How to show your appliances some extra love this spring

2021-03-30T08:05:00

(BPT) – This past year we’ve all made a few changes to our daily lives, but one thing has remained constant — your appliances. It’s easy to forget these machines are working hard in the background, but they’re always helping to keep your household running smoothly. In the spirit of spring cleaning, let’s give some extra love to our dedicated appliances, so they can keep performing at their best. Here are spring cleaning must-dos from Maytag appliance experts.

Deep cleaning for a fresh start
Deep cleaning your appliances may not be top of mind, but it’s important for them to have a good, thorough cleaning to keep everything looking like new.

  • Refrigerators will benefit from regular cleaning every three months, inside and out. This helps maximize storage while maintaining a fresh environment for your groceries. Make sure to wipe down all surfaces and skip the harsh chemicals. Try white vinegar and baking soda to keep out unwanted chemical smells. Finish off by wiping the outside with soap and water or with a special cleaner like affresh Stainless Steel Cleaning Spray.
  • A dirty oven not only looks bad but can cause unpleasant smells in the kitchen. Clean every part of your oven by removing all racks and soaking in hot, soapy water to remove any leftover food and grease. Next create a spreadable paste of baking soda and water and cover the entire inside cavity. After 20 minutes, spray with lemon juice or vinegar and wipe with a damp cloth until clean. Maytag cleaning experts actually advise against chemical oven cleaners, as these products contain harsh chemicals and release fumes that can linger in your oven long after cleaning is done.
  • Clean clothes require having a clean washer. Follow these four easy steps every 30 washes to help keep your washing machine clean. Clean the tub, clean the dispensers, clean in and around the door and lastly clean the outside.
  • Dryers produce a lot of lint, and without proper cleaning can become a fire hazard due to reduced airflow and overheating. Clean the lint screen after every use and the vent screen at least every two years.

Organizing for a less stressful tomorrow

Did you know there’s a science to storing food in your fridge? Not only will your food stay fresh, but you will stay more organized and could even save some money. Here are the basics:

  • Door storage should be reserved for less perishable items such as condiments and soda.
  • Shelves are great for every day, non-produce items. Group similar foods together to eliminate the need for searching.
  • Deli drawers have slightly colder temperatures than the rest of the fridge making it ideal for meats and cheeses.
  • High humidity crisper drawers help thin skin produce like spinach and citrus fruits stay fresh, while low humidity crisper drawers are great for thick skin produce such as peppers and avocados.

Replacing parts for optimal performance

  • Many refrigerators have water filling stations, and the filter should be changed every six months. There is a quick way to replace your water filter in under five minutes. Once replaced, you can enjoy clean, fresh-tasting water.
  • If dishes begin to have grit and grime after they’re cleaned, this can indicate that your dishwasher filter needs a cleaning. On select dishwashers, locate the filter at the bottom of the dishwasher. Remove it by turning it counterclockwise and pulling up. Rinse out the filter under the faucet to remove most soils and debris, and once clean, reinstall.
  • A well-lit oven is essential for efficiently tracking the progress of dishes. You can change your oven light in five easy steps.

Whether you’re a seasoned homeowner or still figuring out how to adult, spring cleaning is a great time to give back to your home and appliances. For more expert tips and tricks to keep your appliances running and looking their best, visit the Maytag Info Hub at maytag.com/blog.

Create a fulfilling long-term career with hourly work opportunities

2021-03-30T05:01:01

(BPT) – With millions of Americans looking for employment, and the population now balancing different roles at home such as an employee, parent or caregiver, teacher and more, there is an increasing need for more jobs with flexible work schedules. Many are taking an opportunity to learn about the benefits of hourly employment. Not only do hourly positions offer flexibility, they also can set many up for a successful and productive career down the line.

Did you know that 90% of The Home Depot’s store leaders began their careers as hourly associates? When searching for hourly employment opportunities that could lead to a long-lasting career, it helps to choose a workplace with a good track record of providing a positive employee experience. The company, known for offering competitive benefits and opportunities to both empower and challenge employees, made both the top 100 on Comparably.com’s list of Happiest Employees 2020, and was also named in Forbes’ 2020 “Best Employers for Diversity” list. The list of advantages to these types of hourly jobs does not stop there.

Variety of positions

Whether you’re looking for part-time or full-time employment, employers offering a variety of positions across different departments are worth exploring, to both challenge and amplify personal passions or skill sets.

The Home Depot, for instance, offers a wide range of positions, both in-stores and in distribution centers. These positions focus on everything from customer service in-store, fulfilling online orders to be picked up by customers or unpacking overnight freight and merchandising. Distribution center roles involve replenishing store inventory, placing and shipping orders. Across all positions, many opportunities are available to play to different employees’ capabilities and strengths.

