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Spotlight on Progress: CDC Shares Community Drug Overdose Prevention Successes in New Resources

2023-07-18T08:01:00

(BPT) – Putting Data into Action

Drug overdoses are preventable, yet more than one million people died from a drug overdose between 1999 and 2021. Every day, almost 300 people lose their lives due to drug overdose. Public health professionals, policymakers and communities all play a role in preventing overdose deaths. Overdose Data to Action (OD2A) is a CDC-funded program that helps state and local health departments, and the communities they serve, to get high-quality, timelier data on nonfatal and fatal drug overdoses and use those data to inform prevention and response efforts. CDC supports OD2A-funded communities in their ability to address drug overdoses by providing access to subject matter experts and tailored technical assistance, and overdose prevention resources. “The impact of this crisis is far-reaching, touching the lives of our families, friends and neighbors in deeply personal and profound ways. By prioritizing successful prevention and response efforts and providing tailored tools and resources, we can help ensure everyone has access to the care and support they need to live healthy, fulfilling lives — building stronger, more resilient communities,” says Christopher M. Jones, PharmD, DrPH, MPH (CAPT U.S. Public Health Service), Director of CDC’s National Center for Injury Prevention and Control.

Sharing state and local overdose prevention and response strategies

CDC developed the OD2A Case Studies to capture in-depth information from funded jurisdictions about current and emerging practices related to overdose prevention and response. Designed for public health practitioners, these case studies share examples that can be adapted at the state and local levels. Partners on the ground asked for more relevant and applicable strategies, so CDC identified six key topic areas for interviews, analysis and write-ups in these case studies.

  • Adverse childhood experiences (ACEs) are preventable, potentially traumatic events that occur in childhood (0-17 years). Recognizing the lasting negative effects ACEs can have and focusing on their intersection with substance use disorders, this case study highlights OD2A-funded initiatives addressing ACEs in Louisiana and South Carolina.
  • Harm reduction is a public health approach that focuses on reducing the harmful consequences of drug use. It can include syringe services programs, naloxone distribution, fentanyl test strip distribution, and community overdose prevention and education. Focusing on the Illinois Harm Reduction Community Linkage Project, this case study describes a novel harm reduction program that funds local organizations.
  • Linkage to care is the process of connecting people at risk of overdose to evidence-based treatment, services and support. Access to care and services is critical to addressing the overdose epidemic. Using an example from Massachusetts, CDC shares practices specific to improving linkage to care in non-public safety settings.
  • Public safety-led post-overdose outreach can help identify people at higher risk of overdose by linking them to care and other overdose prevention and harm reduction efforts. Two case studies describe successful public safety-led post-overdose outreach initiatives in West Virginia and Franklin County, Ohio.
  • State and local health departments are uniquely positioned to respond to the drug overdose crisis, with the authority to enact policies, deploy resources and coordinate various partners. State and local integration activities engage health departments, community organizations, coalitions and community members in working together on prevention. The case studies presented on this topic illustrate what successful state and local integration looks like in Rhode Island and California.
  • Reducing stigma at multiple levels and creating a culture of change is important to helping people at risk of overdose. Stigma occurs when people with certain social identities are labeled, stereotyped and devalued, leading to discriminatory behavior and internalized shame that can negatively affect access to health care and other support services. CDC shared two examples of state programs addressing stigma related to people who use drugs, from Vermont, Motivational Interviewing and Compassion Training, and Stigma/Harm Reduction Training.

Helping communities put effective practices to work

When people’s lives are on the line, integrated data and effective programs help communities take action to protect people from drug overdose and related harms. The overdose crisis requires prevention, treatment, recovery and harm reduction efforts that are tailored to promote optimal health for all.

Communities are demonstrating innovation in reducing overdose and are sharing compelling examples of collaboration and teamwork. CDC is showcasing these so that communities can learn from each other. Beyond promoting the critical work that continues nationwide, tools and resources like the OD2A Case Studies encourage applying solutions that work to help communities that need it most.

For additional OD2A resources or to learn more about how CDC is working to prevent overdoses and substance use-related harms visit: https://www.cdc.gov/drugoverdose/od2a/index.html/.

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Becoming an iconic and beloved brand

2023-07-18T11:21:00

(BPT) – By Kim Hyo-eun, vice president of the Global Marketing Center at LG Electronics

Until now, as a leader in the consumer electronics industry, LG has grown into an innovative and trustworthy brand with a focus on products such as TVs, refrigerators and washing machines. LG has always deeply understood the lives of its customers and, based on this insight, solidified its position as one of the most beloved brands thanks to innovative products boasting reliable quality. However, in our pursuit to take the brand to the next height and transform it into a global iconic brand, we recognized the need to go beyond products and services and effectively communicate our core brand values to customers. This has led us to embark on the brand reinvention journey.

What’s more, as we live in a world of constant change where consumers’ lifestyles are shifting, diversifying and evolving at an increasingly rapid pace, companies have to strive harder to understand the needs and wants of their customers, and that requires a willingness to change and a passion for innovation.

An organization that has always embraced change, LG recently introduced its reinvented brand strategy to build a stronger, consistent brand image and better convey its commitment to providing a message of ‘Life’s Good.’ As the first step toward strengthening its brand identity, the company undertook a rigorous process to redefine its values and philosophy. After clearly defining three core values of ‘Uncompromising Customer Experience,’ ‘Human-centered Innovation’ and ‘Warmth to Power a Smile,’ the company set about reinterpreting and reinvigorating the LG brand, creating new visual assets that mark a new era in its history. The result of this reinvention is a younger and more dynamic visual identity that resonates more deeply with consumers across all generations and backgrounds.

