Category: Brandpoint Health

2023-11-13T08:01:00

(BPT) – It’s the season for family gatherings and resolutions. Family gatherings can bring both joy and stress. Thinking ahead to our goals for the next year, we often focus on self-improvement or showing up for other people in our lives. But there is one action that accomplishes both and can improve our mental health significantly: Deepening connection. The advice here can apply to any space or time, but can create connection and lessen conflict at the holidays.

“Social connection is a fundamental human need, as essential to survival as food, water and shelter,” wrote Surgeon General Vivek H. Murthy, in his recent advisory Our Epidemic of Loneliness and Isolation. He shared the sobering fact that research shows that social disconnection is as bad for our overall health as “smoking up to 15 cigarettes a day,” and emphasized that “Our individual relationships are an untapped resource — a source of healing hiding in plain sight. They can help us live healthier, more productive and more fulfilled lives.”

This year, The Jed Foundation (JED), which is focused on promoting mental health and preventing suicide for our nation’s teens and young adults, is offering concrete ways to start important and vulnerable intergenerational conversations that are the foundation of strong, supportive relationships. They can also be life-changing and — sometimes — life-saving.

Suicide remains the second-leading cause of death among 10- to 34-year-olds in the U.S., but it is preventable. Everyone has three key tools they can use to support young people: showing up, being willing to have hard conversations, and listening deeply. Being able to talk openly about suicide opens the door through which people find help.

“One of the best ways to care for your emotional health, and the emotional health of those around you, is by connecting to people you care about,” said Dr. Katie Hurley, DSW, a child and adolescent psychologist and Senior Clinical Advisor at JED. “Through social connectedness, you can create a solid foundation for mental well-being.”

Dr. Hurley suggests two ways to create a supportive environment along with conversation starters — from the everyday to the philosophical — that can be building blocks for more connected, enjoyable and mentally healthy family gatherings now and in the year ahead.

Make Space for Connection IRL

Create boundaries for social media use as a family. Prioritize spending time with people in person. These face-to-face interactions help to foster authentic connections and allow you, your young people, and others in your circle to share the joys and challenges you are experiencing.

Step Outside Your Comfort Zone

Being vulnerable with the people you trust in your life will help strengthen your bonds and support network. As a parent, caregiver or caring adult, admitting that you’re struggling mentally and emotionally can feel difficult, but there’s a pay-off. Acknowledging challenges makes them feel more manageable and encourages the same openness in the teens and young adults in your lives. This shows them the power of being open and honest. It’s equally important to share the things you do to cope with difficult moments.

Conversation Starters to Spark Family Connection

Caregivers to Teens

• What is something you and your friends know more about than the adults in your lives?
• If you could plan a family trip — on an unlimited budget — where would we go and what would we do?
• If you could host a dinner for six people you admire the most, who would they be?
• If you could fix one problem in the world right now what would it be?
• What is something people don’t usually know about you when they first get to know you?

Teens to Caregivers

• What’s one mistake you made that you were afraid for other people to find out about?
• What’s one thing my generation has that you wish you had when you were my age?
• Who was your go-to person when you were growing up?
• What helps you relax when you are feeling stressed?
• Name one of your most embarrassing moments when you were my age.

Teens to Teens

• What’s something you wish your family understood about you?
• What’s your favorite TikTok account when you want to check out for a bit?
• Do you have a go-to thing you do when you’re feeling down?
• How do you like people to support you when you’re having a hard time?
• Would you rather go to a big party and meet lots of new people or gather with a small group of friends at home?

To learn more about how you can invest in your mental health and that of the young people in your life, visit JED’s Mental Health Resource Center and check out JED’s Guides to having tough — but important — conversations. For example, 10 tips to start a conversation with your teens about their mental well-being.

For media inquiries or interview opportunities, please contact Justin Barbo, Director of Public Relations at JED, at justin@jedfoundation.org.

2023-11-13T08:01:00

(BPT) – Small cell lung cancer (SCLC) is a rare disease in which cancerous cells form in the tissues of the lung, accounting for ~15% of all lung cancers.¹ “Small cell” refers to the small, uniform nature of the cells under the microscope – contrary to non-small cell, where cells vary in both size and shape.

SCLC is typically categorized into two stages: limited stage and extensive stage, the latter describing cancers that have spread widely throughout the lung, to the other lung, to lymph nodes across the chest, or even to other parts of the body, such as the bone marrow. Because of the aggressive nature of the condition, 80-85% of patients are diagnosed with SCLC once it has reached this extensive-stage.² With this, early detection and diagnosis can offer the best chance of successful treatment for people living with SCLC.

In recognition of Lung Cancer Awareness Month, let’s take a closer look to better understand the treatment journey of those living with SCLC.

Chemotherapy helps destroy the tumor, but also healthy bone marrow.

Because SCLC spreads quickly throughout the body, intravenous treatment such as chemotherapy remains a cornerstone of care; however, while chemotherapy works to destroy cancer cells, it does not have the ability to differentiate between cancer cells and healthy cells – ultimately damaging both.

One harmful side effect of chemotherapy is damage to the bone marrow – the parent source of multiple cell types, including red blood cells, white blood cells, and platelets. When the bone marrow is damaged, this results in low blood cell count, also known as myelosuppression.

Myelosuppression can have serious consequences.

Myelosuppression can put people at increased risk of infection, fatigue, and bleeding.³ To better understand its impact, it’s helpful to first understand the functions each of our cell-types play in supporting our bodies:

• White blood cells are responsible for fighting infection, so when white blood cell counts are low – the scientific term is neutropenia – people are at a higher risk of infection;
• Red blood cells carry oxygen around the body, so when red blood cell counts are low – also known as anemia – this can lead to feelings of weakness, fatigue, dizziness or difficulty breathing;
• Platelets help clot blood, so with fewer platelets – called thrombocytopenia – there is a higher risk of bleeding or excessive bruising.

Having low blood cell counts or platelets can negatively impact people’s health and treatment, which can result in hospitalization, the need for blood transfusions or rescue interventions, as well as reduction in dose or delays in chemotherapy treatment.^4,5 In fact, neutropenia and anemia are two of the top reasons people being treated with chemotherapy enter the emergency room or hospital.⁶

Mitigating myelosuppression is possible.

For people undergoing chemotherapy, traditional treatment options for myelosuppression often promote and replace cells that have been damaged or depleted due to the chemotherapy and aim to stimulate the recovery of damaged cells. These interventions are used with the goal of stimulating or replacing individual cell lineages after the damage from chemotherapy occurs and can include:

• G-CSFs (Granulocyte-Colony Stimulating Factor) are typically given to people who experience neutropenia (low white blood cell counts) after chemotherapy to help stimulate the body to produce more white blood cells (neutrophils) to protect against infection;
• ESAs (Erythropoietin Stimulating Agent) are given to people who experience anemia after chemotherapy to stimulate the bone marrow to make red blood cells;
• Red blood cell transfusions provide another option for people with anemia but can create other burdens for the patient including additional travel for appointments and procedures.
• While there are no approved treatments for chemotherapy-induced thrombocytopenia, healthcare providers may consider platelet transfusions for people with low platelets.

Alternatively, some people with SCLC may have the option to receive treatment in advance of chemotherapy which may help reduce the negative effects of chemotherapy on bone marrow cells. If you or someone you know has been diagnosed with SCLC, talk to your healthcare provider about your options. If you are interested in learning more about the effect of chemotherapy on multiple blood cell lineages, click here.

This content is sponsored by G1 Therapeutics.

References

¹American Cancer Society. What Is Lung Cancer? Available from: https://www.cancer.org/cancer/types/lung-cancer/about/what-is.html. Accessed November 2, 2023.

²Schwendenwein A, Megyesfalvi Z, Barany N. et al. Molecular profiles of small cell lung cancer subtypes: therapeutic implications. Mol Ther Oncolytics. 2021;20:470–483.

³Cleveland Clinic. Myelosuppression (Bone Marrow Suppression. Available from: https://my.clevelandclinic.org/health/diseases/24788-myelosuppression. Accessed November 2, 2023.

⁴Kurtin S. Myeloid toxicity of cancer treatment. J Adv Pract Oncol. 2012;3(4):209-224.

⁵American Cancer Society. Kinds of Blood Product Transfusions. Available from: https://www.cancer.org/cancer/managing-cancer/treatment-types/blood-transfusion-and-donation/what-are-transfusions.html. Access November 2, 2023.

⁶Hassett MJ, O’Malley AJ, Pakes JR, et al. Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer. J Natl Cancer Inst. 2006;98(16):1108-1117.

