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The caregiver difference: One man’s journey caring for his father’s COPD

2020-11-18T11:01:01

(BPT) – When Justin found out his dad had been diagnosed with chronic obstructive pulmonary disease (COPD), he wasn’t sure what to expect. Without knowing anything about the condition, he didn’t realize that becoming a primary caregiver at age 30 would mean uprooting his lifestyle to support caring for his dad.

Like Justin and his dad, many families in the U.S. are affected by COPD, a chronic and progressive lung disease for which there is no cure. Approximately 27 million Americans suffer from the condition, which is the country’s fourth leading cause of death, according to the Centers for Disease Control and Prevention. COPD is characterized by symptoms like breathlessness, fatigue, persistent cough and wheezing. These may worsen over time and can negatively impact a person’s ability to perform routine daily activities. While people with COPD can work with their physicians and take other proactive steps to control their symptoms, caregivers often play a critical role as part of the support system.

A new survey from GSK conducted in collaboration with CHEST and COPD Foundations identified significant gaps in communication between patients and their doctors, which create barriers to optimal COPD management. The survey, which was fielded to 351 people with COPD, 151 caregivers, 249 primary care physicians and 252 pulmonologists, found that caregivers play a valuable role in bridging these gaps and positively impact care by ensuring doctors and their patients are on the same page with regard to the true impact of symptoms.

Despite how challenging COPD can be, many patients are hesitant to share important information about their symptoms during medical appointments or are at times not fully aware of the true impact of their COPD. In the survey, 62% of patients said their caregiver notices when they’re struggling to perform routine activities — even without being told.

Further, more than six in 10 caregivers reported speaking up during appointments to share the full extent of symptoms their loved one neglected to mention. Justin says that he always tries to accompany his dad during doctor’s visits to ensure the conversation is accurate and complete. “When I hear my dad downplay his symptoms during his doctor’s appointments, I encourage him to share as much detail as possible so that the doctor is aware of how he’s feeling. I want him to be honest not only with the doctors but, more importantly, with himself.”

The majority of the patients (67%) and physicians (91%) surveyed agreed that appointments are more productive when a caregiver is involved. Many patients even said their caregiver plays a positive role in medication adherence (49%).

“Coming to terms with a chronic and progressive disease can be difficult,” said Dr. Riju Ray, GSK Medical Affairs Lead. “A caregiver may be the right person to help bridge the gap in care to support your personal goals for COPD management.”

Today, Justin has grown into his role as a caregiver and is grateful to spend more time with his dad doing what he loves. An avid runner, Justin has channeled his passion for running into a way to raise awareness about COPD. He’s participated in 60 marathons across the country in honor of his dad to raise awareness about COPD, to raise money for advancing COPD research and to empower other families affected by COPD to not lose hope and better cope with the challenges posed by the disease. His advice to those stepping into the role of COPD caregiver for the first time? Be prepared to be more hands-on and don’t be afraid to speak up and ask questions on behalf of your loved one.

“Do your homework and show up at doctor’s visits with a list of questions, notes and goals you want to discuss,” he said. “Patients sometimes feel overwhelmed by the amount of information they receive. It helps to have someone there who can ask to learn more about how a medication works, along with possible benefits, risks or side effects.”

People living with COPD and their caregivers can visit www.COPD.com for more information and to find resources to help better manage the disease.


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5 ways to add Italian gusto to your next holiday meal

2020-11-18T16:01:00

(BPT) – The holiday season is always a special time, but this year it’s especially important to pause, count your blessings and enjoy some delicious foods as you toast to friends and family near and far. Whether you’re celebrating in a small group or just with your immediate family, you can make this holiday memorable by creating new traditions and trying some authentic Italian recipes. The dynamic and versatile flavors of balsamic vinegar and sweet white vinegar are your key to delicious dishes.

These five ideas from the cuisine experts at Carandini are sure to excite this holiday season. Be inspired to try them in your home kitchen and enjoy the wonderful flavors as you make merry memories and cheer to a new year:

Creative cocktails: The Surprising Emilio

Starting your holiday feast with a tasty libation will inspire a smile. Select a drink that reflects seasonal flavors, such as the Surprising Emilio. This dark rum cocktail is perfectly balanced with apple juice, elderflower syrup and Emilio Balsamic Vinegar of Modena. The creamy texture of this vinegar comes from the grapes used to make it and from the maturing time, which add just the right touch of flavor in this delightful drink. Embrace the tastes of Italy as you raise a glass to happiness throughout the season and beyond.

Amazing appetizers: Vegetable skewers with sweet white vinegar sauce

Photo courtesy @momacy

Select appetizers to prepare the palate without being overfilling, such as fresh vegetables with a hand-prepared dip. Vegetable Skewers with Goat Cheese, Celery and Sweet White Vinegar Sauce are an ideal choice. Fresh vegetables like radish, carrot and cucumber are chopped into bite-size pieces and stacked on appetizer skewers. Complement with a dip made from tangy goat cheese and Bianca Sweet White Vinegar. Serve on a tray for buffet or table serving, or opt for easy grab-and-go small bites by placing a dollop of dip in the bottom of small cups and add a few mini skewers in each.

Marvelous main dish: Balsamic-glazed chicken

When you want a fuss-free main dish guaranteed to impress, opt for Balsamic-Glazed Chicken on a Bed of Arugula with Toasted Crostini. Each bite-sized chicken piece gets its incredible flavor from a glaze featuring Emilio Balsamic Vinegar of Modena. Place the chicken on a bed of the arugula on each plate and garnish with toasted bread before serving while hot. The rich glaze, juicy chicken and fresh greens are a magical combination that will satisfy taste buds for any holiday occasion.

Sensational sides: Using balsamic vinegars to enhance vegetables

It’s the most wonderful time of year, so your vegetables deserve more than basic salt, pepper and olive oil. Emilio Balsamic Vinegar is a wonderful kitchen essential for enhancing any type of vegetable in new and unexpected ways — especially for those following a vegetarian, vegan or keto-friendly lifestyle. For a fresh side salad, balsamic vinegar is the base for a light, luscious dressing. Root vegetables can be enhanced with a tasty balsamic glaze when roasted slowly in the oven. A balsamic vinegar marinade is ideal for grilled veggies, too. Bottom line: keep this on hand and have fun customizing your favorite vegetable dishes!

Delicious dessert: Cinnamon loaf cake with apples

End the celebration on a sweet note with Apple Loaf Cake that is sure to please young, old and anyone in between. Apple, cinnamon, almond milk and a secret ingredient — a delicate and sweet white condiment offering fruity and fresh notes — combine for a tasty conclusion to any holiday meal. When baking, you’ll garnish the apple loaf cake with apple slices and sprinkled with powdered sugar for a lovely-looking dessert that provides a beautiful visual presentation before you cut into thick slices for everyone to enjoy.

Be sure to visit your local Whole Foods Market to pick up Carandini products for your next Italian-inspired holiday menu, or grab a couple of bottles for gifting to your favorite foodies this holiday season.


