Debunking colonoscopy myths: The truth behind the life-saving procedure

2024-03-05T09:21:00

(BPT) – Your doctor just recommended you have a colonoscopy and you’re suddenly struck with a feeling of dread. No one looks forward to having a colonoscopy, but due to numerous myths and misconceptions, many people are unnecessarily worried and delay a screening that could ultimately save their life.

A colonoscopy is a routine procedure that lets doctors get a closer look at the health of the colon and rectum. This important procedure screens for colorectal cancer, the second leading cause of cancer death overall in the United States, according to “Cancer Statistics, 2023” in the American Cancer Society’s (ACS) journal CA: A Cancer Journal for Clinicians.

“Detecting colorectal cancer early means it’s more likely to be treatable,” said Dr. Douglas K. Rex, M.D., Distinguished Professor Emeritus at Indiana University School of Medicine and a full-time practicing clinical gastroenterologist. “Don’t delay getting a colonoscopy. In addition to detecting cancer, this important procedure helps screen for other diseases and conditions such as polyps, ulcers, colitis, diverticulitis and more.”

Dr. Rex says many people who delay a colonoscopy realize their worries were unfounded after it’s complete. He shares some of the top misconceptions about colonoscopies and the truths to put your mind at ease in hopes more people will schedule this potentially life-saving procedure.

Myth: No symptoms mean you don’t need a colonoscopy

Fact: It’s tempting to skip a colonoscopy if you don’t have any symptoms. However, lack of symptoms doesn’t necessarily mean your colon is healthy. For example, colon polyps can grow without any symptoms, and they may turn into cancer if not treated properly. Regular colonoscopies are recommended for anyone 45 and older, regardless of the presence of symptoms, because early detection makes treatment possible.

Myth: The prep for a colonoscopy is difficult

Fact: There’s no getting around it the preparation for a colonoscopy can be unpleasant. However, you no longer need to force yourself to drink a gallon of unpleasant liquid in order to clear your bowels ahead of a colonoscopy. FDA-approved SUFLAVE™ is a low-volume, safe and effective colonoscopy preparation — with a taste similar to a lemon-lime sports drink. The sports drink like taste and lower volume makes for an improved patient experience when preparing for a successful procedure. Ask your doctor about SUFLAVE™ and learn more at Suflave.com.

Myth: Colonoscopies are painful

Fact: A doctor will provide you with a sedative to make you sleepy and relaxed. Once you’re asleep, air is used to expand the colon so the doctor can look at all the interior walls with a tool called an endoscope. Because the colon has no nerve endings, even if polyps are removed, it doesn’t cause pain.

Myth: A polyp indicates cancer

Fact: After your colonoscopy you may learn that the doctor removed polyps. Polyps are noncancerous but they can lead to cancer, so it’s important to have these removed and sent to a laboratory for further testing.

Myth: The procedure and recovery take lots of time

Fact: You’ll be asked to check in for your colonoscopy appointment about an hour before the procedure. The test itself only takes about 30 minutes to complete. You’ll need about another hour to recover from the sedative at the clinic and will need someone else to drive you home once you’re released. Plan to lay low the rest of the day to allow the sedative to fully wear off.

“A colonoscopy takes a bit of time, but it’s a worthwhile investment in your health. Knowing the facts and having access to new options like SUFLAVE™, can improve the prep experience and can make you feel better about getting this important screening done,” said Dr. Rex.

IMPORTANT SAFETY INFORMATION

SUFLAVE(polyethylene glycol 3350, sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride for oral solution) is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults.

DOSAGE AND ADMINISTRATION: A low residue breakfast may be consumed on the day before colonoscopy, followed by clear liquids up to 2 hours prior to colonoscopy. Administration of two doses of SUFLAVE are required for a complete preparation for colonoscopy. Each bottle must be reconstituted with water before ingestion. Each bottle and one flavor-enhancing packet are equivalent to one dose. An additional 16 ounces of water must be consumed after each dose. Stop consumption of all fluids at least 2 hours before the colonoscopy.

CONTRAINDICATIONS: Use is contraindicated in the following conditions: Gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, hypersensitivity to any ingredient in SUFLAVE.

WARNINGS AND PRECAUTIONS: Risk of fluid and electrolyte abnormalities: Encourage adequate hydration, assess concurrent medications and consider laboratory assessments prior to and after each use; Cardiac arrhythmias: Consider pre-dose and post-colonoscopy ECGs in patients at increased risk; Seizures: Use caution in patients with a history of seizures and patients at increased risk of seizures, including medications that lower the seizure threshold; Colonic mucosal ulcerations: Consider potential for mucosal ulcerations when interpreting colonoscopy findings in patients with known or suspected inflammatory bowel disease; Patients with renal impairment or taking concomitant medications that affect renal function: Use caution, ensure adequate hydration and consider laboratory testing; Suspected GI obstruction or perforation: Rule out the diagnosis before administration; Patients at risk for aspiration: Observe during administration; Hypersensitivity reactions, including anaphylaxis: Inform patients to seek immediate medical care if symptoms occur.

ADVERSE REACTIONS: Most common adverse reactions (> 2%) are: nausea, abdominal distension, vomiting, abdominal pain, and headache.

DRUG INTERACTIONS: Drugs that increase risk of fluid and electrolyte imbalance.

See Full Prescribing Information and Medication Guide

2024 Braintree Laboratories, Inc. 550-853-v1 February 2024

Choosing the right weight management medication to best suit your health goals

2024-03-05T08:01:00

(BPT) – Struggling with weight loss is a problem everyone is familiar with – either they themselves or someone close to them has faced challenges in maintaining a healthy weight. Obesity is a disorder involving excessive body fat that increases the risk of health problems.1 A common, serious and costly chronic disease that affects adults and children, obesity is on the rise in the United States.2 About one-third of Americans suffer from obesity.2 Many have other chronic, expensive medical conditions, such as heart disease, diabetes and arthritis.2

“Obesity is a disease caused by many factors, including eating patterns, physical activity levels, sleep routines and genetics,3” said Dr. Anthony Auriemma JD, FOMA, obesity medicine specialist at Ascension Medical Group Illinois. “There is no one size fits all approach to treating obesity, which is a complex condition. While lifestyle intervention is the basis of treatment, it is important to consider the new therapies FDA approved for chronic weight management.4

Obesity is a chronic condition that requires long-term commitment to treatment.5 It’s important to consider the range of options as some therapies may be more appropriate than others to help manage weight loss in people with diabetes or cardiovascular disease.5 In addition, the benefits of weight loss through medication have been shown to have positive effects on managing other diseases such as high cholesterol, sleep apnea, and heart disease.6

