Category: Brandpoint Health

2024-05-30T08:01:00

(BPT) – Did you know carotid artery disease (CAD) is responsible for up to one-third of all strokes? Early detection and treatment of CAD can significantly reduce your risk of having a stroke, and Judy’s story is a testament to this.

After witnessing her grandmother suffer a major stroke, Judy was determined to stay healthy and visited her doctor regularly to get check-ups on her carotid arteries. These vital blood vessels, located on both sides of the neck, deliver oxygen-rich blood to the brain. When they become blocked or narrowed, CAD can develop and lead to a stroke.

With a family history of heart and vascular issues, Judy knew she was at risk. While many people like Judy show no symptoms in the early stages of CAD, patients with one or more of the following risk factors should still pursue screening as early as possible:

• Diabetes
• Family history of stroke
• High cholesterol
• High blood pressure
• Older age, especially for men
• Smoking, or using alcohol or recreational drugs
• Trauma to the neck

During one of her visits, Judy’s doctor discovered her left carotid artery was blocked. After getting referred to surgery, she underwent carotid endarterectomy, the traditional surgical procedure for CAD. Although the blockage was resolved, she experienced severe pain, facial numbing, and a long recovery period.

Two years later, when her right carotid artery also became blocked, Judy sought a different solution. Dissatisfied with her previous experience, she discovered Transcarotid Artery Revascularization (TCAR), a patient-friendly procedure with several advantages over the traditional surgery:

• Exceptional stroke prevention, even for high-risk surgical patients
• Minimally invasive
• Reduced risk of nerve injury and post-procedure heart attack
• Shorter procedure time
• Faster recovery and shorter hospital stays

After undergoing TCAR, Judy stayed one night in the hospital and was able to go home the next morning. She said she felt great after the surgery and quickly returned to her daily activities.

“I look forward to every day,” Judy says. “Without this technology, I would be disabled. I would not have my mental capacity, and that would be a tragedy to me and my family. I have my life because of all the things that people did to make it possible for me to be here. The best thing I can do is just say thank you.”

To learn more about CAD detection and treatment options, please visit Silk Road Medical’s patient education resource: https://protectionfromstroke.com/.

2024-05-29T05:01:00

(BPT) – Summer is just around the corner. After the crazy weather we’ve had nationwide, most everyone is excited to have fun in the sun. As you prepare for lazy days at the beach, traveling with family and backyard barbecues with friends, it’s important to keep your health and safety in mind. Here are some tips to keep you healthy and happy as you and your family enjoy the warmer weather.

1. Be sun safe. Sunscreen is a must! The American Academy of Dermatologists Association recommends using a broad-spectrum sunscreen with SPF 30 or higher, and reapply every two hours, more often if you’re swimming. Make sure you hit places people often miss — your ears, neck and the top of your head. Sun protective clothing is also a great ally, especially if you’re outside hiking, picnicking or watching the kids play softball. A wide-brimmed hat can protect your face and it’s a fashion statement! Good sunglasses round out your ensemble so you’re styling and protected from the sun.

2. Get a summer checkup. If you plan to travel, see your primary care provider before you go to make sure your vaccinations, prescriptions and other healthcare needs are up to date. And don’t forget about your vision! Summer is a great time to schedule an eye exam. Many employee health plans do not include vision, so people can put off this important appointment. But making sure your eyes are in great shape is vital. You can save on your next eye exam with a vision insurance plan, like the one from VSP Individual Vision Plans. Their plans start at as little as $13 per month, and can save you a bundle while you keep your eyes healthy. VSP has the largest doctor network out there and offers 20% savings on additional glasses or prescription sunglasses, including lens enhancements, from a VSP network doctor within 12 months of your last exam. VSP doesn’t have open enrollment periods, so you can start the process anytime, and compare plans to meet your individual needs.

3. Beat the heat. Remember, the sun’s rays are the strongest between 10 a.m. and 4 p.m. If possible, plan outdoor activities before or after this window, or find shady spots for your family to relax and enjoy the day without those harsh rays.

4. Drink plenty of water. Even mild dehydration can make you feel tired, and heat stroke is a dangerous situation. Stay hydrated by carrying water or other non-sugary drinks, and sip often! Watch for signs of heat stroke such as headaches, dizziness, nausea or vomiting. Bottom line, if you notice you’re feeling dragged out and tired in the heat, get inside, drink some water and cool off before it becomes more serious.

5. Plan for bugs. Nobody wants their day outside to be ruined by the irritating creepy-crawlies. Remember to put bug spray or repellent devices in your bag.

6. Travel with a first aid kit. Whether it’s a kids’ soccer game or a family road trip, you should keep a first aid kit in the car. Stock it with antiseptic wipes or spray, bandages of various sizes, gauze and tape, tweezers to remove splinters or ticks, scissors, lotion to soothe sunburn or insect bites, antibiotic ointment like Neosporin, and pain relievers.

7. Practice food safety. Summer is the time for picnics, backyard barbecues and meals on sunny porches. Enjoy eating al fresco, but make sure you think about food safety. In warm temperatures, bacteria can multiply quickly. Remember the two-hour rule: Perishable foods like deli salads and meats should not sit out at room temperature for more than two hours. But, if you’re outside in the heat, that rule goes out the window. Keep hot foods hot, like those burgers you’ve cooked on the grill, and cold foods cold, with ice bowls or freezer packs.

Follow these tips and have a happy, healthy summer! Make the most of the balmy weather with family and friends, find a soothing, shady spot to read a good book, and enjoy!

2024-05-23T11:01:00

(BPT) – In 2018, a vibrant young woman with a passion for theater and education set off on the quest of a lifetime: spending a month walking 500 miles on the Camino de Santiago pilgrimage from France to Spain. Christina K. was also at the beginning of a quest to learn more about a mysterious lump on her collarbone.