2023-11-09T12:01:00

(BPT) – Roy Bragadeste, a husband and father, was living in Seattle and enjoying what many would describe as a relatively normal life, working, spending time with his wife, kids and dog, and enjoying the outdoors. The idea of a cancer diagnosis was far from his mind, but that is exactly what happened.

During an epic storm blanketing Seattle with more snow than the city had seen in decades, Roy slipped and fell on a patch of ice, cracking three ribs. After experiencing severe pain for months from the broken ribs, he was examined by a doctor who pushed on his abdomen, causing Roy to call out in pain. Concerned that Roy shouldn’t be experiencing discomfort there, the doctor recommended that Roy undergo a CT scan, which showed a mass in his pelvis. Roy also had swollen lymph nodes, a common symptom of what would turn out to be an aggressive type of blood cancer called diffuse large B-cell lymphoma (DLBCL).

After undergoing a lymph node biopsy, Roy was diagnosed with this cancer of the lymphatic system, which occurs when abnormal white blood cells grow out of control.¹ DLBCL is the most common type of non-Hodgkin’s lymphoma, responsible for approximately 31,000 new cases in the United States this year.²

Long before Roy moved to Seattle, he came to the United States from Portugal as an eight-year-old. His father, who did not yet speak English, worked three jobs, struggling to make ends meet. To help out his family, Roy started working at age 11, watering his neighbors’ yards for 75 cents each.

Helping support his family at a young age taught Roy determination and resilience, traits that would be important years later – not only when he was diagnosed with DLBCL but again when his cancer relapsed, not once but three times.

Facing the Challenge of a Lymphoma Diagnosis

DLBCL is a fast-growing blood cancer and one of the most aggressive types of non-Hodgkin’s lymphoma.³ For many people diagnosed with DLBCL, their cancer typically goes into remission with standard initial therapy. However, for 40% of them, their cancer either relapses (returns at a later time) or is refractory (doesn’t respond to initial treatment).⁴

Although Roy had advanced-stage DLBCL, his oncologist told him it was treatable.

“It took a few weeks to accept my diagnosis and see myself as a cancer patient in the fight of my life,” Roy said.

He was initially treated with a combination of chemotherapy plus immunotherapy, persevering through six cycles of therapy.

Roy was then referred to a hematologist at the Swedish Cancer Institute in Seattle who is a lymphoma specialist and received radiation treatment.

Experiencing the Burden of Relapse

When a PET scan showed Roy’s cancer had returned, the next step in his treatment journey was a bone marrow transplant.

“It was as close as I’ve ever been to saying ‘this is it, I’m done,’” Roy said, referring to his experience undergoing the bone marrow transplant.

Six months after returning home from the hospital from the bone marrow transplant, Roy felt pain in his hip and couldn’t lift his leg. His hematologist gave him the unfortunate news that the cancer had returned a second time. Roy elected to be treated with a type of cancer therapy in which immune cells were removed from his blood, genetically modified in a lab, and reinfused – which involved a week-long hospital stay.

Three months later, a scan showed a spot in Roy’s lungs, and biopsy results revealed the cancer had returned a third time.

“Every time I heard I had cancer again, it was just as bad as the first time I heard it,” Roy said.

Roy was worried he was out of options, but he followed his hematologist’s suggestion to enroll in a clinical trial evaluating an investigational treatment – a bispecific antibody, designed to utilize the immune system to fight lymphoma – for adults with DLBCL that has come back or did not respond to at least two previous treatments. It may also affect healthy cells.

“After I experienced a third relapse, I wanted to participate in a clinical trial. Even if the study wasn’t successful, I wished to give back by using my condition to help hematologists and researchers advance investigational therapies that might help other people in a similar situation,” Roy said.

Based on the clinical trial results, the Food and Drug Administration (FDA) approved the treatment, Columvi^® (glofitamab-gxbm), under accelerated approval in June 2023 for adults with certain types of relapsed or refractory DLBCL or large B-cell lymphoma (LBCL) after at least two previous rounds of cancer therapy. All medicines have side effects. In the clinical trial of Columvi, a serious side effect that was common was cytokine release syndrome, a type of inflammation throughout the body that can be severe and life-threatening.

For people like Roy with aggressive lymphoma who have relapsed several times and have limited treatment options, Columvi may provide hope.

Columvi is what’s known as a fixed-duration treatment, meaning it’s given for a finite number of treatment cycles, which may allow patients to have time off therapy after completing treatment, rather than continuous therapy, which is given until the cancer progresses. Columvi is ready for infusion, so treatment may be able to start soon after the medicine is prescribed.

After Roy’s long treatment journey, he is now in remission. Today, he enjoys participating in outdoor activities and coaching baseball, and is focused on spending time with his family.

“Having blood cancer has been devastating, but it’s also been a blessing,” he explained. “It’s given me the opportunity to live like I was dying. I got a kick in the butt that told me to wake up!”

If you or a loved one has DLBCL, talk to your doctor about treatment options. For more information about Columvi, visit https://www.columvi.com/.

This sponsored article is presented by Genentech.

# # #

Columvi U.S. Indication

Columvi (glofitamab-gxbm) is a prescription medicine to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL) or large B-cell lymphoma (LBCL) that has come back (relapsed) or that did not respond to previous treatment (refractory), and who have received 2 or more prior treatments for their cancer.

It is not known if Columvi is safe and effective in children.

The conditional approval of Columvi is based on response rate and durability of response. There are ongoing studies to establish how well the drug works.

What is the most important information I should know about Columvi?

Columvi can cause Cytokine Release Syndrome (CRS), a serious side effect that is common during treatment with Columvi, and can also be serious and lead to death.

Call your healthcare provider or get emergency medical help right away if you develop any signs or symptoms of CRS, including:

• fever of 100.4°F (38°C) or higher
• chills or shaking
• fast or irregular heartbeat
• dizziness or light-headedness
• trouble breathing
• shortness of breath

Due to the risk of CRS, you will receive Columvi on a “step-up dosing schedule”.

• A single dose of a medicine called obinutuzumab will be given to you on the first day of your first treatment cycle (Day 1 of Cycle 1).
• You will start the Columvi step-up dosing schedule a week after the obinutuzumab dose. The step-up dosing schedule is when you receive smaller “step-up” doses of Columvi on Day 8 and Day 15 of Cycle 1. This is to help reduce your risk of CRS. You should be hospitalized during your infusion and for 24 hours after receiving the first step-up dose on Day 8. You should be hospitalized during your infusion and for 24 hours after receiving the second step-up dose on Day 15 if you experienced CRS during the first step-up dose.
• You will receive your first full dose of Columvi a week after the second step-up dose (this will be Day 1 of Cycle 2).
• If your dose of Columvi is delayed for any reason, you may need to repeat the “step-up dosing schedule”.
• If you had more than mild CRS with your previous dose of Columvi, you should be hospitalized during and for 24 hours after receiving your next dose of Columvi.
• Before each dose of Columvi, you will receive medicines to help reduce your risk of CRS and infusion-related reactions.

Your healthcare provider will monitor you for CRS during treatment with Columvi and may treat you in a hospital if you develop signs and symptoms of CRS. Your healthcare provider may temporarily stop or completely stop your treatment with Columvi if you have severe side effects.

Carry the Columvi Patient Wallet Card with you at all times and show it to all of your healthcare providers. The Columvi Patient Wallet Card lists the signs and symptoms of CRS you should get emergency medical help for right away.

What are the possible side effects of Columvi?

Columvi may cause serious side effects, including:

• Cytokine Release Syndrome.
• Neurologic problems. Columvi can cause serious neurologic problems that may lead to death. Your healthcare provider will monitor you for neurologic problems during treatment with Columvi. Your healthcare provider may also refer you to a healthcare provider who specializes in neurologic problems. Tell your healthcare provider right away if you develop any signs or symptoms of neurologic problems, including:

3. • headache
   • confusion and disorientation
   • difficulty paying attention or understanding things
   • trouble speaking
   • sleepiness
   • memory problems
   • numbness, tingling, or weakness of the hands or feet
   • dizziness
   • shaking (tremors)

• Serious Infections. Columvi can cause serious infections that may lead to death. Your healthcare provider will monitor you for signs and symptoms of infection and treat you as needed. Tell your health care provider right away if you develop any signs of an infection, including: fever, chills, weakness, cough, shortness of breath, or sore throat.
• Growth in your tumor or worsening of tumor related problems (tumor flare). Tell your healthcare provider if you get any of these signs or symptoms of tumor flare:
• tender or swollen lymph nodes
• pain or swelling at the site of the tumor
• chest pain
• cough
• trouble breathing

The most common side effects of Columvi include: CRS, muscle and bone pain, rash, and tiredness.

