2023-05-01T08:01:00
(BPT) – Tardive dyskinesia (TD) is an involuntary movement disorder characterized by uncontrollable body movements.
Brandpoint Health
2023-04-28T00:00:00
(BPT) – Sponsored by GSK — An estimated 948,000 women will be diagnosed with cancer this year.[i] While breast and cervical cancer may come to mind, a lesser-known, but equally important disease is endometrial cancer, which affects the lining of the uterus. Endometrial cancer is the most common gynecologic malignancy in the US.[ii] Approximately 1 out of 4 people with endometrial cancer have either advanced or recurrent cancer.[iii]
Until recently, people with advanced or recurrent endometrial cancer had limited options.[iv] Unlike breast or cervical cancer, there are no standardized screening tests or exams to detect endometrial cancer early.[v] In addition, advancements in treatment have been slower, especially for recurrent or advanced forms of the disease and for those with specific biomarkers.[vi] A biomarker is a biological marker found in blood, tissue, or cells in the body.[vii] Biomarkers can help your doctor diagnose cancer and may help decide which treatment options may be right for you.[viii] For approximately 25% of people with endometrial cancer, one particular biomarker is mismatch repair deficiency, or dMMR.[ix]
In normal cells, mismatch repair (MMR) is a process that ensures DNA is copied without errors during natural cell growth and replication.[ix] When a repair mechanism is defective, it is known as mismatch repair deficient (dMMR). A dMMR system results in the accumulation of errors, which may lead to an increased risk of cancer.[ix]
To date, there have been limited Food and Drug Administration (FDA)-approved treatment options for those with dMMR recurrent or advanced endometrial cancer whose disease progresses on or after initial treatment with platinum-based chemotherapy; and the prognosis for these patients is poor.[ix] However, with new cases rising and increased attention given to awareness and research, progress is being made for patients.[x]
In 2021, the FDA approved a treatment option, known as JEMPERLI (dostarlimab-gxly for injection 500 mg), for this population of patients with high unmet need, as well as for those with dMMR recurrent or advanced solid tumors.
JEMPERLI is a prescription medicine used to treat adults with certain cancers that have been shown by a laboratory test to be dMMR, and your cancer has returned, or it has spread (advanced cancer). JEMPERLI may be used when:
JEMPERLI is a medicine that may treat certain cancers by working with your immune system. JEMPERLI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.
Please see below for additional Important Safety Information and full Prescribing Information.
Endometrial cancer has the highest rate of dMMR across all types of tumors.[xi] Tumors with dMMR have certain properties that may make them more likely to respond to an immunotherapy like JEMPERLI.[xii]
For those with dMMR recurrent or advanced endometrial cancer, this treatment may give them, as well as their providers, more tools in their arsenal to face this disease.
As research continues to progress, awareness of the disease and the patients it affects remains important.
JEMPERLI is being studied in other types of cancers. JEMPERLI was studied in 209 patients with dMMR recurrent or advanced solid tumors who had progressed on or following systemic therapy and had no satisfactory alternative treatment options. Some of the dMMR tumor types studied included the following: colorectal cancer, small intestinal cancer, gastric cancers, pancreatic carcinoma, biliary neoplasm, liver cancer, ovarian cancer, adrenal cortical cancer, breast cancer, esophageal cancer, malignant neoplasm of the female genitals, pleural cancer and renal cell carcinoma. It is a positive step forward to see treatments being developed for eligible patients who need them.
Those impacted by dMMR recurrent or advanced solid tumors, including endometrial cancer, should talk to their doctors about potentially available treatment options, such as JEMPERLI and visit jemperli.com to learn more.
Approved Uses
JEMPERLI is a prescription medicine used to treat adults with certain cancers that have been shown by a laboratory test to be mismatch repair deficient (dMMR), and your cancer has returned, or it has spread (advanced cancer).
JEMPERLI may be used when:
It is not known if JEMPERLI is safe and effective in children.
Important Safety Information
JEMPERLI is a medicine that may treat certain cancers by working with your immune system. JEMPERLI can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You can have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended.
Call or see your healthcare provider (HCP) right away if you develop any new or worsening signs or symptoms, including:
Lung problems. Signs and symptoms may include cough, shortness of breath, or chest pain.
Intestinal problems. Signs and symptoms may include diarrhea or more bowel movements than usual; stools that are black, tarry, sticky, or have blood or mucus; or severe stomach-area (abdomen) pain or tenderness.