“When treating obesity, it’s essential to consider the specific challenges of each person,” said Dr. Anthony Auriemma JD, FOMA. “Many new therapies are now available; It’s essential to look beyond the hype and, together, carefully evaluate the various options before committing to a weight loss strategy.5 Specifically, people in partnership with their physician should consider efficacy, safety, ease-of-use, and financial cost when choosing an option that best supports achieving and maintaining healthy weight goals.5

Amid this growing health crisis, there has been much attention focused on recently introduced glucagon-like peptide-1 (GLP-1) agonists, like semaglutide.5 Experts caution these GLP-1 medications may not be suitable for the full range of people struggling with weight loss, and a person or patient should consider the option that best aligns with their individual healthy weight goals.5

The good news is there are a number of proven medications for patients who suffer from obesity and are overweight.5 For example, Qsymia® (phentermine and topiramate extended-release capsules) CIV in combination with a reduced-calorie diet and exercise has been proven to help adults and children ages 12 to 17 lose weight and maintain weight loss.7 The once-daily pill is covered by the majority (81%) of commercial healthcare plans and is indicated for long-term use.8

“Obesity continues to threaten the overall well-being of those affected and is a major public health concern – and no one pill will completely reverse the situation,5” said Dr. Anthony Auriemma JD, FOMA. “Take the time to learn about each option with your physician. Remember, weight-loss medications may take time to show noticeable results.5 Be patient and stay committed to your overall weight-loss plan.”

Sponsored by VIVUS LLC.

Dr. Anthony Auriemma JD, FOMA, obesity medicine specialist at Ascension Medical Group Illinois, is a paid consultant of VIVUS LLC.

About QSYMIA

QSYMIA is a combination of phentermine, a sympathomimetic amine anorectic, and topiramate, indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese) or 27 kg/m2 or greater (overweight) in the presence of at least one weight related comorbidity such as hypertension, type 2 diabetes mellitus, or dyslipidemia. QSYMIA may also be used in pediatric patients aged 12 years and older with BMI in the 95th percentile or greater standardized for age and sex.

The effect of QSYMIA on cardiovascular morbidity and mortality has not been established. The safety and effectiveness of QSYMIA in combination with other products intended for weight loss, including prescription and over-the-counter drugs, and herbal preparations, have not been established.

For more information on QSYMIA, please visit https://QSYMIA.com/

Important Safety Information

Do not take QSYMIA if you are pregnant, planning to become pregnant, or become pregnant during QSYMIA treatment; have glaucoma; have thyroid problems (hyperthyroidism); are taking certain medicines called monoamine oxidase inhibitors (MAOIs) or have taken MAOIs in the past 14 days; are allergic to topiramate, sympathomimetic amines such as phentermine, or any of the ingredients in QSYMIA.

Common side effects of QSYMIA in adults include numbness or tingling in the hands, arms, feet, or face (paraesthesia), dizziness, changes in the way foods taste or loss of taste (dysgeusia), trouble sleeping (insomnia), constipation, and dry mouth. Common side effects of Qysmia in children aged 12 years and older include depression, dizziness, joint pain, fever, flu, and ankle sprain.

QSYMIA can cause serious side effects, including birth defects (cleft lip/cleft palate), increases in heart rate, visual field defects (independent of elevated intraocular pressure), suicidal thoughts or actions, serious eye problems, and severe rash with blisters and peeling skin. QSYMIA may slow the increase in height in children 12 years and older.

101225.02-USP

References

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  1. World Health Organization. (n.d.). Obesity. Retrieved from https://www.who.int/health-topics/obesity#tab=tab_1
  2. Centers for Disease Control and Prevention. (2022, May 17). Adult Obesity Facts. Retrieved from https://www.cdc.gov/obesity/data/adult.html
  3. Centers for Disease Control and Prevention. (2023, September 22). Adult Obesity is a Serious Health Problem. Retrieved from https://www.cdc.gov/media/releases/2023/p0922-adult-obesity.html#:~:text=Obesity%20is%20a%20disease%20caused,one%20size%20fits%20all%20approach.
  4. WebMD. (2023, November 9). Prescription Weight Loss Medicine. Retrieved from https://www.webmd.com/obesity/weight-loss-prescription-weight-loss-medicine
  5. Harvard Health Publishing. (2023, November 1). Understanding new weight-loss drugs. Retrieved from https://www.health.harvard.edu/staying-healthy/understanding-new-weight-loss-drugs
  6. Müller, L., & Müller, V. (2018). Obesity and Breast Cancer: Current Insights on the Role of Fatty Acids and Lipid Metabolism in Promoting Breast Cancer Growth and Progression. Frontiers in Endocrinology, 9, 647. https://doi.org/10.3389/fendo.2018.00647
  7. Qsymia. (2023, June). Qsymia (phentermine and topiramate extended-release) capsules, for oral use, CIV. Prescribing Information. Retrieved from https://qsymia.com/patient/include/media/pdf/prescribing-information.pdf
  8. VIVUS LLC (2023, January 23). VIVUS Provides Update on Pipeline and Program Milestones. Retrieved from https://ir.vivus.com/news-releases/news-release-details/vivus-provides-update-pipeline-and-program-milestones

Ready for wellness? 4 unexpected benefits of chiropractic care

2024-03-05T07:01:00

(BPT) – A popular misconception about chiropractic care is that it’s only for people with back pain. However, chiropractic treatment has the potential to treat various physical ailments. Whether you’re an athlete who needs help with sports recovery, a professional suffering from tech neck, or simply dealing with everyday aches and pains, you may benefit from chiropractic care.

Since 1999, The Joint Chiropractic has strived to improve people’s quality of life through routine, affordable chiropractic care. In honor of its 25th anniversary, The Joint offers the top four ways you could benefit from regular chiropractic treatment.

1. Pain relief

The most obvious benefit of chiropractic care is that it may help alleviate pain and discomfort. First, a licensed chiropractor will work with you to identify the source of your pain. Once they find the root cause, they can use various adjustment techniques to align your spine, eliminate joint restrictions and alleviate pressure on the nerves and other tissues.

Beyond back pain, spinal adjustments can help with:

  • Joint discomfort
  • Bursitis
  • Arthritis
  • Chronic injuries
  • Stress and tension disorders
  • Neck, upper and lower back, shoulder and elbow, as well as knee, foot and ankle pain

2. Improved nervous system communication

Your body is a living communication system. The brain sends electrical impulses down the spinal cord through miles of nerves that connect to every cell, system, structure and organ in the body. Those cells, systems, structures and organs send electrical impulses back to the brain so it can respond accordingly.