To be successful in today’s market, a company must be able to connect with consumers at an emotional level. With its reinvented brand identity, LG is already fostering a deep connection with customers, showing that compassion and humanity are as much a part of ‘LG-ness’ as the technological and design innovation that the company has long been known for.

The look of LG’s iconic Life’s Good slogan has also been revamped and refreshed to better communicate the brand’s firm belief that life is good. A custom typography — inspired by various LG products’ form factors — makes the company’s well-known slogan more distinctive and unique, while the period at the end conveys LG’s confidence and sincerity in its mission to make people’s lives better through innovation.

A prime example of the ‘reinvent’ is how LG’s instantly recognizable brand symbol has been brought to life. In digital environments, the iconic LG symbol, designed as a smiling face using the letter ‘l’ and ‘g,’ can now perform eight different actions, including greeting, nodding, spinning and winking. Known as LG’s “face of the future,” the digital logo symbolizes the company’s legacy while also strengthening its bond with today’s consumers.

And, to highlight the brand’s bold and youthful nature, LG has introduced a vibrant new shade of red that will be used across all platforms — physical and digital. The new, energetic “active red,” complemented by LG’s traditional “heritage” red and a deep black, represents a passion for innovation and the boldness to deliver exceptional customer value. By incorporating these dynamic colors, LG aims to express its passion for pushing boundaries and creating meaningful experiences for its customers and attracting younger generations. This approach allows LG to emanate a youthful, dynamic, vibrant, confident and innovative image that aligns with the company’s diverse businesses, products and services.

In addition to introducing its brand reinvent to the world, LG has been sharing its updated brand and visual identity with its own employees, bringing together personnel from all levels and departments to experience first-hand what the new changes mean. LG firmly believes that its employees are the best brand ambassadors. By ensuring they understand the brand’s value and vision and incorporate it into their daily task, the company can more effectively deliver a message of ‘Life’s Good’ to customers.

Aligned with this, the company launched its first Life’s Good event for its employees in South Korea on June 12. With Life’s Good trucks reflecting the new visual identity touring LG Electronics’ business sites in Korea, the company handed out branded coffee cans and provided a chance to win various branded goods during lunch time, enabling everyone to take the time to discover the new changes to the brand. The event garnered overwhelmingly positive and enthusiastic feedback from executives and employees, who expressed their excitement about the brand reinvention. They also shared that the event enabled them to better understand and visualize the reinvented brand.

We are hopeful that LG’s brand reinvent will serve as a starting point for the innovation of new customer experiences that can provide value and benefits for real customers, enabling them to feel that ‘life’s good’ and fully enjoy each precious moment of their lives.

LG acknowledges that there will be moments when people may struggle to resonate with the Life’s Good slogan and message. However, the intention is not to present an unrealistic picture of unwavering hope and positivity. Instead, it serves as a declaration of what life has the potential to be and should strive to be. It also acts as a reminder that even in challenging times, life remains incredibly precious and invaluable. In this context, the Life’s Good slogan embodies the lifestyles that LG aims for and aligns with our commitment to assisting customers in achieving a better life through our products and services.

At LG, we are driven by the desire to make consumers’ lives better than they are now. With this spirit and our unshakable belief that Life’s Good, we will endlessly take on challenges and never stop innovating. LG is a company where people work tirelessly to discover the needs of consumers — needs that they themselves aren’t even aware of — and find smart, practical solutions that deliver convenience, joy and connection.

LG’s new brand identity is infused with the collective effort and enthusiasm of the entire company. It reflects an unwavering determination to make every single day better than the last and showcases the company’s aspiration to become a globally iconic and beloved brand.

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If you’re enrolled in Medicaid, you must take action now. GoodRx is here to help.

2023-07-18T10:01:00

(BPT) – If you’re a Medicaid enrollee, you’re at risk of losing coverage.

Over the past three years, during the COVID-19 public health emergency, states were required to provide continuous coverage for everyone enrolled in Medicaid and the Children’s Health Insurance Program (CHIP). But now that the pandemic has officially come to an end, states have permission to resume their redetermination processes, which means that they will be conducting eligibility checks to ensure enrollees still qualify for the program. As a result, millions of people are at risk of losing coverage — and not just based on eligibility. In the two months since the unwinding started, hundreds of thousands of enrollees have been dropped from Medicaid for procedural reasons, meaning that their paperwork is not up to date.

The bottom line is that all Medicaid enrollees must take action now to ensure they don’t experience gaps in coverage.

Overwhelmed? GoodRx is here to help.

If you’re on Medicaid, here’s what you should do:

1. Read up on what is happening in your state: Go to GoodRx.com/Covered to find state-by-state guides that break down the Medicaid unwinding process, the steps you can take to maintain coverage, and what to do if you are no longer eligible for Medicaid.

2. Ensure your contact information is updated: This is the most important thing Medicaid enrollees can do right now. Make sure your state Medicaid program administrator has your current contact information on file so that you don’t lose coverage even if you’re still eligible.

3. Understand your options for care: Use the GoodRx Medicaid guide to determine your options for everything from insurance to prescription savings.

Lost coverage but think you still qualify?

If you lost coverage but believe you still qualify for Medicaid, you can appeal the decision. This process varies across states, so be sure to consult your state-specific guide. If you missed the renewal deadline, your case will likely be reconsidered if you act within 90 days. You can also reapply or request a fair hearing.

No longer eligible for Medicaid?

You still have options, including purchasing insurance through the Affordable Care Act marketplace, taking advantage of employer-sponsored insurance, or applying for Medicare.

How can I save money regardless of my coverage?