Liver problems. Signs and symptoms may include yellowing of your skin or the whites of your eyes, severe nausea or vomiting, pain on the right side of your stomach area (abdomen), dark urine (tea colored), or bleeding or bruising more easily than usual.
Hormone gland problems. Signs and symptoms may include headaches that will not go away or unusual headaches, eye sensitivity to light, eye problems, rapid heartbeat, increased sweating, extreme tiredness, weight gain or weight loss, feeling more hungry or thirsty than usual, urinating more often than usual, hair loss, feeling cold, constipation, your voice gets deeper, dizziness or fainting, changes in mood or behavior such as decreased sex drive, irritability, or forgetfulness.
Kidney problems. Signs and symptoms may include change in the amount or color of your urine, blood in your urine, swelling in your ankles, or loss of appetite.
Skin problems. Signs and symptoms may include rash; itching; skin blistering or peeling; painful sores or ulcers in your mouth or in your nose, throat, or genital area; fever or flu-like symptoms; or swollen lymph nodes.
Problems can also happen in other organs and tissues. These are not all of the signs and symptoms of immune system problems that can happen with JEMPERLI. Call or see your HCP right away for any new or worse signs or symptoms. Signs and symptoms may include chest pain, irregular heartbeat, shortness of breath, swelling of ankles; confusion, sleepiness, memory problems, changes in mood or behavior, stiff neck, balance problems, tingling or numbness of the arms or legs; double vision, blurry vision, sensitivity to light, eye pain, changes in eyesight; persistent or severe muscle pain or weakness, muscle cramps; low red blood cells, bruising.
Infusion reactions that can sometimes be severe or life-threatening. Signs and symptoms of infusion reactions may include chills or shaking, itching or rash, flushing, shortness of breath or wheezing, dizziness, feel like passing out, fever, back or neck pain.
Rejection of a transplanted organ. Your HCP should tell you what signs and symptoms you should report and monitor you, depending on the type of organ transplant that you have had.
Complications, including graft-versus-host-disease (GVHD), in people who have received a bone marrow (stem cell) transplant that uses donor stem cells (allogeneic). These complications can be serious and can lead to death. These complications may happen if you underwent transplantation either before or after being treated with JEMPERLI. Your HCP will monitor you for these complications.
Getting medical treatment right away may help keep these problems from becoming more serious. Your HCP will check you for these problems during treatment with JEMPERLI and may treat you with corticosteroid or hormone replacement medicines. If you have severe side effects, your HCP may also need to delay or completely stop treatment with JEMPERLI.
Before receiving JEMPERLI, tell your HCP about all of your medical conditions, including immune system problems such as Crohn’s disease, ulcerative colitis, or lupus; received an organ transplant; have received or plan to receive a stem cell transplant that uses donor stem cells (allogeneic); have received radiation treatment to your chest area; have a condition that affects your nervous system, such as myasthenia gravis or Guillain-Barré syndrome.
If you are pregnant or plan to become pregnant, tell your HCP. JEMPERLI can harm your unborn baby. If you are able to become pregnant, your HCP will give you a pregnancy test before you start treatment. Use an effective birth control method during treatment and for 4 months after your last dose of JEMPERLI. Tell your HCP right away if you become pregnant or think you may be pregnant during treatment with JEMPERLI.
If you are breastfeeding or plan to breastfeed, tell your HCP. It is not known if JEMPERLI passes into your breast milk. Do not breastfeed during treatment with JEMPERLI and for 4 months after your last dose.
Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
The most common side effects of JEMPERLI include tiredness and weakness, low red blood cell count (anemia), diarrhea, nausea, decreased number of certain white blood cells, decreased albumin in the blood, increase in certain liver blood tests, decreased salt (sodium) in the blood.
These are not all of the possible side effects of JEMPERLI. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA by calling 1-800-FDA-1088 or visiting www.fda.gov/medwatch.
Please see full Prescribing Information, including Medication Guide for patients.
Trademarks are property of their respective owners.
©2023 GSK or licensor. DSTCOCO230004 March 2023 Produced in USA.
[i] American Cancer Society. Cancer facts & figures 2023. Accessed February 22, 2023. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2023-cancer-facts-figures.html.
