Category: Brandpoint

2018-03-12T15:19:01

(BPT) – Raising backyard chickens has been a growing trend in the United States over the past several years. Consumers crave choice in their family’s diet, which often includes food they have grown or raised themselves. Raising a backyard flock helps consumers have more control over the eggs their family eats, but bringing home chicks for a backyard flock is just the beginning.

The happiest backyard chickens have the healthiest diets, and the best eggs come from hens eating the most nutritious feed. Today, we are increasingly focused on the impact food has on our family’s health. Hobbyists like to feed their flock the way they feed themselves: non-GMO, organic, soy-free, omega-free and all natural.

Having a say in what goes into the food their family eats is one of the main reasons people choose to raise backyard chickens. There are 2.9 million households in the U.S. raising chickens, and 62 percent of backyard hobbyists anticipate adding to their flock in the next three years. Raising chickens is a way to extend food supply, and hobbyists don’t plan to scale back.

Providing healthy food for your family begins with the source. Nutrena poultry feed makes it easy by using wholesome ingredients in its selection of affordable, homegrown, healthy poultry feeds. By providing your chickens with the highest-quality nutrition, you’re sure to have the freshest eggs for that Sunday morning family breakfast.

With companies like Whole Foods Market reporting 426 percent growth in non-GMO sales from 2010 to 2014, it’s evident that consumers want to know what they’re eating. That’s why Nutrena also offers a USDA-certified organic line of poultry feed that is non-GMO.

The Nutrena poultry feed portfolio includes three different feed lines for each type of poultry hobbyist. Whether you’re starting your chicks, supporting your layers or raising meat birds, Nutrena poultry feed offers the nutrition they need.

For more information about the full line of Nutrena feed, visit NutrenaWorld.com.

2018-03-12T09:01:01

(BPT) – Hearing loss is often referred to as a silent disease. It doesn’t hurt and it often occurs so gradually over time that you barely notice the insidious damage it does. As a result, hard-of-hearing people often delay seeking treatment for their hearing loss.

Here are seven reasons you shouldn’t make that mistake.

1. Hearing loss can be a sign of a more serious illness

While in most cases hearing loss is a result of aging and excessive noise exposure, it can also be a symptom of a serious underlying medical condition. Some of these include tumors, cardiovascular disorders and diabetes. As such, hearing loss should never be dismissed.

2. Untreated hearing loss hurts your career and earning potential

Thinking about hiding your hearing loss at work because it makes you look incompetent and old? Think again! Misunderstanding instructions and asking people to repeat themselves all the time makes others question your ability to do your job. Minimizing communication breakdowns at work by wearing hearing aids will ensure that hearing loss doesn’t become a roadblock for your career.

3. Untreated hearing loss hurts your relationships with loved ones

Did your hearing loss cause you to miss out on a private joke with your pals? Or did you inadvertently hurt your grandchild’s feelings because you didn’t hear them calling you? Since good communication is vital to any close relationship, hearing loss can be hardest on the ones we love the most. Left unresolved, mounting resentment and frustration eventually strains your most cherished relationships.

4. Untreated hearing loss leads to rise in fall risk

Did you know that (along with vision) good hearing also helps you maintain spatial orientation and balance? This is why research has shown that those with even a mild untreated hearing loss are nearly three times more likely to have a history of falling than people with good hearing.

5. Untreated hearing loss has been linked to increased risk for cognitive decline and dementia

There is a growing body of evidence linking untreated hearing loss to physical changes in the brain, accelerated rate of cognitive decline, and cognitive disorders like dementia and Alzheimer’s disease. On the other hand, at least one long-term study shows wearing hearing aids reduces cognitive decline. Why would you take chances?

6. Untreated hearing loss can cause social isolation and depression

When you have a hard time hearing, social activities with friends and family start to become more embarrassing than fun. Your natural recourse may be slowly withdrawing from these activities that you once enjoyed. No wonder, then, that untreated hearing loss frequently leads to social isolation and even depression.