Just like with technological communication, structural issues in your body — like restricted range of motion in the spinal joints — can cause signal interference in your nervous system. When a joint is stuck or not moving properly, the ligaments and tissues within the joint, the muscles that attach, and the nerves that exit that area of the spine can be negatively affected.

To keep your body’s nervous system in tip-top shape, schedule regular chiropractic treatments. A consistent chiropractic routine can help unblock your joints, improving communication between your brain, nerves and body. Better communication promotes better function, which can lead to improved health and life experience.

3. Enhanced recovery

Another benefit of improving your nervous system through chiropractic care is the potential to increase rates of healing. Your nervous system controls how quickly your body recovers from infections, diseases and injuries. Consistent chiropractic treatment may improve the brain and body’s communication, improving function and performance.

Because chiropractic care can speed healing and recovery, many athletes and sports programs use chiropractic treatments to improve performance. In fact, according to the American Chiropractic Association, about 80% of professional and Olympic-class athletes use chiropractic care to increase performance and reduce the risk of injury. That’s why The Joint supports various collegiate and professional sports teams across the country through partnerships, thus furthering the connection between chiropractic care, athletics and physical fitness.

4. Increased relaxation

When your body is misaligned, it has to work harder to maintain a consistent state, causing a strain on your sympathetic nervous system. This system governs your fight, flight or freeze instincts, activated in high-stress or dangerous situations. Your body is not made to remain in this state constantly because it makes it more difficult to stay calm or relax.

Unfortunately, spinal misalignment and stiff joints can cause your sympathetic nervous system to activate even when you’re not in danger. You may be able to shift your body out of this state through chiropractic care. Chiropractic adjustments can take pressure off the nervous system, signaling to your body that you’re not in danger and can relax.

A different kind of chiropractic care

Chiropractic care is more than just a solution for back pain. It’s key to a healthy lifestyle. However, many face financial or logistical barriers when looking for a chiropractor. That’s why for the past 25 years, The Joint Chiropractic has made quality chiropractic care accessible.

With over 900 locations nationwide, The Joint is the nation’s largest provider of chiropractic care, serving more than 13 million patients a year. The company continues to expand its clinic network across the U.S., ensuring that quality chiropractic care is readily accessible to diverse communities.

What makes The Joint different from other chiropractic models? The company is known for its convenient retail setting and concierge-style services, including no appointments, no insurance hassles, affordable chiropractic care and accommodating hours of operation, including evenings and weekends.

“We are rounding the corner to our 1,000th clinic milestone, making 2024 a banner year for The Joint Chiropractic,” said Peter D. Holt, president and CEO of The Joint Corp. “This 25-year journey is a testament to our commitment to shaping a future where quality chiropractic care is within reach for everyone.”

Take charge of your wellness. For information on The Joint Chiropractic or to find one of our chiropractors near you, visit TheJoint.com. To learn more about your first visit, go to TheJoint.com/What-to-Expect.

Understanding Pseudobulbar Affect in Patients Caused by Multiple Sclerosis

2024-03-05T07:01:00

(BPT) – This article is sponsored by Otsuka America Pharmaceutical, Inc., for which Dr. Mayer Joshua Hasbani is a paid consultant.

This March is Multiple Sclerosis (MS) Awareness Month and an appropriate time to shine a light on a common neurological condition called Pseudobulbar Affect, otherwise known as PBA1. MS is a chronic and often debilitating disease affecting nearly one million individuals in the U.S.2 PBA can impact some patients within the MS community, yet is frequently misunderstood and underdiagnosed3.

“Pseudobulbar Affect or PBA is characterized by uncontrollable laughing, crying, or a combination of both, and has been reported in an estimated 10 to 46 percent of patients with MS. These symptoms are involuntary, exaggerated, often sudden, and do not necessarily align with the individual’s actual feelings,” according to Dr. Mayer Joshua Hasbani, Board Certified Neurologist, Hasbani Neurology. “PBA is thought to stem from neurological changes caused by MS, that is different from emotional disorders like depression, which PBA is often confused for, so it is increasingly important to understand, recognize and diagnose those affected.”

Because PBA symptoms can be mistaken for emotional disorders like depression, this can lead to misdiagnosis1. As a result, people experiencing PBA may struggle with their symptoms before finally receiving an accurate diagnosis1. Therefore, differentiating PBA from conditions like depression is important since each requires a unique approach to care.

“PBA can present a considerable burden in addition to the struggles of living with MS. This is further compounded by a lack of awareness and understanding about PBA that extends beyond healthcare providers to the general public. As a result, many individuals with PBA and those around them may experience frustration when episodes occur, as the episodes can be misunderstood and lead to confusion and embarrassment,” says Dr. Hasbani. “Therefore, patients with MS who are experiencing PBA-like symptoms of uncontrollable laughing, crying, or a combination of both, or their caregivers and loved ones, should talk to their healthcare provider about potential treatment options available.”

Today, NUEDEXTA® (dextromethorphan HBr and quinidine sulfate) is currently the only FDA-approved treatment for PBA and is clinically proven to reduce PBA episodes. Do not take NUEDEXTA if you are taking other drugs that contain quinidine, quinine, or mefloquine. The most common side effects were diarrhea and dizziness. These are not all the risks from use of NUEDEXTA. Please see additional Important Safety Information below.

“Having the ability to diagnose and treat my patients experiencing uncontrollable crying and laughter is especially rewarding,” says Dr. Hasbani. “While there is no cure for PBA and a diagnosis may seem daunting for patients, treatment with NUEDEXTA is an option that can help appropriate patients decrease laughing and/or crying episodes.”

Patients with MS who experience symptoms of PBA should engage in an open dialogue with their healthcare providers4 or seek consultation with a neurologist that has experience treating individuals with PBA. Specifically, sharing details about the frequency, nature, and impact of laughing or crying episodes can greatly assist a healthcare provider in making an accurate diagnosis and determining proper treatment4. Effectively managing PBA caused by MS needs a holistic approach to communication and a thorough care plan.

For more information about PBA, NUEDEXTA®, and resources for support and education, please visit treatingPBA.com. Please read the full INDICATION and IMPORTANT SAFETY INFORMATION for NUEDEXTA below.

INDICATION and IMPORTANT SAFETY INFORMATION for NUEDEXTA® (dextromethorphan HBr and quinidine sulfate)

INDICATION:

NUEDEXTA is approved for the treatment of Pseudobulbar Affect (PBA).

PBA is a medical condition that causes involuntary, sudden, and frequent episodes of crying and/or laughing in people living with certain neurologic conditions or brain injury. PBA episodes are typically exaggerated or don’t match how the person feels. PBA is distinct and different from other types of emotional changes caused by neurologic disease or injury.