Safety at work

The Home Depot puts the safety and well-being of its associates and customers at the forefront of everything they do, while continuing to serve communities with the products they need. Over the past year, the company has implemented additional safety measures, both in their stores and distribution centers. With these new safety measures, the expansion of associate benefits has also increased, including:

  • Daily health checks for associates.
  • Requiring all associates and customers to wear non-medical face masks in stores and at their facilities and providing non-medical face coverings to all associates.
  • Enhancing cleaning measures throughout all stores and facilities.
  • Promoting social and physical distancing practices in stores by marking floors, adding signage and offering plexiglass shields between associates and customers.
  • Preparing for a safe spring selling season by widening aisles for easier social distancing and providing a variety of convenient shipping and pickup options for customers.

Meaningful core values

Aligning with a company’s core values when job searching is an important part of the application process. One of The Home Depot’s biggest core values is taking care of its people. Last year, the company invested approximately $2 billion in enhanced compensation and benefits for associates, including offering emergency sick time and paid time off for all frontline associates. The company also transitioned from temporary to now permanent COVID-19 benefits and compensation enhancements for frontline hourly associates.

Other top benefits offered by The Home Depot include:

  • On-the-job training and development opportunities
  • Back-up care for dependents
  • Tuition assistance available from the first day
  • Flexible schedules to fit associates’ unique life needs and shorter commutes, thanks to their wide footprint of over 2,000 stores and distribution centers across the U.S.
  • A “Take Care of You” program, which helps associates stay balanced and healthy, with resources like at-home workouts, meditations and more
  • Celebrate professional successes through the “Success Sharing” program — a financial reward program for associates when the company has a successful performance each half of the year

Interested in learning more about open roles within The Home Depot? Visit Careers.homedepot.com/hiring today, or apply by texting “JOBS” to 52270.

Clinical trials lead to better treatments for rare diseases

2021-03-29T17:25:00

(BPT) – People living with rare diseases often find themselves with more questions than answers when it comes to diagnosis and treatment. Symptoms can be unclear, making misdiagnoses common. This is often the case for people living with WHIM syndrome—a rare and difficult-to-diagnose disorder in which the body’s immune system does not function properly. Most people with WHIM syndrome are initially misdiagnosed, and if you don’t have the right diagnosis, you can’t find the right treatment.

As researchers and scientists make strides in discovering new genetic mutations behind certain diseases, diagnoses are getting more accurate and treatments more personalized. A personalized treatment means that doctors can move away from giving the same medicine to everyone and instead provide the right medicine at the right dose at the right time to each individual patient. But according to the National Institutes of Health, the fact remains that more than 90 percent of the approximately 7,000 rare diseases still do not have approved treatments.

Genetic testing and clinical trials (research studies) help researchers and scientists drive progress forward. For some people, a genetic test may simply be a matter of curiosity, the results of which will not alter their life. For people living with a rare disease, genetic testing can provide answers that shift the course of their treatment and help determine what clinical trials may be available for them.

Clinical trials help researchers find new treatments and get them approved. Researchers are looking into potential new treatments through clinical trials, including the 4WHIM clinical trial, which is now enrolling people living with WHIM syndrome.

The 4WHIM trial will help researchers:

  • Learn more about the effectiveness of an investigational medication called mavorixafor for people with WHIM syndrome.
  • Find out if mavorixafor can treat neutropenia, a condition caused by low levels of certain white blood cells. Neutropenia is common in people living with WHIM syndrome, making it hard for them to fight off infection.
  • Gather information needed to get a potential new treatment approved by the FDA.

Who Is Eligible to Join the 4WHIM Clinical Trial?

Individuals who:

  • Are over 12 years old
  • Have a diagnosis of WHIM syndrome
  • Have a low neutrophil count, and
  • Meet other requirements, which your doctor can explain

“If you are living with severe neutropenia, make sure to talk to your physician about getting genetic testing to see if the 4WHIM Clinical Trial is an option for you,” says Frank Firkin, MD, PhD, University of Melbourne Department of Medicine, St Vincent’s Hospital, Melbourne, Australia.

There is no cost to join the 4WHIM clinical study. The 4WHIM Trial is being conducted at multiple medical centers around the world. You do not need to live near a study site to participate in the 4WHIM Trial. For some study participants, visits can occur at home through video calls and home visits. If you need to travel to a study site, the study sponsor, X4 Pharmaceuticals, will pay for travel and lodging. To learn more, visit the study website at 4WHIM.com.

