or faint when you rise too quickly from a sitting or lying position

Falls: VRAYLAR may increase risk of falls, which could cause fractures or other injuries

Seizures

Impaired judgment, thinking, and motor skills: Do NOT drive or use dangerous machinery until you know how VRAYLAR affects you. VRAYLAR may make you drowsy

Increased body temperature: VRAYLAR may make you more sensitive to heat. You may have trouble cooling off. Be careful when exercising or when doing things likely to cause dehydration or make you warm

Difficulty swallowing: VRAYLAR and medicines like it have been associated with difficulty swallowing

Who should not take VRAYLAR?

Do not take VRAYLAR if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (eg, rash, itching, hives, swelling of the tongue, lip, face or throat).


The secret to sticking to your resolutions just may lie in your Medicare benefits

2018-02-15T06:01:01

(BPT) – Despite our best intentions, 80 percent of us have given up on our New Year’s resolutions by mid-February. Determined to make this year different? If you’re enrolled in Medicare, you might be surprised to learn that your benefits could give you an edge in your quest to stay motivated and on track to attaining your goals for the year ahead.

Read on to learn how maximizing your Medicare benefits could help you achieve some of the most common New Year’s resolutions.

Resolution No. 1: Lose weight and get fit.

Exercise is a key part of the equation if you want to finally get out of those elastic-waist pants and back into your jeans. Only problem is, most of us can come up with a whole host of excuses for not making exercise part of our daily routine, with the expense of a gym membership one that’s frequently cited by people living on a fixed income.

If you’re enrolled in a Medicare Advantage or Medicare supplement plan, you might not be able to use that excuse anymore. Many plans include a gym membership as part of their plan benefits, giving their members access to fitness centers in their area at either no extra cost or a discounted rate.

“Regular exercise can help you lose some weight after over-indulging during the holiday season, but it’s important all year round to help improve your well-being and maintain your independence,” said Efrem Castillo, M.D., chief medical officer for UnitedHealthcare Medicare & Retirement. “Taking advantage of your plan’s fitness benefits could have you well on your way to a trimmer and more energized you by spring.”

Resolution No. 2: Make 2018 your healthiest year yet.

Medicare is designed to make it as affordable as possible to get the preventive care you need. And that can make a huge difference to your health and well-being by catching health issues early, when they’re usually easier to treat.

Original Medicare (Parts A and B) covers an annual wellness visit as well as some preventive screenings, such as mammograms and colonoscopies. Your annual wellness visit is a good opportunity to sit down with your doctor and develop a plan to help you achieve your best health in the year ahead. In addition to services covered under Original Medicare, many Medicare Advantage plans provide additional benefits, such as a full annual physical as well as dental, hearing and vision coverage.

Resolution No. 3: Save more money/Get out of debt.

All those gifts you bought over the holidays may have left your credit card statements extra-lengthy. And life can get expensive any time of year, particularly as our health care costs creep up as we get older. Fortunately most people can save money on health care in a variety of ways.

If you’re enrolled in a Medicare Advantage plan, keep the following tips in mind:

* Take advantage of cost savings on prescription drugs. Many plans offer home delivery pharmacy benefits that can be a great way to save money — not to mention trips to the pharmacy. And if your doctor prescribes a high-cost medication, ask if a cheaper alternative is available that could work just as well, such as a generic or a drug on a lower tier of your plan’s formulary (the list of covered drugs).

* Choose doctors and hospitals that have a relationship with your plan. Staying in-network when you need care is one of the best things you can do to manage your health care costs.

* Look for extra plan discounts on everyday health care items and services such as vitamins, hearing aids and alternative medicine services like acupuncture.

Resolution No. 4: Less stress. More happiness.

More and more Medicare Advantage plans are taking a keen interest in helping their members manage their emotional well-being given the direct correlation between our mental health and our physical health. Check to see if your plan offers any resources to help members manage their stress.

Resolution No. 5: Kick the habit.

If you smoke, you know you should quit. Make 2018 your year! Medicare covers up to eight face-to-face visits per year with a doctor or other health care practitioner who can provide counseling to help you make cigarette and other tobacco use part of your past. That personalized, one-on-one attention can make a big difference. So if you’ve tried to quit on your own in the past but struggled, consider taking advantage of these free counseling sessions.