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How to get the most out of open enrollment

2020-11-18T09:38:13

(BPT) – The COVID-19 pandemic means as a parent, you may be juggling your new roles of part-time remote teacher, IT technician and cafeteria chef along with your normal work responsibilities. The physical, mental, and for some, financial toll of this arrangement has left many feeling exhausted and stressed.

In fact, MetLife’s recent study on mental health found that having kids at home or no access to childcare or in-person schooling is the biggest single source of stress for parents of kids under 12 (52%) after fear of contracting the virus or a friend/family member contracting the virus (66%). Compounded by rising financial anxieties from possible financial setbacks, many parents are looking to benefits provided by their employer during open enrollment — the period of time wherein U.S. employees can make changes to their health insurance coverage and enroll in other insurance benefits — to build financial strength and help prepare for the unexpected.

This may be why, according to MetLife’s 2020 open enrollment survey, two-thirds (66%) of parents with kids under age 12 feel that open enrollment is more important this year than last year, and almost 60% plan to spend a greater amount of time selecting their benefits.

Setting aside time to prepare for open enrollment may seem overwhelming with all that’s going on now — particularly for parents with kids at home — but since changes to benefits are not available throughout the year outside of major life events, such as getting married, divorced or having a baby, it’s important to make it a priority. Fortunately, you can get started with three simple steps:

1. Pick benefits best suited to your family.

Even if you’re happy with the coverage you have, don’t assume you can set it and forget it. Employers often introduce new benefit offerings, and plan benefits can shift (like changes to dentists participating in the network or prescription medication coverage).

Start by evaluating what you’ve spent for healthcare over the last few years and think about any significant expenses you expect to incur in the coming year, such as the birth of a baby or braces for your teenager.

Next, read the information provided by your company to see what’s new for 2021. Some companies are now offering additional access to telemedicine or other mental health benefits. Perhaps your family has adopted a pet during the pandemic? Many employers offer pet insurance, which can help pet parents offset costs for vet visits. By taking the time to properly evaluate the plans your company offers, you can save hundreds — or even more — every year.

2. Explore new ways to protect against unexpected, out-of-pocket medical expenses.

Many employers offer a wide array of benefits — beyond medical, dental and vision coverage — that can close potential financial gaps and help parents safeguard their incomes from the unexpected. Critical illness or hospital indemnity plans help protect against unforeseen out-of-pocket costs by providing a lump sum payout if you are diagnosed with certain illnesses or hospitalized. Parents may also look at incorporating health savings or flexible spending accounts that allow you to use pre-tax dollars to cover expenses related to childcare and healthcare, as well as commuting costs, which reduce taxable income and earn interest.

Finally, legal plans provide access to a wide network of attorneys, for a limited additional charge, if any. These professionals can help prepare critical documents, such as wills and estate plans, which are important for new parents, as well as powers of attorney or advance health care directives, which are important when a child turns 18 and heads off to college.

3. Maximize your savings.

The pandemic and its many financial aftershocks have exposed a vulnerability we already knew existed: Americans simply don’t save enough. Therefore, while retirement savings can usually be adjusted throughout the year, open enrollment is a good time to reevaluate and make sure that, if your company matches employee contributions to retirement accounts, you are saving at least the minimum percentage to earn the match. If not, you’re leaving money on the table.

As enrolling in new benefits plays a direct role in your monthly expenses, it’s an opportune time to begin building your savings. Automate your savings by either having a portion of your paycheck directly deposited into your savings account or by setting up regular transfers from your checking to your savings. Automatically moving money to your savings means it will be there when you need it — which can help quell parents’ financial anxieties steadily throughout the year.

Employee benefits, at the most basic level, are provided to help improve your physical and financial well-being. Spending time reviewing benefit options and choices now can, in turn, help to alleviate stress later, giving parents — and all employees — more time to focus on their families. Get started now and help make sure your family is in the best possible position to have a healthy, financially secure new year.

To learn more about making open enrollment decisions and how to maximize your benefits, visit: metlife.com/openenrollment.


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How digital engagement can offer more control over personal finances in unpredictable times

2020-11-18T13:31:00

(BPT) – Since the coronavirus pandemic began taking hold in early 2020, global stock markets have taken investors on a rollercoaster ride, with aggressive climbs in value, precipitous drops and an overall queasy feeling in the pits of our stomachs about what’s next.

COVID-19’s impact on personal investments

Millions globally have been affected financially during the pandemic, and in very different ways. While savings may have resulted from changes in lifestyle and working from home, online spending has increased dramatically. Millions of people lost their jobs and dipped into their retirement accounts. Under the CARES Act, which went into effect during the pandemic, investors were permitted to withdraw money from their retirement funds in 2020 only without paying the 10% early withdrawal penalty — and they did so in record numbers.

A third group of investors and retirees chose to avoid making any investment decisions, believing that the safe move was to not focus on the stock market’s wild ride. This “bunker mentality,” however, may have put them at greater long-term risk by not taking advantage of opportunistic financial management solutions.

What is driving these different behaviors — particularly investors unwilling to make financial moves in such times of stress and volatility? According to a recent Forrester study*, underlying investor inertia is a lack of understanding regarding different types of investment accounts: Consumer involvement in wealth management options offered through insurers and other financial institutions depends in large part on their comfort with financial concepts. Many are unfamiliar with how different wealth management options work and which are best for them. Moreover, due to the pandemic, call centers have longer wait times, leaving many without the resources to make smart decisions on their own.

Digital engagement and education: Key to meeting financial goals

According to Meera Krishnamurthy, Cognizant’s Global Head of Insurance, addressing a lack of financial education is being solved with digital solutions. “Utilizing predictive data analytics, insurers and financial institutions can offer personalized content that is streamed directly to their customers’ dashboards and emails, advising them on opportunities that will help them reach their financial goals,” Krishnamurthy said.

Technology companies like Cognizant are helping insurers and financial institutions directly engage their customers during the pandemic. Using Cognizant’s Personalized Interactive Video solution, one global group insurance provider saw a 45% increase in portal registration for new members, and, at the same time, a significant drop in call center activity, indicating that the online self-service tools and information was meeting customers’ expectations.

“There’s no benefit to social distancing from financial markets,” Krishnamurthy continued. “Insurers are helping plan participants, members and policyholders take control of their financial future through direct virtual client engagement — including easy-to-understand videos that guide them through the details of their coverage and educate them on how to best use 24×7 online app self-service features.”

Smart investing driven by smarter fintech

As the opportunity and demand for personalized, digitized services grow, insurers and financial institutions are rapidly adopting new tools, such as account aggregation, personalized content delivery and accountability triggers. By partnering with technology solutions companies like Cognizant, insurers and financial institutions are delivering personalized wealth management coaching to their clients that is backstopped by powerful data analytics tools, predictive analytics and machine learning.

Financial goals for various age groups naturally differ, and those goals may have changed during the pandemic. Millennials tend to be concerned with paying down debt or saving for a down payment on a home, while Gen X and Baby Boomers generally focus on saving for retirement and investing in education planning via 529 accounts. Yet with the help of digital technology, businesses offering wealth management solutions can better understand their individual investors’ needs and create targeted messaging that accounts for what is in the best interest of plan participants.