The most common severe abnormal lab test results with Columvi include: decreased white blood cells, decreased phosphate (an electrolyte), increased uric acid levels, and decreased fibrinogen (a protein that helps with blood clotting).

Your healthcare provider may temporarily stop or completely stop treatment with Columvi if you develop certain side effects.

Before receiving Columvi, tell your healthcare provider about all of your medical conditions, including if you:

• have an infection
• have kidney problems
• are pregnant or plan to become pregnant. Columvi may harm your unborn baby

Females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test before you start treatment with Columvi.
• You should use effective birth control (contraception) during treatment and for 1 month after your last dose of Columvi. Talk to your healthcare provider about what birth control method is right for you during this time.
• Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Columvi.
• are breastfeeding or plan to breastfeed. Columvi may pass into your breast milk. Do not breastfeed during treatment and for 1 month after your last dose of Columvi.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What should I avoid while receiving Columvi?

Do not drive, operate heavy machinery, or do other dangerous activities if you develop dizziness, confusion, shaking (tremors), sleepiness, or any other symptoms that impair consciousness until your signs and symptoms go away. These may be signs and symptoms of neurologic problems.

These are not all the possible side effects of Columvi. Talk to your health care provider for more information about the benefits and risks of Columvi.

You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.

Please see Important Safety Information, including Serious Side Effects, as well as the Columvi full Prescribing Information and Medication Guide or visit https://www.Columvi.com.

References

1. American Society of Clinical Oncology. Cancer.Net. Lymphoma – Non-Hodgkin: Introduction. https://www.cancer.net/cancer-types/lymphoma-non-hodgkin/introduction. Accessed June 28, 2023.
2. Kanas G, Ge W, Quek RGW, Keeven K, Nersesyan K, Arnason JE. Epidemiology of diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the United States and Western Europe: population-level projections for 2020-2025. Leuk Lymphoma. 2022;63(1):54-63. https://doi.org/10.1080/10428194.2021.1975188. Epub 2021 Sep 11. PMID: 34510995. Accessed June 28, 2023.
3. American Cancer Society. About Non-Hodgkin Lymphoma. What Is Non-Hodgkin Lymphoma? https://www.cancer.org/cancer/non-hodgkin-lymphoma/about/what-is-non-hodgkin-lymphoma.html. Accessed June 28, 2023.
4. Sawalha Y. Relapsed/refractory diffuse large B-cell lymphoma: a look at the approved and emerging therapies. J Pers Med. 2021;11(12):1345. https://doi.org/10.3390/jpm11121345. Accessed June 28, 2023.
5. Columvi (glofitamab-gxbm) Prescribing Information. Genentech, Inc. 2023.

2023-11-08T08:01:00

(BPT) – Diagnosed with breast cancer nearly four years ago at the age of 41, Krisdee Clark*, like many women, was completely taken aback. What laid ahead for her was an inspiring journey of personal growth and recovery. Not only would she harness her own resilience and grace to thrive after treatment, but she would also channel her experience and strength to inspire change. In doing so, she’d create a meaningful platform to support other women who were going through similar struggles.

Facing a diagnosis with numerous hurdles

After feeling a lump and some minor discomfort while in the shower, Krisdee quickly made an appointment with her gynecologist who advised her to have a mammogram and diagnostic ultrasound. A week later, doctors scheduled a biopsy and shared the news of her diagnosis: invasive lobular carcinoma, a form of breast cancer that begins in the milk ducts.

To make a difficult situation even harder, the diagnosis arrived during her husband’s deployment overseas and coincided with the onset of COVID-19.

“The moment I was diagnosed, I knew I had to handle it with grace,” explained Krisdee, a mother of two young children plus three “bonus children.” “I had to show my daughter that we could get through this. I had to show my son what it was like to be a woman and go through something like this, in case he ever has someone in his life who ends up in a similar situation. That was very important to me.”

In addition to the weight of coping with her diagnosis, Krisdee struggled to find the right surgeon who could not only assure the successful removal of cancer but also instill confidence in the reconstruction of her breasts afterward.

Her grace was tested when the initial surgical oncologist she saw commented on her bringing an entourage to her appointment, which included having her husband join via FaceTime since he was deployed. Following this incident, Krisdee’s desire for a double mastectomy was met with resistance, and the plastic surgeon she consulted with offered little reassurance, telling her that while she would never look the same post-reconstruction, the cancer would be removed, and she should be happy with that.

Krisdee left the appointment in tears, knowing there had to be other options. “I struggled because a lot of people had the view that once the cancer’s gone you should be happy,” she said. “Removing the cancer was number one, but at 41 years old, I wasn’t ready to just accept that this is what I’d look like. It was very disheartening, and I knew there had to be more options.”

Moving forward with grace

Throughout her very trying journey, Krisdee drew strength from within and the support of her loved ones to continue searching for a doctor that she knew would be the best fit for her.

This is when Krisdee’s husband, an employee of Johnson & Johnson, sought advice from a colleague at Mentor Worldwide LLC, the #1 global brand in breast aesthetics, and another company within J&J. What Krisdee learned was invaluable: find a plastic surgeon who also specializes in reconstruction because they will work in partnership with some of the best surgical oncologists. Through this contact, Krisdee found surgeons Dr. Garrett Harper and Dr. Peter Turk, who actively involved her in every step of her treatment and reconstruction journey and gave her hope.

At the time of her diagnosis, Krisdee was initially informed of a 2 mm mass in her breast. However, a subsequent MRI showed the mass was closer to 5 mm and near her lymph nodes. In March 2020, just over a month after her diagnosis, and with the support of family, friends, and her doctors, Krisdee underwent a bilateral mastectomy (double mastectomy) and the mass was discovered to be significantly larger, measuring at 7.7cm. During her surgery, she had MENTOR^® Breast Tissue Expanders placed to increase the amount of breast tissue needed prior to her having breast reconstruction with MENTOR^® Breast Implants.

Turning struggle into strength

Like many women facing a breast cancer diagnosis, Krisdee was searching for answers, not just from a medical perspective, but from the shared experiences of women going through similar challenges. Frustrated by the absence of information, she decided to create The Blonde Bombshell, a blog that evolved into a much larger platform for Krisdee — offering a vital online community for women seeking resources, connections, and inspiration.

“I’ve spoken to many women who were talked out of reconstruction or dismissed by doctors. I’m thankful I found doctors that listened to me,” Krisdee said. “I use my blog and platform to educate others about what to expect — and things I wish I knew before I was diagnosed. I want to be a resource for others because I wanted resources so badly.”

Surprised by the global traction her blog was getting, Krisdee considered additional platforms to broaden her impact on raising awareness. Her aim was to ensure that women no longer felt isolated during their breast cancer journeys.

It had been years since she was a teenager in a state beauty pageant, but Krisdee recalled its potential for driving awareness and change. Motivated by this memory, Krisdee re-entered the pageant world, first winning the title of Mrs. Capital City in South Carolina only 8 months post-reconstruction. Shortly after, in April 2022, Krisdee was crowned Mrs. South Carolina American. Her journey continued on the national stage, where, just three months later, she took home the crown and national title of Mrs. American 2022.

Winning Mrs. American presented Krisdee with opportunities for public speaking, connecting with fellow survivors, and discovering a deeper meaning in her cancer journey. She’s since joined Susan G. Komen for the Cure, serving as the Keynote Speaker for their Advocacy Day in Washington, DC, and recently shared her story on the Real Pink Podcast. During her reign, Krisdee also visited women cancer warriors at Walter Reed Medical Center.

Through her journey, Krisdee wants women to have answers to their questions and assurance that they are not walking this path alone. Her platform is clear: Women can thrive and still feel beautiful after breast cancer.

“It was important to me that I didn’t let cancer define me,” Krisdee said. “I really believe that was my mindset from the beginning. It was very important to always have the outlook that I was bigger than cancer, and I would defeat this.”

Learn more about Mentor and breast reconstruction at BreastImplantsByMentor.com

To learn more about Krisdee’s journey, visit www.KrisdeeClark.com.

*Krisdee Clark is being compensated by Mentor for her time and participation in sharing her story.

The sale and distribution of Mentor Breast Implant Devices are restricted to users and/or user facilities that provide information to patients about the risks and benefits of the device prior to its use in the form and manner specified in approved labeling to be provided by Mentor Worldwide LLC.

Important information: Prior to use, refer to the instructions for use supplied with this device for indications, contraindications, side effects, warnings and precautions.

Caution: US law restricts this device to sale by or on the order of a physician.

Important Safety Information:

The MENTOR^® Collection of Breast Implants are indicated for breast reconstruction.