Virtual is here to stay: 5 creative ways people are connecting in a digital world

2021-03-29T23:01:00

(BPT) – A year into the pandemic and a virtual lifestyle is the reality for many people. Remote work and online education are just the start — many people have taken a virtual approach to the way they shop, socialize, stay connected with friends and family, and much more. The interesting thing is that research shows this shift is here to stay.

“Working remotely has accelerated the use of video meeting platforms that keep us connected, whether that’s through a computer, mobile device or — as we ease back to offices — conference room system,” says John Knightly, chief marketing officer for BlueJeans by Verizon. “What’s interesting is our research shows that these platforms are being used for personal reasons more frequently than ever before. People are handling personal to-do’s and connecting with friends and family virtually, which signals that video communications platforms have become commonplace in everyday life.”

Knightly says the findings from a recent survey from BlueJeans by Verizon demonstrates that people are connecting via videoconferencing for a variety of reasons, both personal and professional.* BlueJeans is a meetings and events platform that empowers organizations with secure video collaboration for a work-from-anywhere world.

How are people using video connections in their personal lives to stay connected in meaningful ways? Here are the top findings:

Sharing festive meals virtually

Nearly half of all respondents (45.11%) said they would celebrate family meals virtually for everyday events like sporting events, as well as holidays, like Passover and Easter. Whether it’s cooking a formal meal and enjoying it together via video chat or making favorite stadium snacks and watching the game together digitally, this trend is growing.

Attending religious services virtually

The survey found nearly one-third (31.69%) of people would consider attending religious services together. This helps keep people safe because large groups are not gathering together indoors. Many will continue to participate in religious services together using video conferencing platforms, like BlueJeans and others online, for upcoming holidays.

Virtual shopping with friends and family

People who enjoy shopping together are finding new ways to shop from the safety and comfort of their homes. When it comes to shopping habits, nearly one-third (31.29%) of people would consider gathering with friends and family for virtual shopping gatherings, while more than half were seeking to purchase household goods (52.62%) and the others clothing (50.25%).

Family gatherings and gaming virtually

Nearly one-third (31.29%) would consider gathering with friends and family for virtual get-togethers and many others (35.74%) would participate in trivia games virtually with friends and family. Pick a date for an upcoming weekend, send invites to your friends and family, and get ready to make memories with an awesome virtual game night gathering.

Looking ahead to the future of virtual life

According to the study, half of people (50.25%) would consider attending virtual concerts and entertainment via videoconferencing, like BlueJeans, while more than one-third (37.31%) would take up virtual cooking, wine tastings or craft classes in 2021. Another 20% expressed interest in adding an interactive virtual component to their “watch parties” for live broadcasts like sporting events. Whether it’s enjoying a favorite hobby, a get-together with friends or a date night in, virtual possibilities are plentiful in the future.

No matter what you plan to do to stay connected, you need a video meeting platform that is flexible and reliable. Thousands of companies from growing businesses to Fortune 500 leaders use BlueJeans every day for video meetings and interactive virtual events, so people can work productively where and how they want. For more information, visit www.bluejeans.com.

* The survey was conducted the week of Nov. 20, 2020, by BizRate Insights with a total of 1,013 recipients ranging in age from 18-65+ (350/663 Male/Female).

A special seat at the table: Honoring and supporting military children

2021-03-29T11:01:00

(BPT) – Bravery in the face of adversity. Resiliency during unforeseen challenges. Growing wherever you are planted. These are traits of the servicemembers who protect our country every day, but the same patience and optimism take root in the children of our military members. Through every hasty relocation and birthday phone call to a faraway parent, military children persevere during challenges that may be completely unfamiliar to their peers. Every April, during the Month of the Military Child, we show our support for military children and reflect on the sacrifices they continually must make.

The American Legion Auxiliary (ALA) is an organization made up of male and female spouses, grandmothers, mothers, sisters, and direct and adopted female descendants of members of The American Legion. Some are veterans themselves. One special way the ALA celebrates the Month of the Military Child is with the Military Child’s Table Setting Ceremony. Junior members of the ALA and younger Sons of The American Legion participate in this event to honor the resilience of their friends and classmates who have parents in the military.

Inspired by the POW/MIA remembrance table ceremony, the Military Child’s Table Setting Ceremony includes:

  • A potted plant to symbolize that a military child can flourish where they are planted
  • A hand spade to recognize that military children may be relocated at a moment’s notice
  • A collection of childhood keepsakes like a birthday hat and unlit candles, a baseball and glove and ballet slippers to represent special occasions that a servicemember may miss in their child’s life
  • A family photo shows the child with their uniformed parent to remind us of the strength of our country and the steadfast love of a family in trying times
  • The American flag unites all military families in their commitment to national service, at home or away

ALA Junior members (those under 17 years old) perform this ceremony as a tribute to their peers who are military children. As the kids set the table with these symbolic tokens of bravery, love and sacrifice, they read from a ceremonial script that guides participants through the meaning of each item and allows time for quiet reflection. This ceremony is performed by ALA and American Legion members, but if you’d like to get involved, check out your local ALA unit.