Months before her trip, one of Christina’s colleagues insisted she get the lump on her collarbone looked at. While it was bothering her and even made some activities difficult, Christina was hesitant to have it checked because she didn’t want to disrupt her long-planned European trip.

She relented, though, and an initial X-ray and ultrasound led her doctor to conclude it was a lipoma, a common, usually benign, fatty tumor that grows under the skin. With that diagnosis, Christina went on her trip, walking the 500-mile pilgrimage without giving the lipoma more thought.

When she returned, she prepared for surgery to remove the lipoma, taking time off from her rewarding job as a school drama teacher. But instead of hearing that the lump was indeed a lipoma that had been successfully removed, Christina was told by her doctor that he wasn’t sure what type of tumor it was.

Sensing that something was seriously wrong, Christina decided to seek answers from various specialists. She finally received a diagnosis at a university-based medical center. But the answer turned out to be something she’d never heard of: a desmoid tumor. At the time, her surgeon spoke to her about the possibility of removing the tumor. However, he said that it would be a very invasive surgery. In addition to the tumor, he would need to remove her collarbone, surrounding muscle tissue, and part of her sternum. She was informed that the surgery could potentially affect her vocal cords, which were her lifeblood as a singer, actress and educator.

“I went into the specialist’s office as someone who called herself healthy, who went yearly for my checkup, who was proactive in all the ways that I should have been — green smoothies in the morning, lots of exercise through yoga and dance. I was shocked and crushed when I got the diagnosis of a desmoid tumor.”

What is a desmoid tumor?

Desmoid tumors are rare, locally aggressive soft tissue tumors that can form anywhere in the body where there is connective tissue.^[1],[2],[3] Also called aggressive fibromatosis or desmoid fibromatosis, these tumors can cause significant pain, loss of physical function and mobility, disfigurement and a diminished quality of life.^{[1],[2],[4],[5],[6],[7],[8]}

Managing desmoid tumors can prove to be challenging.^[2],[5],[6] Unpredictable by nature and with a high likelihood of recurrence, desmoid tumors have a significant impact on people’s lives.^[6],[9],[10] Their invasive growth patterns exert pressure on nearby connective tissue and, in some instances, vital organs, potentially leading to life-threatening complications.^[2],[5],[11]

Alternatives to surgery

Before making a decision about surgery, Christina met with her new oncologist and learned that surgery to remove desmoid tumors can be extremely complicated and often not successful.

“Desmoid tumors have these tendrils, like an octopus,” Christina said. “You need to make sure you get every trace of them, because otherwise they can recur.”

In fact, up to 77% of people with a desmoid tumor can experience recurrence following surgical removal.^[12],[13]

With no U.S. Food and Drug Administration (FDA)-approved treatment for desmoid tumors available at the time, Christina’s oncologist recommended several off-label treatments, including chemotherapy to try to shrink the tumor, which had grown to the size of a grapefruit.

The next few years were difficult for Christina, as she experienced severe reactions to the treatments that ranged from swelling and aching joints to nausea and her hair turning white. Unfortunately, none of the medicines slowed the tumor’s growth, much less shrank it. During that time, the COVID-19 pandemic began, forcing Christina into isolation to protect her now immuno-compromised system and making it impossible to continue working as an educator.

A new treatment option

Just as it seemed there might not be any medical treatments left to try, Christina’s doctor told her she could try an investigational treatment that was being studied specifically for desmoid tumors. In 2020, she began taking nirogacestat, now marketed by SpringWorks Therapeutics, Inc. under the brand name OGSIVEO^®, and has been on that treatment ever since.

OGSIVEO (nirogacestat) is the first and only FDA-approved treatment for adults with progressing desmoid tumors who require systemic therapy.^[14],[15] See Important Safety Information below.

Christina recently marked the six-year anniversary of her desmoid tumor diagnosis. She remembers hoping her tumor would stop growing and stabilize, exactly like her current situation.

Christina is still taking OGSIVEO and says that she has experienced a reduction in pain.

She has become a rare disease advocate through her Girl Meets Cancer Instagram and works as a program coordinator for the Cactus Cancer Society, which helps young adults facing cancer find support, connection and creative outlets.

Just as she confronted the challenge of a 500-mile walk from France to Spain, Christina views all these hurdles as part of her life adventure with a positive attitude that gets her through even the toughest days.

“I don’t like the word ‘journey,'” Christina said. “It’s not. I try to say the word adventure. I’m ready to take this all on as a new adventure.”

Learn more about the FDA-approved treatment option at OGSIVEO.com.

Important Safety Information

What is OGSIVEO?

OGSIVEO is a prescription medication used to treat adults with progressing desmoid tumors who require a medicine by mouth or injection (systemic therapy). It is not known if OGSIVEO is safe and effective in children.

Before taking OGSIVEO tell your healthcare provider about all of your medical conditions, including if you:

• Have liver problems.
• Are pregnant or plan to become pregnant. OGSIVEO can harm your unborn baby. Tell your healthcare provider if you become pregnant or think you may be pregnant during treatment.

• Females who are able to become pregnant:
• Your healthcare provider will give you a pregnancy test before you start treatment with OGSIVEO.
• You should use effective birth control during treatment and for 1 week after the last dose. Talk to your healthcare provider about methods that may be right for you.
• Stop taking OGSIVEO and tell your healthcare provider right away if you become pregnant.
• Males with female partners who are able to become pregnant should use effective birth control during treatment with OGSIVEO and for 1 week after the last dose.

• Are breastfeeding or plan to breastfeed. It is not known if OGSIVEO passes into your breast milk. Do not breastfeed during treatment with OGSIVEO and for 1 week after the last dose.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

You should avoid taking proton pump inhibitors (PPIs) and H2 blockers during treatment with OGSIVEO. Ask your healthcare provider if you are not sure if you take one of these medicines.