Breast implant surgery should not be performed in women:

• With active infection anywhere in their body
• With existing cancer or pre-cancer of their breasts who have not received adequate treatment for those conditions
• Who are currently pregnant or nursing

Safety and effectiveness have not been established in patients with autoimmune diseases (for example lupus and scleroderma), a weakened immune system, conditions that interfere with wound healing and blood clotting, or reduced blood supply to breast tissue. Patients with a diagnosis of depression, or other mental health disorders, should wait until resolution or stabilization of these conditions prior to undergoing breast implantation surgery.

There are risks associated with breast implant surgery. You should be aware that breast implants are not lifetime devices and breast implantation may not be a one-time surgery. The chance of developing complications increases over time. You may need additional unplanned surgeries on your breasts because of complications or unacceptable cosmetic outcomes. Many of the changes to your breast following implantation are irreversible (cannot be undone) and breast implants may affect your ability to breastfeed, either by reducing or eliminating milk production.

Breast implants are not lifetime devices and breast implantation may not be a one-time surgery. The most common complications for breast reconstruction with MENTOR^® MemoryGel^® Breast Implants include any reoperation, implant removal with or without replacement, and capsular contracture. The most common complications with MENTOR^® MemoryShape^® Breast Implants for breast reconstruction include reoperation for any reason, implant removal with or without replacement, and capsular contracture. A lower risk of complication is rupture. The health consequences of a ruptured silicone gel breast implant have not been fully established. MRI screenings are recommended three years after initial implant surgery and then every two years after to detect silent rupture. Breast implants are also associated with the risk of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), an uncommon type of lymphoma. An individual’s risk of developing BIA-ALCL with MENTOR^® Breast Implants is low based on the incidence of worldwide cases. The most common complications for breast reconstruction with MENTOR^® Saline-filled Breast Implants include re-operation, implant removal, capsular contracture, breast pain, and implant deflation.

Detailed information regarding the risks and benefits associated with MENTOR^® Breast Implants is provided in several educational brochures. For MemoryGel^® Implants: Important Information for Reconstruction Patients about MENTOR^® MemoryGel^® Breast Implants. For MemoryShape^® Implants: Patient Educational Brochure – Breast Reconstruction with MENTOR^® MemoryShape^® Breast Implants and Quick Facts about Breast Augmentation & Reconstruction with MENTOR^® MemoryShape^® Breast Implants. For MENTOR^® Saline-filled Implants: Saline-Filled Breast Implants: Making an Informed Decision. These brochures are available from your surgeon or visit www.mentorwwllc.com. It is important that you read and understand these brochures when considering MENTOR^® Breast Implants.

ARTOURA^® Breast Tissue Expanders and CONTOUR PROFILE^® Breast Tissue Expanders are used for breast reconstruction after mastectomy, correction of an underdeveloped breast, scar revision, and tissue defect procedures. The expander is intended for temporary subcutaneous or submuscular implantation and is not intended for use beyond six months. ARTOURA^® Breast Tissue Expanders and CONTOUR PROFILE^® Tissue Expanders contain a magnet within the internal injection domes and are NOT MRI compatible. The device could be moved by the MRI causing pain or displacement, potentially resulting in a revision surgery. DO NOT use the ARTOURA^® Breast Tissue Expander and CONTOUR PROFILE^® Tissue Expander in patients that have a previously implanted device such as pacemakers, drug infusion devices, artificial sensing devices, etc. that could be affected by a magnetic field. Mentor has not tested the effects of radiation therapy with ARTOURA^® Breast Tissue Expanders and CONTOUR PROFILE^® Expander devices. The incidence of extrusion of the expander has been shown to increase when the expander has been placed in injured areas: scarred, heavily irradiated or burned tissue, crushed bone areas, where severe surgical reduction of the area has previously been performed; and where steroids are used in the surgical pocket. Detailed information about indications, contraindications, warnings, and precautions associated with the use of ARTOURA^® Breast Tissue Expanders CONTOUR PROFILE^® Expanders are provided in the Instructions for Use (IFU) available online at www.mentorwwllc.com

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2023-11-07T08:01:00

(BPT) – Sponsored by GSK.

Nurses use their knowledge, training and compassion to help patients cope with the most difficult times in their lives. Retired nurses, Peg and Debbie, share their stories of how they adjusted from nurse to patient after being diagnosed with advanced ovarian cancer, along with their advice for anyone impacted by the disease.

These are the stories of Peg and Debbie and how they managed their disease.

Peg and Debbie are spokespeople for GSK. This is their experience and others’ may be different.

From nurse to patient

While both nurses recognized symptoms that seemed abnormal, they also had to face the reality that it can take time to reach a correct diagnosis.

After testing positive for COVID during the pandemic, Peg’s abdominal pain was assumed by her health care providers to be caused by COVID-related colitis. She had a number of abdominal CT scans due to her abdominal discomfort for several months that were inconclusive until an ovarian cyst and potential bowel infection were shown. Peg’s experience as a nurse told her she shouldn’t be developing cysts at age 65, so she immediately contacted her gynecologist. After undergoing laparoscopic surgery to address these issues, Peg was told in the recovery room that she had ovarian cancer. There are currently no recommended screening tests for ovarian cancer, and PAP smears do not detect the disease.¹

Upon her diagnosis, she met with her gynecologic oncologist within two days and underwent a total hysterectomy along with partial colectomy (removal of uterus and cervix, and part of the bowel) days later.

Although Peg found the transition to becoming a patient challenging, she also gained clarity about her role. “I told every healthcare professional I interacted with that I did not want to be spoken to like a nurse,” Peg explained. “I wanted to be treated like a patient — someone with a serious condition who needed a treatment plan that could help prolong my life.”

Debbie’s diagnosis was especially shocking to her as a former obstetrics and gynecology nurse. Though she routinely “reinforced the importance of regular PAP smears, breast self-exams, and mammograms” to her patients at the clinic, “symptoms of ovarian cancer were never a priority in patient education.” Debbie’s situation is not uncommon, as the signs and symptoms of ovarian cancer can be similar to common health conditions.²

After Debbie mentioned irregular brown spotting she was experiencing at a check-up, an ultrasound discovered a thickened uterine lining and abnormal bilateral ovaries. The gynecologist explained that her ovaries showed cysts and lesions.

Debbie’s ovarian cancer wasn’t discovered until after she had surgery to remove a polyp, the thick uterine lining, and her tubes and ovaries. She was surprised by the diagnosis, as she had experienced none of the symptoms — such as pelvic pain — that the gynecologist had asked her about. Debbie’s experience is not abnormal, as ovarian cancer often produces symptoms caused by less serious conditions and can even cause no symptoms at all.¹

Debbie’s diagnosis disrupted plans to enjoy retirement at the beach with her husband. “I’ve always been a planner. In junior high, when I was asked what I wanted to be when I grew up, I said I planned to be a nurse,” said Debbie. “But I never planned to have cancer.”

Ovarian cancer facts

About 20,000 people will receive a new diagnosis of ovarian cancer in the U.S. this year, according to current estimates from the American Cancer Society — and about 13,000 will die from ovarian cancer.³ In fact, ovarian cancer ranks fifth in cancer deaths for women.³ The American Cancer Society reports that ovarian cancer often develops in older women, with about one-half of those diagnosed being 63 or older.³

First-line treatment for advanced ovarian cancer

For both women, their initial treatment involved at least one surgery, followed by chemotherapy. Another vital aspect of their treatment plans was the pursuit of maintenance therapy, a treatment approach that may extend the time before cancer comes back. Maintenance therapy can be an important approach to ovarian cancer treatment as about 85% of people with ovarian cancer experience recurrence after their initial treatment.⁴

In Peg’s case, she was eligible to receive a type of maintenance therapy, a poly (ADP-ribose) polymerase (PARP) inhibitor, that might be beneficial for her long-term care. These inhibitors work to prevent cells from repairing their damaged DNA, which may help slow the return of progression of cancer.⁵ “When discussing options with my oncologist, she recommended ZEJULA (niraparib) as a first-line maintenance treatment as my best course to help prolong remission,” Peg explained. Maintenance therapy options, like ZEJULA, may help delay certain types of advanced ovarian cancer from coming back.⁶

APPROVED USES
ZEJULA tablet is a prescription medicine used for the:

• maintenance treatment of adults with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. ZEJULA is used after the cancer has responded (complete or partial response) to treatment with platinum-based chemotherapy

It is not known if ZEJULA is safe and effective in children.