The secret to sticking to your New Year’s resolutions may just lie in your Medicare benefits. So rather than rely on sheer willpower alone, put those benefits to use to help you stay on track toward your goals. When you close out 2018 as a thinner, happier and healthier version of yourself, you’ll probably wonder why you waited so long to make Medicare your secret weapon in conquering your resolutions once and for all.

Plans are insured through UnitedHealthcare Insurance Company or one of its affiliated companies. For Medicare Advantage and Prescription Drug Plans: A Medicare Advantage organization with a Medicare contract and a Medicare-approved Part D sponsor. Enrollment in these plans depends on the plan’s contract renewal with Medicare.


An underutilized retirement strategy

2018-02-14T14:41:00

(BPT) – Across the nation, thousands of seniors have used a Home Equity Conversion Mortgage (HECM), commonly called a reverse mortgage loan, as a savvy way to access the equity in their homes as part of their retirement strategy.

Those who are interested in a reverse mortgage loan should know that there are six main phases to the process: 1) educating and qualifying, 2) counseling, 3) approval, 4) funding, 5) using and 6) settling.

1. Educating and qualifying

The HECM process begins by contacting an FHA-approved lender who will review the borrower’s situation, educate them on the HECM program, and determine if they would likely qualify for a reverse mortgage loan.

“Once the lender has determined that the borrower is eligible, they work closely with them to shape the loan so it fits their needs,” says Paul Fiore, Chief Sales Officer for American Advisors Group, the leading reverse mortgage lender in the nation. “At AAG, this is a highly personalized process designed to give the borrower the best outcome for their financial situation.”

2. Counseling

Once qualified, borrowers are referred to reverse mortgage counseling, an important consumer safeguard mandated by the government. During counseling, a HUD-approved HECM counselor reviews the borrower’s needs and circumstances. They consider how the funds might best be distributed, the financial and tax implications, and whether a HECM is right for them. If so, an application is submitted to the lender.

3. Approval

Next, the property will be appraised, and after that the approval process will begin. Before closing on the loan, borrowers will choose between several loan disbursement options, from taking it all out in a lump sum, receiving fixed monthly payments, opening a line of credit or any combination.

4. Funding

After the closing papers are signed, the homeowner has three business days to change their mind and cancel the loan (except if the loan is being used to purchase a new home). After the rescission period has passed, the funds are ready to be paid out through the payment option selected, subject to an initial disbursement limit that is determined by HUD.

5. Using your loan

The loan servicer will generally disburse funds via direct deposit or mail on the first business day of the month, following the funding of the loan. The borrower can live in the home as long as they like without making monthly mortgage payments, as long as they continue to pay property taxes and insurance on the home, maintain it in good condition and comply with any other loan terms.

6. Settling your loan

If the last surviving borrower sells or transfers the property, passes away, or does not use the property as a principal residence for more than 12 months, the loan has reached a “maturity event,” meaning that the loan comes due and no further funds can be disbursed. Borrowers also have the option of paying off their loan in full at any time without penalty.

Following a maturity event, an appraisal will be ordered by the loan servicer to determine the property’s current market value. The heirs can sell the property to repay the loan, or purchase the property for 95 percent of its appraised value. Since HECMs are non-recourse loans, the proceeds from the sale of the home are the only asset that can be taken to pay the loan’s balance, even if the loan amount exceeds the value of the home.

A home equity conversion mortgage can be shaped to fit an individual’s needs. With new consumer safeguards in place, many seniors are discovering that it is an important part of their retirement strategy.


Navigating Medicare: 5 allies who can help

2018-02-16T12:01:00

(BPT) – Enrolling in Medicare for the first time or starting coverage under a new plan? It might bring you back to that first day starting a new job. You knew some of the basics, but you also knew there was a lot more to learn. More than likely, you got help from colleagues who have been around for a while and helped show you the ropes.

Don’t worry. With Medicare, you have the same kind of knowledgeable support. You’ve got a team on your side that can help make navigating the health care system easier. Goodbye hassles, hello helpers.