NUEDEXTA is only available by prescription.

IMPORTANT SAFETY INFORMATION:

Before you take NUEDEXTA, tell your doctor:

  • If you are taking monoamine oxidase inhibitors (MAOIs), quinidine, or quinidine-related drugs. These can interact with NUEDEXTA causing serious side effects. MAOIs cannot be taken within 14 days before or after taking NUEDEXTA.
  • If you have previously had an allergic reaction to dextromethorphan, quinidine or quinidine-like drugs.
  • About all medicines, herbal supplements, and vitamins you take as NUEDEXTA and certain other medicines can interact causing side effects.
  • If you have had heart disease or have a family history of heart rhythm problems. NUEDEXTA may cause serious side effects, including changes in heart rhythm. If you have certain heart problems, NUEDEXTA may not be right for you. Your doctor may test your heart rhythm (heartbeats) before you start NUEDEXTA.
  • If you have myasthenia gravis.

While taking NUEDEXTA, call your doctor right away:

  • If you feel faint or lose consciousness.
  • If you experience lightheadedness, chills, fever, nausea, or vomiting as these may be signs of an allergic reaction to NUEDEXTA. Hepatitis has been seen in patients taking quinidine, an ingredient in NUEDEXTA.
  • If you have unexplained bleeding or bruising. Quinidine, an ingredient in NUEDEXTA, can cause a reduction in the number of platelets in your blood which can be severe and, if left untreated, can be fatal.
  • If you feel dizzy, since it may increase your risk of falling.
  • If you have muscle twitching, confusion, high blood pressure, fever, restlessness, sweating, or shivering, as these may be signs of a potential drug interaction called serotonin syndrome.

The most common side effects of NUEDEXTA include: diarrhea, dizziness, cough, vomiting, weakness, and swelling of feet and ankles. This is not a complete list of side effects. Tell your doctor about any side effect that bothers you or does not go away.

You are encouraged to report side effects of NUEDEXTA® (dextromethorphan HBr and quinidine sulfate). Please contact Otsuka America Pharmaceutical, Inc. at 1-800-438-9927 or FDA at 1-800-FDA-1088 (www.fda.gov/medwatch).

Please read accompanying FULL PRESCRIBING INFORMATION and IMPORTANT SAFETY INFORMATION, also available at treatingPBA.com.

References

  1. Ahmed A, Simmons Z. Pseudobulbar affect: Prevalence and management: TCRM. Therapeutics and Clinical Risk Management. November 29, 2013. Accessed December 13, 2023. https://doi.org/10.2147/TCRM.S53906.
  2. Understanding multiple sclerosis. National Multiple Sclerosis Society. Accessed December 13, 2023. https://www.nationalmssociety.org/What-is-MS/MS-FAQ-s.
  3. Vidović V, Rovazdi MC, Kraml O, Kes VB. PSEUDOBULBAR AFFECT IN MULTIPLE SCLEROSIS PATIENTS. Acta Clinica Croatica. 2015;54(2):159-163. Accessed January 31, 2024. https://pubmed.ncbi.nlm.nih.gov/26415311/
  4. Pseudobulbar affect (PBA). Brain Injury Association of America. November 7, 2023. Accessed December 13, 2023. https://www.biausa.org/brain-injury/about-brain-injury/pba.

How to support your nutritional needs while taking weight loss medications

2024-03-04T13:49:00

(BPT) – Are you considering taking or are currently taking a glucagon-like peptide 1 agonist (GLP-1) medication for weight loss? If so, it’s important to know how these drugs can affect your body. Most importantly, this is because most weight-loss medications’ main impact is through decreasing your desire to eat. While you may be eating far less than you used to, your body’s nutrient needs have not changed. It will be vital to ensure your body gets enough essential nutrients including protein, fiber, vitamins and minerals. Make sure to talk to your health care provider about potential side effects of these medications, and the best ways to maintain your optimal health while taking these drugs.

“Weight-loss drugs that work using the GLP-1 receptors curb your appetite, so you may have difficulty getting all the nutrients, micronutrients or even physical activity you need for optimal muscular, cardiovascular and brain health,” said Kent L. Bradley, M.D., MBA, MPH and chief health and nutrition officer at Herbalife. “If you’re taking these medications, you should supplement with products that help you get essential nutrients so that when you do eat, your meal is high in nutrient density, while at the same time making the foundational lifestyle changes needed to achieve sustainable weight loss.”

Side effects of GLP-1 medications

GLP-1 medications help regulate your blood sugar levels and make you feel fuller after eating. However, like most drugs, they’re not without potential side effects. According to the Cleveland Clinic, common side effects include loss of appetite, nausea, vomiting and diarrhea. The side effects each person experiences may vary, so it’s always best to consult your health care provider before and while you’re taking medications about any side effects you’re noticing.

Because of the feeling of satiety (fullness) and loss of appetite, typically experienced by people taking these medications, you’re likely going to be eating less while on the medication. This raises the possibility of your body not getting the protein, vitamins and minerals necessary to perform functions like fighting infection, building and repairing muscles and regulating hormones.

“Recent research has shown people taking weight-loss medications like GLP-1 may experience decreases in muscle density,” explained Bradley. “Herbalife is dedicated to addressing nutritional deficiencies through these new combos that include nutrition products designed to deliver protein and fiber, as well as critical vitamins.”

Why are macronutrients and micronutrients important?

You may know the terms macro and micronutrients, but you may not be aware of the impact they have on your body and the role they play in supporting healthy weight loss. Macronutrients like proteins are made up of amino acids that are essential for the growth and repair of tissues in the body. They can also be used as an energy source. Additionally, a higher protein intake can boost metabolism and reduce appetite by affecting the levels of weight-regulating hormones in your body.

Micronutrients such as vitamins have also been shown to play a part in a healthy metabolism. For example, B-complex vitamins help metabolize carbohydrates, fats and proteins to use as energy, instead of letting them turn into fat. Additionally, vitamins are necessary for energy production, immune function, blood clotting and other functions, while minerals play an important role in growth, bone health, fluid balance and several other processes.

How to supplement nutrition during weight loss

To help anyone taking GLP-1 medications, the premier health and wellness company and community Herbalife is offering a Herbalife GLP-1 Nutrition Companion, which offers food and supplement product combos intended to support the nutritional needs of individuals on weight-loss medications.