[ii] Mahdy H, Casey MJ, Crotzer D. Endometrial Cancer. StatPearls [Internet]. January 2022. [Updated September 26, 2022]. Accessed February 22, 2023. https://www.ncbi.nlm.nih.gov/books/NBK525981/
[iii] CancerMPact® Patient Metric, Cerner Enviza. Accessed February 22, 2023. https://cancermpact.khapps.com/
[iv] Halla K. J Adv Pract Oncol. 2022;13(1):4559.
[v] National Cancer Institute (NCI). NCI Endometrial Cancer Screening. Bethesda, MD: U.S. National Institutes of Health (NIH); 2021. Accessed February 22, 2023. https://www.cancer.gov/types/uterine/patient/endometrial-screening-pdq
[vi] Brooks RA, et al. CA Cancer J Clin. 2019;69(4):258279.
[vii] National Cancer Institute (NCI). NCI Dictionary of Cancer Terms. Bethesda, MD: U.S. National Institutes of Health (NIH); 2021. Accessed February 22, 2023. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/biomarker
[viii] National Cancer Institute (NCI). Biomarker Testing for Cancer Treatment. Bethesda, MD: U.S. National Institutes of Health (NIH); 2021. Accessed February 22, 2023. https://www.cancer.gov/about-cancer/treatment/types/biomarker-testing-cancer-treatment
[ix] Lorenzi M, et al. J Oncol. 2020;2020:117.
[x] Ferriss JS, et al. Int J Gynecol Cancer. 2021;31:11651174.
[xi] Le DT, et al. Science. 2017;357(6349):409413.
[xii] Le DT, et al. N Engl J Med. 2015;372(26):25092520.

2023-04-27T09:01:00
(BPT) – While hormonal acne tends to be associated with the teenage years, it can affect adults of all ages, and is especially common in women with monthly hormonal changes and the onset of menopause. Some adults continue to get acne well into their 30s, 40s and even 50s, and you may even get acne for the first time as an adult, according to the American Academy of Dermatology.1 So what’s the source of these breakouts? Overproduction of sebum is to blame and is one of the leading causes of acne at all ages.2
Enter AviClear™, the future of clear skin, and the first and original FDA-cleared energy device for the treatment of mild, moderate and severe acne.3 According to Mary Jane Salo, Family Nurse Practitioner at Wellness Marketplace Spa in American Canyon, CA, “AviClear treats acne at the source by selectively targeting and suppressing the oil glands. We can selectively deliver energy and damage the glands to suppress sebum production.
“My patients are very excited about this safe and effective acne laser treatment. I have seen results after their very first AviClear session, and they continue to see improvement over the course of three treatments, which demonstrates the long-term effects of this novel therapy. Another plus is that no topical numbing is needed and patients can go back to their normal activities right after a treatment,” says Nurse Salo.
Among the benefits of AviClear, when compared to over-the-counter creams and topical medications, is that it delivers clear skin that lasts. “We are seeing that results continue to improve over time for our clients. It works for all skin types and severities of acne from mild to moderate and even severe breakouts,” says Heather Callahan, PA-C at Dermestetics in Vienna, VA. “They are loving these treatments because it is quick, safe and comes with adjustable comfort due to the addition of AviCool™ cooling technology. Patients can get back to work and their busy lives immediately, while achieving the results they want quickly and effectively,” she says.
Studies have shown long-lasting results with up to two-year clearance that continues to improve over time, even after the initial series of treatments are complete.4 Ninety-three percent of patients saw visible improvement after their final treatment session with two-thirds of patients assessed as clear or almost clear 12 months after their final treatment session.3
So, if acne breakouts are affecting your quality of life and stopping you from enjoying social events, find an AviClear practice near you and say buh-bye to stubborn acne once and for all.
1https://www.aad.org/public/diseases/acne/really-acne/adult-acne
2O’Neill AM, Gallo RL. Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris. Microbiome. 2018;6:177.
3Data on file. FDA clearance study. Cutera, Inc.
4Data on file. FDA clearance study. Cutera, Inc

2023-04-26T10:25:00
(BPT) – Many of us know the basics for positive wellbeing — exercise consistently, sleep well, eat right — but what if we’re overlooking a crucial and simple component of health? Emerging research shows that adding time outside to our wellness routines can bring powerful benefits.
In recognition of Mental Health Awareness Month this May, we’re encouraged to evaluate the state of our own wellbeing and integrate helpful tips for managing stress and staying healthy. L.L.Bean recently partnered with Mental Health America to help raise awareness by “going off the grid” (logging off our social channels) and sharing tips, research and insights on how to make the most of what is all around us. Together with L.L.Bean wellness operations expert Stephanie Harvie, we explored some of the facts that surprised us the most about nature’s power in our lives.