All are invited to recognize military children by participating in Purple Up! Day for Military Kids on April 15. Purple symbolizes the combined colors of each military branch, showing unified solidarity for military children with parents in any branch of the military. On Purple Up! Day, wear purple in support of military children everywhere and post on your social media about what the Month of the Military Child means to you.

As part of its ongoing support of military children, the ALA also sponsors the Children of Warriors National Presidents’ Scholarship, which offers financial assistance to 15 military children, grandchildren or great-grandchildren across the country every year. Visit the Scholarships page on the ALA website for more information.

As our servicemembers defend our freedom at home and overseas, let’s ensure that we show up for the children who remain strong throughout the changes and uncertainty that often come with being a military child. If you’d like to explore new ways to engage with military families and support people in your community who have family members in the military, visit www.ALAforVeterans.org to learn how you can get involved with your local ALA unit.

2021 Brings Renewed Meaning to Cleaning

2021-03-29T14:01:00

(BPT) – This year, National Cleaning Week takes on newfound importance as we look back at how our cleaning habits changed in 2020. For many, pre-pandemic cleaning was just another chore, but as COVID-19 emerged in the U.S., cleaning quickly became a way to protect against the spread of germs and illnesses. In fact, a new survey conducted by the American Cleaning Institute found that 70% of Americans now view cleaning as a way to ensure the health and safety of themselves and their families, and more than 85% of Americans plan to keep up their cleaning practices after the pandemic ends. As the pandemic assigned new meaning to cleaning, here is a snapshot of what we’ve learned along the way.

Hygiene Is Handy

More than 75% of Americans plan to continue to wash their hands frequently once the pandemic is over. We all know, especially now, that handwashing is one of the most effective and simplest ways to remove germs, avoid getting sick and prevent the spread of germs to others. Reminder: Key times to wash your hands include: before, during and after preparing food; before and after caring for someone who is sick; and after handling items like garbage or dirty laundry!

GPS for Germs

They may be microscopic, but over the last year the majority of us have developed a radar for germ hotspots. We now know cleaning and disinfecting are critical for health, but that doesn’t mean you have to clean every single thing, every single second. For daily disinfecting, we’ve learned the importance of focusing on frequently touched areas where germs can quickly build up, like door knobs, light switches and faucets. While some areas of the home should be cleaned weekly, others only need a yearly clean — check out this home cleaning schedule for more information.

Labels Do Matter!

When it comes to your cleaning products, 2020 provided a crash course in the importance of reading labels. There are four elements of the label to focus on: directions, caution warnings, ingredients, and storage and disposal instructions. Remember, reading the label before using a product will help ensure effective and safe results. Once your product is empty, read the label for information on the best way to dispose or recycle the container.

Laundry Is a Cycle of Health

Beyond stains and fresh wardrobes, laundry routines have become our not-so-secret weapon against germs. Whether you’re washing your mask, reusable grocery bags or favorite sweatshirt, laundry is an important step to staying healthy. If someone in your household is sick, you may need to elevate your normal routine.

Health and Safety Must Go Together

With the increase in cleaning product use around the home, we were also quickly reminded of the importance of being vigilant about proper product safety practices and safe storage. Speaking of storage, while clear bins and glass jars may be a beautiful way to organize your home, they aren’t a safe place for cleaning products like liquid laundry packets. It is crucial that all products are safety stored and kept in their original containers to avoid accidental exposures among young children and adults with cognitive disorders, like dementia. Next time you’re unloading your grocery bags and putting away your cleaning products, remember to put your Packets Up and Store Not Décor!

Today, we no longer view cleaning as a routine chore. Cleaning is a way to prevent the spread of germs and illness, to rebuild our economy and to revitalize our planet. Perhaps what we’ve learned most of all is that cleaning gives us a way to protect our loved ones and express how we care for one another. In 2021 and beyond, cleaning is caring. For more cleaning information, visit https://www.cleaninginstitute.org/.

3 must-haves to transform your bath into a luxury retreat

2021-03-29T14:01:00

(BPT) – Blending fashion and function, the best bathroom design will address the needs of the homeowner while also reflecting their personal tastes. What often separates good from great design can be found in the details.

Sophisticated designer touches elevate a bathroom in an upscale way that defines a space as a luxury retreat within the home. If you’re planning a master bathroom remodel or adding a new luxury bathroom space within your home, don’t forget these three important facets.