Did you know prescription prices can vary by upwards of $100 from one pharmacy to the next? GoodRx helps you find the lowest prices for free. Whether you have health insurance or are facing a gap in care due to a loss of coverage, you should always check GoodRx to find low prices on your medications. You can find savings of up to 80% from pharmacy retail price and prices that are lower than an insurance copay over half the time based on GoodRx’s research. The best part? GoodRx is accepted at more than 70,000 pharmacies nationwide. GoodRx is not insurance.

Visit GoodRx.com/Covered to find the information and savings you need, and ensure a gap in coverage is not a gap in care.

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Unlock optimal health: Discover the 4 key factors for choosing the right nutritional supplements for you

2023-07-18T08:01:00

(BPT) – As more people focus on their health with goals to boost their immune system and improve fitness, diet is center stage. Eating healthy, well-balanced meals supports overall wellness, but it’s not always easy to get all the vitamins and nutrients you need.

Whether it’s to fill gaps in diet or a meal replacement option, there are a variety of products to support a healthy and active lifestyle. Some might argue there are too many, causing confusion for consumers on what they really need and what’s actually effective.

How can you feel confident in a supplement’s claims? Consider this expert insight from Kristy Appelhans, doctor of Naturopathic Medicine and vice president of Global Consumer Safety for Herbalife, a leader in the dietary supplement market.

1. Review ingredients

The first step is to identify a brand of interest and review the ingredients of the product to make sure they are well-suited for your nutritional goals.

It is also helpful to explore the Company’s FAQ or customer support portal online for additional information. Some good things to know include:

  • How ingredients are sourced
  • Manufacturing process of products
  • If the product is compatible with your specific conditions, dietary restrictions or other preferences
  • Additional ingredients that you should be aware of such as those identified in allergen disclosure statements or cautionary wording on the label
  • Certifications, logos and other product label claims

Transparency is key. A credible brand should be open and honest about these points and your other questions. Lack of this information or non-response to your inquiries is a red flag that you should continue your research elsewhere. You can also discuss questions you have about ingredients or products with your doctor.

2. Evaluate brand reputation

The market is filled with new nutrition products that promise compelling results. However, these claims can be inflated or misleading. Before adding a new product to your diet, take the time to research the company you are purchasing from.

Here are some questions you should ask:

  • How long has the company been in business?
  • Does it have a reputable group of advisors, such as a science-backed advisory board?
  • Are they meeting or exceeding expectations for current Good Manufacturing Practices (cGMP)?
  • Has the company been a recipient of any industry awards or recognition for product quality, research or customer service?
  • Do they stand behind their products with a guarantee?

It’s important to use products from a company with a long history of results and commitment to quality standards.

3. Be critical

Reading health articles and other information online is smart, but it’s important to be critical and search for the truth. Sometimes researchers have a predisposed bias, which can be detrimental to a product’s reputation and misinform consumers.

For example, in 2013 a group of independent scientists set out to prove that hepatotoxins, which cause liver disease, would be found in Herbalife products. Their research did not prove their hypothesis, but instead, they had to conclude in their publication that they did not see any association between liver disease and the company’s products, based on their study results.

4. Compare options

Supplements today come in many forms, including pills, protein shakes, nutritious snacks and beverages. After you decide which are best for your needs and lifestyle, it’s time to dig in to learn more about testing, processing and sourcing for each option.

Take time to explore the company’s level of testing they do with their ingredients, the third-party verifications (such as NSF and ISO), and their manufacturing transparency. Sourcing is critical in ensuring that your supplements, vitamins and other nutritional products are created with care.

Adding supplements or other nutritional support to your diet can help you reach your wellness goals. By taking these steps, you’ll learn more about what you’re putting into your body to ensure it’s what you need to feel your best. Learn more at IAmHerbalifeNutrition.com.

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Empowering the Rare Disease Community for 20 Years: The Fabry Patient

2023-07-17T10:57:00

(BPT) – Living with a rare disease may not be as rare as you would think: Affecting one in 10 Americans, there are more than 10,000 known rare diseases in the U.S.1 While significant strides to develop treatments have been made in recent decades, broadscale awareness of disease remains a challenge. The path to diagnosis and proper care can be long and frustrating.

For example, Fabry disease is a rare genetic disease. Classic Fabry disease affects approximately 1 in 40,000 males and 1 in 20,000 females in the U.S.2 Fabry disease can affect multiple organs and tissues, including the heart, kidney and central nervous system in both males and females. Symptoms can include pain, gastrointestinal difficulties, fatigue, and skin lesions called angiokeratomas.3 Undiagnosed and untreated, Fabry disease can reduce life expectancy by 5-14 years in women and 16 years in men. Fabry disease is progressive and challenging to diagnose.4

Understanding a rare disease diagnosis can be cumbersome and stressful; for this reason, the power of community is exceptionally critical for these individuals. Through the collective sharing of Fabry journeys, hurdles and victories, valuable insights into the long-term impact of the disease can fuel ongoing research. These learnings have and continue to help the research and development of Fabry disease treatment — including Fabrazyme (agalsidase beta), which is approved in adults and pediatric patients two years of age and older with a confirmed Fabry diagnosis. Fabrazyme was approved in the United States 20 years ago and is currently used by more than 6,000 adult and pediatric patients worldwide and continues to serve as a safe and efficacious option for those living with Fabry.

“The path to receiving a Fabry diagnosis can be both time-consuming and overwhelming,” said Jennifer Ibrahim, Head of North America Medical Affairs, Rare Disease at Sanofi. “Since its approval in 2003, Sanofi has been proud to continue to offer hope to this important rare disease community.”

In the world of rare diseases, knowledge is power. Making the effort to familiarize oneself with rare diseases, symptoms and resources could be the key to a diagnosis and proper treatment.