Peg’s doctor discussed the most serious potential side effects of ZEJULA with her, such as bone marrow problems called MDS (myelodysplatic syndrome) or a type of blood cancer called AML (acute myeloid Leukemia) which may lead to death. Routine monitoring of high blood pressure, heart rate and monitoring of blood counts will be required during treatment. ZEJULA has also been associated with PRES (posterior reversible encephalopathy syndrome) which may cause headaches, vision changes, confusion or seizures.

Peg experienced elevated blood pressure and headaches with her initial dose of ZEJULA. This was Peg’s experience, yours may be different. “It’s important to keep your doctor informed of any side effects you may be experiencing,” Peg added. Some of the more common side effects for ZEJULA are nausea, tiredness, constipation, and pain in the muscles or back. These are not all the potential side effects of ZEJULA; please review the Important Safety Information below, as well as the full Prescribing Information.

ZEJULA should be taken at the same time every day. Peg takes her treatment every night at bedtime and although the routine works for her, she strongly recommends other patients work with their doctor to find a regimen that works best for them.

“Today, my bloodwork is monitored monthly, and I still actively see my oncologist. It’s important to work with your physician to follow the monitoring schedule,” Peg said. “I had to put a lot of trust and faith in letting the professionals do what they knew how to do in helping me find the right treatment. I’m grateful to have found a maintenance treatment for advanced ovarian cancer that works for me.”

In Debbie’s case, she was also able to get through chemotherapy with manageable side effects. “After the third round of chemo, my doctor brought up the idea of using a PARP inhibitor as a maintenance treatment for advanced ovarian cancer,” said Debbie.

Debbie underwent genetic testing to discover that she was negative for the BRCA (BReast CAncer) gene. However, her tumor was positive for the homologous recombination deficiency (HRD) biomarker. Because of her HRD mutation, Debbie explained, “my doctor recommended ZEJULA which may help delay any potential recurrence.”

BRCA genes produce proteins that repair damaged DNA, and mutations in these genes can carry increased risks of certain types of cancers, such as ovarian cancer.⁷ HRD means that the body’s cell repair system no longer works properly, and therefore is unable to repair damaged DNA in the body’s cells.⁸ When a cancerous tumor tests positive for HRD, this means that its cancer cells have a harder time repairing themselves.⁸

Debbie experienced side effects including nausea, feeling winded with any exertion and dropping blood counts. This was Debbie’s experience, yours may be different. After adjusting the dose of ZEJULA and addressing her side effects, Debbie’s doctor was able to find the right amount of medicine that worked for her.

Everyone’s reaction to medication may be different, so both women stressed the importance of frequent communication with your healthcare team.

“I encourage others to listen to their bodies and not ignore subtle symptoms. Find a doctor who is willing to listen to you and educate you on your disease,” Debbie noted. “I’m now planning on living my life the best way that I can! Advanced ovarian cancer has changed a lot of things in my life, but one thing will never change: I’ll always be a planner.”

APPROVED USES
ZEJULA (niraparib, tablets 100 mg/200 mg/300 mg) tablet is a prescription medicine used for the:

• maintenance treatment of adults with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. ZEJULA is used after the cancer has responded (complete or partial response) to treatment with platinum-based chemotherapy

It is not known if ZEJULA is safe and effective in children.

Important Safety Information

ZEJULA (niraparib, tablets 100 mg/200 mg/ 300 mg) may cause serious side effects, including:

Bone marrow problems called Myelodysplastic Syndrome (MDS) or a type of blood cancer called Acute Myeloid Leukemia (AML). Some people who have ovarian cancer and who have received previous treatment with chemotherapy or certain other medicines for their cancer have developed MDS or AML during treatment with ZEJULA. MDS or AML may lead to death.

Symptoms of low blood cell counts (low red blood cells, low white blood cells, and low platelets) are common during treatment with ZEJULA. They can be a sign of serious bone marrow problems, including MDS or AML. These symptoms may include the following:

Weakness	Frequent infections	Blood in urine or stool
Feeling tired	Fever	Bruising or bleeding more easily
Weight loss	Shortness of breath

Your doctor will do blood tests to check your blood cell counts before treatment with ZEJULA. You will be tested weekly for the first month of treatment with ZEJULA, monthly for the next 11 months of treatment, and from time to time afterward.

High blood pressure is common during treatment with ZEJULA, and it can become serious. Your doctor will check your blood pressure and heart rate at least weekly for the first two months, then monthly for the first year, and as needed thereafter during your treatment with ZEJULA.

Posterior reversible encephalopathy syndrome (PRES) is a condition that affects the brain and may happen during treatment with ZEJULA. If you have headache, vision changes, confusion, or seizure, with or without high blood pressure, please contact your doctor.

Before starting to take ZEJULA, tell your doctor about all of your medical conditions, including if you:

• Have heart problems
• Have liver problems
• Have high blood pressure
• Are pregnant or plan to become pregnant. ZEJULA may harm an unborn baby and may cause loss of pregnancy (miscarriage)
• If you are able to become pregnant, you should use effective birth control (contraception) during treatment with ZEJULA and for 6 months after taking the last dose of ZEJULA
• If you are able to become pregnant, your doctor may perform a pregnancy test before you start treatment with ZEJULA
• You should tell your doctor right away if you become pregnant
• Are breastfeeding or plan to breastfeed
• ZEJULA may harm your baby. You should not breastfeed your baby during treatment with ZEJULA and for 1 month after taking the last dose of ZEJULA

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ZEJULA include the following:

Nausea Tiredness Constipation Pain in your muscles and back Pain in the stomach area Vomiting Loss of appetite Trouble sleeping Headache

Shortness of breath Rash Diarrhea Cough Dizziness Changes in the amount or color of your urine Urinary tract infection Low levels of magnesium in the blood

If you have certain side effects, then your doctor may change your dose of ZEJULA, temporarily stop, or permanently stop treatment with ZEJULA.

These are not all the possible side effects of ZEJULA. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information.

To learn more about this treatment option, visit ZEJULA.com.

Trademarks are owned by or licensed to the GSK group of companies.

©2023 GSK or licensor.

NRPCOCO230010 October 2023

Produced in USA.

References

1. American Cancer Society. Can Ovarian Cancer Be Found Early? https://www.cancer.org/cancer/ovarian-cancer/detection-diagnosis-staging/detection. Last Updated July 24, 2020. Accessed October 2023.
2. American Cancer Society. Signs and Symptoms of Ovarian Cancer. https://www.cancer.org/cancer/types/ovarian-cancer/detection-diagnosis-staging/signs-and-symptoms.html. Last Updated April 11, 2018. Accessed October 2023.
3. American Cancer Society. Key Statistics for Ovarian Cancer. https://www.cancer.org/cancer/ovarian-cancer/detection-diagnosis-staging/detection.html. Last Updated January 12, 2022. Accessed October 2023.
4. Lorusso D, Mancini M, Di Rocco R, et al. The role of secondary surgery in recurrent ovarian cancer [published online August 5, 2012]. Int J Surg Oncol. 2012;2012:613980. doi:10.1155/2012/613980. Accessed October 2023.
5. NCI Dictionary of Cancer Terms: PARP inhibitor. National Cancer Institute website. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/parp-inhibitor. Accessed October 2023.
6. ZEJULA Tablet PI. GSK 2023. Accessed October 2023.
7. National Cancer Institute. BRCA Mutations: Cancer Risk and Genetic Testing. https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet. Last Updated November 19, 2020. Accessed October 2023.
8. Target Ovarian Cancer. Homologous recombination deficiency. https://targetovariancancer.org.uk/about-ovarian-cancer/hereditary-ovarian-cancer/homologous-recombination-deficiency. Accessed October 2023.

2023-11-05T17:03:00

(BPT) – Menopause is a natural transition every woman goes through. Yet, it remains misunderstood and often misidentified.

A groundbreaking study of more than 32,000 women may revolutionize this. The study, conducted by Phenology — a pioneering women’s health brand that provides non-hormonal menopause solutions — offers insights that debunk some of the most prevalent myths surrounding menopause. Knowing the facts can empower women to advocate for effective care from healthcare professionals.

Myth 1: Menopause usually happens after age 50.

According to Phenology’s study, the average age of menopause onset was 53, but women as young as 35 were observed in the early stage of perimenopause.

Ultimately, there’s no standard timeframe for the menopausal transition, which can last between 7 and 14 years. In the Phenology study, 50-year-old women were in the 25-75th percentile range across four different menopause stages: early perimenopause, late perimenopause, early postmenopause and late postmenopause. This means that at the age of 50, some women are just starting their journey in early perimenopause while others have already entered late postmenopause.

Myth 2: Postmenopause means it’s over.