Now, the opportunity to merge the benefit of interpersonal wealth management, the ease of making investment changes online, and the knowledge on how to best benefit from both is arriving. With a modern form of personalized digital engagement, investors are becoming more empowered through their knowledge and ability to act on that information.

“As we look toward 2021, we expect the digital acceleration that was brought on by the pandemic to continue,” says Cognizant’s Krishnamurthy. “Insurers and retirement services companies will provide the personalized tools and the ease with which to access those tools to empower plan participants and members to take charge of their financial wellness.”

*Forrester study*: https://www.forrester.com/report/Use+Digital+Technologies+To+Boost+Customers+Financial+Capability/-/E-RES160519?objectid=RES160519


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How you can afford a retirement community

2020-11-18T12:01:00

(BPT) – Are you retired or approaching retirement age? You may be thinking about the best options for where to live moving forward. Perhaps your house has become more than you can handle, or you have health concerns that require more care — or maybe you’d just like to live in a warmer climate. Whatever your reasons for considering a change, you’re probably concerned about the cost of such a move.

You may be surprised to learn that there can be financial advantages to moving to a retirement community.

Here’s what you need to know:

Your (or your spouse’s) care needs may change

Choosing a “continuing care retirement community” (CCRC) means that you will have options within a continuum of care, so you’ll be taken care of no matter what your needs are, and how they may change over time. This can make it much easier — and much less costly — to transfer from an independent living situation all the way to receiving any level of care that you may need in the future.

For example, within one single community like The Spires at Berry College in Rome, Georgia, your options include Independent Living, Assisted Living, Skilled Nursing & Rehab and Memory Care.

It may be more affordable than you expect

While many CCRCs require a significant entrance fee, most of the time that fee is almost fully refundable at the end of the contract, meaning that you get money back if you decide to move somewhere else or your family inherits money when you pass. It’s important to review the different types of contracts that are available to you within the CCRC model.

The sale of your home can help pay the entrance fee for this model, and if you add up all the costs of living in your home now, you may find that a retirement community is actually much more affordable than you thought — especially if you need or may soon need in-home care as well.

Your current expenses probably include items like:

  • Homeowners insurance
  • Property taxes
  • Utilities
  • Lawn service
  • Home maintenance and repairs
  • Mortgage and/or association fees
  • Cable, internet and phone
  • Recycling and sanitation

Once you total up these costs, remember that at a retirement community you won’t have any of these expenses or worries.

Tax benefits may apply

Everyone’s situation is unique, so you should always consult your personal tax advisor for specific advice before making a move. However, there are potential tax benefits you should be aware of when making your decision.

For example, residents of entry-fee retirement communities may be eligible to deduct a portion of the entry fee and possibly monthly fees as well, depending on the type of contract offered by that community.

Continuing care retirement communities may offer financial assistance

Many CCRCs can help you find bridge financing to help bridge the time between the sale of your current home and moving in to the community, among other possible financial resources.

“Check with the community you’re interested in to find out about financial options they may have that may not be advertised,” advises Jill Trapp, marketing director for The Spires. “For example, we work with potential residents on finding creative solutions to help with their financial needs.”

Moving in sooner can save you money

Over the long term, the sooner you make your move to a CCRC, the less expensive it will be. Many communities offer an easy-to-use online calculation tool that can help you determine if moving there would be a good financial fit for you. To evaluate your situation, try out the Affordability Calculator offered by The Spires at Retireatberry.com/pricing/affordability-calculator.

Making any move can be challenging, but continuing care retirement communities are focused on helping you relax and enjoy this time of your life to the fullest. To learn more about some of your options, visit RetireatBerry.com.


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How Rosacea Patients Can Take Action Against the Threat of Antibiotic Resistance

2020-11-18T08:01:01

(BPT) – With the COVID-19 pandemic on the minds of people worldwide, the spotlight on public health is more present than ever before. But before COVID-19 became a top public health concern, we were already in the throes of one of the biggest public health challenges of our time: antibiotic resistance. The Centers for Disease Control and Prevention (CDC) noted that annually at least 2.8 million people get an antibiotic-resistant infection in the United States, and more than 35,000 people die as a result.1 The threat of antibiotic resistance grows stronger as more antibiotics are used, yet the CDC estimates 30 percent of all antibiotics prescribed in outpatient clinics are “unnecessary.”2,3 Who are the top prescribers of antibiotics in the U.S.? Dermatologists.4

To treat chronic inflammatory skin conditions — like rosacea — dermatologists will often employ antibiotics because of their anti-inflammatory properties.5 The issue? While antibiotics are life-saving drugs used to treat infections caused by bacteria, rosacea is not a bacterial condition.6,7

Once bacteria become resistant, antibiotics cannot fight the resistant infection and bacteria begin to multiply.8 Resistance doesn’t mean the body is becoming resistant to antibiotics; ultimately, the bacteria become resistant to the treatments designed to kill them.8 Infections then become longer lasting, surmounting to a public health concern of global scale.6 The threat has become so widespread that the CDC has identified 18 “urgent, serious and concerning” antibiotic resistant threats.9

As rosacea afflicts an estimated 16 million Americans, the treatment decisions rosacea sufferers make today can greatly impact the fight against antibiotic resistance.10 It’s important not to take antibiotic treatments unless a physician deems it necessary.

Thankfully, not all rosacea treatment options are created equally. There is a non-antibiotic dose option that can help reduce the symptoms of rosacea without contributing to antibiotic resistance, as seen in a long term study.5[*] ORACEA® (doxycycline, USP) 40mg* Capsules, a convenient, once-daily oral prescription treatment, combats inflammation from the inside out to reduce the bumps and blemishes of rosacea through its anti-inflammatory properties.5,11,12 The safety and efficacy of ORACEA Capsules in the treatment of bumps and blemishes of rosacea was evaluated in two randomized, placebo-controlled, multi-centered, double-blind, clinical trials which found many people taking ORACEA Capsules started to see significant improvements (reduction in inflammatory lesions) in as little as 3 weeks, and improvements continued through the full 16-week course of the study.12,13[†] In controlled studies, the most commonly reported adverse events (>2%) in patients treated with ORACEA Capsules were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase.[†]

Unlike the most commonly prescribed 100mg dose of doxycycline, which demonstrated microbial resistance as early as day seven, ORACEA Capsules’ formula proved to not contribute to antibiotic resistance, in a nine-month study.12,13 The choices patients make today impact their health tomorrow. So, it’s important for people with rosacea to engage in the conversation with their dermatologists about an effective option to treat the bumps and blemishes of rosacea with a non-antibiotic dose.

Aside from safe and effective treatment options like ORACEA Capsules, people can join the fight against antibiotic resistance by following these tips:

  • Follow doctor’s orders: When prescribed, complete an antibiotic course as instructed. Unfinished antibiotic regimens can allow bacteria to survive (even if symptoms are relieved) and adapt to the treatment, increasing rates of resistance.14 If doctors don’t prescribe antibiotics, patients should not push for them. It’s important for patients to trust their doctor’s expertise when told that antibiotics won’t help.
  • Don’t save or share leftover antibiotics: Self-medicating may not treat the illness properly and could lead to adverse side effects.6,15 Taking antibiotics when not required allows bacteria to grow stronger.6
  • Focus on the long-term: For rosacea patients, consider that a long-term action plan may be a better option to treat the bumps and blemishes of rosacea rather than a short-term course of antibiotics.11

For more information about antibiotic resistance, connect with a dermatologist today. Visit Oracea.com to learn about rosacea and this non-antibiotic dose treatment option. With proper care, it’s possible to treat rosacea and help limit the risk of antibiotic resistance for a clearer and healthier future.