Here are five allies in your corner:

1. Your Primary Care Physician. This physician is the “go-to” doctor who provides guidance on your health care needs, taking the time to really get to know you, your medical history and your health goals. Think of your Primary Care Physician as the “quarterback” of your medical team — someone who can take charge of knowing the ins and outs of your health status and help drive decisions to get you on the right track and keep you there.

2. A caregiver. Perhaps the “unsung hero” of your health care team, caregivers are the ones you know you can count on — the ones you know are there to offer support and care for you, whenever you need it. Whether a family member, neighbor, friend or professional assistant, these are the people in your life who help you along the way. Their assistance can span everything from bringing you to appointments or getting prescriptions filled to making meals or offering emotional support.

3. Your pharmacist. This team member keeps an eye on the medications you take — prescription and over-the-counter — to make sure they work safely together. Your pharmacist is a great person to talk with about how medications are making you feel and answer any questions you have on topics including what side effects to expect, what to do if you miss a dose, or how to store your meds.

4. An insurance agent. Original Medicare. Medicare Supplement. Part D. Medicare Advantage. There are many options and decisions to make when it comes to your Medicare coverage, and a licensed insurance agent can help you find the right plan, or plans, for you. Once you’ve selected a plan, you can also always call your agent to ask questions if your health or coverage needs change or if your plan changes from year to year.

5. Your insurance company. Within your insurance company, there are more people than you likely realize who are working hard on your behalf to ensure you get the medical care and support you need. Insurers can offer tools, resources and support that can help you live a healthier life.

For more information to help you navigate Medicare, visit MedicareMadeClear.com.


New Treatment Option for People With Cystic Fibrosis

2018-02-20T12:01:00

(BPT) – For patients with cystic fibrosis (CF) 12 years and older with certain mutations

At 17 years old, Taylor Brown is a straight-A student balancing a 10-hour work week and competitive dancing. She is also one of approximately 30,000 Americans living with cystic fibrosis (CF), a progressive genetic disease that makes it difficult to breathei.

Taylor has been taking a combination of medicines to treat and manage her disease since her diagnosis when she was six days old. In the U.S., approximately 1,000 people are diagnosed with CF each yeari. CF is a disease you are born with.

“Cystic fibrosis has always been a part of my life, but I don’t let it define me,” said Taylor. “I’m still able to do the things I love, like competitive dancing and advocating for other people with cystic fibrosis.”

There is no cure for the life-shortening disease, but therapies are available for some people that target the underlying cause of CFii. CF is caused by a reduction in the quantity and/or function of cystic fibrosis transmembrane conductance regulator (CFTR) proteins resulting from gene mutations that leads to the buildup of mucus in organs, such as the lungsi.

After talking with her treatment team and family, Taylor participated in a clinical trial for SYMDEKO™ (tezacaftor/ivacaftor and ivacaftor). SYMDEKO was recently approved by the Food and Drug Administration (FDA) for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have two copies of the F508del mutation or who have at least one mutation in the CF gene that is responsive to SYMDEKO.

“SYMDEKO is a new treatment option that helps the body’s CFTR proteins work better,” said Patrick Flume, M.D., Director of the Cystic Fibrosis Program at the Medical University of South Carolina. “Scientific innovations have enabled medicines to target cystic fibrosis at its root. I encourage patients and their families to work with their doctors to understand how these developments may help them.”

SYMDEKO is made up of two medicines that work to help increase the quantity and function of CFTR protein in certain people with CF. The FDA approval of SYMDEKO was based on results from two global Phase 3 trials in approximately 750 patients, which demonstrated the safety and efficacy of SYMDEKO in people with CF ages 12 and older who had certain mutations in the CFTR gene.

“I’m excited about new discoveries and research in cystic fibrosis, because they have a very real impact on my life and the lives of others with cystic fibrosis,” said Taylor.

Indication and Important Safety Information for SYMDEKO tablets (tezacaftor 100 mg/ivacaftor 150 mg and ivacaftor 150 mg)

What is SYMDEKO (tezacaftor/ivacaftor and ivacaftor)?
  • SYMDEKO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with SYMDEKO.
  • Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if SYMDEKO is safe and effective in children under 12 years of age.