“Sanofi wants those living with Fabry to know they’re not alone,” said Duane Clark, General Manager, Rare Disease at Sanofi. “We see you, we hear you and we will continue to put our science toward supporting you.”

For more information about Fabry disease, visit www.fabrazyme.com.

IMPORTANT SAFETY INFORMATION

Fabrazyme can cause serious side effects, including:

Severe Allergic (anaphylaxis) and Hypersensitivity Reactions

Approximately 1% of patients who have received Fabrazyme either during a clinical study or after Fabrazyme was approved have experienced anaphylactic (allergic) or severe hypersensitivity reactions during their infusion. Life-threatening severe anaphylactic (allergic) or severe hypersensitivity reactions have been seen in patients during Fabrazyme infusions.

  • These reactions included: swelling of the face, mouth and throat, narrowing of breathing airways, low blood pressure, hives, difficulty swallowing, rash, trouble breathing, flushing, chest discomfort, itching and nasal congestion.
  • People who have experienced these reactions have required treatment including heart/lung resuscitation, oxygen, fluids given through a vein, hospitalization, and treatment with inhaled drugs called beta-adrenergic agonists to help open the breathing airways, antihistamines, epinephrine (also known as adrenaline), and a medication given through the vein called a corticosteroid (or steroid) which helps to decrease the body’s allergic reaction by decreasing inflammation.
  • If you experience a severe allergic or anaphylactic reaction, your healthcare professional will immediately stop the infusion of Fabrazyme and provide you the necessary emergency medical treatment. Because of the possibility that severe hypersensitivity reactions may occur, appropriate medical support should be available during your Fabrazyme infusion.

In the clinical studies, some patients developed IgE antibodies or a reaction to an allergy skin test specific to Fabrazyme. IgE antibodies are a specific kind of antibody that can sometimes be produced by the body’s immune system during an allergic reaction.

  • Higher amounts of hypersensitivity reactions were seen in adult patients whose immune systems repeatedly made anti-Fabrazyme antibodies and in patients who had high antibody titers (units used to measure how much anti-drug-antibody your immune system is making) compared to adult patients with negative antibody titers.
  • Your doctor should consider testing for IgE antibodies if you experience suspected allergic reactions. Providing Fabrazyme to patients who have experienced severe or serious allergic reactions to Fabrazyme should only be done after carefully considering the risks and benefits of continuing the treatment, and only under the direct supervision of a qualified healthcare professional and with appropriate medical support readily available.

Infusion-Associated Reactions

In clinical studies with Fabrazyme, 59% of patients experienced infusion-associated reactions during Fabrazyme administration, some of which were severe. Infusion-associated reactions are defined as adverse reactions occurring on the same day as your infusion. During the clinical trials, infusion-associated reactions occurred more frequently in patients who were positive for anti-Fabrazyme antibodies than in patients who did not have anti-Fabrazyme antibodies.

  • For patients who have had reactions to their infusions, it is recommended that they be given anti-fever and antihistamine medications right before their next infusions. Infusion-associated reactions have happened in some patients even after taking these medications before their infusions.
  • If an infusion-associated reaction occurs, slowing the infusion rate, stopping the infusion for a short time and/or giving more anti-fever and antihistamine medications and or steroids may improve the symptoms.
  • If severe infusion-associated reactions happen, your healthcare professional should consider stopping the Fabrazyme infusion right away and should provide medical care for your condition. Severe reactions are generally managed by giving antihistamine medications, corticosteroids, fluids through the vein, and/or oxygen when needed. Because severe infusion-associated reactions may happen, medical treatment should be readily available during your Fabrazyme infusion.
  • People with advanced Fabry disease may have heart problems which could put them at a higher risk for severe complications from infusion-associated reactions. These patients should be watched closely during their infusion if the decision is made to give them Fabrazyme.

Common and Other Possible Side Effects: Common side effects reported in 20% or more of Fabrazyme treated patients in clinical studies compared to placebo were upper respiratory tract infection, chills, fever, headache, cough, burning and/or tingling sensation, fatigue, swelling in the legs, dizziness and rash.

INDICATION AND USAGE

Fabrazyme® is used to treat adults and children 2 years of age and older with confirmed Fabry disease.

Please see full Prescribing Information for Fabrazyme.

_____________________________

[1] Genetic and Rare Diseases Information Center. What is a Rare Disease. Available at https://rarediseases.info.nih.gov/about. Accessed on May 16, 2023

[2] Fabry Institute. Epidemiology of Fabry Disease. Available at https://fabry-institute.com/burden-of-disease/epidemiology-of-fabry-disease. Accessed on May 16, 2023

[3] Genetic and Rare Diseases Information Center. Fabry disease. Available at https://rarediseases.info.nih.gov/diseases/6400/fabry-disease. Accessed on May 16, 2023

[4] Waldek S, Patel M, Banikazemi M, et al., American College of Medical Genetics. Life expectancy and cause of death in males and females with Fabry disease: Findings from Fabry. Accessed on May 16, 2023