1. Nature can positively affect our mood and mental health
Exploring nature can provide wide-reaching benefits, helping to alleviate stress and providing physiological benefits like lower blood pressure and enhanced immune system function. “Being mindful in nature helps re-center your mind and energy level and can have a really big impact in controlling your nervous system and preparing yourself for the rest of the day,” Harvie said.
And, studies show self-reported improvements in focus, mood and even depression following time spent outside. In one experiment, researchers “cleaned and greened” empty lots in urban areas, removing trash and planting trees, flowers and grass. They found that a staggering 41.5% of nearby residents of one green lot reported a decrease in depressive feelings compared to those who lived by untouched lots.
2. Even a small amount of daily outside time makes a difference
Though it’s tempting to equate “spending time in nature” with long hikes, all-day fishing trips and other time-intensive activities, evidence suggests that even a few minutes outside can make a difference in our mental health. “I want to normalize the idea that doing anything has impact,” Harvie said. “If you don’t have much time, changing your position or going outside can help.”
In a meta-analysis of studies, scientists found that just 10 minutes in nature provides psychological and physiological benefits. And, the more time spent outside the better. Researchers conducted a survey of 20,000 people and found respondents who spent 120 minutes outside weekly are substantially more likely to say they feel a strong sense of wellbeing.
3. Outdoor experiences make us better people
An emerging area of research called “The Science of Awe” studies the distinct feelings of mystery and wonder we experience in nature and the impressive range of benefits received from them. L.L.Bean partner and researcher Dr. Paul Piff found that experiencing awe helps increase ethical decision making, generosity and “pro-social” values like compassion. When we connect with the spaces around us, it also helps us plug into our communities, offering societal benefits beyond the individual.
4. Even hearing or thinking of nature can help
Engaging your senses through nature creates surprising effects. Scientists found that people who were exposed to nature sounds — like crickets chirping or waves crashing — performed better on tests than those who listened to sounds from the city. And other research noted that visualizing nature can help provide physiological benefits, meaning we can access the power of the outdoors at any time and from anywhere. “I would recommend having a place in mind that has been meaningful to you, or a place that inspires you to feel peace outdoors,” Harvie said.
5. Some spaces seem to have more healing power
It’s clear that enjoying nature in any capacity is helpful, but scientists are finding that not all spaces are created equal. Though green spaces have long been confirmed as aids to our wellbeing, research has found that blue spaces (waterside locations), remote areas, nature reserves and habitats are also highly beneficial. In fact, studies show that exposure to a variety of natural environments can produce positive outcomes.
As we learn more about the benefits of nature, it is clear that there are seemingly endless ways to experience the restorative power of the outdoors. So, don’t be discouraged by your level of experience or time constraints. Rather, establish a routine that inspires you, and find spaces that give you an easy opportunity to tap into the health benefits provided by time spent outside.
“Taking care of yourself is mission critical,” Harvie added. “Learning how to manage stress helps you bring your fullest self to work and to life.”
Join L.L.Bean in “going off the grid” and heading outside during Mental Health Awareness Month, and learn more by checking out these resources from L.L.Bean.

2023-04-25T08:31:00
(BPT) – It’s easy to ignore feelings of tiredness and sleepiness during the day. For many people, these feelings may be a result of a poor night’s sleep; however, for others, excessive daytime sleepiness can be a sign of an underlying sleep disorder, like narcolepsy, which can impact and disrupt daily life.
Narcolepsy is a chronic neurological disorder, that can be life-altering and is oftentimes misdiagnosed. It is thought to affect approximately 165,000 people in the United States. All people living with narcolepsy have excessive daytime sleepiness (EDS), which can make staying awake and alert during the day a challenge. The urge to sleep may be so great that people living with narcolepsy may need to nap multiple times a day or fall asleep unintentionally.
The science of normal sleep and wakefulness
For people living with narcolepsy, the separate states of wakefulness and sleep do not work properly and can happen at the wrong time. To better understand narcolepsy, it is helpful to know what happens in the brain during normal wakefulness and sleep in those without narcolepsy.