Postmenopause is the last stage of menopause; but counterintuitively, it’s marked by an increase in symptom number and frequency. Phenology found that women experience an average of 11 symptoms during postmenopause, compared to 8 during perimenopause. Late postmenopause had the highest incidence of hot flashes (73%), night sweats (68%), brain fog (77%), and insomnia (70%). Sexual issues also intensified in this phase, with 62% of women reporting low libido and 52% noting vaginal dryness, which can lead to painful intercourse.

The label “post” in this case is somewhat deceiving, and doesn’t capture women’s actual experience.

Myth 3: Hot flashes are the main symptom worth treating.

Menopause is more than just hot flashes, with women experiencing an average of 9 symptoms simultaneously over the course of the transition. They range from physical — hot flashes, night sweats, insomnia and brain fog — to emotional — anxiety, mood swings, irritability and depression — to sexual, like low libido and vaginal dryness. These are frustrating at best, life-disrupting at worst, and plenty deserving of treatment.

Early perimenopause especially is marked by emotional symptoms that could be mistaken for mental health. Phenology’s study found that 72% of women in this stage reported mood swings, 70% felt anxiety, 67% experienced irritability and 60% indicated a depressed mood. Understanding that these emotional changes might be caused by hormonal shifts can help women get proper care.

Myth 4: Menopause is the same for everyone.

While all women will go through the menopausal transition, Phenology’s study found that the experience is remarkably different for each individual. Across 32,000 women, Phenology identified over 15,000 completely unique symptom combinations. Chances are, a woman and her closest friends will each experience different symptoms — making it near impossible to get accurate advice from peers.

With only 31% of OB-GYNs receiving formal menopause training, getting proper care from a doctor isn’t always easy, either. Private companies like Phenology are stepping in to fill this gap, leveraging technology to deliver the personalized, non-hormonal relief that 82% of women prefer. They’ve partnered with Vitamin Shoppe to make non-prescription menopause solutions more accessible. Women can now get personalized supplement advice at Vitamin Shoppe, paving the way for a transformed menopause experience.

2023-11-01T07:01:01

(BPT) – Self-care means different things to different people. Its essence, though, is focused on wellbeing. According to the National Institute of Mental Health, “Self-care means taking the time to do things that help you live well and improve both your physical health and mental health,” adding, “even small acts of self-care in your daily life can have a big impact.”

This is especially true for those who spend their days caring for loved ones, helping with everything from meals and bathing to dressing and overall care. Being a caregiver requires energy, patience and focus to perform tasks for others that most of us take for granted. It is a selfless and demanding role that can wear out even the hardiest among us.

Finding ways to be more efficient and to prioritize one’s own wellbeing can ultimately result in better care for the recipient. Fortunately, people can take advantage of their AARP member benefits that can help make self-care for the caregiver even easier.

Prioritize Your Health

When you’re taking care of others, it’s easy to overlook your own health, especially preventive care. However, it isn’t a good idea to skip wellness checkups or postpone appointments to ensure there are no underlying concerns and any ailments can be addressed before they become serious.

If you have not yet established care with a physician, AARP members can access quality care with Oak Street Health, a primary care provider specializing in older adults on Medicare with a team of doctors, nurses and other professionals dedicated to keeping you well — physically, mentally and socially — at more than 190 centers across 24 states. Benefits include personalized preventive care plans, same-day/next-day appointments where available, a 24/7 healthcare patient support line and more. AARP membership is not required to visit an Oak Street Health location.

If you are already in pain, either from providing physical support for loved ones as you help them move in and out of the car or up and down stairs, or from an older injury, physical therapy can help. Fortunately, scheduling an appointment is more convenient than ever through AARP^® Physical Therapy at Home™ by Luna, and it can help ensure you continue to provide the necessary care and even avoid future injuries. Luna allows you to schedule physical therapy where and when it works for you. It provides access to highly experienced physical therapists who specialize in a wide range of disorders and ailments, and who come directly to you. AARP members and non-members alike can receive at-home physical therapy from Luna. Most insurances and Medicare are accepted by Luna and a prescription may not be needed to start.

Get Some Help of Your Own

It’s difficult to replace the primary caregiver, but there are some exceptional tools and services that enable you to step back and take a break without sacrificing care and safety. Taking time off periodically can be beneficial to your mental and physical health.

If you’re planning a trip or simply need some help around the house, the online marketplace Carelinx is there to help. AARP members have access to pre-screened, professional caregivers and receive a 3% discount on in-home caregiving services. Whether it’s for a few hours or every day, the Carelinx network of caregivers can provide personalized care to help with daily life.

If a visiting caregiver is stepping in, your loved one has periods alone, or you simply want to stay on schedule, the Hero^® smart pill dispenser can help you track what you took and when. The Hero^® smart pill dispenser is an all-in-one medication management platform designed to help make managing medications easier and more convenient for any health condition. You can set a medication schedule in Hero’s mobile app, load up to a 90-day supply of ten different medications, and receive alerts from Hero’s smart dispenser. AARP members receive an 8% discount and pay no initiation fee when they register for a Hero subscription.

If falls are a concern, technology can help. Lifeline offers medical alert systems with automatic fall detection, providing peace of mind that your loved one can get the help they need even if you are not present. AARP members save 15% on medical alert service and get free shipping and activation. You can choose the service option that fits your lifestyle and get fast, 24/7/365 access to help when you need it.

Plan for Your Care

As a caregiver, you have unique insight into your own potential need for care in the future. It’s a good idea to prioritize it, even while providing care for someone else.

Approximately 70% of Americans who reach age 65 will need some long-term care at some point in their life, and nearly half will need some sort of paid assistance. AARP members have access to information on options to help protect assets, maintain their lifestyles, and prepare for the future within their budget.

It’s also understandable that the demands as a caregiver may cause you to push off thinking about the future, especially when it comes to estate planning. You can make it less onerous with the help of Trust & Will, a secure and easy-to-use online estate planning platform with access to top-rated member support, free shipping, and one year of unlimited updates. As an AARP member, you receive a 20% discount on trusts, wills and estate planning documents.

You Can’t Pour from an Empty Cup

To be the best caregiver possible, try to avoid thinking of self-care as indulgent or selfish and instead consider it an investment in your capacity to provide care. Remaining healthy, calm and focused requires taking proactive steps on your own behalf. When you fill your own cup first, you can better help your loved one fill theirs. To find more ways to simplify self-care, visit AARP.com/benefits.

AARP and its affiliates are not insurers, agents, brokers or producers. AARP member benefits are provided by third parties, not by AARP or its affiliates. Providers pay a royalty fee to AARP for the use of its intellectual property. These fees are used for the general purposes of AARP. Some provider offers are subject to change and may have restrictions. Please contact the provider directly for details.

2023-11-01T07:01:01

(BPT) – Thirty-nine years ago, Hector and Nora met right after high school, marrying just eight months later — and have been inseparable ever since. Over the decades, the two have grown together with their family, now living in Los Angeles close to their two grown children. The strength of this family bond is now helping Hector face the biggest challenge of his life — being diagnosed with stage IV, metastatic pancreatic cancer.

For Hector, the first sign that something wasn’t right was when he started having stomach problems, which seemed to occur with each meal he ate. After several doctor and hospital visits over the course of months, Hector was diagnosed with pancreatic cancer — the cancer had spread (or metastasized) beyond his pancreas to other parts of the body.

“We both knew what it meant,” says Nora, referring to the seriousness of the diagnosis. But, the pair decided they were going to face the challenge together, “We’re going to fight it. We’re going to do everything we can.”

From that moment, Nora became Hector’s strongest advocate and caregiver.

What is pancreatic cancer?

The most common form of pancreatic cancer is Pancreatic Ductal Adenocarcinoma (PDAC), which is also one of the most deadly forms of cancer as the third leading cause of cancer death in the U.S.[i],[ii] PDAC is one of the hardest to detect cancers because there are often no noticeable symptoms in its initial stages and symptoms can appear similar to other diseases. So, PDAC is difficult to diagnose early.[iii] It is also one of the most difficult to treat of all solid tumor cancers as the cancer can spread quickly and invade surrounding tissues and organs.[iii] Overall, people diagnosed with PDAC face a poor prognosis with a five-year survival rate of just 12.5%.[iv]

As much as the impact on physical health, living with PDAC can negatively impact a person’s psychological and emotional well-being.[v] The condition causes significant stress for patients and their loved ones,[v] making it so important to have a strong support system when coping with this disease.

And people living with PDAC experience sometimes serious symptoms, including significant weight loss.[vi]

Advances in treatment options for PDAC have been limited over the past few decades, but researchers continue to work toward developing new approaches with the potential to increase survival rates.[vii]

How you can help a loved one with pancreatic cancer

For the past two years, Nora has been Hector’s caregiver, learning valuable lessons about how to be supportive throughout this difficult time. “One person alone cannot handle this disease,” Nora observes. “Support is really important.”