The Herbalife GLP-1 Nutrition Companion has two combo choices:

Classic Product Combo
Formula 1 Healthy Meal Nutritional Shake Mix
Protein Drink Mix
Active Fiber Complex

Vegan Product Combo
HERBALIFE V Plant-Based Classic and Chocolate Protein Shake
HERBALIFE V Plant-Based Digestive Support
HERBALIFE V Plant-Based Greens Booster

Each product bundle provides vital protein to sustain lean muscle and boost your energy, as well as fiber to support good digestion and a healthy gut microbiome. The Classic bundle also offers vitamins and minerals to support overall good health.

Note: The Herbalife product bundle is not a drug. Remember to consult your physician before you make changes to your diet during medically supervised weight loss.

Making the weight loss journey easier

Choosing foods and supplements that provide essential nutrients is a convenient way to take the guesswork out of nutrition and help ensure your body isn’t missing out on crucial nourishment while you’re on your weight loss journey.

“There really is no magic pill or shot. We still need foundational lifestyle changes,” Bradley added. “To sustain your results over time, it’s important that you continue to prioritize good nutrition and regular physical activity as part of your daily routine. It also helps to have the support of a community that understands your journey.”

Herbalife’s independent distributors also create a supportive community and can help you build better eating habits, whether you’re on weight-loss drugs or not — and support you in maintaining those habits after the drug treatment ends, so you can continue to benefit from your efforts.

Learn more from Dr. Kent Bradley, Board Certified Preventive Medicine and Public Health physician, about how good nutrition can support people on a GLP-1 weight-loss journey, by watching this video.

For more healthy lifestyle tips and information, visit Herbalife.com.

Snacking for dinner? You’re right on trend

2024-03-01T06:01:00

(BPT) – How do you get your snack on in 2024? Dip for dinner? Are you creating your own perfect bite like a snack savant? In advance of National Snack Day this weekend, find out if your snack and food game aligns with the nation’s palate in Frito-Lay’s fifth annual U.S. Snack Index survey. Some of the results might surprise you.

There’s no doubt about it. Frito-Lay’s beloved foods — Lay’s, Doritos, Tostitos, Cheetos, PopCorners and more — are an integral part of American game days, celebrations and adventures. This privilege does not happen overnight and the company is committed to keeping a pulse on societal shifts, ensuring it is meeting our ever-evolving preferences and needs.

This year’s survey discovered there is a real lack of time in people’s lives to prepare, eat and enjoy their meals, especially among parents and younger generations. One-third of Americans have just 30 minutes for meals, and that includes cooking! When you think about it, that’s less time than most work commutes. Sound familiar?

This is leading to the rise of the “no-prep dinner,” a simple meal that tastes great, doesn’t require a whole lot of effort and often is inspired by their favorite snacks. Snack-focused dinners are so popular today there’s even a trending hashtag, #GirlDinner. But the trend involves everyone, with more than 92% men and women noting they reach for snack foods at dinnertime.

Here are some other snack trends the survey found.

A dash to dine: According to the Index, the average American has only 52 total minutes per day to prepare, eat and enjoy their meals. One-third of consumers note having even less time, scraping together less than 30 minutes a day to prep and enjoy meals.

Snacks moving to center plate: With a 35% increase in consumers integrating their favorite snack products into meals, snacks are taking center stage in a new way. Ninety-two percent of men and 93% of women use snack foods when making meals. Whether it’s yearning for a specific snack (51%) or simply being too busy to cook (44%), Frito-Lay’s 2024 Snack Index predictions suggest that snacks will only continue to be essential ingredients for easy, no-prep meals.

The dip dynasty: Dive into the timeless tradition of chips and dip, where Salsa (27%), French Onion (21%), and Queso (20%) reign supreme as the top three rival dips. While Salsa steals the spotlight among Gen Z, Millennials and Gen X dippers, Baby Boomers crown French Onion as their dip MVP.

Snacking as an art, not an act: Eighty percent agree that combining multiple food products to create the perfect bite is an art form. While 65% of Americans admit to having eccentric snack combos, they are not the slightest bit embarrassed and will proudly “shout their unique combos from the rooftops” anyway.

Defining the “Snack Savant”: Millennials (83%) and Gen Z (82%) are most likely to embrace this title, with the majority of these Snack Savants also being city dwellers (77%). They are resourceful — 55% report their favorite snack combinations are inspired by what is already in the pantry — and lean on social media for additional ideas (32%).

Protein power: When eyeing snacks at the grocery store, Americans cite protein as the most important nutritional attribute (55%). Compared to previous years, an overwhelming 79% of consumers admit it’s more critical than ever for protein to take center stage — especially true for those most crunched on time (80%).

Energy boost: At least once a week, 60% of consumers look to their favorite snack products to provide energy. Millennials (72%) are by far the generation most in need of a pick-me-up, compared to Gen Z (62%), Gen X (61%) and Baby Boomers (46%). Parents have everyone beat, with 72% leveraging snacks for energy.

Taste triumphs: Across generations, nearly three-quarters of consumers (74%) refuse to sacrifice taste when selecting their snacks. Baby Boomers are the most unwilling to compromise on taste (84%), followed by Gen Xers at 75%.

Find out more about what the survey revealed, and how your snacking habits are stacking up to America’s, in the Frito-Lay Snack Index. And go ahead — break out the Fritos and enjoy some Frito Pie tonight!

Often misdiagnosed, it’s time to raise awareness of the rare disease amyloidosis

2024-02-29T09:01:00

(BPT) – What started as a dream trip to Hawaii became a medical turning point for Sally Cox. While snorkeling in the crystal-clear waters, she suddenly found it difficult to breathe and nearly drowned. Shocked, scared and confused, she immediately went to a local doctor to get answers.

The doctor in Hawaii said she had pulmonary edema and should be assessed further. She met with a cardiologist as quickly as possible, and ultimately received a diagnosis she had never heard of before: amyloidosis.

What is amyloidosis?

Amyloidosis is a group of rare diseases caused by abnormal proteins that misfold and clump together to form toxic amyloids that deposit in tissues or organs. When amyloid builds up in certain body parts such as the heart, kidneys, liver, nervous system and digestive tract, it can result in significant organ damage or organ failure that can severely impact quality of life and can be fatal.

The symptoms of amyloidosis

Sally began to learn more about her amyloidosis and, in hindsight, realized there were signs of the disease that had started three years before, including carpal tunnel syndrome in both hands, skin bruising, hair loss, lack of appetite and an abnormal EKG. Many symptoms are frequently overlooked or misdiagnosed.

While Sally was diagnosed with amyloidosis relatively quickly, that is not generally the case. This was the experience for Michael Lane, whose amyloidosis diagnosis journey took 10 years and was riddled with misdiagnoses.*

Michael’s symptoms started as tingling in the legs and numbness in his hands. He would also lose his breath easily. Looking for answers, he went to a neurologist, orthopedic specialist and a cardiologist — just to name a few. It wasn’t until he was in the hospital for a heart procedure that the doctor on rounds stopped and ultimately refused to continue until more was understood about his condition.