MAT-US-2304200-v1.0-07/2023

Empowering the Rare Disease Community for 20 Years: The Fabry Patient
(BPT) – Living with a rare disease may not be as rare as you would think: Affecting one in 10 Americans, there are more than 10,000 known rare diseases in the U.S.1 While significant strides to develop treatments have been made in recent decades, broadscale awareness of disease remains a challenge. The path to diagnosis and proper care can be long and frustrating.
For example, Fabry disease is a rare genetic disease. Classic Fabry disease affects approximately 1 in 40,000 males and 1 in 20,000 females in the U.S.2 Fabry disease can affect multiple organs and tissues, including the heart, kidney and central nervous system in both males and females. Symptoms can include pain, gastrointestinal difficulties, fatigue, and skin lesions called angiokeratomas.3 Undiagnosed and untreated, Fabry disease can reduce life expectancy by 5-14 years in women and 16 years in men. Fabry disease is progressive and challenging to diagnose.4
Understanding a rare disease diagnosis can be cumbersome and stressful; for this reason, the power of community is exceptionally critical for these individuals. Through the collective sharing of Fabry journeys, hurdles and victories, valuable insights into the long-term impact of the disease can fuel ongoing research. These learnings have and continue to help the research and development of Fabry disease treatment — including Fabrazyme (agalsidase beta), which is approved in adults and pediatric patients two years of age and older with a confirmed Fabry diagnosis. Fabrazyme was approved in the United States 20 years ago and is currently used by more than 6,000 adult and pediatric patients worldwide and continues to serve as a safe and efficacious option for those living with Fabry.
“The path to receiving a Fabry diagnosis can be both time-consuming and overwhelming,” said Jennifer Ibrahim, Head of North America Medical Affairs, Rare Disease at Sanofi. “Since its approval in 2003, Sanofi has been proud to continue to offer hope to this important rare disease community.”
In the world of rare diseases, knowledge is power. Making the effort to familiarize oneself with rare diseases, symptoms and resources could be the key to a diagnosis and proper treatment.
“Sanofi wants those living with Fabry to know they’re not alone,” said Duane Clark, General Manager, Rare Disease at Sanofi. “We see you, we hear you and we will continue to put our science toward supporting you.”
For more information about Fabry disease, visit www.fabrazyme.com.
###
IMPORTANT SAFETY INFORMATION
Fabrazyme can cause serious side effects, including:
Severe Allergic (anaphylaxis) and Hypersensitivity Reactions
Approximately 1% of patients who have received Fabrazyme either during a clinical study or after Fabrazyme was approved have experienced anaphylactic (allergic) or severe hypersensitivity reactions during their infusion. Life-threatening severe anaphylactic (allergic) or severe hypersensitivity reactions have been seen in patients during Fabrazyme infusions.
• These reactions included: swelling of the face, mouth and throat, narrowing of breathing airways, low blood pressure, hives, difficulty swallowing, rash, trouble breathing, flushing, chest discomfort, itching and nasal congestion.
• People who have experienced these reactions have required treatment including heart/lung resuscitation, oxygen, fluids given through a vein, hospitalization, and treatment with inhaled drugs called beta-adrenergic agonists to help open the breathing airways, antihistamines, epinephrine (also known as adrenaline), and a medication given through the vein called a corticosteroid (or steroid) which helps to decrease the body’s allergic reaction by decreasing inflammation.
• If you experience a severe allergic or anaphylactic reaction, your healthcare professional will immediately stop the infusion of Fabrazyme and provide you the necessary emergency medical treatment. Because of the possibility that severe hypersensitivity reactions may occur, appropriate medical support should be available during your Fabrazyme infusion.
In the clinical studies, some patients developed IgE antibodies or a reaction to an allergy skin test specific to Fabrazyme. IgE antibodies are a specific kind of antibody that can sometimes be produced by the body’s immune system during an allergic reaction.
• Higher amounts of hypersensitivity reactions were seen in adult patients whose immune systems repeatedly made anti-Fabrazyme antibodies and in patients who had high antibody titers (units used to measure how much anti-drug-antibody your immune system is making) compared to adult patients with negative antibody titers.
• Your doctor should consider testing for IgE antibodies if you experience suspected allergic reactions. Providing Fabrazyme to patients who have experienced severe or serious allergic reactions to Fabrazyme should only be done after carefully considering the risks and benefits of continuing the treatment, and only under the direct supervision of a qualified healthcare professional and with appropriate medical support readily available.
Infusion-Associated Reactions
In clinical studies with Fabrazyme, 59% of patients experienced infusion-associated reactions during Fabrazyme administration, some of which were severe. Infusion-associated reactions are defined as adverse reactions occurring on the same day as your infusion. During the clinical trials, infusion-associated reactions occurred more frequently in patients who were positive for anti-Fabrazyme antibodies than in patients who did not have anti-Fabrazyme antibodies.
• For patients who have had reactions to their infusions, it is recommended that they be given anti-fever and antihistamine medications right before their next infusions. Infusion-associated reactions have happened in some patients even after taking these medications before their infusions.
• If an infusion-associated reaction occurs, slowing the infusion rate, stopping the infusion for a short time and/or giving more anti-fever and antihistamine medications and or steroids may improve the symptoms.
• If severe infusion-associated reactions happen, your healthcare professional should consider stopping the Fabrazyme infusion right away and should provide medical care for your condition. Severe reactions are generally managed by giving antihistamine medications, corticosteroids, fluids through the vein, and/or oxygen when needed. Because severe infusion-associated reactions may happen, medical treatment should be readily available during your Fabrazyme infusion.
• People with advanced Fabry disease may have heart problems which could put them at a higher risk for severe complications from infusion-associated reactions. These patients should be watched closely during their infusion if the decision is made to give them Fabrazyme.
Common and Other Possible Side Effects: Common side effects reported in 20% or more of Fabrazyme treated patients in clinical studies compared to placebo were upper respiratory tract infection, chills, fever, headache, cough, burning and/or tingling sensation, fatigue, swelling in the legs, dizziness and rash.
INDICATION AND USAGE
Fabrazyme® is used to treat adults and children 2 years of age and older with confirmed Fabry disease.
Please see full Prescribing Information for Fabrazyme.
_____________________________
[1] Genetic and Rare Diseases Information Center. What is a Rare Disease. Available at https://rarediseases.info.nih.gov/about. Accessed on May 16, 2023
[2] Fabry Institute. Epidemiology of Fabry Disease. Available at https://fabry-institute.com/burden-of-disease/epidemiology-of-fabry-disease. Accessed on May 16, 2023
[3] Genetic and Rare Diseases Information Center. Fabry disease. Available at https://rarediseases.info.nih.gov/diseases/6400/fabry-disease. Accessed on May 16, 2023
[4] Waldek S, Patel M, Banikazemi M, et al., American College of Medical Genetics. Life expectancy and cause of death in males and females with Fabry disease: Findings from Fabry. Accessed on May 16, 2023
MAT-US-2304200-v1.0-07/2023