7. Treating hearing loss is easy and painless

Given all these reasons why untreated hearing loss is bad, here’s one piece of good news: Getting treated for hearing loss is easy! Unlike other serious medical conditions that may require surgeries or painful treatments, having your hearing loss evaluated and treated with hearing aids is easy and painless. In fact, most people who finally start to wear hearing aids regret that they didn’t seek treatment earlier.

2018-03-12T08:07:01

(BPT) – The Pill is the most popular form of contraception. There are over 35 varieties available to the more than 10 million women who have been prescribed the Pill in the U.S. These statistics would not be possible without thought leaders rallying together for progress in women’s reproductive healthcare.

2018-03-27T13:01:00

(BPT) – When someone says blood cancer, the average person may typically think of lymphoma or leukemia. However, for an estimated 229,468 worldwide, blood cancer means multiple myeloma.[I]

In fact, multiple myeloma is the second most common blood cancer.[ii] An estimated 30,280 new cases of multiple myeloma were diagnosed in 2017 in the United States alone.[iii] March 1 marked the beginning of Multiple Myeloma Action Month, an annual observance helping to shed light on this disease. While supporting patients with multiple myeloma is a 365-day-a-year effort, March offers an opportunity to reflect on how far we’ve come and what’s next in improving patient care.

What is multiple myeloma?

Multiple myeloma is a cancer formed by malignant plasma cells.[iv],[v] Normal plasma cells are found in the bone marrow and are an important part of the immune system.[iv],[v] Genetic changes in plasma cells cause them to transform into cancer cells, replicate uncontrollably and accumulate in the bone marrow.[v] The exact cause is unknown, and most people with multiple myeloma have no known risk factors other than age and race.[iii],[vi] African Americans are twice as likely to be diagnosed with multiple myeloma compared to white Americans.[iii] The average age at diagnosis is 69 years.[iii]

Patient outcomes are improving

In the 1990s, only one-third of patients survived five years following diagnosis.[vii] Now, nearly half of all multiple myeloma patients are expected to survive five years or more.[iii],[vii] This is largely due to ongoing research efforts that have led to the approval of new and novel treatments.

The multiple myeloma advocacy community is powerful

The International Myeloma Foundation declared March 2009 the first ever Myeloma Awareness Month and has since elevated the program to Myeloma Action Month, inspiring people to take action to drive awareness and progress. The International Myeloma Foundation and other patient organizations like the Multiple Myeloma Research Foundation, Leukemia & Lymphoma Society and Myeloma Crowd have become driving forces in the multiple myeloma community, helping to advance patient care through research and fundraising efforts while furthering public awareness. Patient demographics gathered through the MMRF CoMMpass Study^SM are helping patients to better assess their treatment options, while programs like LLS’ Light The Night^® and the MMRF’s The Journey Towards a Cure have infused the patient community with immense strength. Those involved often create long-lasting relationships and expand their support networks.

The search for a cure is an ongoing priority

While significant improvements in patient care have been made, there is still no cure for multiple myeloma. Patient advocates and researchers alike are dedicated to improving understanding of the disease and driving medical innovation. Projects, like the Myeloma Genome Project, are assessing genetic data associated with patient outcomes in an effort to improve diagnosis, prognosis and treatment. Additionally, research initiatives continue to investigate new uses for current therapies, while also exploring promising new approaches like utilizing patients’ own immune systems to fight the disease.

Nadim Ahmed, President, Hematology and Oncology, Celgene, notes that, “It is not just during the month of March, but every day throughout the year that we must continue to discover new ways to provide a brighter future for people with multiple myeloma. Through dedicated research and continued partnership with an amazing group of patients, caregivers, advocacy organizations and researchers, it is our hope that one day we can find a cure for this devastating disease.”

2018-03-20T07:01:17

(BPT) – Did you know planting a tree is one of the easiest and most powerful things you can do to have a positive impact on the environment? It’s true. Trees clean the air, prevent rainwater runoff, help you save energy and even combat global warming. And they’re a snap to plant! No horticultural degree required. With Arbor Day just around the corner in April, there’s no better time to give Mother Nature a little TLC by planting a tree.