Important Safety Information

Indication: ORACEA Capsules are indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. ORACEA Capsules do not lessen the facial redness caused by rosacea. Adverse Events: In controlled clinical studies, the most commonly reported adverse events (>2%) in patients treated with ORACEA Capsules were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase. Warnings/Precautions: ORACEA Capsules should not be used to treat or prevent infections. ORACEA Capsules should not be taken by patients who have a known hypersensitivity to doxycycline or other tetracyclines. ORACEA Capsules should not be taken during pregnancy, by nursing mothers, or during tooth development (up to the age of 8 years). Although photosensitivity was not observed in clinical trials, ORACEA Capsules patients should minimize or avoid exposure to natural or artificial sunlight. The efficacy of ORACEA Capsules treatment beyond 16 weeks and safety beyond 9 months have not been established.

*30 mg immediate release & 10 mg delayed release beads

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

© 2020 Galderma Laboratories, L.P. United States, All Rights Reserved. All trademarks are the property of their respective owners.

1 Centers for Disease Control and Prevention. Antibiotic / Antimicrobial Resistance. https://www.cdc.gov/drugresistance/index.html. Accessed on October 8, 2020.

2 Centers for Disease Control and Prevention. Antibiotic use in the United States, 2018 update: progress and opportunities. Atlanta, GA: US Department of Health and Human Services, CDC; 2019.

3 Centers for Disease Control and Prevention. Be antibiotics aware: smart use, best care. https://www.cdc.gov/features/antibioticuse/index.html. Accessed on October 8, 2020.

4 Penn Medicine News. Dermatologists prescribe the most antibiotics, but which uses are driving the trend? https://www.pennmedicine.org/news/news-releases/2019/january/dermatologists-prescribe-the-most-antibiotics-but-which-uses-are-driving-the-trend/. Accessed on October 8, 2020.

5 Del Rosso, J. and Zeichner, J. The clinical relevance of antibiotic resistance: thirteen principles that every dermatologist needs to consider when prescribing antibiotic therapy. Dermatology Clinics: 2016. 34, pp. 167-173.

6 World Health Organization. Antibiotic resistance. https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. Accessed on October 8, 2020.

7 National Rosacea Society. All About Rosacea. https://www.rosacea.org/patients/all-about-rosacea. Accessed on October 8, 2020.

8 Centers for Disease Control and Prevention. Antibiotic resistance questions and answers. https://www.cdc.gov/antibiotic-use/community/about/antibiotic-resistance-faqs.html. Accessed on October 8, 2020.

9 Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States. Atlanta, GA: US Department of Health and Human Services, CDC; 2019.

10 National Rosacea Society. What is rosacea? https://www.rosacea.org/. Accessed on October 8, 2020.

11 Oracea (doxycycline) capsules for oral use. Prescribing information. 2014.

12 Valentin, Sheila, et al. Safety and efficacy of doxycycline in the treatment of rosacea. Clinical, cosmetic and investigational dermatology: CCID 2 (2009): 129.

13 Walker C, Bradshaw M. The effect of oral doxycycline 100 mg once-daily for 14 days on the nasopharyngeal flora of healthy volunteers: a preliminary analysis. Presented at: Fall Clinical Dermatology; October 18-21, 2007; Las Vegas, NV.

14 University of California Berkley. Antibiotic resistance: delaying the inevitable. https://evolution.berkeley.edu/evolibrary/article/0_0_0/medicine_03. Accessed on October 8, 2020.

15 Consumer Reports. The dangers of left over antibiotics. https://www.consumerreports.org/antibiotics/the-danger-of-leftover-antibiotics/. Accessed on October 8, 2020.

[*] 9-Month Study

[†] The safety and efficacy of ORACEA Capsules in the treatment of inflammatory lesions (papules and pustules) of rosacea was evaluated in two randomized, placebo-controlled, multi-centered, double-blind, 16-week Phase 3 trials involving 537 subjects (total of 269 subjects on ORACEA from the two trials) with rosacea (10 to 40 papules and pustules and two fewer nodules).1,5

Mean change in lesion count ORACEA Capsules vs Placebo : Study 1 -11.8 vs -5.9, Study 2 -9.5 vs -4.3

Most common adverse events (>2%) were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase.


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The Most Common Symptom of Uterine Fibroids? Heavy Menstrual Bleeding. Learn More About An Oral Treatment Option.

2020-11-18T10:01:00

(BPT) – Most women learn how to manage their periods beginning in their teenage years, often juggling work and school with an extra tampon or two on hand. However, for many women, managing a period often becomes a major burden due to symptoms stemming from uterine fibroids as they get into their 20s and 30s.1,2 Uterine fibroids, also known as leiomyomas, are the most common type of non-cancerous pelvic tumors in women affecting up to 80 percent of African American women and 70 percent of Caucasian women that can develop before the age of 50.3-6

For some, uterine fibroids can be completely asymptomatic, but approximately six million women in the U.S. are estimated to be suffering from symptoms due to uterine fibroids.1,7,8,9 The most common uterine fibroid symptom is excessive menstrual bleeding.4,5 Women who experience heavy menstrual bleeding commonly have to change their pads or tampons frequently and may experience blood loss that is two to three times greater, or more, than what is considered normal.3,10,11 Heavy bleeding is also the main reason women seek treatment, with 65 percent of patients with fibroids symptoms reporting they worry about bleeding accidents through their clothes or bedding.12

Each woman’s experience is unique, but the symptoms can interfere with her daily activities, relationships with family, friends and loved ones, and the ability to work.12 “I lived in constant fear of leakage,” said Julie B., a woman living with uterine fibroids. “I carried a towel with me and tried to plan trips around my heavy periods. I purchased several pairs of black pants, just in case.”

Traditionally, uterine fibroids are commonly managed through surgery and are one of the leading causes for hysterectomies in the U.S.3,6,13 However, women with heavy menstrual bleeding due to uterine fibroids now have a non-surgical option to consider. Earlier this year, the U.S. Food and Drug Administration (FDA) approved Oriahnn™ (elagolix, estradiol, and norethindrone acetate capsules; elagolix capsules). Oriahnn is the first and only FDA-approved oral medication specifically designed to treat heavy menstrual bleeding due to uterine fibroids.

Oriahnn was studied in two six-month clinical trials, including premenopausal women with heavy periods due to uterine fibroids aged 25-53. In clinical trials, Oriahnn was clinically proven to reduce heavy menstrual bleeding in women with uterine fibroids in the first month of use by at least 50 percent (six percent in placebo). By the third month of therapy, Oriahnn was able to reduce heavy bleeding due to uterine fibroids by more than 85 percent (10 percent in placebo). Ultimately, Oriahnn was proven to lighten heavy periods in about seven in ten women, compared to about one in ten women that took placebo. This finding was based on the number of women that saw both a bleeding volume reduction of 50 percent or more from the start of the clinical trial, and had an amount of 80 mL (about a third of one cup) or less by the final month of treatment. The most common adverse reactions (>5%) in clinical trials were hot flushes, headache, fatigue, and metrorrhagia.14,15

Please click to see the full prescribing information including medication guide.