How should I take OGSIVEO?

• Take OGSIVEO exactly as your healthcare provider tells you to take it.
• Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO if you develop side effects.
• Take OGSIVEO 2 times a day with or without food.
• Swallow OGSIVEO tablets whole. Do not break, crush, or chew.
• If you take an antacid medicine, take OGSIVEO 2 hours before or 2 hours after the antacid.
• If you vomit after taking a dose or miss a dose of OGSIVEO, take your next dose at your regular time. Do not take 2 doses of OGSIVEO to make up the dose.

What should I avoid while taking OGSIVEO?

Avoid eating or drinking grapefruit products, Seville oranges, and starfruit during treatment with OGSIVEO.

What are the possible side effects of OGSIVEO?

OGSIVEO can cause serious side effects, including:

• Diarrhea. Diarrhea is common with OGSIVEO and may sometimes be severe. Your healthcare provider may tell you to drink more fluids or to take antidiarrheal medicines. Tell your healthcare provider right away if you have diarrhea that lasts longer than a few days and does not get better after taking antidiarrheal medicines.
• Ovarian problems. Females who are able to become pregnant may have ovarian problems and changes in their menstrual cycle during treatment. OGSIVEO may affect fertility which may affect your ability to have a child. Tell your healthcare provider if you have any changes in your menstrual cycle or hot flashes, night sweats, or vaginal dryness during treatment.
• Liver problems. OGSIVEO can increase liver enzymes. Your healthcare provider will do blood tests to check your liver function before you start and during treatment with OGSIVEO.
• New non-melanoma skin cancers. Your healthcare provider will do skin exams before and during treatment with OGSIVEO if you are at risk for skin cancer. Tell your healthcare provider if you have any new or changing skin lesions.
• Electrolyte (salt) problems. Your healthcare provider will do blood tests to check your phosphate and potassium levels during treatment and may give you medicines to treat low phosphate or low potassium if needed. Tell your healthcare provider if you develop any muscle pain or weakness.

Tell your healthcare provider right away if you have any side effect that bothers you or that does not go away. Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with OGSIVEO.

The most common side effects of OGSIVEO are:

• rash
• nausea
• tiredness
• mouth sores
• headache
• stomach (abdominal) pain
• cough
• hair loss
• upper respiratory infection
• shortness of breath

OGSIVEO can affect fertility in females and males, which may affect your ability to have a child. Talk to your healthcare provider if this is a concern for you.

These are not all of the possible side effects of OGSIVEO. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please click here for full Prescribing Information including Patient Information.

[1] Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives. Pathologica. 2021;113(2):70-84. doi:10.32074/1591-951X-213.

[2] Penel N, Chibon F, Salas S. Adult desmoid tumors: biology, management and ongoing trials. Curr Opin Oncol. 2017;29(4):268-274. doi:10.1097/CCO.0000000000000374.

[3] NIH. National Cancer Institute Center for Cancer Research. Desmoid tumor. Accessed October 16, 2023. https://www.cancer.gov/pediatric-adult-rare-tumor/rare-tumors/rare-soft-tissue-tumors/desmoid-tumor.

[4] Cancer.Net. Desmoid tumor: introduction. Accessed October 16, 2023. https://www.cancer.net/cancer-types/desmoid-tumor/introduction.

[5] Constantinidou A, Scurr M, Judson I, Litchman C. Clinical presentation of desmoid tumors. In: Litchman C, ed. Desmoid Tumors. Springer; 2012: Accessed August 2023. https://www.researchgate.net/publication/226455135. doi:10.1007/978-94-007-1685-8_2.

[6] Bektas, M, et al. Desmoid Tumors: A Comprehensive Review. Adv Therapeutics. 2023. doi.org/10.1007/s12325-023-02592-0.

[7] Husson O, Younger E, Dunlop A, et al. Desmoid fibromatosis through the patients’ eyes: time to change the focus and organisation of care? Support Care Cancer. 2019;27(3):965-980. doi:10.1007/s00520-018-4386-8.

[8] Gounder MM, Maddux L, Paty J, Atkinson TM. Prospective development of a patient-reported outcomes instrument for desmoid tumors or aggressive fibromatosis. Cancer. 2020;126(3):531-539. doi:10.1002/cncr.32555.

[9] Skubitz KM. Biology and treatment of aggressive fibromatosis or desmoid tumor. Mayo Clin Proc. 2017;92(6):947-964. doi:10.1016/j.mayocp.2017.02.012.

[10] Easter DW, Halasz NA. Recent trends in the management of desmoid tumors. Summary of 19 cases and review of the literature. Ann Surg. 1989;210(6):765-769. doi:10.1097/00000658-198912000-00012.

[11] Joglekar SB, Rose PS, Sim F, Okuno S, Petersen I. Current perspectives on desmoid tumors: the Mayo Clinic approach. Cancers (Basel). 2011;3(3):3143-3155. doi:10.3390/cancers3033143.

[12] Skubitz KM. Biology and treatment of aggressive fibromatosis or desmoid tumor. Mayo Clin Proc. 2017;92(6):947-964. doi:10.1016/j.mayocp.2017.02.012.

[13] Easter DW, Halasz NA. Recent trends in the management of desmoid tumors. Summary of 19 cases and review of the literature. Ann Surg. 1989;210(6):765-769. doi:10.1097/00000658-198912000-00012.

[14] OGSIVEO. Prescribing Information. SpringWorks Therapeutics, Inc.

[15] Riedel RF, Agulnik M. Evolving strategies for management of desmoid tumor. Cancer. 2022;128(16):3027-3040. doi:10.1002/cncr.34332.

© 2024 SpringWorks Therapeutics, Inc. All rights reserved. OGSIVEO is a registered trademark of SpringWorks Therapeutics, Inc. C_OGS_US_0309 05/24.