Important Safety Information

Do not take SYMDEKO if you take certain medicines or herbal supplements such as:
  • antibiotics such as rifampin (Rifamate®, Rifater®) or rifabutin (Mycobutin®)
  • seizure medicines such as phenobarbital, carbamazepine (Tegretol®, Carbatrol®, Equetro®) or phenytoin (Dilantin®, Phenytek®)
  • St. John’s wort

Talk to your doctor before taking SYMDEKO if you take any of the medicines or herbal supplements listed above.

Before taking SYMDEKO, tell your doctor about all of your medical conditions, including if you:
  • have or have had liver problems
  • have kidney problems
  • are pregnant or plan to become pregnant. It is not known if SYMDEKO will harm your unborn baby. You and your doctor should decide if you will take SYMDEKO while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if SYMDEKO passes into your breast milk. You and your doctor should decide if you will take SYMDEKO while you are breastfeeding

SYMDEKO may affect the way other medicines work, and other medicines may affect how SYMDEKO works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of SYMDEKO may need to be adjusted when taken with certain medicines.

Especially tell your doctor if you take:
  • antifungal medicines such as ketoconazole (e.g., Nizoral®), itraconazole (e.g., Sporanox®), posaconazole (e.g., Noxafil®), voriconazole (e.g., Vfend®), or fluconazole (e.g., Diflucan®)
  • antibiotics such as telithromycin (e.g., Ketek®), clarithromycin (e.g., Biaxin®), or erythromycin (e.g., Ery-Tab®)
What should I avoid while taking SYMDEKO?
  • SYMDEKO can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how SYMDEKO affects you.
  • Avoid food or drink that contains grapefruit or Seville oranges while you are taking SYMDEKO.
What are the possible side effects of SYMDEKO?
SYMDEKO can cause serious side effects, including:
  • High liver enzymes in the blood have been reported in people treated with SYMDEKO or treated with ivacaftor alone. Your doctor will do blood tests to check your liver:
    • before you start SYMDEKO
    • every 3 months during your first year of taking SYMDEKO
    • every year while you are taking SYMDEKO
  • Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.
  • Call your doctor right away if you have any of the following symptoms of liver problems:
    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) in some children and adolescents treated with SYMDEKO or with ivacaftor alone. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with SYMDEKO to look for cataracts.
The most common side effects of SYMDEKO include headache, nausea, sinus congestion, and dizziness.

These are not all the possible side effects of SYMDEKO. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

Please click here to see the full US Prescribing Information for SYMDEKO.

To learn more about SYMDEKO, visit www.SYMDEKO.com.

i Cystic Fibrosis Foundation. About Cystic Fibrosis. Available at https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/. Accessed February, 2018.
ii Pettit, RS and Fellner C. CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 July; 39(7): 500-511. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103577/.

© 2018 Vertex Pharmaceuticals Incorporated | VXR-US-23-00149 | 02/2018


Visit Durban for an unforgettable South African experience

2018-02-08T10:32:00

(BPT) – Think of South Africa, and images of majestic savannas and roaming wildlife come to mind. A South African safari is an unforgettable experience, but no visit to the country is truly complete without a cultural immersion. The vibrant city of Durban combines the best of both worlds. Located along the Indian Ocean coast an hour from Johannesburg by air, Durban offers an eclectic array of activities where you can explore the city’s significant role in world history, the rich heritage of its Zulu people, and innumerable natural wonders — from the beach to the bush.

Experience authentic Zulu culture

Named for its dramatic surrounding landscape, the Valley of 1,000 Hills has been home to the Zulu people, South Africa’s largest ethnic group, for centuries.

Visitors can take an organized tour deep into tribal lands to experience Zulu culture with its exuberant ceremonies, traditional music and dancing. You’ll learn about Zulu beliefs and healing practices, break bread with local families and learn the hidden meanings behind their colorful beadwork. You can even arrange one-on-one sessions with the village healer or spend the night with a Zulu family in their home.

Walk in Gandhi’s and Mandela’s footsteps

Not everyone is aware that Mahatma Gandhi’s life work was inspired by his experiences in Durban. In 1893, he arrived as a young lawyer, and the discrimination he witnessed personally and against his fellow Indians drove him to start his worldwide movement of passive resistance fighting for the rights of the Indian population. At the Phoenix Settlement, you will see Gandhi’s house and the printing press he used to publish his newspaper, The Indian Opinion. Many of the more than one million Indians living in the city make the pilgrimage to this historical site alongside visitors from around the world.