For women exploring treatment who don’t want to undergo surgery, Oriahnn may be an option. “My doctor had recommended a hysterectomy because my periods were horrific, but that’s just not in my plans right now,” Julie B. said. “I’m glad there is a non-surgical option available.”

Women who have heavy menstrual bleeding associated with uterine fibroids and want to learn more about a non-surgical treatment option, can visit Oriahnn.com and talk to an OB/GYN to see if Oriahnn may be right for them.

USE

ORIAHNN™ (elagolix, estradiol, and norethindrone acetate capsules; elagolix capsules) is a prescription medicine used to control heavy menstrual bleeding related to uterine fibroids in women before menopause. It should not be taken for more than 24 months. It is not known if ORIAHNN is safe and effective in children under 18 years of age.

Important Safety Information

What is the most important information I should know about ORIAHNN?

ORIAHNN may cause serious side effects, including:

  • Cardiovascular Conditions
    • ORIAHNN may increase your chances of heart attack, stroke, or blood clots, especially if you are over 35 years of age and smoke, have uncontrolled high blood pressure, high cholesterol, diabetes, or are obese. Stop taking ORIAHNN and call your healthcare provider right away or go to the nearest hospital emergency room right away if you have:
      • Leg pain or swelling that will not go away
      • Sudden shortness of breath
      • Double vision, bulging of the eyes, or sudden blindness (partial or complete)
      • Pain or pressure in your chest, arm, or jaw
      • Sudden, severe headache unlike your usual headaches
      • Weakness or numbness in an arm or leg, or trouble speaking
  • Bone Loss (Decreased Bone Mineral Density [BMD])
    • While taking ORIAHNN, your estrogen levels may be low. Low estrogen levels can lead to BMD loss.
    • If you have bone loss on ORIAHNN, your BMD may improve after you stop taking ORIAHNN, but complete recovery may not occur. It is unknown if these BMD changes could increase your risk for broken bones as you age. For this reason, you should not take ORIAHNN for more than 24 months.
    • Your healthcare provider may order an X-ray test called a DXA scan to check your bone mineral density when you start taking ORIAHNN and periodically after you start.
    • Your doctor may advise you to take vitamin D and calcium supplements as part of a healthy lifestyle.
  • Effects on Pregnancy
    • Do not take ORIAHNN if you are pregnant or trying to become pregnant, as it may increase the risk of early pregnancy loss.
    • If you think you may be pregnant, stop taking ORIAHNN right away and call your HCP.
    • ORIAHNN can decrease your menstrual bleeding or result in no menstrual bleeding at all, making it hard to know if you are pregnant. Watch for other pregnancy signs like breast tenderness, weight gain, and nausea.
    • ORIAHNN does not prevent pregnancy. You will need to use effective methods of birth control while taking ORIAHNN and for 1 week after you stop taking ORIAHNN. Examples of effective methods can include condoms or spermicide, which do not contain hormones.
    • Talk to your HCP about which birth control to use during treatment with ORIAHNN. Your HCP may change the birth control you are on before you start taking ORIAHNN.

Do not take ORIAHNN if you:

  • Have or have had:
    • A stroke or heart attack
    • A problem that makes your blood clot more than normal
    • Blood circulation disorder
    • Certain heart valve problems or heart rhythm abnormalities that can cause blood clots to form in the heart
    • Blood clots in your legs (deep vein thrombosis), lungs (pulmonary embolism), or eyes (retinal thrombosis)
    • High blood pressure not well controlled by medicine
    • Diabetes with kidney, eye, nerve, or blood vessel damage
    • Certain kinds of headaches with numbness, weakness, or changes in vision, or have migraine headaches with aura if you are over age 35
    • Breast cancer or any cancer that is sensitive to female hormones
    • Osteoporosis
    • Unexplained vaginal bleeding that has not been diagnosed
    • Liver problems including liver disease
  • Smoke and are over 35 years old
  • Are taking medicines known as strong OATP1B1 inhibitors that are known or expected to significantly increase the blood levels of elagolix. Ask your HCP if you are not sure if you are taking this type of medicine.
  • Have had a serious allergic reaction to elagolix, estradiol, norethindrone acetate, or any of the ingredients in ORIAHNN. Ask your HCP if you are not sure.
  • FD&C Yellow No. 5 (tartrazine) is an ingredient in ORIAHNN, which may cause an allergic type reaction such as bronchial asthma in some patients who are also allergic to aspirin.

What should I discuss with my HCP before taking ORIAHNN?

Tell your HCP about all your medical conditions, including if you:

  • Have or have had:
    • Broken bones or other conditions that may cause bone problems
    • Depression, mood swings, or suicidal thoughts or behavior
    • Yellowing of the skin or eyes (jaundice) or jaundice caused by pregnancy (cholestasis of pregnancy)
  • Are scheduled for surgery. ORIAHNN may increase your risk of blood clots after surgery. Your doctor may advise you to stop taking ORIAHNN before you have surgery. If this happens, talk to your HCP about when to restart ORIAHNN after surgery.
  • Are pregnant or think you may be pregnant.
  • Are breastfeeding. It is not known if ORIAHNN can pass into your breastmilk. Talk to your HCP about the best way to feed your baby if you take ORIAHNN.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Women on thyroid or cortisol replacement therapy may need increased doses of the hormone.

Keep a list of your medicines with you to show to your HCP and pharmacist when you get a new medicine.

What should I avoid while taking ORIAHNN?

  • Avoid grapefruit and grapefruit juice during treatment with ORIAHNN since they may affect the level of ORIAHNN in your blood, which may increase side effects.

What are the possible side effects of ORIAHNN?

ORIAHNN can cause additional serious side effects, including:

  • Suicidal thoughts, suicidal behavior, and worsening of mood. ORIAHNN may cause suicidal thoughts or actions. Call your HCP or get emergency medical help right away if you have any of these symptoms, especially if they are new, worse, or bother you: thoughts about suicide or dying, attempts to commit suicide, new or worse depression or anxiety, or other unusual changes in behavior or mood. Pay attention to any changes, especially sudden changes, in your mood, behaviors, thoughts, or feelings.
  • Abnormal liver tests. Call your HCP right away if you have any of these signs and symptoms of liver problems: jaundice, dark amber-colored urine, feeling tired, nausea and vomiting, generalized swelling, right upper stomach area pain, or bruising easily.
  • High blood pressure. You should see your HCP to check your blood pressure regularly.
  • Gallbladder problems (cholestasis), especially if you had cholestasis of pregnancy.
  • Increases in blood sugar, cholesterol, and fat (triglyceride) levels.
  • Hair loss (alopecia). Hair loss and hair thinning can happen while taking ORIAHNN, and it can continue even after you stop taking ORIAHNN. It is not known if this hair loss or hair thinning is reversible. Talk to your HCP if this is a concern for you.
  • Changes in laboratory tests, including thyroid and other hormone, cholesterol, and blood clotting tests.