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Help a good cause and be part of history by uploading a photo of your smile today

2023-07-17T07:01:00

(BPT) – A smile is universal. No matter your age or geography, the act of smiling is positive, uplifting and unifying. Now, when you submit a photo of your smile, you can help an important nonprofit achieve a world record of the largest online photo album of smiling mouths.

Smile Train, the world’s largest cleft-focused organization, is looking to make history by setting a GUINNESS WORLD RECORDS™ title for the largest online photo album of smiling mouths. Once the record is set, Dentsply Sirona, the world’s largest manufacturer of dental products and technologies, and a Smile Train partner, will make a cash donation to Smile Train on World Smile Day®.

Why is this effort so important?

Cleft lip and cleft palate are common birth conditions that occur when a baby’s lip or mouth do not form properly during pregnancy. Cleft-affected children have difficulty with eating, breathing, hearing and speaking. Clefts can even lead to malnutrition and death. Children with clefts are regularly harassed and bullied so much for the way they look and speak that they are often forced to drop out of school for their own safety.

Fortunately, there is a solution. Smile Train partners with local health care professionals around the world to provide free surgery and comprehensive cleft care, including nutrition, speech therapy, psychosocial support, dental services and more. Since its inception in 1999, Smile Train has supported more than 1.5 million free cleft surgeries worldwide.

“We’re passionate about smiles because we know what a serious business they are. As an organization that supports free cleft surgeries and comprehensive cleft care, including oral health care, we are embarking on a global effort to honor all smiles by setting a world record,” said Susannah Schaefer, president and CEO of Smile Train.

Your smile can make a difference

The GUINNESS WORLD RECORDS™ title attempt is currently running until World Smile Day® on October 6, 2023. In all, 20,000 images of smiling mouths need to be uploaded to the online photo album.

Samantha Hanratty, star of Showtime’s Yellowjackets and Smile Train Celebrity Ambassador, is sharing her smile in support of the campaign. “I’m proud to partner with Smile Train on this global, and hopefully record-setting, effort,” she said.

Anyone over the age of 13 can participate, and it’s simple to do by following these three easy steps:

  1. Go to EverySmile.org.
  2. Click on “I want to make history”
  3. Take and upload a clear and well-lit photo of yourself smiling (just follow the guide provided)

The campaign launch coincides with National Cleft and Craniofacial Awareness and Prevention Month in July.

“This is another opportunity to raise awareness, support and celebrate people born with a facial difference. We strive to give every child with a cleft the opportunity to smile and lead a full and happy life by empowering medical professionals with training, funding and resources to provide free cleft surgery and comprehensive cleft care to children globally,” Schaefer added.

Will you help them reach their goal so they can help even more kids? The cash donation from Dentsply Sirona will support Smile Train’s vision of a world where every person has access to high-quality comprehensive cleft care and is able to live a full and healthy life.

“We are proud to help shine a light on the important work that Smile Train does to help children and all people with clefts around the world,” said Erania Brackett, senior vice president, Orthodontic Aligner Solutions & Customer Experience and head of Sustainability at Dentsply Sirona.

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5 ways to refresh your scalp care routine

2023-07-17T06:01:00

(BPT) – A healthy head of hair starts with your scalp, so there’s nothing better for your beauty and wellness routine than focusing on good scalp care. When your scalp isn’t healthy, you may be just as likely to notice issues with your hair as your skin.

If you experience issues including itching, dandruff or irritation, dullness or breakage, you may want to talk to an expert. In the meantime, there are simple things you can do at home to refresh your routine and boost the condition of your scalp.

Here are five easy ways to help promote better scalp health.

1. Watch how you wash

Over-washing your hair can upset the balance of your scalp’s natural oils. Not everyone needs to wash their hair every day for the best results and appearance. Consider washing less frequently and try a clarifying shampoo. The Centers for Disease Control and Prevention (CDC) also recommends using a scalp exfoliant to help remove product buildup. While shampooing, don’t scrub or scratch your scalp — a gentle scalp massage can help loosen dirt without causing irritation.

Especially if you have sensitive skin, choose hair products without potential irritants like sulfates, allergens or silicones. The National Institutes of Health advises against products containing parabens or fragrances. Today’s options for hair products are numerous, so check the ingredients before buying. If any new product irritates your skin or scalp, stop using it.

2. Rinse thoroughly

Scalp care is the new self-care, and that can start with changing your shower head. To help rinse your hair and scalp better, the Waterpik® HairWand Pulse Spa System provides a luxurious way to nurture your hair and body. Clinically shown to provide fast, effective rinsing, its pulsating comb-shape spray delivers a relaxing scalp massage that reaches down to the roots and is shown to help remove visible flakes, rejuvenate the scalp, and leave it feeling clean.

For a two-for-one scalp care and relaxing massage experience, the Waterpik HairWand Pulse Spa System has multiple spray settings and goes beyond helping you care for your scalp. Its PowerPulse Therapeutic Strength Massage also helps to soothe muscle tension, increase flexibility, and promote restful sleep. You can find the Waterpik HairWand Pulse Spa System in Chrome or Brushed Nickel online, at HomeDepot.com.