2024-05-22T05:01:00

(BPT) – Everyone is buzzing about prescription GLP-1 medications like Ozempic and Wegovy for weight loss — and rightfully so. GLP-1s (more formally known as glucagon-like peptide 1 agonists) represent an enormous step forward in ending the obesity epidemic in this country. Already, GLP-1s have helped millions of Americans shed stubborn pounds without resorting to unhealthy dieting and unsustainable fitness routines.

But, one aspect of these drugs is often glossed over: GLP-1s are intended to be an “adjunct therapy” — not a standalone treatment — for losing weight and improving your health.

This knowledge has helped the online healthcare giant, LifeMD, outline a unique path for patients using GLP-1s. In connection with its Weight Management Program, the company recently introduced the 6S Framework, its guide to holistic well-being in the era of prescription weight loss drugs. Backed by extensive real-world evidence, this unique ideology is tethered to the notion that true health is about balance — not just the number on the scale. Not surprisingly, the framework has gained traction with those who want to make lasting, sustainable changes to their health.

But what is the 6S Framework and how does it fit into the context of your overall health? It comes down to 6 S’s — six components of a cared-for body and mind. Here’s a rundown:

Sleep. Like an electric vehicle, you need time to recharge your batteries. Far from “down time,” sleep is an active stage of recovery and rejuvenation — a time when some of your mind and body’s most important health-sustaining processes take place.

Sustenance. Sticking with the vehicle analogy, you could think of the foods, drinks and supplements you consume as your fuel. They should provide your body with the nourishment it needs to not only survive, but to thrive. Sustenance is also about avoiding or limiting harmful substances like alcohol and nicotine.

Sweat. Your body is made to move, and it depends on a mixture of resistance, aerobic and flexibility exercises to stay healthy and functional. Think of sweat as the necessary lubricant for all your vehicle’s important parts — parts that include your joints, muscles, tendons and even your brain. Without that lubricant, those parts become weak and rusty. Sweat also balances your systems; it helps you burn off excess energy, and it can also help generate the kind of healthy energy your brain and body need to stay sharp, focused and productive.

Stillness and self-talk. Self-talk is your GPS: it keeps you on the road leading to your goals (and away from detours that lead to trouble). It’s all your questions, reflections, ambitions and doubts — about the past and the future — that together act like dashboard gauges on your lifelong voyage. While a little self-talk is necessary, too much of it can be distracting. It can steer you astray. Self-talk must be balanced with stillness — a state of being that focuses on the here and now.

Stress management. Stress is another form of energy; it can power you forward, but it’s all about how you use it. A little stress can ensure that your needs and wants are adequately satisfied. It can motivate you. But too much stress can lead to excess energy — the kind that causes you to stall out. It’s like revving your engine in the wrong gear.

Social interactions. Think of these as the other cars traveling on the road beside you. These may be your cherished companions — lighting the way forward — or they may be pure congestion that slows your progress. While you rely on others, you also feel the pressure of social connections; they can be a source of external demands, judgments and comparisons. Finding balance in your social life allows you to glean strength and comfort from close friends and loved ones while also limiting the interactions that hold you back.

“At LifeMD, we believe orienting your weight loss journey around the 6S Framework can help you achieve the kind of balance that supports lifelong functional health,” said Anthony Puopolo, President, LifeMD Affiliated P.C.s. “Finding a weight management program that supports your overall health needs, with guidance from licensed providers, in concert with the 6 S’s, can make a meaningful difference in your long-term health and wellness.”

Healthy change is always possible. The impact of GLP-1s has proven that. But while GLP-1s can act as a springboard for improving your overall health, they work best when they are integrated with the 6S Framework, which can help you make smart choices, and “course correct” as needed. To learn more about LifeMD’s unique approach to serving GLP-1 patients, visit us at LifeMD and download our new eBook, “The 6S Framework for Sustainable Wellness.”

2024-05-20T09:01:00

(BPT) – Article is sponsored and developed by Sanofi. Natalie and Samuel were compensated by Sanofi.

When Natalie and her husband adopted four-year-old Samuel from China, they were excited to learn more about his culture and spend quality time together. However, during the process, Samuel experienced bruising and joint pain that made it difficult for him to walk. This led Natalie to consult with a doctor who recognized Samuel’s symptoms as possible signs of a rare blood disorder. Facing uncertainty about their son’s future, Natalie and her husband brought Samuel to America and prioritized his care and diagnosis.

After seeing a hematologist, Samuel was diagnosed with severe hemophilia A, a rare, lifelong condition that impairs the ability of a person’s blood to clot properly. If left untreated, it can lead to excessive or spontaneous bleeds that can result in joint damage, chronic pain, and potentially impact quality of life.¹

While prophylaxis treatment was effective for Samuel, the dosing scheduling was demanding for him, Natalie, and their family. Despite training to conduct Samuel’s infusions at home, they had days when his veins didn’t cooperate. Because of this, they switched to a subcutaneous injection administered under the skin rather than into a vein.

Then one day at school, Samuel fell out of his chair and hit his head. He didn’t show any noticeable symptoms of a bleed at first, but his condition quickly got worse.

“I forgot how to spell my name and couldn’t find my classroom anymore. I had a CT scan, and they found a minor brain bleed,” Samuel said.

“As Samuel grew up (now 12 years old), what we needed in a treatment became clear. He had to be well protected against bleeds, and we knew Samuel preferred infusions,” said Natalie. “And, of course, he wants to stay busy, so minimizing how frequently he has to infuse was a significant consideration, too.”