Layer lighting

There are three main types of lighting: task, ambient and accent. Layering these lights thoughtfully in the bathroom will not only make the space more functional, but will also elevate the appearance and provide high levels of flexibility.

The main light — often an overhead light — provides ambient lighting for the overall illumination of the space. Many people choose dimmer options for this bathroom light to give it maximum customization.

Task lighting is essential in the bathroom since so many personal grooming tasks take place in the space. Task lighting might include lights over the mirror or vanity lighting. When planning and positioning task lighting, remember to position fixtures to minimize shadows to facilitate activities like shaving or applying makeup.

Finally, accent lighting is a key feature of luxury bathrooms and makes one space stand out from another. Accent lighting is meant to highlight the special features of the space and might include a light positioned over a painting, a decorative chandelier in a changing space or wall sconces by a soaking tub.

Select shower drains

Sophisticated touches make your bathroom design come together, so as you plan your shower space, don’t overlook the aesthetic potential of the drain. Choosing an upscale drain option blends elegance and performance to elevate the shower experience and the overall bathroom design.

For example, QuickDrain USA offers a variety of unique drain options. For the ultimate in-shower design, consider WallDrain, which is concealed behind the base of the wall — rendering it virtually invisible. The clean lines of this innovative drain system provide a seamless visual flow in the shower, ideal for a variety of décors, including contemporary or transitional designs.

However, if you prefer a drain that remains visible along the wall or in the center of the floor, you still have numerous options to elevate your look. QuickDrain’s Euro-styled linear drains and its new SquareDrain are ideal for conventional curbed or zero-entry, curbless applications that allow wheelchair access and ADA compliance.

Among the biggest trends of 2021 are rose gold and matte black finishes for shower drains. But there are a variety of finishes you can choose from to get the ideal look for your space.

Looking to take your bathroom design to an even higher level? The world-renowned firm of Michael Graves Architecture & Design collaborated with QuickDrain on two drain cover designs: the Cosmo and the Stream. Crafted from durable 18-gauge, 304 stainless steel, these removable, slim-profile covers are both offered with a brushed stainless steel finish, while the Cosmo is also available in a polished stainless finish. Learn more at www.quickdrain.com.

Evaluate hardware

Just like that special watch or necklace makes an outfit, the hardware you choose for the bathroom is the jewelry that enhances that space. Because the bathroom features a substantial amount of hardware relative to the size of the room, choosing the right option can make a big visual impact.

Hardware in bathrooms includes knobs and pulls on the vanity, but extends to other accessories as well. This includes towel racks for bathing and hand towels, toilet paper holders, soap dispensers and shower curtain rods. When planning hardware details, don’t forget to add in light switch covers, wall plates and vent covers to create a cohesive, professionally designed look.

Keep in mind, finishes for hardware don’t necessarily need to all match as long as the tones blend nicely and you don’t mix too many finishes together. For example, brushed steel and matte black work well together, but if you mix in more colors you risk the space looking disconnected and not well thought out.

There are many factors that go into creating a bathroom design. It’s important to pay attention to the details if you want to create a luxury space. These three details will help ensure fashion and function go hand in hand for a space you’ll love for years to come.

There are three basic types of lightingambient, task and accent. Layered throughout a room—especially multipurpose ones—they work together to achieve a rich and flexible lighting design.

The missed home improvement step putting you and your community at risk

2021-03-29T07:01:00

(BPT) – What do planting a tree, building a patio, installing a pool and putting up a fence have in common? These popular home improvement projects add value to your home, and they all require an important safety step: getting utility lines marked before digging.

With so many people spending more time at home during the pandemic, homeowners are tackling DIY projects at growing levels — 19.5 million Americans plan to dig this year for a home improvement project, according to the Spring 2021 Homeowner Omnibus Research from Common Ground Alliance (CGA). Unfortunately, two in five homeowners will miss the crucial step to call 811 to get utility lines marked before they dig.

Tempted to skip this step? You are putting yourself, your family and your entire community at risk. Unintentionally striking one of these lines can result in inconvenient outages for entire neighborhoods, serious harm to yourself or your neighbors, and significant repair costs.

CGA research found that a third of American homeowners have been affected by a utility service interruption during the pandemic. This can be particularly frustrating as people spend more time at home, relying on essential utilities to work, study and stay entertained. You don’t want your digging activity to be the reason your neighborhood faces an inconvenient outage, or worse.

If you think it won’t happen, think again. “A utility line is damaged every few minutes in the U.S. because someone decided to dig without making a call to 811 to learn the approximate location of buried utilities in their area,” says Sarah Magruder Lyle, President and CEO of CGA. “Calling 811 to get utilities marked before digging is free and easy, and will protect you, your community and the utilities you rely on.”