Michael switched to this new doctor who gave him a battery of tests and ultimately the correct diagnosis of amyloidosis.

*A transthyretin-mediated amyloidosis diagnosis can be delayed by 3-4 years on average.

Diagnosing amyloidosis

There are different types of amyloidosis with varying severities, including amyloid light chain (AL) amyloidosis and transthyretin-mediated amyloidosis (ATTR), such as ATTR-CM, which can cause heart failure (cardiomyopathy) and ATTR-PN, which affects the function of peripheral nerves (polyneuropathy). Without treatment, these diseases can lead to impairment, disability and even death. Regardless of the type, there is no cure for amyloidosis.

Identifying amyloidosis diseases can be difficult because signs and symptoms may manifest similarly to other diseases. Once suspected, blood and urine tests may be conducted, in addition to a tissue biopsy to confirm the type of amyloidosis. Imaging, such as a CT scan, of the impacted organs may determine the severity of the condition. Genetic testing may also aid in the diagnosis for those with hereditary forms of ATTR amyloidosis.

Treatments and therapies

When Sally was diagnosed with AL amyloidosis in 2019, she was told she had six months to live. She joined a clinical trial hoping to receive the new medicine that was being tested. Although she was disheartened when she was selected to receive the current standard of care instead, she showed a positive response to the treatment and that response continues today.

“When I was diagnosed, there were about three options for treatment. Today there are many more,” said Sally, who is trying to raise awareness about the disease.

Michael, living with transthyretin-mediated amyloid cardiomyopathy

When Michael was diagnosed with ATTR-CM in 2018, he was told he had about two years to live. Desperate for options, he thoroughly searched for clinical trials where he might be able to receive an investigational treatment, but only found one that was taking place overseas, which made him ineligible to participate. After more research, he learned he qualified to receive an investigational therapy, which helped his condition.

Like Sally, Michael recognizes the expansion of treatment options in the US over the last five years and has benefited from some of them. However, most existing amyloidosis treatment options focus on preventing or suppressing the formation of new amyloid deposits rather than addressing the amyloids that have existing deposits that drive organ dysfunction. Given the progressive nature of amyloidosis and the significant impact on quality of life, there is a need for additional treatment options to halt and reduce organ damage across all stages of disease.

AstraZeneca and its Rare Disease Unit, Alexion are committed to raising awareness of the disease and the need for additional treatment options. Learn more at Alexion.com and Astrazeneca-us.com.

Advice to others with amyloidosis

Learning you or a loved one has amyloidosis can be a complex and emotional time. Michael’s advice to others: “Be your own best advocate. Fight for yourself. Make sure you have a doctor that specializes in amyloidosis. If not around you, go to a center that does. A lot of doctors don’t know about this disease. It’s not on their radar.”

Sally agrees that it’s important to ask questions, educate yourself and make the best choices for you. She continues to spread hope for people with amyloidosis. Her advice to others is, “You can get better. Stay positive — it makes a difference.”

This article is sponsored by Alexion, AstraZeneca Rare Disease.

US/NP/0036 V1 11/2023

Maximize your protein intake with these 3 expert tips!

2024-02-27T12:53:00

(BPT) – Are you eating enough protein? If you feel hungry after a meal, are often fatigued or have brittle hair and nails, chances are you are protein deficient.

Why protein?

Protein is essential to maintaining your overall well-being. When you eat protein, your body breaks it down into amino acids and uses them to form your muscles, bones, skin, tissues and organs. Without enough protein, your body will be forced to break down your muscles for amino acids to continue functioning.

According to the U.S. Food and Drug Administration (FDA), the recommended daily protein intake is 50 grams. However, this amount is merely a guideline.

“How much protein you need depends on a few factors,” said Michelle Ricker, registered dietitian, nutritionist and director of Worldwide Health Education and Training at Herbalife. “Your age, body size, gender and activity level are just a few aspects that determine how much protein you should eat every day.”

In honor of National Protein Day, take stock of your eating habits and see how you can make sure you get enough of this critical nutrient. If you think you’re not eating enough, check out these three expert tips that will put you on the right track to a protein-packed diet.

1. Choose a variety of protein sources

When you think of eating protein, you probably picture a plate filled with beef, chicken or fish. But protein comes from many sources. Also, eating various protein-rich foods doesn’t just keep you from getting bored with your meal plan. It also ensures you get all the minerals and other nutrients your body needs to function at its best.

The next time you’re at the store, make sure to pick up Greek yogurt, cottage cheese, milk and eggs. These are all great sources of protein that you can easily use to make breakfast or as snacks between meals.

2. Play around with plant-based protein

Animal products aren’t the only way to get protein. You can also power up with protein by eating plant-based meals.

“For many people, a large portion of protein intake comes from meat and dairy,” said Ricker. “But there are many plant-based foods you should eat, even if you’re not vegetarian or vegan.”

Ricker recommends the following plant-based protein sources:

  • Buckwheat
  • Hummus plus pita
  • Soy products (tofu, tempeh, edamame beans)
  • Peanut butter
  • Beans and rice
  • Quinoa
  • Hemp and chia seeds
  • Spirulina

3. Keep easy protein on hand

When you’re constantly on the go, sitting down for a meal can be difficult. However, to keep you fueled all day, whether at work or school, you need to prioritize protein.

If you have a busy schedule, make sure to keep easy protein foods on hand. Protein snack packs with nuts, cheese or jerky can be helpful in a pinch.

A simple way to ensure you get a protein meal on the go is to add protein shakes to your routine. A product like Herbalife® Formula 1 Healthy Meal Nutritional Shake Mix is a delicious and easy way to treat your body to a nutritious and balanced meal in no time!

Available in a variety of flavors, this shake mix, when prepared according to label, provides 25 grams of protein in just one serving to help satisfy hunger, build muscle tissue, maintain lean muscle mass and give you energy. For vegan, vegetarian and flexitarian folks, you can opt for Herbalife’s V Plant-Based Protein Shake for 20 grams of plant-based protein. To learn more, visit Herbalife.com or to connect with an Herbalife independent distributor, call 866-866-4744.

Are you ready to power up with protein? Use these three tips to get started on a more protein-fueled meal plan so you can feel and do your best every day.