Omavi Bailey, M.D., MPH, a somnologist, epidemiologist, and medical director practicing pediatric and adult sleep medicine at The BioRhythm Institute, explains, “There are three separate and distinct states of wakefulness and sleep: wake, non-REM sleep, and REM sleep. Normally, states of wakefulness and sleep occur one at a time in a regular pattern. People can stay awake all day and stay asleep at night, switching between non-REM sleep and REM sleep. This normal sleep pattern is characterized by specific physiological differences that allows individuals to stay awake and function during the day, building up their sleep drive that will eventually allow them to efficiently achieve proper sleep at night. Normal sleep goes through four or five cycles at night that progress from non-REM sleep to longer periods of REM or vivid dream sleep.”
Many naturally occurring chemicals in the brain play important roles in wakefulness and sleep. One of these chemicals, hypocretin, which is sometimes called orexin, plays a crucial role in stabilizing sleep and wake states. This is so that non-REM or REM sleep don’t impose themselves during wakefulness, causing excessive daytime sleepiness or cataplexy. Cataplexy is the sudden and brief loss of muscle strength or muscle tone often brought on by strong emotions such as laughter.
What happens in narcolepsy
In most people living with narcolepsy, hypocretin levels are low — sometimes too low to be detected. With low or no hypocretin, the separate states of wakefulness and sleep can happen at any time. People living with narcolepsy may feel sleepy or fall asleep during the day. “This is precisely why severe sleepiness and sleep attacks are experienced by those living with narcolepsy. A person living with narcolepsy can suddenly fall into a deep sleep in the middle of a conversation,” Dr. Bailey describes.
“For people living with narcolepsy, the brain also doesn’t always hold boundaries between states of sleep and wakefulness,” Dr. Bailey explains. “When this happens, some parts of sleep can interrupt wakefulness.” During normal REM sleep, muscle tone is absent and people are essentially paralyzed so they do not act their dreams. For people living with narcolepsy, REM sleep can suddenly impose itself during wakefulness, resulting in a sudden paralysis or inability to move certain muscles while awake (cataplexy).
The role of histamine in wakefulness
In addition to researchers understanding the importance of hypocretin, another naturally occurring chemical has also been found to be important for wakefulness: histamine.
Histamine plays many important roles in the body. In the brain, histamine works together with hypocretin to help people stay awake and alert throughout the day. Like hypocretin, it also helps prevent non-REM sleep and REM sleep from happening during the day.
Research has shown that histamine plays an important role in helping hypocretin produce long periods of wakefulness during the day. In narcolepsy, when hypocretin levels are low, histamine and other naturally occurring chemicals in the brain don’t work well enough, and wakefulness is reduced.
Dr. Bailey highlights that “researchers are encouraged by the community’s heightened understanding of the role histamine plays in stabilizing sleep-wake states and are hopeful to advance research in the future.”
If you’re interested in learning more about narcolepsy and the role of histamine, visit KnowNarcolepsy.com/Science-Of-Narcolepsy.
Know Narcolepsy is a registered trademark of Harmony Biosciences.
Harmony Biosciences name is a registered trademark.
© 2023 Harmony Biosciences. All rights reserved.
US-NAR-2200176/April 2023

2023-04-25T15:59:00
(BPT) – Stay focused for $2,500 toward your car insurance premiums, no strings attached
Did you know that three-quarters of Americans admit to texting while driving, as well as other behaviors like eating, watching movies, and even sexting? While distracted driving may seem innocuous, it can be dangerous and even life-threatening. This is why, during Distracted Driving Month, we’re rewarding people who drive, well, undistracted.
The concept is simple: if you drive undistracted for a week, you’ll receive up to $2,500 in cash toward your auto insurance premiums. Here’s how it works:
Not sure how much you already drive distracted? Take our distracted driving quiz to find out.

2023-04-25T12:17:00
(BPT) – Polycythemia vera (PV) is a rare, chronic cancer that leads to overproduction of red blood cells, increasing the “stickiness” of blood. People with PV experience a range of symptoms, some of which may be dismissed as less serious. These include visual disturbances, shortness of breath, severe itching and poor concentration.
But the excess number of red blood cells slows blood flow, which puts people with PV at risk for additional serious health threats, including blood clots and cardiovascular events like heart attacks, strokes and mini-strokes.