Follow these safe digging steps each time you dig:

Step 1: A free phone call to 811 makes it easy for your local one call center to notify appropriate utility companies of your intent to dig. Call a few days prior to digging to ensure enough time for the approximate location of utility lines to be marked with flags or paint.

Step 2: Know where you plan to dig and have a basic idea of what you plan to do. When you call 811, a representative from your local one call center will ask for the location and description of your digging project.

Step 3: Your local one call center will notify affected utility companies, which will then send professional locators to the proposed dig site to mark the approximate location of buried utility lines with colored flags and paint.

Step 4: Wait the required amount of time for the lines to be marked. Once all lines have been accurately marked, carefully dig around the marked areas.

There are nearly 20 million miles of underground utility lines in the United States, which equates to more than a football field’s length of utilities for every person in the U.S. Your family depends on this buried infrastructure for your everyday needs, including electric, natural gas, water and sewer, cable TV, high-speed internet and landline telephone.

With that much critical infrastructure underground, it’s important to know what’s below and call 811 before digging. To find out more information about 811 or the one call center in your area, visit www.call811.com.

Navigating Challenges of Parkinson’s Disease: Understanding OFF Episodes

2021-03-28T23:01:00

(BPT) – Living with Parkinson’s disease (PD) can be hard for the nearly 1 million Americans with the disease[i] and may present unexpected daily challenges. As the disease progresses, a person’s response to medications to treat their PD symptoms can change, leading to the re-emergence or worsening of PD symptoms between doses. These periods are known as OFF episodes and are experienced by an estimated 350,000 people in the U.S. living with PD.

The symptoms of OFF episodes may include motor symptoms like tremor, stiffness, slow movement, and difficulty communicating, as well as non-motor symptoms like anxiety and depression.[ii],[iii] During OFF episodes, someone with PD may have difficulties doing everyday tasks like walking unassisted or getting up out of a chair.

OFF episodes are more common than people might think

OFF episodes may occur in as many as 50% of people with PD after five years of levodopa treatment, and the percentage increases over time.[iv] 70% of patients beyond nine years of oral levodopa treatment will experience OFF episodes.[v] These episodes can take place in the morning upon waking or throughout the day.

Drew Falconer, M.D., a leading movement disorder specialist at the Inova Parkinson’s and Movement Disorders Center in Fairfax, Va., and Associate Professor of Neurology at the UVA School of Medicine, Inova Campus, has worked with people with PD and their families for over six years and recognizes that OFF episodes can be a challenge.

“The first signs of OFF episodes may be as subtle as realizing that PD medications do not last as long as they once did, having difficulty getting out of bed in the morning, or getting dressed for the day,” said Dr. Falconer. “As PD progresses, symptoms may get worse, and these episodes may become more frequent.”

The impact of OFF episodes

Living with OFF episodes may be challenging for some patients and their care partners. They may affect a person’s ability to perform daily activities, such as buttoning a shirt or eating meals. In addition, the often unpredictable nature of OFF episodes can make them difficult to identify and even discuss effectively with healthcare providers.

Talking to the doctor about difficult parts of PD like OFF episodes is important. Some people may accept these episodes as part of PD, without realizing that they are manageable. Other people may find it hard to choose which symptoms to share and find the right words to explain their experiences to their physician.

“As people notice OFF episodes becoming more frequent and disruptive, they can keep a journal to track symptoms and identify patterns of when they occur most often, and discuss a treatment plan with their physician,” says Dr. Falconer. “It’s important for people living with PD and their families to know that OFF episodes can be managed. Fortunately, there are medicines available that can safely and effectively treat OFF episodes as they occur.”

New options for patients

Most medicines focus on keeping people ON (when levodopa/carbidopa is working and symptoms are improved) rather than treating OFF episodes as they happen. Patients now have treatment options to treat OFF episodes on-demand, as they occur, wherever they occur.

The newest FDA-approved treatment for OFF episodes associated with PD is KYNMOBI™ (apomorphine HCl) sublingual film, which is now available by prescription in the U.S. KYNMOBI is the first and only sublingual (under the tongue) treatment for PD OFF episodes. It dissolves under the tongue and may help people improve motor symptoms when they need it.

Before starting any treatment, people should talk to their doctor to determine which treatment options may be right for them and to understand the potential benefits and risks.

For more information about OFF episodes and treatment with KYNMOBI, visit KYNMOBI.com. Please see below for Important Safety Information.