3. Protect from the sun

Don’t forget — your scalp is skin, too. Avoid pain and skin peeling from sunburn by wearing a hat when outside in the sun. The Cleveland Clinic also recommends using sunscreen to help protect your scalp from UV rays. Sunburn on your scalp is not only painful and irritating, but over time could even develop into something serious, like skin cancer. Fortunately, you can find sunscreen in a lightweight spray for use on your scalp.

4. Nourish hair and scalp from the inside

Just like the rest of your body, your scalp needs the right nutrients to be at its best. You may want to consider your skin and hair health when doing your meal planning to ensure that you get sufficient nutrition. According to the Mayo Clinic, the best nutrients for hair and skin health include proteins, omega 3s, vitamins A, E and D, plus healthy plant-based fats such as those found in olive oil, nuts and avocadoes.

5. Take steps to reduce your stress

Anytime you’re feeling stressed, this can affect any of your body’s systems, including your scalp and hair. Stress you experience can take the form of scalp acne, dandruff, oily or damaged hair and other conditions.

Explore ways to help reduce your stress levels for well-being that’s not just skin deep. Try mindfulness practices like deep breathing or meditation, yoga, walking, spending time in nature or taking breaks from electronic devices. Do something relaxing, like getting a massage, or consider a meditation app or class that teaches stress reduction techniques.

Your scalp is a crucial part of your body, and when it’s not healthy, you can quickly see it in how your skin and hair look and feel. Following these tips can help you create a new routine to help you maintain your best scalp health.

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5 tips to help parents and students with back-to-school prep

2023-07-17T02:01:00

(BPT) – There’s something special about this time of year, no matter how old you are — with plenty of excitement and anticipation as the next school year approaches, mixed with just a little anxiety about the upcoming changes. Parents and kids of all ages, especially those who are college-bound, can sometimes feel overwhelmed by everything that needs to happen to be ready for this big transition.

Fortunately, you can make preparing for the upcoming academic year a lot easier with some tips and tools to help everyone stay on track during the shift from summer to school mode.

1. Tackle time management

One of the biggest shifts from the lazy days of summer back to school again is keeping on top of everyone’s schedules. A tried-and-true tactic is to create and post one big family calendar where everyone can see it (like on your fridge or other central location). That way everyone can add their appointments, extracurricular activities and upcoming events so the whole family knows what to plan for and look forward to each week. Try using color-coded markers so everyone knows which events are for which family member — or for everyone.

To make this task easier, one helpful tool you can use is downloading and printing out a family calendar template from a site like CalendarLabs.com.

2. Make mealtimes easier

Another important adjustment that takes place each fall is the need to plan ahead for speedy breakfasts, packable lunches, after-school snacks and easy-to-prep meals for busy weeknights. Preparing nutritious meals for kids takes some advance planning, so it’s a good idea to print out a useful tool like a printable meal chart from TwoPeasAndTheirPod.com.

With a planning tool like this, you’ll be ready to shop and prep for meals more efficiently, so you can continue to feed your kids well before, during and after school. Involve kids in the planning by asking what they want to eat for each meal, while introducing different colors based on each of the food groups to show them what a balanced meal looks like.

3. Get ready for the move to campus

For college students, the move away from home can be a real test of their organizational abilities. Help ensure they’ll have what they need by printing a list of everything they think they’ll have to pack for the big move. They can share their list with older siblings, friends and family to get everyone’s advice. Once their list is complete, they can print out their finalized list for shopping and crossing off items they’ve already gotten.

They can also help reduce the homesickness they’re bound to feel their first year away from home by printing out pictures of beloved family members (and pets) from their phone so they can always have loved ones with them, while also making a welcome addition to their dorm room decor.

4. Maximize technology to help with planning

You and your kids can easily print out all of these types of helpful calendars, scheduling tools, mealtime planners, photos and to-do lists using the Mopria Print Service app, which enhances print functionality on any Android phone or tablet, allowing you to connect and print to one of over 120 million Mopria certified printers without any additional set-up — eliminating the need to install additional software or drivers so you can easily print, regardless of the printer’s brand.

Simply download the app from Mopria.org/print-from-android or Google Play to get started.

5. Stay organized at every stage

Each year also brings with it a new slew of important papers to keep copies of, including information that your kids will need to have. The Mopria Scan app offers a convenient way for you to scan documents from your scanner or multi-function printer directly to your Android device. This saves you the hassle of installing apps for every scanner you use, and facilitates easy access to your scanned pages for viewing on your Android devices. You can download the Mopria Scan app from Google Play or directly from their website.

With these tools and tactics, you should all feel better prepared for the changes to come — helping you and your kids make the transition seamlessly, no matter what the new school year brings.

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Do You Have High Cholesterol? What You Need to Know to Lower Your Risk of Heart Disease

2023-07-14T08:01:00

(BPT) – By JoAnne Foody, MD, FACC, FAHA, Chief Medical Officer, Esperion

While most people are likely familiar with and know someone impacted by cardiovascular (heart) disease, many don’t know that it is the leading killer of men and women in this country.

Many so-called “risk factors” increase the chance that someone will have cardiovascular disease, which includes heart attacks and strokes and affects hundreds of millions of people, but one of the most common is high cholesterol — specifically the type known as low-density lipoprotein (LDL), or “bad,” cholesterol. This type of cholesterol is dangerous because it collects inside blood vessels and hardens as plaque, making it difficult for blood to flow through arteries. When the plaque is irritated or inflamed, a blood clot can form in the blood vessel, depriving the brain and heart of oxygen, causing a heart attack or stroke.