Nora offers these tips for others to help care for a loved one:

Become an advocate for your loved one. Be present at all doctor visits, take detailed notes and ask questions. Help your loved one track symptoms and other factors recommended by your health care provider.

Educate yourself. Ask questions and do research to help your family become more informed about the disease, treatment options, and how to cope with symptoms and side effects of medications. For example, Nora learned about the importance of nutrition for people with pancreatic cancer, and spoke up to Hector’s doctor about it.

Take care of yourself. If you don’t care for your own physical and emotional health, it’s harder to be there for your loved one. Nora finds listening to music and going for hikes give her a break and helps clear her head. “It’s important to make time for yourself as a caregiver,” says Nora. “By taking care of yourself, you’ll be able to support your loved one.”

Get organized. From maintaining an appointment calendar and getting a pill organizer to track medications, staying organized can help relieve the stress of caring for someone else.

Stay positive. Although Hector and his family are coping with a very difficult diagnosis of metastatic pancreatic cancer, Nora believes in the power of positivity. She makes it a point to plan family events like concerts to give everyone something to look forward to. “Don’t give up,” Nora advises. “There’s always hope.”

You can learn more about Hector and Nora’s story by watching this video.

Sponsored by Ipsen Biopharmaceuticals, Inc.

2023-10-31T05:01:00

(BPT) – If you’re suffering from chronic pain, you’re not alone. According to the CDC, 58.9% of adults experienced some kind of pain in the past 3 months. 39% of adults had back pain, 36.5% had lower limb pain, and 30.7% had upper limb pain during that period.¹ Studies have shown the effectiveness of electrical muscle stimulation to strengthen muscle and reduce pain in various populations, from healthy young adults to the elderly.^2-4

truFlex is a fully customizable muscle stimulation device featuring multidirectional stimulation (MDS) technology to strengthen, tone, and define muscles on the abdomen, obliques, glutes and thighs. This award-winning muscle sculpting treatment can increase muscle mass up to 30%.^5,6

A single truFlex treatment delivers the equivalent of 54,000 crunches per session, plus it can treat up to 8 areas simultaneously and simulate 5 different workouts in as little as 15 minutes. It’s safe for all body types, skin types, and fitness levels.⁵

Dr. Shay Pathare of Advanced Spine Care and Pain Management in Staten Island, NY, is an expert in functional medicine who takes a holistic approach to diagnosing and treating patients. He develops customized treatment plans and prioritizes non-invasive procedures that lead to faster recovery.

“All of the treatments I utilize are to improve function as well as provide other benefits such as reduced pain, improved sleep, and quality of life. We assess each patient’s concerns, and improving function is one of our main goals. For patients experiencing persistent lumbar pain, it can be difficult to do exercises to strengthen the core muscles, such as the abdominal muscles, obliques, lumbar muscles, and upper gluteal muscles. truFlex offers an innovative treatment option that can strengthen their thigh muscles, gluteal muscles, buttocks, abdominal muscles, and back muscles without having to do strenuous exercises that could lead to further injury,” says Dr. Pathare.

Dr. Tammy Chen of Central Park Laser Aesthetics in New York City uses truFlex to help strengthen the core for her patients. “Cutera’s truFlex is very versatile. I can use it to target our patients’ specific needs, placing the handpieces where their chief complaints are. Popular treatment areas include the abs, obliques, legs, and glutes. It can be used for all fitness levels,” she explains. “You can be a couch potato and jump-start your strength to start working out with truFlex, and even fit athletes still see an improvement. My husband was in the best shape of his life training for an Ironman where he qualified for world championships, but he only got abdominal definition after using truFlex. He finally had the six-pack abs he always wanted,” Dr. Chen adds.

She continues, “truFlex only takes 15 minutes and patients can feel the effects instantly. After doing 54,000 ‘crunches’ they feel like it’s easier to stand up taller and engage their core. I also use it post-injury as part of their physical therapy regimen to help speed recovery because it strengthens the muscles so they can get back to their activities faster and pain-free!”

“Women postpartum who have struggled to get their deeper core stronger can also benefit from truFlex, which stimulates muscles deeper than traditional exercises they can do on their own,” Dr. Chen adds. “It’s not about being a size zero but being stronger and preventing injury. If your core is strong, you’ll have better overall health.”

Learn more about how truFlex can strengthen and tone your body.

References:

1. Lucas JW, Connor EM, Bose J. Back, lower limb, and upper limb pain among U.S. adults, 2019. NCHS Data Brief, no 415. Hyattsville, MD: National Center for Health Statistics. 2021. DOI: https://dx.doi.org/10.15620/cdc:107894external icon
2. Matos F, Amaral J, Martinez E, et al. Changes in muscle thickness after 8 weeks of strength training, electromyostimulation, and both combined in healthy young adults. Int J Environ Res Public Health. 2022;19:3184.
3. Wirtz N, Zinner C, Doermann U, et al.. Effects of loaded squat exercise with and without application of superimposed EMS on physical performance. J Sports Sci Med. 2016;15:26–33.
4. Picorelli AMA, Pereira LS, Pereira DS, et al.. Adherence to exercise programs for older people is influenced by program characteristics and personal factors: a systematic review. J Physiother. 2014;60:151–6.
5. truFlex Clinical Guidelines, Cutera, Inc.
6. Ronan SJ. A Novel Bio-Electric Current Stimulation Device For Improvement Of Muscle Tone [white paper, Cutera Inc.]. 7/2019.

2023-10-30T11:01:00

(BPT) – This is a promotional message sponsored by Intra-Cellular Therapies, Inc.

Starting in her early twenties, Lindsay noticed some extreme changes in her mood and behavior.

“I was making all kinds of impulsive decisions,” Lindsay remembered. “One day I would go on a huge shopping spree, not worrying about the money I didn’t have. The next day I felt so depressed I would end up in bed all day not doing anything. There was no happy medium.”

These highs and lows were unpredictable, making it hard for her to know what each day would look like, even after she became a mother. “Living with these symptoms was driving me crazy and I didn’t know what to do,” Lindsay said. “As a mother, it was becoming tougher to take care of my kids. I always worried that today would be the day they couldn’t count on me to be there for them.”

These concerns led Lindsay to seek help. Although she didn’t receive a diagnosis from her doctor, she was treated for the symptoms she was experiencing.

“The antidepressants I was taking helped a little, but nothing was working the way I needed it to,” Lindsay said. “A few years later, I found a new doctor that talked with me and diagnosed me right away with bipolar I depression.”

Difficulties with diagnoses

Lindsay’s story is not unusual, as uncovering the correct diagnosis for bipolar disorder can take time.

“Diagnosing bipolar I and II depression is sadly often a lengthy process — five years for bipolar I and ten for bipolar II, on average,” said Dr. Greg Mattingly. “In general, both bipolar I and II can be misdiagnosed as major depressive disorder up to 3/4 of the time.”¹

Dr. Mattingly advises other providers to seek additional clues, beyond depressive episodes, to diagnose bipolar disorder. “Additional symptoms may include the 4 ‘A’s: anxiety, agitation, anger and attention problems,” explained Dr. Mattingly. “Also, inadequate response to multiple antidepressants can suggest bipolar depression, as was the case for Lindsay.”

What is bipolar disorder?

Bipolar disorder is a common mental health condition that causes extreme changes in mood and behavior. These changes, or mood episodes, can cause you to experience lows (depression) and highs (mania).^3,4 Mood episodes can affect your sleep, energy, activity, judgment, behavior, and the ability to think clearly.²

The Lows

The lows of bipolar disorder, also known as bipolar depression or depressive episodes, can make people feel sad or hopeless. They may lose interest or pleasure in most activities, even those they once enjoyed. These depressive episodes may be present through their lives, and some episodes may even last several months.⁵

People with bipolar depression typically spend more time in the lows than in the highs of the illness. The lows can be the more debilitating state for some people and may have a greater impact than manic episodes on everyday function. About 90% of people report severe impairment due to depressive episodes.^4,6

The Highs

The highs of bipolar disorder, known as manic or hypomanic episodes, can cause people to feel euphoric, impulsive, unusually irritable, or have an abnormal amount of increased energy. Symptoms during hypomanic episodes are milder than manic episodes.⁵

Manic symptoms are usually reported less frequently and can often be easily overlooked or seen as something positive rather than a sign of bipolar disorder. People with bipolar disorder are three times more likely to experience bipolar depression than mania.⁴

Effective treatment for bipolar disorder

Discovering the correct diagnosis is the first step toward finding effective treatment. If you’re experiencing symptoms of bipolar depression, it’s important to talk to a healthcare provider who specializes in mental health, and to have open conversations about all your symptoms to identify bipolar depression and the best treatment path.⁴

“When I was finally diagnosed with bipolar I depression, I worried about the stigma associated with it,” said Lindsay. “But my doctor told me that together, we could manage this! After a few years of trying different treatments, I had a doctor tell me about a medication called CAPLYTA.”