“PV is diagnosed not only by detecting an elevated hematocrit but also elevated white blood cell counts and platelet counts, detection of an acquired mutation in the gene JAK2, which controls blood cell production, and characteristic changes in how bone marrow looks,” says Dr. Ronald Hoffman, Albert A. and Vera G. List Professor of Medicine and Director of the Myeloproliferative Disorders Research Program at the Icahn School of Medicine at Mount Sinai in New York, New York.
If diagnosed, people with PV can regularly undergo a standard of care procedure called phlebotomy to normalize their hematocrit, with the goal of reducing their risk of developing clots, heart attacks or strokes, he says. Phlebotomy removes blood from the body using the same procedure as donating a unit of blood.
“The established goal of phlebotomy therapy is to maintain red blood cell levels, as measured by hematocrit, below 45%,” says Hoffman. “Research shows phlebotomy is an effective treatment for PV patients, but frequently the target hematocrit level is not achieved between physician visits, leaving the patient at risk for developing clots.”
Patients with poorly controlled PV can develop scarring of their marrow known as myelofibrosis and can sometimes develop leukemia.
“PV is one of those blood cancers that you don’t hear about as much, but it is a serious disease. It’s important that patients get diagnosed and understand their treatment options,” Hoffman says.
“In addition to phlebotomy, there are a number of approved medicines that can be used to control this condition, and experimental therapeutics are also being evaluated,” he says.
An example is rusfertide. An investigational new medicine, rusfertide is still being studied by doctors and is not approved by regulatory authorities like the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA).
“Rusfertide was designed with the potential to control the malignant proliferation of red blood cells by limiting the supply of iron to the cells in the marrow that makes red cells,” says Dr. Arturo Molina, a physician-scientist specializing in the development of new treatments for rare and more prevalent diseases at Protagonist Therapeutics. “Rusfertide is a synthetic version of an iron regulator called hepcidin, something all people have.”
Rusfertide is currently being studied to evaluate its safety and ability to control the production of red blood cells and to keep hematocrit levels within the recommended range, potentially reducing the need for phlebotomies, its ability to impact symptoms as well as if patients experience fewer blood clots or cardiovascular complications.
“We hope that by advancing research and development of drug candidates like rusfertide, we may be able to help people with diseases like PV,” says Molina, “and to potentially add to available treatment options for PV and other rare diseases.”

2023-04-19T05:01:00
(BPT) – Prepping to make a glam entrance for a birthday bash or an office party with your co-workers takes your best effort. With their newest range of advanced aesthetic treatments, Cutera® has you covered.
The pros know that getting your skin in tip-top shape before an event is the best place to start. If your breakouts are out of control, there is a revolutionary new laser treatment that has been clinically proven to clear skin without the need for medications. Enter AviClear™ by Cutera, the first and original FDA-cleared energy device for the treatment of mild, moderate and severe acne.1 It significantly eliminates acne in three, 30-minute treatment sessions and helps prevent future acne by suppressing the sebaceous (oil) glands.2
If your skin needs some extra love to refine its texture, brightness, scars, sun damage and even stretchmarks, Secret PRO™ by Cutera can provide noticeable results. This versatile award-winning treatment combines two clinically proven technologies — RF microneedling and fractional CO2 laser — for signature treatments that can be customized just for you.
According to Dr. Abrahem Kazemi, Director, Cosmetic and Laser Dermatology at Pinnacle Dermatology in Centreville, VA, “Secret PRO is my favorite tool in my practice. I have been using this innovative platform to revitalize and refresh the skin of the face and body. With this technology, I can offer my patients the most effective solutions with minimal-to-no downtime. They can see results within a few weeks or less and will continue to have more improvement as the collagen and elastin is stimulated. It’s a win-win.”
Looking your best for a night out is also about slipping into an outfit that shows off your body confidence. If you’re keen to reduce body fat and tone muscle without spending countless hours training, body shaping solution truBody® by Cutera may be just what you need to achieve your goals. This innovative treatment uses the Trim & Tone Protocol, combining two complementary devices — truSculpt® for fat reduction and truFlex™ for muscle sculpting. Both technologies deliver personalized results and are ideal for different body types addressing both large and small treatment areas.
According to Dr. Lindsey Kettinger, DNP at Newton Family Medicine in Charleston, SC, “Decreased muscle mass and truncal obesity — excess fat in the abdomen, flanks, and back — are harder to target as we age.”
With truBody, patients may see results after one treatment session3, with maximum results after 12 weeks. “I love truBody because it provides a combined solution for targeting stubborn areas of fat while toning muscles in 15-minute treatment sessions customized to each patient. One of the great advantages with both treatments is that multiple areas of the body can be treated simultaneously,” she adds.