Five years after his death, Nelson Mandela remains South Africa’s most revered public figure. 2018 marks a year-long celebration of his life and what would have been his 100th birthday on July 18. Honor his work when you’re in Durban by visiting the Nelson Mandela Capture Site, at the exact spot where he began his “Long Walk to Freedom” after being arrested for anti-Apartheid activism in 1952. Visit the striking monument and educational exhibition walking you through Mandela’s life and role in establishing a democratic South Africa.

Hit the beach at Umhlanga Rocks

Umhlanga Rocks, Durban’s laidback beach village, is on a picturesque stretch of the Indian Ocean. It beckons visitors with a scenic promenade passing by local landmarks including Umhlanga Lighthouse and Whale Bone Pier. A walkable downtown makes dining and nightlife easily accessible from the area’s many boutique hotels and guesthouses, and opportunities to get on the water abound — from surfing to deep sea fishing, scuba diving, whale watching and kiteboarding.

Discover an underwater wonderland

Consistently rated one of the top warm water diving and snorkeling sites in the world, Aliwal Shoal is also the spot to get up close and personal with blacktip reef sharks. Those brave enough can swim or dive alongside these mysterious creatures in the open ocean, but viewing from inside a cage is always an option.

Experience a Big Five safari

Back on land, the South African bush is less than four hours away by car. Private game reserves offer high-end safari lodge accommodations, minimal crowds and optimal chances for getting the perfect photos of the “Big Five” — elephants, rhinos, water buffalo, lions and leopards. In iSimangaliso Wetland Park, a UNESCO World Heritage Site, hippos, crocodiles, pelicans and flamingos roam Lake St. Lucia, while elephants, giraffes and leopards inhabit the adjacent grasslands.

Visit www.durbanexperience.co.za to learn more.


7 things you didn’t know about adult vaccination in the U.S.

2018-02-08T10:31:00

(BPT) – Even though vaccines are one of the greatest health innovations of the last century, a new survey shows that among some adults in America there is a lack of awareness about the immunizations they need as adults.

According to an online survey of 1,000 American adults aged 18 years and older, there is a critical gap between awareness and action when it comes to vaccination.1

Adults should talk to their healthcare providers about the Centers for Disease Control and Prevention’s list of recommended adult vaccines. The best way to protect yourself and those closest to you is to vaccinate for life. So, ask your doctor if you are up to date on all your vaccines. It’s a simple step that can help protect you, your family and your community.

1. Adults may think they know, but they have no idea

Nearly half of adults consider themselves to be “very” or “quite” knowledgeable about vaccines,2 yet fewer than three in ten Americans are aware of the vaccines recommended for adults their age.1

2. Vaccines are not just for kids

Most of us are familiar with the importance of vaccination during childhood; however, vaccination is equally important throughout adulthood, as the immune system begins to decline with age.3 Immunosenescence, also known as age-related decline in immunity, significantly contributes to the susceptibility of older adults to serious, yet preventable conditions including: influenza, pneumonia and shingles.3 Despite this, 65 percent of adults are not fully up to date on their vaccines.1

3. Vaccines may help save your life

Six million deaths are prevented globally each year as a result of vaccination. If global vaccination rates increased, even more deaths could be prevented.4

4. Vaccination may prevent unnecessary death

Vaccine-preventable diseases can cause long-term illness and even death. In fact, 99 percent of the more than 50,000 deaths from vaccine-preventable diseases that occur every year in the U.S. are in adults.5

5. Vaccination may protect against more than just vaccine-preventable diseases

Vaccination can also protect against other health problems. In fact, vaccinating against the flu can also help protect people against heart attacks and stroke.6

6. Vaccine knowledge may supersede action

Despite longstanding recommendations for the use of many vaccines, adult vaccination rates remain low. In 2015, the flu vaccination rate for adults aged 19 and older was less than 45 percent, Tdap (Tetanus/diphtheria/pertussis) vaccination rate for adults was only about 23 percent, and shingles vaccination rate for adults 60 and older was just about 31 percent.7

7. Vaccination may impact all of us in unexpected ways

Medical costs related to vaccine-preventable diseases in older adults are high and are expected to grow substantially in the coming years. One study forecasts U.S. medical costs for Americans 65 and older in the Medicare population to be $4.74 billion annually by 2030 for just one vaccine-preventable disease.8


1 Vaccinate for Life consumer survey. Exploration based on Q9. Which of the following statements best describes how up-to-date you consider yourself to be on vaccinations. I am aware of the vaccines recommended to adults of my age and have received all of these recommended vaccinations. Total base all respondents n=1000.