IMPORTANT SAFETY INFORMATION FOR KYNMOBI (apomorphine HCI) SUBLINGUAL FILM

Do not take KYNMOBI if you are taking certain medicines to treat nausea called 5HT3 antagonists, including ondansetron, granisetron, dolasetron, palonosetron, and alosetron. People taking ondansetron together with apomorphine, the active ingredient in KYNMOBI, have had very low blood pressure and lost consciousness or “blacked out.”

Do not use KYNMOBI if you are allergic to apomorphine hydrochloride or to any of the ingredients in KYNMOBI. KYNMOBI also contains a sulfite called sodium metabisulfite. Sulfites can cause severe, life-threatening allergic reactions in some people. An allergy to sulfites is not the same as an allergy to sulfa. People with asthma are more likely to be allergic to sulfites. Call your healthcare provider if you have hives, itching, rash, swelling of the lips, tongue and mouth, redness of your face (flushing), throat tightness, trouble breathing or swallowing.

Before starting KYNMOBI, tell your healthcare provider:

About all of your medical conditions, including if you:

  • have difficulty staying awake during the daytime
  • have liver problems
  • have dizziness
  • have kidney problems
  • have fainting spells
  • have heart problems
  • have low blood pressure
  • have had a stroke or other brain problems
  • have asthma
  • have a mental problem called a major psychotic disorder
  • are allergic to any medicines containing sulfites
  • drink alcohol
  • are pregnant or plan to become pregnant. It is not known if KYNMOBI will harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if KYNMOBI passes into your breast milk. You and your healthcare provider should decide if you will take KYNMOBI or breastfeed.

Tell your healthcare provider about all the medicines you take, including:

  • prescription medicines
  • over-the-counter medicines
  • vitamins
  • herbal supplements

KYNMOBI may affect the way other medicines work, and other medicines can affect how KYNMOBI works. Taking KYNMOBI with other medicines may cause serious side effects.

If you take nitroglycerin under your tongue (sublingual) while using KYNMOBI, your blood pressure may decrease and cause dizziness. You should lie down before and after taking sublingual nitroglycerin.

KYNMOBI can cause serious side effects, including:

  • nausea and vomiting. Nausea is a common side effect of KYNMOBI. Nausea and vomiting can happen with KYNMOBI. Your healthcare provider may prescribe a medicine called an antiemetic, such as trimethobenzamide to help prevent nausea and vomiting. If trimethobenzamide is prescribed, talk to your healthcare provider about how long you should remain on this medicine.
  • sleepiness or falling asleep during the day. Sleepiness is a serious, and common side effect of KYNMOBI. Some people treated with KYNMOBI may get sleepy during the day or fall asleep without warning while doing everyday activities such as talking, eating, or driving a car.
  • dizziness. Dizziness is a serious, and common side effect of KYNMOBI. KYNMOBI may lower blood pressure and cause dizziness. Dizziness can happen when KYNMOBI treatment is started or when the KYNMOBI dose is increased. Do not get up too fast from sitting or after lying down, especially if you have been sitting or lying down for a long period of time.
  • mouth (oral) irritation. Mouth (oral) irritation is a common side effect of KYNMOBI. You should call your healthcare provider if you develop any of these signs or symptoms.
    • redness
    • mouth sores (ulceration)
    • dryness of the mouth, lips or tongue
    • swelling
    • pain
    • pain with swallowing
  • falls. The changes that can happen with PD, and the effects of some PD medicines, can increase the risk of falling. KYNMOBI may also increase your risk of falling.
  • hallucinations or psychotic-like behavior. KYNMOBI may cause or make psychotic-like behavior worse including hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking.
  • strong (intense) urges. Some people with PD have reported new or strong uncontrollable urges to gamble, increased sexual urges, increased urges to spend money (compulsive shopping), and other intense urges, while taking PD medicines, including KYNMOBI. If you or your family members notice that you have strong urges, talk to your healthcare provider. The strong urges may go away if your KYNMOBI dose is lowered or stopped.
  • high fever and confusion. KYNMOBI may cause a problem that can happen in people who suddenly lower their dose, stop using, or change their dose of KYNMOBI. Symptoms include:
    • very high fever
    • confusion
    • stiff muscles
    • changes in breathing and heartbeat

Do not stop taking KYNMOBI or change your dose unless you are told to do so by your healthcare provider.

  • heart problems. If you have shortness of breath, fast heartbeat, chest pain, or feel like you are going to pass out (faint) while taking KYNMOBI, call your healthcare provider or get emergency help right away.
  • tissue changes (fibrotic complications). Some people have had changes in the tissues of their pelvis, lungs, and heart valves when taking medicines called nonergot derived dopamine agonists like KYNMOBI.
  • prolonged painful erections (priapism). KYNMOBI may cause prolonged, painful erections in some people. If you have a prolonged and painful erection, you should call your healthcare provider or go to the nearest hospital emergency room right away.