Embracing the Future by Switching to ALTUVIIIO^®

Natalie and Samuel spoke to their doctor about ALTUVIIIO, a once-weekly, first-in-class factor VIII replacement therapy for adults and children with hemophilia A.² They learned it offers proven bleed protection and helps keep factor levels in the normal to near-normal range (over 40%) for ~3 days in children <12 years old, and in May 2024, the US Food & Drug Administration updated ALTUVIIIO’s label to include positive results from a phase 3 study in children under 12. This pediatric study demonstrated a mean annualized bleeding rate (ABR) of 0.6 with ALTUVIIIO prophylaxis and a safety profile similar to the profile in an earlier ALTUVIIIO study for people with hemophilia A aged 12 years or older. ²

Their doctor helped them understand the benefits of switching to ALTUVIIIO and its most common side effects, including headache and joint pain in adults and adolescents, and fever in children under 12.² Since switching, Samuel has responded well to treatment, with proven bleed protection and factor activity levels.

Natalie and Samuel worked with their CoRe (Community Resource and Education Manager) and Sanofi Patient Support Services to transition to ALTUVIIIO and secure financial assistance through Sanofi’s Copay Program.

“We felt great about switching to ALTUVIIIO. We are living with a treatment and schedule that works for us and Samuel is getting the most out of being a kid,” Natalie said. “We’re also very pleased with his trough levels, which are around 15% on day seven.” Trough levels measure factor VIII in the blood, which is essential for managing the risk of bleeding.³ “Remember that each person’s hemophilia treatment plan may differ, so you need to work with your HCP to find a treatment plan that is right for you,” Natalie added.

Samuel is now able to spend plenty of time with his family at the beach, play with his friends, and master the Rubik’s Cube. Together, Natalie and Samuel encourage people living with hemophilia, and their care networks, to stay educated and engage with the community.

“If anything about your current treatment is not working for you, from bleed protection to infusion schedules, you should always be confident in advocating for your care,” Natalie emphasized.

Patient experiences on ALTUVIIIO may vary, so talk to your doctor when making treatment decisions. To learn more, visit ALTUVIIIO.com.

INDICATION

ALTUVIIIO^® [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl] is an injectable medicine that is used to control and reduce the number of bleeding episodes in people with hemophilia A (congenital Factor VIII deficiency).

Your healthcare provider may give you ALTUVIIIO when you have surgery.

IMPORTANT SAFETY INFORMATION

What is the most important information I need to know about ALTUVIIIO?

Do not attempt to give yourself an injection unless you have been taught how by your healthcare provider or hemophilia center. You must carefully follow your healthcare provider’s instructions regarding the dose and schedule for injecting ALTUVIIIO so that your treatment will work best for you.

Who should not use ALTUVIIIO?

You should not use ALTUVIIIO if you have had an allergic reaction to it in the past.

What should I tell my healthcare provider before using ALTUVIIIO?

Tell your healthcare provider if you have had any medical problems, take any medications, including prescription and non-prescription medicines, supplements, or herbal medicines, are breastfeeding, or are pregnant or planning to become pregnant.

What are the possible side effects of ALTUVIIIO?

You can have an allergic reaction to ALTUVIIIO. Call your healthcare provider or emergency department right away if you have any of the following symptoms: difficulty breathing, chest tightness, swelling of the face, rash, or hives.

Your body can also make antibodies called “inhibitors” against ALTUVIIIO. This can stop ALTUVIIIO from working properly. Your healthcare provider may give you blood tests to check for inhibitors.

The common side effects of ALTUVIIIO are headache and joint pain.

These are not the only possible side effects of ALTUVIIIO. Tell your healthcare provider about any side effect that bothers you or does not go away.

Please see full Prescribing Information.

References

1. What is Hemophilia? Centers for Disease Control and Prevention (CDC). Last reviewed October 24, 2023. Accessed March 21, 2024. https://www.cdc.gov/ncbddd/hemophilia/facts.html.
2. ALTUVIIIO [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl] prescribing information. Bioverativ Therapeutics, Inc. May 2024
3. Srivastava A, Santagostino E, Dougall A, et al. WFH Guidelines for the Management of Hemophilia, 3rd edition. Haemophilia. 2020;26 Suppl 6:1-158

MAT-US-2401906-v1.0-05/2024

© 2024 Sanofi. All rights reserved. ALTUVIIIO and Sanofi are registered trademarks of Sanofi or an affiliate.

2024-05-16T06:01:00

(BPT) – Putting Health First

Gym owner and avid fitness enthusiast, Rich, has always prioritized his health. He prides himself on being health conscious, taking steps to maintain his health and keeping up with his annual exams.

After learning about the Galleri^® test, a multi-cancer early detection blood test that screens for a “fingerprint” of some of the deadliest cancers before people have symptoms, Rich was interested.

“When I heard the Galleri test screened for cancer, I was very much about that. My wife — a registered nurse — also thought it was a great idea,” said Rich, whose mother passed away of colon cancer.

Rich was able to receive the Galleri test as a benefit from his Nationwide life insurance policy. After speaking with his doctor and obtaining a prescription, Rich moved forward with the test. “I made the appointment, and they did the blood draw. It was as simple as that,” he said.

While doctors can test individually for five specific cancers today, nearly 70% of deaths are caused by cancers without recommended screenings.^1,2

The Galleri test is a new proactive tool to screen for cancer. The test looks for DNA shed into the bloodstream by cancers growing in the body. Though there are many types of cancer, these DNA fragments act like a unique “fingerprint” of cancer, which allows the Galleri test to provide direction to a doctor on the cancer’s origin and help guide next steps for diagnosis.³

When Rich received his Galleri test result, he and his wife, Barbara, were surprised to hear it was a Cancer Signal Detected. After a diagnostic evaluation and conversations with his oncologist, Rich was told he had stage three cancer in his head and neck.

“When we found out Rich had cancer, our whole life just turned on a dime. My daughter and I just started crying,” said Barbara.

“But once we learned it was localized and caught early, I felt relief,” Rich recalled. “Because I didn’t have any symptoms, without the Galleri test, we might not have caught my cancer for another six months or a year or longer. If my cancer wasn’t caught when it was, it could have spread and my treatment options could have been more limited.”