2 Vaccinate for Life consumer survey. Exploration based Q4A. How knowledgeable do you consider yourself to be on adult vaccinations, also referred to as immunizations? Are you … very knowledgeable, quite knowledgeable, not quite knowledgeable, not at all knowledgeable. Total base all respondents n=1000.

3 American College of Physicians et al. Aging and Immunity: The Important Role of Vaccines, 2017. Available at https://www.acponline.org/system/files/documents/clinical_information/resources/adult_immunization/aging_and_immunity_guide.pdf.

4 Ehreth J. The global value of vaccination. Vaccine. 2003;21:596-600.

5 Rice HR, Varkey P. What immunizations should I offer to my patients? A primer on adult immunizations. J Assoc Physicians India. 2011; 59:568-72.

6 Hung IFN et al. Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study. Clin Infect Dis. 2010; 51:1007–1016.

7 U.S. Centers for Disease Control and Prevention. Surveillance of Vaccination Coverage Among Adult Populations — United States, 2015. MMWR Surveill Summ. 2017; 66(11):1–28.

8 Varghese L et al. The temporal impact of aging on the burden of herpes zoster. BMC Geriatrics. 2017;17:30.


Fight for your sight: 5 tips to fight Age-related Macular Degeneration

2018-02-08T16:01:00

(BPT) – The ability to see is one of our most precious gifts. Like most things in life, our vision may be impacted as we age. That’s why it’s important to learn about Age-related Macular Degeneration (AMD). Prevalent among older Americans, it affects one in five adults age 65 and older, and is the leading cause of blindness for this population. While there is no cure for this condition, there are steps that you can take to help reduce the risk of progression, including:

1) Schedule routine eye exams. As early stages of AMD may not present any symptoms, you may not think to consult your eye doctor. Keeping routine eye exams that include eye dilation may help to identify the condition early, as well as help maintain overall eye health.

2) Address symptoms immediately. See your eye care professional right away if you experience sudden or gradual changes in vision quality. As AMD progresses, straight lines may appear distorted, central vision may look dark, blurry or white, or changes in color perception may become noticeable. If you have been diagnosed with AMD, you should also regularly check your eyes with an Amsler grid tool that helps track incremental vision changes.

3) Lead a healthy lifestyle. If you smoke, quit. Regular exercise can also help to maintain eye health and minimize the risk of progression. Other risk factors for AMD include obesity, high cholesterol and high blood pressure.

4) Eat right. A diet rich in green, leafy vegetables as well as healthy fatty acids may also help reduce the risk of progression. Foods that contain these nutrients include: spinach, kale, broccoli, cabbage, romaine and chard, and fatty fish such as salmon, sea bass, herring, whitefish, mackerel, anchovies and sardines.

5) Consider supplements recommended by the National Eye Institute. If you’ve been diagnosed with moderate to advanced AMD, The National Eye Institute recommends taking a specific nutrient formula based on the AREDS 2 study, that may help reduce your risk of progression. Talk with your doctor to see if an AREDS 2 formula eye vitamin is right for you.

To raise awareness of this public health issue, Bausch + Lomb, in collaboration with Prevent Blindness, the nation’s oldest volunteer eye health and safety organization dedicated to fighting blindness and saving sight, has launched the Why Eye Fight campaign.

To learn more about AMD, what steps you can take to help fight for your sight or to watch the patient stories or PSA, visit www.WhyEyeFight.com. You can also join the online conversation and share your story using #WhyEyeFight on Facebook and Twitter.