The most common side effects of ORIAHNN include: hot flashes, headache, fatigue, and irregular periods.

These are not all of the possible side effects of ORIAHNN. Tell your HCP if you have any side effect that bothers you or that does not go away. Call your HCP for medical advice about side effects.

Take ORIAHNN exactly as your HCP tells you. The recommended oral dosage of ORIAHNN is one yellow/white capsule in the morning and one blue/white capsule in the evening, with or without food.

This is the most important information to know about ORIAHNN. For more information, talk to your doctor or HCP.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.

Please click to see the full prescribing information including medication guide.

References

  1. Fuldeore MJ, Soliman AM. Patient-reported prevalence and symptomatic burden of uterine fibroids among women in the United States: findings from a cross-sectional survey analysis. Int J Womens Health. 2017;9:403-411.
  2. Zimmermann A, Bernuit D, Gerlinger C, Schaefers M, Geppert K. Prevalence, symptoms and management of uterine fibroids: an international internet-based survey of 21,746 women. BMC Womens Health. 2012;12:6. doi: 10.1186/1472-6874-12-6.
  3. U.S. Department of Health and Human Services: WomensHealth.gov. Uterine Fibroids. https://www.womenshealth.gov/a-z-topics/uterine-fibroids. Accessed July 21, 2020.
  4. Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2013;188:100-107.
  5. Wallach EE, Vlahos NF. Uterine myomas: an overview of development, clinical features, and management. Obstet Gynecol. 2004;104:393–406.
  6. De La Cruz MS, Buchanan EM. Uterine Fibroids: Diagnosis and Treatment. Am Fam Physician. 2017;95(2):100-107.
  7. United States Census Bureau website. American Community Survey (ACS) 2017 1-Year Estimates Subject Tables.
  8. ACOG. Uterine Fibroids. https://www.acog.org/womens-health/faqs/uterine-fibroids. Accessed September 2020.
  9. Donnez J, Dolmans MM. Uterine fibroid management: from the present to the future. Hum Reprod Update. 2016;22(6):665-686.
  10. Bulun S. Physiology and pathology of the female reproductive axis. Williams Textbook. Chapter 17;590-663.
  11. Apgar BS, Kaufman AH, George-Nwogu U, Kittendorf A. Treatment of menorrhagia. Am Fam Physician. 2007 Jun 15;75(12):1813-9.
  12. Borah BJ, Nicholson WK, Bradley L, Stewart EA. The impact of uterine leiomyomas: a national survey of affected women. Am J Obstet Gynecol. 2013;209(4): 319.e1–319.e20.
  13. American College of Obstetricians and Gynecologists. ACOG practice bulletin. Alternatives to hysterectomy in the management of leiomyomas. Obstet Gynecol. 2008 Aug;112(2 Pt 1):387-400.
  14. Schlaff WD, Ackerman RT, Al-Hendy A, et al. Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids. N Engl J Med. 2020;382(4):328-340.
  15. ORIAHNN™ (elagolix, estradiol and norethindrone acetate capsules co-formulated) [Package Insert]. North Chicago, Ill.: AbbVie Inc.


Posted on

Clinical trials advance science for patients with melanoma

2020-11-18T15:01:02

(BPT) – Your skin is the largest organ of your body. And, like other parts of the body, it can get cancer. Melanoma is a rare form of skin cancer, and if caught early is often treatable. When it spreads to other parts of the body, the cancer is advanced – stage III or IV. Advanced stages of melanoma are harder to treat.

Cancers like melanoma can be caused by mutations, or changes, in the DNA of skin cells. In melanoma, these mutations can happen randomly or through ongoing exposure to the sun and UV rays. When this type of damage happens, it can lead to uncontrolled cell growth and may cause cancer cells to spread. One of the most common changes in melanoma cells that increase tumor cell growth is a BRAF mutation. Approximately one in two people diagnosed with melanoma have a BRAF mutation in their tumor cells.

Researchers are working to better understand the role of mutations like BRAF in melanoma. When people with melanoma participate in research and clinical trials, it helps to advance the science. Scientific advancements have led to more treatment options for people living with stage III and IV melanoma.

Read the Q&A below to learn more about this type of melanoma and important information to consider when you discuss with your doctor, including safety and potential long-term benefits shown in a clinical trial of a targeted therapy to treat stage III melanoma after surgery.

Q: How many people get melanoma and what role do gene alterations play in melanoma?

A: Approximately 100,000 adults in the United States will be diagnosed with melanoma in 2020 and approximately 6,850 people will die from the disease. Melanoma is a complex disease; changes or alterations to the genes play a role in its progression. Approximately one in two people diagnosed with melanoma have a BRAF mutation in their tumors, which is a specific change in the BRAF gene that may lead to the growth and spread of cancer cells. Biomarker testing can determine whether a tumor has a BRAF mutation.

Q: Why is biomarker testing and knowing your BRAF status so important for melanoma?

A: One of the most important things people diagnosed with melanoma can do is speak to their doctor about getting a biomarker test. The biomarker test helps people learn their BRAF mutation status. When the doctor and the patient know the BRAF mutation status, it helps identify all possible treatment options and may help make an informed treatment plan. People with a BRAF mutation may be candidates for therapies that target the mutation.

For example, one Phase III study that included patients with BRAF+, stage III melanoma showed the benefits of taking Tafinlar® (dabrafenib) plus Mekinist® (trametinib) for one year after having surgery to remove melanoma. At first analysis of this data, the results showed that the combination of Tafinlar plus Mekinist reduced the risk of relapse or death by 53% compared to placebo.

Later on, during an updated analysis, at five years, an estimated 52% of patients treated with Tafinlar plus Mekinist were alive without their cancer coming back compared to 36% of those who were treated with two placebo (pills with no active medication). During this update, it showed that there was a 49% reduction in risk of relapse or death.

Q: What do clinical experts say about a treatment for BRAF-mutated melanoma following surgery?

A: Researchers recently announced results from the COMBI-AD study published in the New England Journal of Medicine in September 2020. The 5-year results showed treatment with Tafinlar® (dabrafenib) plus Mekinist® (trametinib) for one year after surgery for BRAF+ stage III melanoma may result in relapse-free survival for some patients. An estimated 52% of patients treated with Tafinlar plus Mekinist were alive without their cancer coming back compared to 36% of those who were treated with two placebo (pills with no active medication). Information about side effects, some of which can be severe, for Tafinlar plus Mekinist are included at the end of this article.

Q: What does the COMBI-AD study mean for patients with stage III melanoma?

A: Some patients who have their melanoma removed by surgery still face the potential risk of their cancer coming back. Patients who have BRAF-positive stage III melanoma may be at a higher risk of their cancer coming back.

The findings from COMBI-AD support the important role a targeted therapy like Tafinlar plus Mekinist may play after surgery.

Q: What should people know about the safety results of the COMBI-AD study?