From the single homeowner in Nebraska planting a maple in her backyard to the 250 Comcast employees volunteering in communities devastated by hurricanes, fires and Emerald Ash Borer infestation by planting hundreds of trees on Comcast Cares Day (the nation’s largest single-day corporate volunteer event), people nationwide are getting their tree on this spring. Here are 10 reasons why you should join them.

Trees fight climate change

Wish you could do more than recycling and reducing your carbon footprint to combat climate change? Trees have you covered. Through photosynthesis, trees absorb harmful carbon dioxide, removing and storing the carbon and releasing oxygen back into the air.

Trees clean the air and help you breathe

Trees don’t just absorb CO2. They also absorb odors and pollutants like nitrogen oxides, ammonia, sulfur dioxide and ozone. It’s estimated that one tree can absorb nearly 10 pounds of polluted air each year and release 260 pounds of oxygen.

Trees prevent soil erosion and rainwater runoff

During heavy rains, water runoff finds its way to streams, lakes and wetlands, creating the potential for flooding. It also picks up and carries pollutants along the way. The EPA and the Center for Watershed Protection are recognizing the importance of trees in managing runoff. Leaf canopies help buffer the falling rain and their roots hold the soil in place, encouraging the water to seep into the ground rather than run off.

Planting trees is easy

Gardening can be intimidating for newbies because there are so many variables. Which plants and flowers should you put next to each other and which should you separate? Which bloom in the summer and which bloom in the fall? When you’re dealing with trees, there’s none of that. Just choose a spot in your yard and you’re good to go. Here’s a video showing you all you need to know about planting your young trees: https://www.youtube.com/watch?v=d5FiqoypXfo.

You’ll save money

Trees conserve energy in summer and winter, providing shade from the hot summer sun and shelter from cold winter winds. With trees standing between you and the elements, you’ll spend less on your energy bill to heat and cool your home.

Trees increase your home’s value

Studies of comparable homes with and without trees show that, if you have trees in your yard, your home’s value increases by up to 15 percent. It’s all about curb appeal, and trees make your home and yard more beautiful.

You’ll attract birds (and critters)

Trees provide nesting sites, food and shelter for your bird friends. Hang a feeder in one of the branches and enjoy the birdsong all year long. Squirrels love to make their homes in trees, too, and watching their antics is a great way to spend a lazy summer afternoon.

Trees are good for your mental and physical health

A view of trees in urban areas has been proven to reduce stress, anxiety and even the crime rate. Tree-filled gardens on hospital grounds speed healing in hospital patients.

You’ll be giving your descendants a gift

Trees can live hundreds of years, so when you plant one, you’re giving a gift to your children and grandchildren. It’s a symbol of your commitment to the environment and the beauty of the world around you that will live on far beyond your own lifetime.

Free trees!

Join the nonprofit Arbor Day Foundation for $10 and they’ll send you 10 trees selected for the region of the country where you live, at the right time to plant them. You’ll also get planting instructions and other information. The trees are guaranteed to grow or the Foundation will replace them. Visit www.arborday.org to join.

An ancient Chinese proverb states: “The best time to plant a tree was 20 years ago. The second best time is now.” To find out more about planting trees, visit the Arbor Day Foundation at www.arborday.org.

2018-03-27T10:11:00

(BPT) – Farm-fresh eggs. Locally grown tomatoes. Herbs sourced onsite.

If you’ve eaten out recently, you’ve probably noticed the menus feature locally sourced ingredients. The farm-to-table movement continues to flourish at restaurants throughout the country.

In fact, rather than the exception, it’s become the expectation. According to the National Restaurant Association, farm-to-table is quickly becoming the new norm. Diners are so attracted to the freshest fare possible, it’s inspiring some restaurants to start their own gardens, on a rooftop, terrace or simple outdoor plot. Hyper-local culinary concepts like these represent the top trend on the annual “2018 Culinary Forecast” report.