Five Ways You Can Support Your SweetHeart This Valentine’s Day

2018-02-13T15:07:00

(BPT) – Like millions of Americans, your loved one may be living in a bad relationship this Valentine’s Day — the relationship between diabetes and their heart. People with type 2 diabetes are up to four times more likely to develop cardiovascular disease than people without diabetes. Yet, over half of Americans with type 2 diabetes are unaware of this link as they celebrate the holiday with those they cherish most. In fact, people with type 2 diabetes spend 1,000 percent more time planning for Valentine’s Day than talking to their doctor about their heart disease risk.

But, this year, caregivers who have joined the For Your SweetHeart® movement are making sure their sweethearts with type 2 diabetes know their risk and take action. Here are five ways to support and celebrate your sweetheart, so they can be around for a long time:

1. Have a heart-to-heart with your loved ones

Award-winning actress Angela Bassett has a heart-to-heart with her uncle Ralph, who has type 2 diabetes.

Don’t wait to open up to those you love. Award-winning actress Angela Bassett had a heart-to-heart with her uncle Ralph, who has type 2 diabetes, about managing his risk for heart disease. Bassett learned about the connection between the two conditions after her mom, Ralph’s sister, died of heart disease related to her type 2 diabetes. “For my mom, this knowledge came too late. But the good news is the sooner you know your risk, the more you and your doctor can do about it,” Bassett said. You can find tips for talking to your sweetheart about their risk on ForYourSweetHeart.com.

2. Know the facts

People with diabetes spend over 1,000 percent more time planning for Valentine’s Day than talking to their doctor.

Over 80 percent of adults with type 2 diabetes would change their diet, exercise and talk to their doctor if they knew they were at an increased risk for heart disease. Yet, more than half are still unaware of the connection. Endocrinologist Jennifer Green, M.D., associate professor of Medicine, Duke University Division of Endocrinology and Duke Clinical Research Institute, explained that people with diabetes are at higher risk for plaque to build up on the walls of arteries, which makes it easier for cholesterol to gather. Eventually, this reduces the space through which blood can flow, and may lead to life-threatening problems like heart attacks and strokes. “Diabetes is a progressive condition and even if blood sugar is controlled, the heart disease risk remains,” Dr. Green said. Encourage your sweetheart to talk to their doctor at their next appointment about available treatment options.

3. Show support at your sweetheart’s next appointment

Cardiologist Dr. Karol Watson and her father, Edward, who has type 2 diabetes and experienced a heart attack related to his diabetes.

Scheduling an appointment with a healthcare provider is an important first step to addressing the link between type 2 diabetes and heart disease. And you can lend a hand by going with your sweetheart. After her dad, Edward, who has type 2 diabetes, had a heart attack, Karol Watson, M.D., Ph.D., FACC, professor of medicine/cardiology, co-director, UCLA Program in Preventive Cardiology, decided to pursue cardiology to dedicate her life’s work to helping people with diabetes understand their risk for cardiovascular disease. She sees firsthand how overwhelming it can be for people to learn about their increased risk for heart disease, so she suggests bringing your sweetheart to help take notes and ask questions. People can start this conversation with their sweetheart by downloading the patient discussion guide on ForYourSweetHeart.com and bringing it to their next doctor’s appointment.

4. Make a diabetes- and heart-friendly commitment

Jacqueline encourages her sweetheart, Sadegh, to do all he can to manage his type 2 diabetes and heart disease risk.

Sometimes the sweetest gift isn’t a box of chocolates — instead, you can show how much you care by making a commitment to support your sweetheart’s healthy choices to help manage their type 2 diabetes and heart disease risk. As a self-proclaimed “cupcake-lover,” heart-health advocate Jacqueline modifies her Valentine’s Day celebration to help her sweetheart, her husband Sadegh, eat well, exercise and manage his blood sugar. Sadegh has type 2 diabetes and suffered a heart attack from complications associated with the condition. Jacqueline encourages him to do everything he can to manage his condition so he can be around for many more Valentine’s Days.

5. Spread the love

Talk to your sweetheart about resources available to them to help them get smart about their heart disease risk.

If your loved one has type 2 diabetes, encourage them to visit ForYourSweetHeart.com to take the Heart You Quiz and understand their risk for heart disease, so they can be around for a long time. Sign up to receive more information about type 2 diabetes and heart disease that may help them talk with their doctor at their next appointment about their heart disease risk and available treatment options to help manage it. Spread the word about the connection and show your love because, by having a heart, you might just save theirs.