A: The COMBI-AD study helped researchers and physicians understand the side effects seen with treatment with Tafinlar plus Mekinist. Tafinlar plus Mekinist, in combination, may cause serious side effects. As part of informed treatment decision-making, patients and their physicians should review and discuss medication risks and benefits.

Some of the side effects can be severe and lead to death. Some of the side effects can cause patients to pause or completely stop taking their treatment. Patients should immediately talk to their doctor or healthcare provider if they experience any side effect. Please review the Important Safety Information towards the end of this article and visit us.tafinlarmekinist.com for the full Prescribing Information for Tafinlar and the full Prescribing Information for Mekinist.

Q: What can people do to try to prevent melanoma?

A: There are simple things you can do each day to help protect your skin. Here are a few:

  • Wear protective clothing
  • Apply broad-spectrum sunscreen SPF 15 or higher
  • Avoid indoor or outdoor tanning
  • Do a monthly skin self-examination
  • Speak with your doctor about unusual marks or spots on the skin

Q: Where to go for more information?

A: Visit these web sites for additional information on melanoma, treatment and protecting the skin you’re in:

What is Tafinlar + Mekinist
Tafinlar and Mekinist are prescription medicines that can be used in combination to treat people with a type of skin cancer called melanoma:

  • That has spread to other parts of the body (metastatic) or cannot be removed by surgery (unresectable), and
  • That has a certain type of abnormal “BRAF” (V600E or V600K mutation-positive) gene

Tafinlar and Mekinist are prescription medicines that can be used in combination to help prevent melanoma that has a certain type of abnormal “BRAF” gene from coming back after the cancer has been removed by surgery.

Tafinlar and Mekinist are prescription medications that can be used in combination to treat a type of lung cancer called non-small cell lung cancer (NSCLC) that has spread to other parts of the body (metastatic NSCLC), and that has a certain type of abnormal “BRAF V600E” gene.

Tafinlar and Mekinist are prescription medications that can be used in combination to treat a type of thyroid cancer called anaplastic thyroid cancer (ATC):

  • That has spread to other parts of the body and you have no satisfactory treatment options, and
  • That has a certain type of abnormal “BRAF” gene

Tafinlar, in combination with Mekinist, should not be used to treat people with wild-type BRAF melanoma. Mekinist should not be used to treat people who already have received a BRAF inhibitor for treatment of their melanoma and it did not work or is no longer working.

Your health care provider will perform a test to make sure that Tafinlar and Mekinist, in combination, are right for you.

It is not known if Tafinlar and Mekinist are safe and effective in children.

Important Safety Information

Tafinlar and Mekinist, in combination, may cause serious side effects such as the risk of new cancers, including both skin cancer and nonskin cancer. Patients should be advised to contact their health care provider immediately for any skin changes, including a new wart, skin sore, or bump that bleeds or does not heal, or a change in the size or color of a mole.

When Tafinlar is used in combination with Mekinist, it can cause serious bleeding problems, especially in the brain or stomach, that can lead to death. Patients should be advised to call their health care provider and get medical help right away if they have any signs of bleeding, including headaches, dizziness, or feel weak, cough up blood or blood clots, vomit blood or their vomit looks like “coffee grounds,” or red or black stools that look like tar.

Mekinist, alone or in combination with Tafinlar, can cause inflammation of the intestines or tears in the stomach or intestines that can lead to death. Patients should report to their health care provider immediately if they have any of the following symptoms: bleeding, diarrhea (loose stools) or more bowel movements than usual, stomach-area (abdomen) pain or tenderness, fever, or nausea.

Tafinlar, in combination with Mekinist, can cause blood clots in the arms or legs, which can travel to the lungs and can lead to death. Patients should be advised to get medical help right away if they have the following symptoms: chest pain, sudden shortness of breath or trouble breathing, pain in their legs with or without swelling, swelling in their arms or legs, or a cool or pale arm or leg.

The combination of Tafinlar and Mekinist can cause heart problems, including heart failure. A patient’s heart function should be checked before and during treatment. Patients should be advised to call their health care provider right away if they have any of the following signs and symptoms of a heart problem: feeling like their heart is pounding or racing, shortness of breath, swelling of their ankles and feet, or feeling lightheaded.

Tafinlar, in combination with Mekinist, can cause severe eye problems that can lead to blindness. Patients should be advised to call their health care provider right away if they get: blurred vision, loss of vision, or other vision changes, seeing color dots, halo (seeing blurred outline around objects), eye pain, swelling, or redness.

Tafinlar, in combination with Mekinist, can cause lung or breathing problems. Patients should be advised to tell their health care provider if they have new or worsening symptoms of lung or breathing problems, including shortness of breath or cough.

Fever is common during treatment with Tafinlar in combination with Mekinist, but may also be serious. In some cases, chills or shaking chills, too much fluid loss (dehydration), low blood pressure, dizziness, or kidney problems may happen with the fever. Patients should be advised to call their health care provider right away if they get a fever.

Rash and other skin reactions are common side effects of Tafinlar in combination with Mekinist. In some cases, these rashes and other skin reactions can be severe or serious, may need to be treated in a hospital, or lead to death. Patients should be advised to call their health care provider if they get any of the following symptoms: blisters or peeling of skin, mouth sores, blisters on the lips or around the mouth or eyes, high fever or flu-like symptoms, and/or enlarged lymph nodes.

Some people may develop high blood sugar or worsening diabetes during treatment with Tafinlar in combination with Mekinist. For patients who are diabetic, their health care provider should check their blood sugar levels closely during treatment. Their diabetes medicine may need to be changed. Patients should be advised to tell their health care provider if they have increased thirst, urinate more often than normal, or produce an increased amount of urine.

Tafinlar may cause healthy red blood cells to break down too early in people with glucose-6-phosphate dehydrogenase deficiency. This may lead to a type of anemia called hemolytic anemia, where the body does not have enough healthy red blood cells. Patients should be advised to tell their health care provider if they have yellow skin (jaundice), weakness or dizziness, or shortness of breath.

Tafinlar, in combination with Mekinist, can cause new or worsening high blood pressure (hypertension). A patient’s blood pressure should be checked during treatment. Patients should be advised to tell their health care provider if they develop high blood pressure, their blood pressure worsens, or if they have severe headache, lightheadedness, blurry vision, or dizziness.

Men (including those who have had a vasectomy) should use condoms during sexual intercourse during treatment with Tafinlar and Mekinist and for at least 4 months after the last dose of Tafinlar and Mekinist. For women of reproductive potential, Tafinlar and Mekinist, in combination, may harm your unborn baby. Use effective birth control (contraception) during treatment with Tafinlar and Mekinist in combination, and for 4 months after stopping treatment with Tafinlar and Mekinist. The most common side effects for patients with metastatic melanoma are: pyrexia, nausea, rash, chills, diarrhea, headache, vomiting, hypertension, arthralgia, peripheral edema, and cough. The most common side effects for patients with stage III melanoma receiving the combination as adjuvant therapy are: pyrexia, fatigue, nausea, headache, rash, chills, diarrhea, vomiting, arthralgia, and myalgia. The most common side effects for patients with NSCLC: pyrexia, fatigue, nausea, vomiting, diarrhea, dry skin, decreased appetite, edema, rash, chills, hemorrhage, cough, and dyspnea.