Road to Recovery

Rich worked with his oncologist to start treatment and now considers himself on the road to recovery.

“The treatment for cancer can knock you out, and that definitely happened in my case,” said Rich, a self-proclaimed “gym nut.” “It’s going to be a long process to get back to where I was, but I am confident that I’ll conquer it.”

Rich credited Galleri with giving him more control when it came to cancer. Today, he is continuing to focus on his health, including taking other proactive measures to stay healthy, and is thankful for those that brought the Galleri test to him.

Learn More

The Galleri test must be prescribed by a healthcare provider and should be used in addition to recommended cancer screenings such as mammography, colonoscopy, prostate specific antigen (PSA) test and/or cervical cancer screening. It is intended for use in adults with an elevated risk for cancer, such as those aged 50 or older.

The Galleri test does not detect a signal for all cancers, and not all cancers can be detected in the blood. False-positive and false-negative results do occur.

Based on a clinical study of people ages 50 to 79, around 1% are expected to receive a Cancer Signal Detected result, which includes predicted Cancer Signal Origin(s). After diagnostic evaluation, around 40% of people are expected to have a confirmed cancer diagnosis. The overall sensitivity in study participants in head and neck cancer was 85.7% (63.2% for stage I, 82.4% for stage II, 84.2% stage III, 96.0% stage IV).

Learn more at Galleri.com.

Important Safety Information

The Galleri test is recommended for use in adults with an elevated risk for cancer, such as those aged 50 or older. The Galleri test does not detect all cancers and should be used in addition to routine cancer screening tests recommended by a healthcare provider. Galleri is intended to detect cancer signals and predict where in the body the cancer signal is located. Use of Galleri is not recommended in individuals who are pregnant, 21 years old or younger, or undergoing active cancer treatment.

Results should be interpreted by a healthcare provider in the context of medical history, clinical signs and symptoms. A test result of “Cancer Signal Not Detected” does not rule out cancer. A test result of “Cancer Signal Detected” requires confirmatory diagnostic evaluation by medically established procedures (e.g., imaging) to confirm cancer.

If cancer is not confirmed with further testing, it could mean that cancer is not present or testing was insufficient to detect cancer, including due to the cancer being located in a different part of the body. False-­positive (a cancer signal detected when cancer is not present) and false-­negative (a cancer signal not detected when cancer is present) test results do occur. Rx only.

Laboratory/Test Information

GRAIL’s clinical laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and accredited by the College of American Pathologists. The Galleri test was developed, and its performance characteristics were determined by GRAIL. The Galleri test has not been cleared or approved by the U.S. Food and Drug Administration. GRAIL’s clinical laboratory is regulated under CLIA to perform high ­complexity testing. The Galleri test is intended for clinical purposes.

_________________________

[1] US Preventive Services Task Force (USPSTF) recommended cancer screening tests, Grade A,B,C. https://www.uspreventiveservicestaskforce.org/uspstf/topic_search_results.

[2] American Cancer Society Cancer Facts and Figures 2022. Available at: https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2022/2022-cancer-facts-and-figures.pdf. Data on file GA-2021-0065.

[3] Klein EA, Richards D, Cohn A, et al. Clinical Validation of a Targeted Methylation N-Based Multi-Cancer Early Detection Test Using an Independent Validation Set. Ann Oncol. 2021;32(9):1167-1177. Doi: 10.1016/j.annonc.2021.05.806.

2024-05-14T09:01:00

(BPT) – Have you ever looked at your dog’s big sweet eyes and wondered, “What is going on inside your head?” If your answer is yes, you’re not alone. While your dog can’t communicate with you verbally, you can still pick up on the signs of separation anxiety. The sooner you do, the sooner you can talk to your veterinarian about potential treatments, such as Reconcile^® (fluoxetine hydrochloride). Knowing what your furry friend is thinking could help save you both a lot of stress. Here’s what your pup might say about the struggles of separation anxiety.

1. “I hate it when you leave.”

Separation anxiety causes up to 17% of dogs to engage in problematic behavior when left alone, such as when you leave for work or to run an errand.^1,2 While some dogs are predisposed to separation anxiety, others seem to develop it out of nowhere. Several things can trigger your dog’s nervous tendencies, such as a change in routine, loss of a family member, or a new living situation. If your dog’s separation anxiety developed suddenly, try pinpointing what may have changed in your life.

2. “When you get overly affectionate, I worry you’re not coming back.”

Dogs are empathetic creatures that can sense when something’s up. When you show an exaggerated amount of emotion before you leave, they can start to freak out.³ You may believe you’re showing love, but your dog sees it as a sign of impending doom — in other words, you walking out the door. To avoid this, remain calm and ignore your dog for 20 to 30 minutes before leaving so you don’t create a heightened state of arousal just prior to your departure.

3. “I destroy things because I feel the need to escape or distract myself.”

The signs that your dog has separation anxiety are often easy to spot. Think of the things that shock you when you get home: chewed-up doorways, torn-up cushions, trash strewn everywhere, or maybe a note from your neighbor saying your pup barked constantly all day.⁴ If it’s something that rarely happens when you’re home, it could be a sign of separation anxiety.

4. “I’m not misbehaving. I’m scared.”

Your dog isn’t being naughty. Your dog isn’t being spiteful. Your dog is anxious. When left alone, dogs with separation anxiety often feel compelled to escape or do something else to release their nervous energy, which manifests to you as “acting out.” If you arrive home and find a mess, stay calm. Your dog doesn’t realize they did something “wrong.” Never punish your dog for house soiling or destruction — this will only increase the anxiety associated with anticipating your return.

5. “I wish I had something fun to do while you’re gone.”