CAPLYTA^® (lumateperone) is a once-daily pill that is proven to deliver significant relief across bipolar depression in adults and can be taken alone or with the medicines lithium or valproate.⁷

Studies have shown CAPLYTA is proven to provide significant relief from depressive symptoms of bipolar disorder and can reduce the overall severity of bipolar depression. Unlike some medications that can only treat bipolar I depression, CAPLYTA treats both bipolar I and bipolar II depression and can be taken alone or with lithium or valproate.

CAPLYTA has Boxed Warnings for increased risk of death in elderly people with dementia-related psychosis and increased risk of suicidal thoughts and behaviors in children and young adults. CAPLYTA is not approved for people under 18. See additional important safety information below.

“When I talked to my doctor about CAPLYTA, I liked hearing that CAPLYTA could make a difference when it comes to improving my bipolar depression symptoms,” said Lindsay. Getting her symptoms under control was important to Lindsay and her doctor.

At first, Lindsay was worried about weight gain with CAPLYTA. But her healthcare provider reassured her that most people who took CAPLYTA did not gain weight or have changes in their blood sugar or cholesterol in short- or long-term clinical trials. At 6 months, the average weight change for people on CAPLYTA was -0.02 lbs.

CAPLYTA may cause problems with your metabolism including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood and weight gain. Most people in clinical studies did not have a change in their blood sugar, cholesterol, or weight. Your healthcare provider should check your blood sugar, fat levels, and weight before you start, or soon after you start CAPLYTA, and then periodically during treatment.

“I like that CAPLYTA is approved to treat both bipolar I and bipolar II depression,” said Dr. Mattingly. “The proven efficacy and well-established safety and tolerability profile, along with the convenient once-daily dosing, make CAPLYTA an excellent choice for a patient like Lindsay. But remember, every patient experience will be unique, so it’s important to monitor for potential side effects such as sudden mood changes, behaviors, or suicidal thoughts. It’s really important to talk to your healthcare provider about any concerns or questions you have. I encourage all of my patients to be proactive and to come to me with any questions they may have or side effects they may experience.”

“Since taking CAPLYTA I’ve noticed a real difference,” Lindsay noted. “I have fewer extreme highs and lows. I have some energy back and I get out of bed in the morning ready to face the day.”

The most common side effects experienced by people with bipolar depression taking CAPLYTA were sleepiness, dizziness, nausea, and dry mouth. CAPLYTA can cause sleepiness and difficulty thinking. Until a patient is aware of how CAPLYTA may affect them, they should not drive, operate heavy machinery, or do other dangerous activities. These are not all the possible side effects, please see the Important Safety Information, including Boxed Warnings, below.

If you or a loved one is struggling with bipolar depression, CAPLYTA may be able to help. Talk to your healthcare provider and ask if CAPLYTA is right for you. To learn more, visit CAPLYTA.com.

CAPLYTA^® (lumateperone) is a prescription medication used in adults for the treatment of depressive episodes associated with bipolar I or bipolar II disorder (bipolar depression). CAPLYTA can be taken alone or with the medicines lithium or valproate for bipolar depression. It is not known if CAPLYTA is safe and effective in children.

Important Safety Information

Medicines like CAPLYTA can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). CAPLYTA is not approved for treating people with dementia-related psychosis.

CAPLYTA and antidepressant medicines may increase suicidal thoughts and actions in some children, adolescents, and young adults especially within the first few months of treatment or when the dose is changed. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Patients and their families or caregivers should watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. This is very important when CAPLYTA or an antidepressant medicine is started or when the dose is changed. Report any change in these symptoms to your healthcare provider immediately.

Do not take CAPLYTA if you are allergic to any of its ingredients. Get emergency medical help if you are having an allergic reaction (e.g., rash, itching, hives, swelling of the tongue, lip, face, or throat).

CAPLYTA may cause serious side effects, including:

• Stroke (cerebrovascular problems) in elderly people with dementia-related psychosis that can lead to death.
• Neuroleptic malignant syndrome (NMS): high fever, confusion, changes in your breathing, heart rate, and blood pressure, stiff muscles, and increased sweating; these may be symptoms of a rare but potentially fatal condition. Contact your healthcare provider or go to the emergency room if you experience signs and symptoms of NMS.
• Uncontrolled body movements (tardive dyskinesia, TD) in your face, tongue, or other body parts. TD may not go away, even if you stop taking CAPLYTA. It may also occur after you stop taking CAPLYTA.
• Problems with your metabolism including high blood sugar, diabetes, increased fat (cholesterol and triglyceride) levels in your blood and weight gain. Your healthcare provider should check your blood sugar, fat levels and weight before you start and during your treatment with CAPLYTA. Extremely high blood sugar levels can lead to coma or death. Call your healthcare provider if you have any of the following symptoms of high blood sugar: feeling very thirsty, hungry, sick to your stomach, needing to urinate more than usual, weak/tired, or confused, or your breath smells fruity.
• Low white blood cell count. Your healthcare provider may do blood tests during the first few months of treatment with CAPLYTA.
• Decreased blood pressure (orthostatic hypotension). You may feel lightheaded, dizzy, or faint when you rise too quickly from a sitting or lying position.
• Falls. CAPLYTA may make you sleepy or dizzy, may cause a decrease in your blood pressure when changing position (orthostatic hypotension), and can slow your thinking and motor skills which may lead to falls that can cause broken bones or other injuries.
• Seizures (convulsions).
• Sleepiness, drowsiness, feeling tired, difficulty thinking and doing normal activities. Until you know how CAPLYTA affects you, do not drive, operate heavy machinery, or do other dangerous activities.
• Problems controlling your body temperature so that you feel too warm. Avoid getting overheated or dehydrated while taking CAPLYTA.
• Difficulty swallowing that can cause food or liquid to get into the lungs.

The most common side effects of CAPLYTA include sleepiness, dizziness, nausea, and dry mouth.

These are not all the possible side effects of CAPLYTA. Tell your healthcare provider if you have or have had heart problems or a stroke, high or low blood pressure, diabetes, or high blood sugar, problems with cholesterol, have or have had seizures (convulsions), kidney or liver problems, or a low white blood cell count. CAPLYTA may cause fertility problems in females and males. You should notify your healthcare provider if you become pregnant or intend to become pregnant while taking CAPLYTA. CAPLYTA may cause abnormal involuntary movements and/or withdrawal symptoms in newborn babies exposed to CAPLYTA during the third trimester. Talk to your healthcare provider if you breastfeed or are planning to breastfeed as CAPLYTA passes into breast milk. Tell your healthcare provider about all the medicines you’re taking. CAPLYTA may affect the way other medicines work, and other medicines may affect how CAPLYTA works, causing possible serious side effects. Do not start or stop any medicines while taking CAPLYTA without talking to your healthcare provider. You are encouraged to report negative side effects of prescription drugs. Contact Intra-Cellular Therapies, Inc. at 1-888-611-4824 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

CAPLYTA is available in 10.5 mg, 21 mg, and 42 mg capsules.

Please see Medication Guide, including Boxed Warnings.

References:

1. Frye MA, Calabrese JR, Reed ML, et al. Use of health care services among persons who screen positive for bipolar disorder. Psychiatr Serv. 2005;56(12):1529-1533.
2. Bipolar disorder. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/bipolar-disorders/symptoms-causes/syc-20355955. February 16, 2021. Accessed April 20, 2023.
3. National Institute of Mental Health. https://www.nimh.nih.gov/health/topics/bipolar-disorder. Accessed April 21, 2023.
4. Miller S, Dell’Ossa B, Kettera TA. The prevalence and burden of bipolar depression. J Affect Disorder. 2014; 169(1): S3-S11. Accessed April 19, 2023.
5. National Institute of Mental Health. https://www.nimh.nih.gov/health/statistics/bipolar-disorder. Accessed April 21, 2023.
6. Merikangas KR, Akiskal HS, Angst J, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2007;64(5):543-522.
7. CAPLYTA (lumateperone) [package insert]. New York, NY: Intra-Cellular Therapies, Inc.; 2023.

US-CAP-2300545 10/2023