You can take a cue from this hot trend by starting your own farm-to-table concept garden at home. Just imagine plucking ruby red tomatoes and rich green basil straight from your garden to make a farm-fresh, scrumptious caprese salad without ever leaving home. An at-home take on the farm-to-table trend can easily be translated to a convenient “garden-to-table” concept in your own backyard. Growing your own at home will elevate your cooking and you’ll feel good about being able to produce your own food while lowering your grocery bill (and certainly save by not dining out as much).

No matter the size of your garden space, you can grow fresh foods that are readily available right at your fingertips, even if you just have a small patio or balcony. What’s more, some of the most popular produce to eat is also easy to grow.

The experts at Bonnie Plants offer some easy-to-grow, space-saving suggestions to encourage a garden-to-table trend at home.

Caged tomatoes

Whether you choose big, juicy slicers or sweet cherry-sized snackers, caged tomatoes are easy to grow and offer endless cooking opportunities. Determinate varieties of tomatoes are container favorites because the vines are relatively compact yet bear a productive harvest. Or create your own container garden using tomato varieties especially bred for small spaces.

Caged peppers

Try popular and versatile Green Bell, a heavy yielder of large fruits and a good all-round pepper for slicing and stuffing. Or, spice up your recipes with jalapeño chile peppers, which yield a bountiful harvest.

Strawberries in hanging baskets

Sweet, juicy strawberries add loads of flavor to salads, dressings, drinks and desserts. Think you need a plot to grow a productive strawberry patch? Think again. Maximize space with Bonnie Plants’ strawberries in hanging baskets, which are everbearing and produce cascades of berries throughout the growing season.

Herbs in combo pots

Want to raise the flavor profile of any culinary dish? Fresh herbs are your best bet. Herb gardens can be grown in compact spaces, which means you can fit your favorites in no matter how much space you have.

For example, a kitchen herb combo container featuring sweet basil, cilantro and curled parsley is a powerhouse pot that’s both practical and pretty. You can set it right outside your door for convenient access and continuous harvest. Herbs are ready for harvest upon purchase and will keep growing and giving all season long.

Bonnie Plants offers more than 250 varieties of vegetables and herbs, from tried and true classics to some unusual varieties you may not have tried, such as Holy Basil, Tepin Chili Pepper, Barbeque Rosemary, Little Napoli Patio Roma and many more.

Once it’s time to harvest, have fun exploring new recipes and experimenting with home-grown, fresh-picked produce that will shake up your supper and then some. For more inspiration for easy at-home gardening, visit bonnieplants.com.

This recipe for a classic caprese salad is sure to hit the spot as a light lunch or satisfying start to dinner.

Caprese salad

Ingredients:

1 fresh tomato
1 ball fresh mozzarella cheese
Basil leaves
Olive oil
Balsamic vinegar
Salt and pepper to taste

Directions:

Slice tomato in 1/4-inch thick slices. Do the same for the mozzarella. Alternate layers between the tomato, mozzarella and basil. First, a tomato slice, then a mozzarella slice, then a few leaves of basil; begin and end with tomato. Drizzle with olive oil and balsamic vinegar, or your favorite Italian dressing. Add salt and pepper to taste.

2018-03-19T15:01:01

(BPT) – –

2018-03-27T09:07:00

(BPT) – It’s amazing what parents do in a day. You help your kids with homework, drive them to and from practice, whip up a meal everyone will like, make sure they brush their teeth … the list goes on. Not to mention you have a job to go to. It’s a wonder parents can ever find a few minutes to relax.

While hectic can be an understatement when it comes to describing a day in the life of a parent, there are some simple and savvy ways you can save time and energy when preparing meals. Here are five tips for providing delicious weekday meals for the entire family.

1. Get in the habit of meal planning. Most people don’t realize how much time they spend stressing out about what to make for dinner each night. Something as simple as planning a weekly menu in advance can make things infinitely easier. Try sitting down on Sunday, writing down what you want to eat on each day that week and shopping accordingly. This is a simple and effective way to streamline the whole process.