Keeping your dog occupied when you leave can help alleviate anxiety and keep them focused on something besides your absence. Giving them their favorite toy or treat can help them focus on something other than the stress of you leaving, as well as associate your departure with something wonderful and delicious!

6. “I don’t want to be anxious anymore. Can we work on it together?”

Behavior modification training is an important part of managing separation anxiety in dogs. Following the BOND^® training program is a great place to start. BOND stands for: Be Positive, Only Reward Calm Behavior, No More Drama When You Come and Go, and Develop Your Dog’s Independence. These easy-to-follow steps can help build your dog’s confidence and gain a sense of security when alone. To learn more, visit reconcile.com/bond-training-information.

7. “Will you ask my veterinarian about Reconcile?”

Reconcile is a once-a-day chewable tablet and FDA-approved medication commonly used to treat separation anxiety in dogs in conjunction with behavior modification training, like the BOND program. If you think your dog has separation anxiety, talk to your veterinarian about a training plan that includes Reconcile and learn more at reconcile.com.

There is no overnight solution or quick fix for your dog’s separation anxiety. It takes hard work and dedication, but when you approach it with empathy, a challenging situation becomes an opportunity for growth and bonding. Remember, your dog looks to you for guidance and reassurance, so approaching separation anxiety with patience, love, and a proactive mindset will lead to a happier, healthier relationship for both of you. If you think your dog has separation anxiety, speak with your veterinarian today.

¹Bamberger M, Houpt KA. Signalment factors, comorbidity, and trends in behavior diagnoses in dogs: 1,644 cases (1991-2001). JAVMA. 2006;229(10):1593.

²Tiira K, Sulkama S, Lohi H. Prevalence, comorbidity, and behavioral variation in canine anxiety. J Vet Behav. 2016;16:38.

³Horwitz DF. In Horwitz D, Mills D (eds). Separation-related problems in dogs. BSAVA Manual of Canine and Feline Behavioural Medicine, 2nd ed. Gloucester, UK: British Small Animal Veterinary Association, 2010.

⁴Schwartz S. Separation anxiety syndrome in dogs and cats. J Am Vet Med Assoc. 2003;22(11):1526-1532.

IMPORTANT SAFETY INFORMATION: The most common adverse events reported in decreasing order of reported frequency are: decreased appetite, depression/lethargy, shaking/shivering/tremor, vomiting, restlessness and anxiety, seizures, aggression, diarrhea, dilated pupils, vocalization, weight loss, panting, confusion, incoordination, and excessive salivation. Reconcile chewable tablets are contraindicated for dogs with a history of seizures or when used with drugs that may cause seizures. Consult your veterinarian for complete safety information or click here to read the package insert.

The information, tools and material presented on this site are provided for informational and educational purposes only. Please consult your veterinarian for an official diagnosis of canine separation anxiety and to learn more about Reconcile. Click here to read the complete terms and conditions regarding use of this website.

2024-05-14T05:01:00

(BPT) – While you can’t predict everything life may throw at you, you can still set yourself up for some of life’s uncertainties. One way you can prepare for any situation and provide for your loved ones in the future is through life insurance.

The ins and outs of life insurance can seem complicated and overwhelming, but don’t get discouraged. Boston Mutual Life Insurance Company offers tips and insights to help you identify the best life insurance options that make sense for you and your family. Check out the company’s answers to some of the most common life insurance questions.

What is life insurance?

The basic concept of life insurance is pretty simple. You pay premiums to an insurance company for the length of your policy. When you pass away, the company pays a death benefit to your beneficiaries that can be used for funeral and final expenses, medical bills, credit card bills, mortgage payments, living expenses, and more.

Why do I need life insurance?

A life insurance policy can help you secure your and your family’s future. At its core, life insurance is a key component of a good financial plan and provides peace of mind for you and your loved ones. Many people assume life insurance only covers funeral costs but claims payments can be used for an array of other expenses to relieve family members of having to cover certain outstanding bills after the policyholder is gone.

When should I get life insurance?

A common myth about life insurance is that it’s only for older adults, not for healthy young adults. However, purchasing life insurance while you’re young establishes protection right away before you may even need it. It can also be a smart financial decision because you typically can secure lower premiums when you’re at a younger age.

If you’re a parent or grandparent, consider setting your children or grandchildren up for success by purchasing a whole life insurance policy for them. One idea could be to gift a whole life insurance policy to your child or children (or grandchild or grandchildren) for high school or college graduation. This is a sensible present that builds cash value that can help them plan for their own future.

What are the different types of life insurance?

There are two main types of life insurance policies. Which one you choose will most likely depend on your present and future needs.

• Whole life insurance is permanent life insurance that provides protection for your entire life and offers financial support through a claims payout to your beneficiary or beneficiaries at the time of your passing. Whole life accumulates a cash value that you can access during your life if needed for certain expenses, such as to buy a home, settle debts, or pay for college.
• Term life insurance offers financial support for a loss only during a specified period. The premiums may be lower than whole life insurance premiums, but it won’t offer coverage for your entire life. Term also doesn’t accumulate value.

How much life insurance do I need?

Life insurance is not a one-size-fits-all product. How much life insurance you would consider purchasing depends on your age, family situation, and future plans. Luckily, there are a number of options, including riders (or add-on benefits to a policy) that offer you flexibility. The best way to figure out what type and how much life insurance you may need is to talk with a local insurance professional.

Curious about learning more about life insurance options that would fit your needs? Visit Boston Mutual.com for more details.

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2024-05-13T10:01:00

(BPT) – By Kenji Inaba, MD, FACS, FRCSC

You’re on your way to work when a car crash happens. A backyard bonfire takes a turn while chopping firewood. While in your backyard, a neighbor has an accident with a lawnmower. These scenarios share a common thread — a person in need of help due to severe bleeding. This is where the American College of Surgeons Stop the Bleed^® program comes in. Stop the Bleed is a simple set of skills that empowers everyday people to save lives in critical moments by learning a few basic techniques.