An estimated 93 million American adults have a cholesterol level above the recommended limit. People most likely to have high cholesterol are those who smoke, drink excess alcohol, have obesity, diabetes or a family history of high cholesterol, or aren’t active.

The most commonly prescribed cholesterol-lowering medicines are statins. Approved by the U.S. Food and Drug Administration, or FDA, statins are very effective in lowering cholesterol and have been proven to significantly reduce the risk of having a cardiovascular event and even dying from a cardiovascular event. In fact, statins have been considered the standard of care for treating high cholesterol for many years.

Challenges associated with taking statins

Unfortunately, statins are not appropriate for all people with high cholesterol. As many as 30% of patients do not tolerate statins because of serious side effects, particularly muscle pain or weakness. Other patients don’t have side effects from statins but can’t get their cholesterol level down low enough to reduce their risk of a cardiovascular event.

Lowering cholesterol is important both for primary and secondary prevention of cardiovascular disease. Primary prevention means preventing heart disease in people who have not had a prior heart attack, stroke or other cardiovascular event but are at high risk of having one. Secondary prevention means preventing a cardiovascular event in someone who already has existing heart disease.

However, in the United States, primary prevention patients are currently under-treated when it comes to cholesterol lowering. Research shows that half of people at high risk of having a cardiovascular event are not currently receiving cholesterol-lowering drugs.

Statins remain the gold standard when it comes to the first medicine doctors prescribe both for patients who have already had and those who have not yet had a cardiovascular event. But for those patients who can’t tolerate statins or can’t get their cholesterol low enough to meet their goal, it is important to know about other treatment options.

A recent analysis from a Cleveland Clinic-led clinical trial of nearly 14,000 patients showed the use of another cholesterol-lowering treatment in statin-intolerant patients who had not had a cardiovascular event but who had risk factors, such as diabetes, significantly reduced the chance of major adverse cardiovascular events, including:

  • heart attacks
  • strokes
  • a procedure to put a stent in a blocked coronary artery
  • death from cardiovascular disease

If you have high cholesterol and could benefit from lowering your cholesterol but can’t take a statin, talk to your doctor about treatment options for managing your high cholesterol and reducing your cardiovascular risk.

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What is skill gaming? 5 facts about today’s hottest hidden hobby

2023-07-14T07:31:00

(BPT) – Whether it’s during a lunch break or just relaxing, more and more people are turning to casual, mobile games to interject moments for entertainment and unwinding into their days. Beyond bragging rights and achievement, many are also enjoying paid competitive gaming contests as part of the fun. According to Game Taco, the parent company of skill-based gaming platform WorldWinner, nearly 46% of mobile gamers are either currently playing or are interested in playing skill games.

By definition, skill games require the player to use their physical or mental abilities and come in many forms. Traditional skill games include familiar favorites like Atari Breakout, solitaire and chess; word games like Scrabble or recently released Word Slots and even arcade games like Bejeweled. All of these games require players to flex their abilities instead of relying on luck when competing in real money tournaments and for the chance to win cash and prizes. Plus, all can be played on a smartphone or PC.

Still not sure if skill-gaming is for you? Check out these five ways you can benefit from playing these fun games.

1. Sharpen your skills and have fun

Playing skill-based mobile games can help players improve natural abilities and acquire new skills while having fun and, in some cases, winning money. Mobile games of skill require strategic planning, problem-solving, spatial awareness and other skills that are handy in everyday situations, extending their benefits beyond that initial sense of accomplishment. There’s science to back this up; recent studies demonstrate playing digital games can improve everything from leadership aptitude to collaboration and work ethic.

2. Join the craze

Digital gaming has almost always had a reputation for being most popular amongst men, but studies paint a much more even gender divide, especially on mobile.

According to a recent market research survey by AdColony and DISQO, the number of men and women playing mobile games is fairly equal. In some cases, women take the lead: a consumer insights report by Newzoo found that when it comes to mobile games, women are more likely to play more often than their male counterparts.

Skill-based mobile games encourage players to be social and find community with others. The category has the widest player demographic, with one-third of players over 45 and it appeals to both men and women. Best of all, players are matched by skill level, so there’s always someone for you to play with.

3. Relax at home or on the go

Mobile games are a great way to unwind in-between activities or at the end of a long day. The same AdColony and DISQO survey found that 47% of mobile gamers play games to relax. Since mobile games can be accessed on your phone anytime, anywhere, they’re a convenient way to take a break from daily responsibilities and stressors. Skill games, particularly, are attractive because they are created to be played in bursts, providing you the opportunity to inject short doses of entertainment and joy throughout your daily routine.

4. A workout for your brain

Just like your muscles, your brain also needs a fitness routine; research shows keeping your mind active can help prevent cognitive impairment as you age. Incorporating skill-based mobile games into your day is a simple, low-cost way to strengthen your strategic building, problem-solving and decision-making abilities. Skill-based games encourage players to adapt to changing situations and find creative solutions while challenging memory, attention span and critical thinking — all on a device they already own.

5. Earn money just by playing

Turn your entertainment into a side hustle. Many skill-based mobile games allow players to earn cash by playing or competing against others. The prizes are big enough to go around; WorldWinner, one of the leading companies in the space, has already awarded more than $1.5 billion to players.

Adding to the appeal, players can win from a large list of games. To use the WorldWinner example again, players can put extra cash in their pocket by selecting from their expanding library of games, including newly released entries like Word Slots, as well classic favorites like Bingo and premium titles like Wheel of Fortune®, TRIVIAL PURSUIT, YAHTZEE® and Boggle.

Skill-based mobile games are popular because they have something for everyone. Whether you want to have fun, relax, boost your cognitive skills or even earn some cash, there’s a game (or two) out there that’s just right for you.