Get ready to glow and start looking and feeling your best. Find a treatment provider near you.
1 Data on file. Cutera, Inc
2 Results may vary
3 Somenek MT, Ronan SJ, Pittman TA. Lasers Surg Med. 2021;53(3):337-343

2023-04-19T06:01:00
(BPT) – If you’ve ever experienced a urinary tract infection (UTI), you know how uncomfortable it can be. Symptoms like pain or burning with urination, along with a frequent urge to go to the bathroom, can really disrupt your daily life. According to the National Institutes of Health, over 40-60% of women have a UTI at least once in their lives, with 10% of women experiencing them yearly — and nearly half of those with infections get a second one within a year.
When you have these recurring symptoms, the main thing you want is to treat them quickly, and to reduce recurrence. Unfortunately, standard methods for diagnosing UTIs have limitations, which may delay effective treatment or lead to your doctor prescribing a less effective antibiotic to address your particular infection.
The challenges in diagnosing and treating UTIs
The current standard for UTI diagnosis is through urinalysis and standard urine culture (SUC). However, SUC has many shortcomings, including failure to detect bacteria that may be causing a UTI. One study found that SUC missed 50% of all detected uropathogens in patients with severe urinary tract symptoms.1
In addition, SUC can take up to 3-5 days, often causing providers to treat patients with antibiotics without first determining the individual bacteria that contribute to the UTI, or which antibiotics those individual bacteria are sensitive or resistant to. This means you may be treated with an antibiotic that won’t be effective in eliminating the specific cause of your infection, so the treatment doesn’t resolve the infection completely, and your infection may persist or recur.
Having an infection with more than one bacteria present is also common. A standard urine culture will often cite this finding as “contaminated” or as “mixed flora,” providing no additional information on the organisms detected — or antibiotic sensitivity results to help guide specific treatment.
Improved antibiotic prescribing and usage is critical to effectively treat infections, to protect patients from adverse effects caused by unnecessary antibiotic use — and combat antibiotic resistance. In cases of recurrent and complicated UTIs, especially when initial antibiotic use may have failed, personalized therapy options can make all the difference in a patient’s treatment results.
UTI testing tailored for patients’ needs
Fortunately, newer technologies have been developed to improve the diagnosis of UTIs. Some of these tests include PCR technology, which is used in clinical settings for sexually transmitted diseases, respiratory illness and COVID-19 testing. When combined with unique antibiotic sensitivity testing methods, this new class of advanced testing provides helpful information to address the shortcomings of standard urine culture testing.
To help improve testing and diagnosis, Guidance UTI is 43% more sensitive than standard urine culture, helping to ensure more accurate diagnoses. This is vital particularly for those with recurrent, persistent and complicated UTIs or who have elevated risks. This testing process uses PCR technology to identify commonly tested uropathogens, including many that are difficult to detect by standard urine culture. Guidance UTI detects 27 individual organisms (bacteria and yeast) and three bacterial groups known to be associated with UTIs. Not an at-home test, this advanced diagnostic testing is chosen by physicians to provide personalized results in less than one day from receipt at a lab to help identify the right treatment for each patient faster.
This is also the only test that combines PCR testing with Pooled Antibiotic Susceptibility Testing (P-AST), a unique technology that accounts for bacterial interactions that occur in polymicrobial infections (those with more than one bacteria present), which can impact antibiotic resistance. Together, PCR and P-AST technologies provide more detailed and accurate information to health care providers, to help provide personalized therapy options that result in better treatment.
“When you have UTI symptoms, timely, accurate testing is crucial for quicker, more effective treatment to relieve those symptoms and eradicate their cause,” said board-certified urogynecologist and female pelvic medicine and reconstructive surgeon Dr. Terri-Ann Samuels. “With this advanced UTI testing that is now available, we can much more accurately pinpoint the cause or causes of a patient’s UTI, helping us identify the best possible treatment plan for that particular patient.”
If you are experiencing UTI symptoms, visit Pathnostics.com to learn more, and ask your doctor about Guidance UTI.
Reference:
1. Price, T. K. et al. The Clinical Urine Culture: Enhanced Techniques Improve Detection of Clinically Relevant Microorganisms. Journal of Clinical Microbiology 54, 1216–1222 (2016).