Please see full Prescribing Information for Tafinlar at https://www.novartis.us/sites/www.novartis.us/files/tafinlar.pdf and Mekinist at https://www.novartis.us/sites/www.novartis.us/files/mekinist.pdf.

This content is sponsored by Novartis.


Posted on

Green Christmas: 7 great gift ideas for your lawn and garden enthusiast

2020-11-18T09:01:00

(BPT) – As people are sheltering in the comfort of their homes, many are spending more time in their yards, gardens and other outdoor spaces. And as a result, they’re putting more time and energy into turning those areas into well-tended natural retreats.

Not surprisingly, they’re also spending money on quality tools and machinery that will help them accomplish their goals — and make the work more enjoyable.

As a result, yard and garden tools are expected to be a hugely popular category for holiday gifts this season.

Do you know a backyard warrior who would appreciate effective and efficient outdoor power equipment? Consider choosing from this holiday gift guide that features top-selling tools from Husqvarna, the world’s largest manufacturer of outdoor power equipment products.

Robotic mowers

On Black Friday, the maker offers the astounding sale price of $699 (a savings of $500) for its Automower® 115H, a weather-resistant machine that uses smart technology to automatically cut grass in yards of up to .4 acres in size. It powers through even when faced with obstacles, slopes or tight spaces, making it the ideal solution for those who love an immaculate lawn but want to have their time back to focus on family, friends or other endeavors. Bonus? Controls are intuitive and can be adjusted via smartphone for even more convenience.

Comfortable work wear

Husqvarna’s new line of premium apparel known as the Xplorer collection optimizes well-chosen materials to provide your gift recipient comfort, fit and functionality while working outside. Options include shirts, hats, backpacks and water bottles.

Effective safety gear

Using power equipment always comes with risk, which is why Husqvarna has developed a line of safety gear and personal protection equipment that would make a great gift for any backyard warrior. The impressive span of products includes gloves, helmets, boots, braces, moisture-wicking work shirts, eye and hearing protection and chainsaw-protective clothing.

Battery-powered, low-emission tools

Depending on where your recipient lives, he/she may be concerned about making too much noise with power tools — or potentially polluting the environment through emissions. Fortunately, Husqvarna offers a full line of battery-powered tools ranging from weed trimmers to chainsaws to blowers and hedge trimmers. Not only are they maintenance- and emissions-free, but they’re more comfortable to operate because they create fewer vibrations. Plus, Husqvarna’s battery was created to fit in all battery-powered tools, so you can switch products with ease.

Hatchets and axes

Choose from a plethora of timber-cutting tools, saws, pruners, tongs and drag hooks constructed with classic Husqvarna quality, then create delight by tucking them under your tree or into a loved one’s stocking.

A powerful snowblower

For those coping with snow and ice, Husqvarna’s snowblowers get the job done by grinding down hard-packed snow before it’s fed in and discharged. Their cast iron gear boxes and impellers are backed up by 10-Year Limited Warranties for years of trouble-free operation.

A range of other labor-reducing machines

Still seeking ideas for the yard aficionado who may already have everything? Check out the company’s extensive lines of leaf blowers, string trimmers and other high-quality lawnmowers, including zero-turn models that offer precision steering and unmatched maneuverability.

The holiday season is an excellent time to show your loved ones you care through gifts designed to make their lives easier. Consider giving practical yard and garden equipment that will be used and appreciated all through the year.


Posted on

Hypertrophic Cardiomyopathy: Know the Signs in Your Family Tree

2020-11-17T19:01:00

(BPT) – Imagine your family members were at risk for a life-threatening heart disease but had absolutely no idea.

At age 12, Carmen’s doctor noticed a heart murmur, but could not find an explanation. Little did they realize, but this symptom would turn out to be one piece in his family’s larger heart disease puzzle.

Beginning in 1982, several of his family members passed away unexpectedly with no identified cause. The first family member was Carmen’s maternal aunt, who passed away at the age of 50. In 1998, over 15 years after the first sudden death, Carmen’s cousin died at the age of 53 while out on a run, and the family finally discovered the cause: hypertrophic cardiomyopathy (HCM). HCM is a progressive cardiovascular disease that affects the structure and function of the heart and is often hereditary. People with HCM can suffer debilitating symptoms, like being short of breath, passing out, chest pain and a decreased ability to exercise, all of which can interfere with daily life. HCM can also lead to stroke, heart failure or — as had happened to Carmen’s aunt and cousin — sudden cardiac death.

After abruptly blacking out while at work one day, Carmen realized that his symptoms could be signs of HCM. He underwent genetic testing and was diagnosed with HCM in 2006. Since then, he’s had to give up his pizza shop and stop flying radio-controlled aircraft due to his worsening symptoms and the risk of passing out.

“The doctors told me I could no longer drive, or even ride a bike, for that matter,” Carmen said. “And although everything seems OK from the outside, I don’t always feel like myself on the inside.” In the years since his diagnosis, Carmen has become an advocate within his large extended family, connecting multiple generations to encourage testing and share disease information.

Recognizing HCM signs and symptoms

HCM is the most common inherited heart disease. It is estimated to affect approximately one in 500 adults in the United States.

Signs and symptoms of HCM include:

  • Chest pain, commonly experienced during physical exertion
  • Arrhythmias (irregular heartbeat)
  • Shortness of breath
  • Palpitations
  • Fatigue & lightheadedness
  • Dizzy spells & fainting

Identifying early symptoms and receiving a diagnosis are crucial in managing HCM and implementing strategies to reduce risks associated with long-term complications. Many patients are prescribed heart failure medications to address certain symptoms. As HCM progresses, patients may need procedures, such as surgically implanted devices or open-heart surgery. For some, heart transplants may be the only viable option. Currently, there is no therapy available to treat the underlying cause of HCM, but there is increasing research in the field.

Talking to family about your genetic risk

Experts say that it’s not unusual that families aren’t aware they could be at risk for HCM until after a relative passes away. It is estimated that as many as 85% of individuals with HCM remain undiagnosed because many of the most common symptoms, such as shortness of breath and fatigue, overlap with other conditions.

It is important to talk to family about your genetic risks. With loved ones planning to gather in-person or connect virtually this holiday season, make time to discuss your family’s shared medical history. Specific questions to ask could include:

  • Is there a history of chronic diseases, such as heart disease, or health conditions in our family?
  • How old were individual family members when their chronic diseases or health conditions were diagnosed?
  • For relatives who have died, what was the cause and age of death?

Share this information with your healthcare provider to explore your risk factors for disease. In Carmen’s case, after his family’s risk for HCM was discovered, his cardiologist was integral in finding ways to manage the disease, as well as identifying extended family members also at risk. Today, Carmen is grateful to have been diagnosed, and grateful that the increased connections with his extended family have helped him raise awareness of HCM risks and the importance of seeking diagnosis and treatment.

Knowing your medical history and whether you’re experiencing common signs and symptoms of HCM is an important first step of receiving care. For more information on HCM, please visit the American Heart Association.

This article is sponsored by MyoKardia, Inc.