2. Embrace convenience. There are far more convenient ways of getting a delicious weekday meal than chopping and sweating your way through a home-cooked recipe. You can order take out from most any restaurant these days, but Applebee’s adds an extra layer of convenience for time-crunched parents — Carside To Go(R) pickup. You simply place an order online, through the Applebee’s app, or by phone and schedule a pickup time that works for you. Then, on your way home from work, the gym or soccer practice, just pull into a designated Carside To Go parking spot outside your neighborhood Applebee’s and a team member will bring your food out to you. Deliciously simple.

3. Make food prep a family activity. Parents are always looking for a fun activity everyone will enjoy or a way to constructively engage their kids. You can knock out a few birds with one stone by encouraging your kids to become more involved with preparing family meals. For instance, you can assign them a simple side dish (it can be as easy as defrosting peas or peeling carrots) or have each kid pick a meal they want to help make each week. Whatever your approach, this is an educational and enjoyable way to spend time with your kids.

4. Don’t try to imitate the chefs on TV. We would all love to cook like those celebrity chefs on TV who don’t miss a beat and saute, grill, bake and broil any and all ingredients into a perfect dish. Don’t hold yourself to such impossible standards. Instead, focus on making delicious and nutritious meals that match your skill set and tastes. If you want to wow your family with culinary masterpieces, consider some quick and easy take out options.

5. Embrace leftovers. If you’re already in the kitchen cooking, why not add more ingredients to the pot so you can have extra meals to eat through the week? Or, instead of ordering just enough food for one night, order a couple of extra sides or entrees that you can heat up for lunch or dinner the next day.

No one said life as a parent would be a breeze, but with a few easy tweaks to how you plan, order and cook, you can make mealtime into a fun and easy part of your day.

2018-03-19T12:01:00

(BPT) – It’s no surprise that we all feel the need to get more sleep. However, for some people who feel tired all the time, it may be a sign of a bigger problem. If the urge to sleep during the day is overwhelming and irresistible, it may be excessive daytime sleepiness (EDS).

Roughly 20 percent of Americans have EDS. It is one of the most common complaints people make to a sleep specialist and a symptom that can be seen in a variety of sleep disorders. Being able to recognize the difference between normal sleepiness and EDS is important to your health, but more than 60 percent of Americans find it difficult to do, according to a new survey of 3,000 people conducted by Jazz Pharmaceuticals.

“Occasionally feeling tired is normal,” says Dr. Raj Dasgupta, pulmonary and sleep specialist at the University of Southern California’s Keck School of Medicine. “People with EDS have a hard time staying awake or alert during the day and may doze off during inappropriate times such as during meals, in the middle of a conversation or even when in a car stopped for a few minutes in traffic.”

EDS is a hallmark symptom of narcolepsy. Not everyone who has EDS has narcolepsy, but everyone who has narcolepsy has EDS. Narcolepsy affects approximately 1 in 2,000 Americans. It is a chronic neurological disorder in which the brain can’t control sleep-wake cycles normally. A narcolepsy diagnosis can be tricky because many disorders, such as depression, insomnia and sleep apnea, have some of the same symptoms. This may be why it is estimated that half of those with narcolepsy are undiagnosed.

Narcolepsy has five major symptoms, but you don’t need to experience them all to have it.

1. Excessive Daytime Sleepiness: This is when you have an uncontrollable urge to sleep during the day.

2. Cataplexy: The weakening of muscles when you feel strong emotions like embarrassment, laughter, surprise or anger. Cataplexy can cause your head to drop, your face to droop, your jaw to weaken or make your knees give way.

3. Sleep disruption: This is when you often fall asleep quickly but wake up frequently throughout the night.

4. Sleep paralysis: Feeling unable to move or speak for a short time when falling asleep or waking up. You may also feel like you can’t breathe deeply.

5. Vivid dreaming: Often frightening dreamlike experiences that seem real and happen when falling asleep or waking up. You may experience hearing sounds or words when drifting to sleep or have unwanted visions. Sleep paralysis often accompanies these vivid dreams.