Listen to Your Heart: One Woman’s Experience Overcoming AFib

2024-02-22T19:27:00

(BPT) – Many of us have likely already broken our New Year’s resolutions. Even so, now is still a good time to focus on our health. Whether it’s an annual exam or a new fitness plan, taking care of ourselves should always be top priority. Maintaining a healthy heart, one of our most vital organs, is especially important. With heart disease being the leading cause of death in the United States, it’s critical for everyone to take a pause and listen to their heart.[1] Thankfully for one woman, she did just that.

Ann and her husband live in Virginia and together run a small business. Working side-by-side, their career path has been rewarding, but it also comes with a fair share of stress. On more than one occasion, Ann experienced heart flutter, mixed with nausea and discomfort. She regularly ignored her symptoms and attributed them to long hours working, or just another symptom of her diabetes.

“One morning I woke up in bed with the same heart flutter I’d experienced during the day at work,” Ann explained. “It was at that moment I knew I couldn’t ignore my symptoms any longer, so I admitted myself to the emergency room. Lucky for me, that’s where I met Dr. Ayinde, an electrophysiologist (EP) who assessed my symptoms and diagnosed me with AFib.”

Atrial fibrillation, also known as AFib, is the most common type of cardiac arrhythmia affecting more than 6 million people in the United States and nearly 38 million people worldwide.[2],[3] Approximately 1 in 4 adults over 40 are at risk for AFib.[4] Despite these projections, many people are unfamiliar with the signs and symptoms of AFib which include feelings of a fast, fluttering or pounding heartbeat (palpitations), fatigue, shortness of breath, difficulty exercising, anxiety, chest pain, and dizziness.[5] Similarly, many are unaware of available treatment options and the importance of early treatment to avoid disease progression.[6]

“Most people don’t recognize the symptoms of AFib, which makes it difficult to get proper treatment,” stated Dr. Hakeem Ayinde, Cardiac Electrophysiologist at Cardiology Associates of Fredericksburg in Virginia. “If left untreated, AFib can progress or lead to other cardiovascular diseases. Therefore, the best way to avoid further complications is to see a cardiac electrophysiologist, a doctor who treats abnormal heart rhythm, right away to determine the best treatment plan.”

After discussions with Dr. Ayinde, Ann began oral medication to treat her AFib but did not tolerate it well. After discussing the risks of catheter ablation* together, they determined the best option would be for Ann to receive a catheter ablation – a safe and effective, minimally invasive procedure to restore the heart’s incorrect electrical signals, which causes an abnormal heart rhythm.[7] Three months after her diagnosis, Ann received the ablation treatment and has remained AFib free.

“I am very grateful I didn’t ignore my symptoms,” said Ann. “By going to the ER and having Dr. Ayinde as part of my care team, we were able to create a plan so I could be treated and make a full recovery.”

AFib is responsible for more than 450,000 hospitalizations annually and yet less than 5% of patients undergo a cardiac ablation.[8],[9] Dr. Ayinde’s recommendation for an ablation was critical for Ann before her condition progressed. Patients who have an ablation early to treat their AFib are likely to have better survival and less likely to revisit the ER or be hospitalized.[10] In addition, it’s reported that 50% of AFib patients do not respond to or cannot tolerate drug therapy10 so catheter ablation is an important treatment option to consider.

Today, Ann feels healthier and her quality of life has improved. She no longer experiences heart flutter and feels at ease. Post-cardiac ablation, Ann has the energy to engage in everyday activities.

Ann’s message to everyone is to listen to your heart. Do not wait for symptoms to worsen. As AFib becomes more common, it’s important to know there are effective treatments that offer long-term solutions.

If you or someone you know is experiencing symptoms of AFib, speak to a doctor right away. To learn more about AFib and treatment options, visit getsmartaboutafib.com.

*As with any medical treatment, individual results may vary. Only a cardiologist or electrophysiologist can determine whether ablation is an appropriate course of treatment. There are potential risks including bleeding, swelling or bruising at the catheter insertion site, and infection. More serious complications are rare, which can include damage to the heart or blood vessels; blood clots (which may lead to stroke); heart attack, or death. These risks need to be discussed with your doctor and recovery takes time. The success of this procedure depends on many factors, including your physical condition and your body’s ability to tolerate the procedure. Use care in the selection of your doctors and hospital, based on their skill and experience.

© Biosense Webster, Inc. 2024 US_BWI_NAVI_305371


[2] Lippi G, Sanchis-Gomar F, Cervellin G. Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. Int J Stroke. 2021 Feb;16(2):217-221. doi: 10.1177/1747493019897870. Epub 2020 Jan 19. Erratum in: Int J Stroke. 2020 Jan 28;1747493020905964. PMID: 31955707.

[3] Kornej J, Börschel CS, Emelia J. Benjamin EJ, Schnabel RB. Epidemiology of Atrial Fibrillation in the 21st Century. Circulation Research. 2020 June;127(1):4-20. doi: 10.1161/CIRCRESAHA.120.316340

[4] Staerk, et al. 2018 Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study. BMJ 2018;361:k1453 doi: 10.1136/bmj.k1453

[6] Kuck KH, Lebedev DS, Mikhaylov EN, et al. Catheter ablation or medical therapy to delay progression of atrial fibrillation: the randomized controlled atrial fibrillation progression trial (ATTEST). Europace 2021;23(3)362-369. doi: 10.1093/europace/euaa298.

[7] Natale, A. Reddy VY, Monir G, et al. Paroxysmal AF catheter ablation with a contact force sensing catheter: results of the prospective, multicenter SMART-AF trial. J Am Coll Cardiol, 2014;64(7),647–656. doi: 10.1016/j.jacc.2014.04.072

[8] Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., de Ferranti, S. D., Ferguson, J. F., Fornage, M., Gillespie, C., Isasi, C. R., Jiménez, M. C., Jordan, L. C., Judd, S. E., Lackland, D., Lichtman, J. H., … American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee (2018). Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation, 137(12), e67–e492. https://doi.org/10.1161/CIR.0000000000000558

[9] Internal Epidemiological Analysis.

[10] Calkins H, Reynolds MR, Spector P, et al. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analyses. Circ Arrhythm Electrophysiol. 2(4):349-61. doi: 10.1161/CIRCEP.108.824789.

5 Tips to Manage Heart Health After a Heart Attack

2024-02-23T09:01:00

(BPT) – By Dr. Norman Lepor

Sponsored by Novartis Pharmaceuticals Corporation
Dr. Lepor was not compensated for his contributions to this article.

If you or a loved one has ever had a cardiovascular event like a heart attack, you know the devastating impact these events can have on a person’s physical and emotional health. And rightfully so – these traumatizing events leave many people feeling anxious and uncertain of the future.