Training That Empowers All

May is National Stop the Bleed month and training is for everyone — parents, students, office workers, teachers — literally everyone. No background in health care is needed to get trained. Before helping, ensure your own safety and that 911 has been called. The techniques can be distilled into three lifesaving steps:

1. Apply Direct Pressure: The first and most immediate step involves applying firm pressure directly to the wound, which helps to control bleeding.
2. Pack the Wound: If direct pressure alone is not enough, packing the wound with gauze or a cloth can help control more severe bleeding.
3. Apply a Tourniquet: For severe limb bleeding that does not stop with direct pressure or packing, a tourniquet may be necessary. This method is highly effective in stopping blood flow to a limb, thereby preventing further blood loss.

These steps form the core of Stop the Bleed training, which takes about an hour to complete — less time than it takes to watch a movie. The training is available in a variety of formats, including in-person and online options.

Originally launched in 2015, the Stop the Bleed initiative is driven by a clear vision: to equip ordinary people with the skills to prevent death from bleeding. Since then, nearly 4 million individuals globally have learned these essential skills through the program.

The Urgency of Early Action

With any injury that causes severe bleeding, the first few minutes are critical and can mean the difference between life and death. As a trauma surgeon, I have witnessed the profound impact of immediate bleeding control, observing firsthand how quick actions by bystanders can save lives. Conversely, I’ve also seen the tragic outcomes when help arrives too late.

A Call to Action

As we observe National Stop the Bleed Month in May, it’s a timely reminder of the critical importance of being prepared. Whether you’re attending a neighborhood barbecue, enjoying a day at the park, or simply going about your daily routine, the skills you learn from Stop the Bleed can prepare you to act quickly and confidently in an emergency. Lives are saved not just by the actions of medical professionals, but also by ordinary people who make extraordinary decisions to help others in need.

To join a course and buy a Stop the Bleed kit, visit stopthebleed.org.

Kenji Inaba, MD, FACS, is the Chair of the Stop the Bleed^® Committee of the American College of Surgeons Committee on Trauma, Chief of Trauma at the Los Angeles General Medical Center, and a Professor of Surgery at the University of Southern California.

2024-05-13T09:01:00

(BPT) – Do you find it difficult to swallow food? Does food feel like it gets stuck in your throat when you eat? These are common symptoms of eosinophilic esophagitis (EoE), a disease that affects an estimated one in 2,000 people in the U.S. EoE is reportedly increasing around the world.

What is EoE?

EoE is a chronic allergic condition. It involves inflammation and swelling in the esophagus. This can make it difficult to swallow food. The esophagus is the tube connecting the mouth to the stomach. Chronic inflammation from EoE causes damage to the esophagus that makes eating difficult or uncomfortable.

The main symptom of EoE is difficulty swallowing, but it’s not the only sign. According to the American College of Allergy, Asthma & Immunology (ACAAI), other symptoms may include:

• Irritability
• Problems with feeding
• Poor weight gain and growth among infants and toddlers
• Acid reflux
• Regurgitation
• Vomiting
• Stomach pain
• Chest pain in teens and adults

Infants and toddlers may refuse food or show poor growth, malnutrition or weight loss. School-age children may have chronic stomach pain, trouble swallowing and/or vomiting.

People with EoE tend to drink a lot of liquids to swallow food. They often feel full halfway through a meal. If solid food gets stuck in the throat, it is a medical emergency. Left untreated, long-term inflammation from EoE can narrow the esophagus and cause permanent damage.

Anyone can develop EoE — and although it’s a rare disease, it’s becoming increasingly more common. Children, adults, men and women of all ethnicities can develop the condition. For some families, EoE is hereditary.

Is EoE related to food allergies?

While doctors and researchers aren’t sure what causes EoE, it can be triggered by food or environmental allergies. People with other allergic conditions like asthma and eczema also often develop EoE. Some with EoE mistakenly believe they have gastroesophageal reflux disease (GERD). They do not realize that reflux could be related to EoE, and that treatments between the two conditions are different.

To manage your symptoms, your doctor may recommend different treatments to reduce the symptoms and inflammation.

Your doctor may recommend removing certain foods from your diet to treat EoE. This is known as a dietary restriction or diet therapy. Diet therapy removes potential food triggers from your diet. The triggers may include common food allergens, such as cow’s milk, egg, peanut, tree nuts, fin fish, shellfish, wheat, soy and sesame. A special amino acid-based liquid formula may be recommended by your doctor. These formulas are referred to as elemental formulas. They do not trigger allergies.

When do I need medication to treat EoE?

Your doctor may recommend medicines to help manage your symptoms. Since EoE is an inflammatory disease, treatments will focus on decreasing inflammation. A common treatment is taking pills called proton pump inhibitors (PPIs). While PPIs reduce stomach acid production, they can also reduce inflammation in some EoE patients.

Another treatment a doctor may prescribe is a corticosteroid to help control inflammation. These types of medications can come in an inhaler or liquid form.

How do biologics work to treat EoE?

Your doctor may recommend a biologic medication. Currently in the U.S., there is one biologic approved to treat EoE — dupilumab. It is administered via an injection. Dupilumab can reduce the number of eosinophils in the esophagus and relieve symptoms caused by EoE inflammation. It can also improve patients’ ability to swallow food.

Learn more about biologic medications at BiologicMeds.org.

If you recognize the symptoms of EoE in yourself or a loved one, speak to your doctor. You may want to see a specialist such as an allergist or gastroenterologist. If you’ve already been diagnosed with EoE, continue to work with your doctor for ongoing disease management and to discuss new treatment options.

Don’t wait. Take an active role in your health by talking to your doctor if you’re experiencing EoE symptoms. To learn more about the condition and how to manage it, visit AllergyAsthmaNetwork.org or APFED.org.