The survey also revealed that a majority of Americans don’t feel they know enough about sleep disorders. Less than 50 percent report being familiar with narcolepsy and only 70 percent report being familiar with sleep apnea. Approximately 60 percent of Americans said that they find it difficult to know when they need to talk to a doctor about daytime sleepiness.

Dasgupta adds, “If you’re having trouble staying awake during the day or experiencing other sleep-related problems, it may be time to talk to your doctor.”

To learn more about narcolepsy, take the Narcolepsy Symptom Screener or to find a sleep specialist near you, visit MoreThanTired.com.

This content is provided by Jazz Pharmaceuticals.

2018-03-26T14:49:00

(BPT) – This article is sponsored advertising content from Amgen, Inc.

Those who have faced a cancer diagnosis know the experience can be overwhelming. It can present several challenges and prompt countless questions from both patients and their loved ones. But for many patients diagnosed with one incurable form of blood cancer, their first question is, “What is multiple myeloma?”

Multiple myeloma is a life-threatening blood cancer of the plasma cells, a type of white blood cell originating in the bone marrow that helps fight infection. Myeloma cells are cancerous plasma cells that multiply too quickly.

March is Multiple Myeloma Awareness Month, a time to take charge in the fight against multiple myeloma and bring attention to this rare blood disease that accounts for approximately one percent of all cancers globally. Although rare, multiple myeloma is increasingly becoming more prevalent in the U.S. due to a growing number of diagnoses.

Robert Lasco is one of those patients. “In my mind everything was racing,” Lasco recalled, when he learned of his multiple myeloma diagnosis, “I know several friends and family members who have dealt with different types of cancer, but I had never heard of multiple myeloma.”

While most patients respond to initial therapy, nearly all patients eventually relapse or become refractory (non-responsive) to treatment. For this reason, patients with multiple myeloma often need multiple therapies during their journey with the disease, and Lasco was no exception.

After receiving a stem cell transplant Lasco experienced a relapse. “At that point, I decided I needed to take charge of my disease and began reading everything I could about multiple myeloma and my treatment options,” Lasco explained. “After discussing with my doctor, we decided KYPROLIS^® (carfilzomib) would be the best option for me.”

KYPROLIS is a prescription medication used to treat patients with relapsed or refractory multiple myeloma who have received one to three previous treatments. KYPROLIS is approved for use in combination with dexamethasone or with lenalidomide plus dexamethasone, which are other medicines used to treat multiple myeloma. According to results from two large Phase 3 clinical trials, KYPROLIS plus dexamethasone (Kd) and KYPROLIS, lenalidomide, and dexamethasone (KRd) each reduced the risk of death by 21 percent in relapsed multiple myeloma patients versus two different widely used treatment combinations (bortezomib plus dexamethasone and lenalidomide plus dexamethasone, respectively), resulting in patients living around 7.6 and 7.9 months longer, respectively.

Lasco was prescribed KRd by his doctor. Once back in remission, he was able to continue his advocacy work. He and his wife formed the Multiple Myeloma Education Fund, a nonprofit organization, aimed at building awareness of multiple myeloma.

“My experience with multiple myeloma has caused me to become very passionate about awareness and educating other people about this disease,” Lasco remarked. “You don’t have to walk with multiple myeloma by yourself. Take charge of your disease and ask for help when you need it.”

To take action and learn more about multiple myeloma during the month of March visit mam.myeloma.org.

If you would like to learn more about KYPROLIS, visit www.KYPROLIS.com.

IMPORTANT SAFETY INFORMATION

KYPROLIS^® (carfilzomib) can cause serious side effects:

• Heart problems: KYPROLIS can cause heart problems or worsen pre-existing heart conditions. Death due to cardiac arrest has occurred within one day of KYPROLIS administration. Before starting KYPROLIS, you should have a full medical work-up (including blood pressure and fluid management). You should be closely monitored during treatment.
• Kidney problems: There have been reports of sudden kidney failure in patients receiving KYPROLIS. Your kidney function should be closely monitored during treatment.
• Tumor lysis syndrome (TLS): Cases of TLS have been reported in patients receiving KYPROLIS, including fatalities. You should be closely monitored during treatment for any signs of TLS.
• Lung damage: Cases of lung damage have been reported in patients receiving KYPROLIS, including fatal cases.
• Pulmonary hypertension (high blood pressure in the lungs): There have been reports of pulmonary hypertension in patients receiving KYPROLIS.
• Lung complications: Shortness of breath was reported in patients receiving KYPROLIS. Your lung function should be closely monitored during treatment.
• High blood pressure: Cases of high blood pressure, including fatal cases, have been reported in patients receiving KYPROLIS. Your blood pressure should be closely monitored during treatment.
• Blood clots: There have been reports of blood clots in patients receiving KYPROLIS. If you are at high risk for blood clots, your doctor can recommend ways to lower the risk.
• If you are using KYPROLIS in combination with dexamethasone or with lenalidomide plus dexamethasone, your doctor should assess and may prescribe another medicine to help lower your risk for blood clots.
• If you are using birth control pills or other medical forms of birth control associated with a risk of blood clots, talk to your doctor and consider a different method of birth control during treatment with KYPROLIS in combination with dexamethasone or with lenalidomide plus dexamethasone.
• Infusion reactions: Symptoms of infusion reactions included fever, chills, joint pain, muscle pain, facial flushing and/or swelling, vomiting, weakness, shortness of breath, low blood pressure, fainting, chest tightness, and chest pain. These symptoms can occur immediately following infusion or up to 24 hours after administration of KYPROLIS. If you experience any of these symptoms, contact your doctor immediately.
• Severe bleeding problems: Fatal or serious cases of bleeding problems have been reported in patients receiving KYPROLIS. Your doctor should monitor your signs and symptoms of blood loss.
• Very low platelet count: Low platelet levels can cause unusual bruising and bleeding. You should have regular blood tests to check your platelet count during treatment.
• Liver problems: Cases of liver failure, including fatal cases, have been reported in patients receiving KYPROLIS. Your liver function should be closely monitored during treatment.
• Blood problems: Cases of a blood disease called thrombotic microangiopathy, including thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), including fatal cases, have been reported in patients who received KYPROLIS. Your doctor should monitor your signs and symptoms.
• Brain problems: A nerve disease called Posterior Reversible Encephalopathy Syndrome (PRES), formerly called Reversible Posterior Leukoencephalopathy Syndrome (RPLS), has been reported in patients receiving KYPROLIS. It can cause seizure, headache, lack of energy, confusion, blindness, altered consciousness, and other visual and nerve disturbances, along with high blood pressure. Your doctor should monitor your signs and symptoms.
• KYPROLIS should not be combined with melphalan and prednisone: Newly diagnosed transplant ineligible multiple myeloma patients have shown an increased risk of serious and fatal side effects when using KYPROLIS in combination with melphalan and prednisone.
• Possible fetal harm: KYPROLIS can cause harm to a fetus (unborn baby) when given to a pregnant woman. Women should avoid becoming pregnant during treatment with KYPROLIS. Men should avoid fathering a child during treatment with KYPROLIS. KYPROLIS can cause harm to a fetus if used during pregnancy or if you or your partner become pregnant during treatment with KYPROLIS.

You should contact your doctor immediately if you experience any of the following:

• Shortness of breath
• Prolonged, unusual or excessive bleeding
• Yellowing of the skin and/or eyes (jaundice)
• Headaches, confusion, seizures, or loss of sight
• Pregnancy (women should not receive KYPROLIS if they are pregnant or breastfeeding)
• Any other side effect that bothers you or does not go away

What are the possible side effects of KYPROLIS?

• The most common side effects occurring in at least 20% of patients receiving KYPROLIS in the combination therapy trials are: low red blood cell count, low white blood cell count, diarrhea, difficulty breathing, tiredness (fatigue), low platelets, fever, sleeplessness (insomnia), muscle spasm, cough, upper airway (respiratory tract) infection, and decreased potassium levels.

These are not all the possible side effects of KYPROLIS. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Full Product Information.