I see this impact nearly every day when patients share their stories, expressing their hope to never experience anything like these events ever again. But my 35 years in cardiology have unfortunately taught me that for a significant percentage of these patients, it will happen again.1

Thankfully, there’s hope for people who have experienced a cardiovascular event. Working with your health care provider can help you better manage your risk factors and look after your heart post-event. Here are a few considerations to guide your care journey.

1. Explore additional treatment options

Lowering your low-density lipoprotein cholesterol (LDL-C) is one of the simplest and most effective ways to improve your heart health. Known as “bad” cholesterol, LDL-C builds up in the arteries, placing your heart at increased risk of harmful blockages.2

While statins and changes to your diet and exercise regimen can help lower bad cholesterol, these improvements don’t always get your cholesterol where it needs to be.3,4 You need a treatment plan that you can stick with long term. That’s why I recommend Leqvio (inclisiran) to my patients for lowering their bad cholesterol. This prescription injectable is a lipid-lowering medication shown to help lower bad cholesterol by approximately 50% on average when combined with taking a statin and dietary changes.5,6

Leqvio is designed with the patient in mind, requiring only two doses a year.* Since this medicine is administered in a health care setting, you and your health care provider can feel confident that you are receiving your dose. Leqvio works with the liver’s natural processes to reduce bad cholesterol in your blood. The therapy provides cholesterol lowering through each six-month dosing interval. Leqvio can help you reach your target bad cholesterol level and, importantly, help you maintain that level. It is not known if LEQVIO can decrease problems related to high levels of bad cholesterol, such as heart attacks or stroke. The most common side effects of LEQVIO were: injection site reaction (including pain, redness, and rash), joint pain, and chest cold.

2. Limit alcohol and tobacco

Tobacco and heavy alcohol use can heighten your risk of a recurring cardiovascular event by increasing levels of triglycerides, a fatty deposit that can build up and create a blockage within blood vessels.7,8 You can take action to protect your heart by limiting alcohol and tobacco consumption. If either of those is challenging, consult your health care provider.

3. Partner with your health care provider

The road to managing your heart health following a cardiovascular event isn’t always linear. That’s why having an open and consistent dialogue with your health care provider is really important. Your health care provider will understand your unique risk factors and can help you build a realistic treatment plan. Don’t be afraid to proactively ask questions and speak up.

4. Switch it up in the kitchen & get your body moving

Proper nutrition is essential for lowering your bad cholesterol after you’ve had a cardiovascular event. Eating foods rich in fiber and low in saturated or trans fats, such as fruits, vegetables, whole grains, nuts, poultry, or fish can result in better heart health.9,10 I recommend my patients to limit their consumption of red meats, processed foods, and food and beverages with added sugar or salt.11 Your health care provider can work with you on creating a diet plan that best fits your nutritional needs.

In addition to dietary changes, it’s important to add physical activity to your daily routine – it could be as simple as walking around the neighborhood for thirty minutes several times a week.12 Your health care provider can help you determine what types of physical activity are safe for you.12

5. Consistency is key

Heart health is a lifelong investment. After a cardiovascular event, it’s important to take aggressive and consistent steps toward managing your heart health.13,14 This means prioritizing regular management of cholesterol levels and risk factors such as tobacco and heavy alcohol use, incorporating physical activity, proper nutrition, and keeping follow-up appointments with your health care team to monitor your condition and recovery.13,15

Your health care provider can be a valuable resource in prescribing a treatment plan that fits your lifestyle.

Much like the tortoise and the hare taught many of us as children, slow and steady wins the race; the same goes for managing your heart health. But this cherished fable fails to teach us that there’s help along the way.

To learn more about Leqvio, visit www.Leqvio.com.

*After an initial dose and another at three months.

What is LEQVIO?

LEQVIO (inclisiran) is an injectable prescription medicine used along with diet and other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia [HeFH]) to reduce low-density lipoprotein (LDL-C) or “bad” cholesterol.

IMPORTANT SAFETY INFORMATION

The most common side effects of LEQVIO were: injection site reaction (including pain, redness, and rash), joint pain, and chest cold.

These are not all the possible side effects of LEQVIO. Ask your health care provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please click here for Leqvio full Prescribing Information.

References

  1. Peters SAE, Colantonio LD, Dai, Y, et al. Trends in Recurrent Coronary Heart Disease After Myocardial Infarction Among US Women and Men Between 2008 and 2017. Circulation. 2021;143:650-660.
  2. Mayo Clinic. Arteriosclerosis / atherosclerosis. Accessed January 21, 2024. https://www.mayoclinic.org/diseases-conditions/arteriosclerosis-atherosclerosis/symptoms-causes/syc-20350569?p=1
  3. Kirkpatrick CF, Sikand G, Petersen KS, et al. Nutrition interventions for adults with dyslipidemia: A Clinical Perspective from the National Lipid Association. J Clin Lipidol. 2023;17:428-451.
  4. Scirica BM and Cannon CP. Treatment of Elevated Cholesterol. Circulation. 2005;111:e360-e363.
  5. Ray KK, Wright RS, Kallend D, et al. Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol. N Engl J Med. 2020;382(16):1507-1519.
  6. Raal FJ, Kallend D, Ray KK, et al. Inclisiran for the treatment of heterozygous familial hypercholesterolemia. N Engl J Med. 2020;382(16):1520-1530.
  7. Mukamal KJ. The Effects of Smoking and Drinking on Cardiovascular Disease and Risk Factors. Alcohol Res Health. 2006;29(3):199–202.
  8. Schwartz GG, Abt M, Bao W, et al. Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins. J Am Coll Cardiol. 2015;65(21):2267-75.
  9. Diab A, Dastmalchi LN, Gulati M, et al. A Heart-Healthy Diet for Cardiovascular Disease Prevention: Where Are We Now?, Vascular Health and Risk Management. Vasc. Health and Risk Mgmt. 2023;19:237-253.
  10. de Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study. Circulation. 1999;99(6):779-85.
  11. Delgado-Lista J, Alcala-Diaz JF, Torres-Peña JD, et al. Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial. The Lancet. 2022;399(10338):1876-1885.
  12. Smith SC Jr, Benjamin EJ, Bonow RO, et al. AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients with Coronary and other Atherosclerotic Vascular Disease: 2011 update. Circulation. 2011;124:2458-2473.
  13. Grundy SM, Stone NJ, Bailey AL, et al. 2018 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140:e596-e646.
  14. Authors/Task Force Members, ESC Committee for Practice Guidelines (CPG), ESC National Cardiac Societies. 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. European Heart Journal. 2019;140-205.
  15. American Heart Association. Life After a Heart Attack. Accessed February 9, 2024. https://www.heart.org/en/health-topics/heart-attack/life-after-a-heart-attack

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