The most common side effects of KYNMOBI include:

  • nausea
  • dizziness
  • sleepiness
  • mouth swelling, pain, or sores

INDICATION

KYNMOBI™ (apomorphine HCl) sublingual film is a prescription medicine used to treat short-term (acute), intermittent “off” episodes in people with Parkinson’s disease (PD).

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For more information, please see the KYNMOBI Patient Information, full Prescribing Information, and Instructions for Use at www.KYNMOBI.com.

References



[ii] The Michael J. Fox Foundation. “Ask the MD: The Language of Parkinson’s, ‘Off’ Time.’” https://www.michaeljfox.org/news/ask-md-language-parkinsons-time. Accessed December 2020.

[iii] Racette BA, et al. “Clinical features and comorbidity of mood fluctuations in Parkinson’s disease.” Journal of Neuropsychiatry and Clinical Neurosciences. 2002 Fall;14(4):438-42. https://doi.org/10.1176/jnp.14.4.438.

[iv] Thanvi BR, Lo TCN. Long term motor complications of levodopa: clinical features, mechanisms, and management strategies. Postgrad Med J. 2004;80:452-458.

[v] Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord. 2001;16(3):448-458.

The right diagnosis for a rare disease

2021-03-27T23:01:00

(BPT) – Aldelly always liked to wear heels — “even to the supermarket,” she says. But in 2013, when she was 25, she began to have difficulty walking in her favorite shoes. “My foot just started not working well.”

She began to experience other strange symptoms, including weird pains in her body, fatigue and troubles with her bladder. But when she saw her doctor, every symptom got explained away. Her feet problems might have been caused by a childhood of dancing. The bladder issues and fatigue could be due to having recently given birth.

Despite being told everything was OK, Aldelly knew something was wrong. One day, at a work event, she broke down. She couldn’t walk, couldn’t control her bladder and she felt exhausted. She called her primary care physician from the party, who said she was going to send her to a neurologist.

In 2016, the neurologist did some tests, including an MRI, and later called Aldelly to tell her she had a rare disease called neuromyelitis optica spectrum disorder (NMOSD).

NMOSD is a debilitating autoimmune disease of the central nervous system (CNS), where the immune system mistakes normal tissues of the CNS as foreign. NMOSD affects up to 15,000 people in the U.S., primarily women, and mainly attacks the optic nerve and spinal cord. With NMOSD, recurring attacks can lead to an accumulation of debilitating symptoms and blindness, muscle weakness, and paralysis. But understanding the disease and early diagnosis offer the best opportunities to help treat the condition.

In some ways, it was lucky that Aldelly was diagnosed quickly. Many people with NMOSD are misdiagnosed, especially since the symptoms often seem similar to those of multiple sclerosis. But with two small children, a job and a new house, Aldelly denied she had the debilitating disorder. “I just didn’t have time for this.” After other neurologists confirmed the diagnosis, she began treatment.

Still, for a long time, she pretended nothing was wrong. She would make excuses about a twisted ankle when she limped or explain away her cane by saying she’d been in a car accident. Then she decided to come out to her friends, and her wider social media community. “It allowed people to understand me, and for me to be open about my physical limitations.”

She has since learned to adjust to living with NMOSD. The disease has made her life unpredictable — she often has spasticity in her limbs, incontinence, numbness and tingling sensations. Unlike many people with NMOSD, Aldelly is grateful she hasn’t had troubles with her eyes. But it has prevented her from doing everyday activities, like take her boys to football practice and watch them play. “It’s a roller coaster,” she says.

Aldelly has a strong family support system — her parents live nearby — and she says social media has given her a powerful community. “People just started reaching out,” she says. “That’s helped a lot.”

Social media has played a key role in bringing together many people living with NMOSD, including Sumaira Ahmed, who started The Sumaira Foundation after she was diagnosed with NMOSD at the age of 25. Her foundation aims to generate global awareness, fund research to find a cure and build a community of support for patients and caregivers while providing education about NMOSD to a variety of audiences through social media events, conferences, a podcast and more.

“We’re passionate about building positivity and communities of support,” says Sumaira. “None of us can go through this alone. I know that if I’m having a tough day, there are people around the world, on social media and in advocacy groups, who will help me through and support me unconditionally.”

Three other organizations — the Guthy-Jackson Charitable Foundation, the Connor B. Judge Foundation, and the Siegel Rare Neuroimmune Association — have played a critical role in creating the NMOSD support community, which also collaborates with academia and industry to drive research, and educates health care professionals and the public about what people living with the condition experience.

Aldelly knows that stress can make her symptoms worse, so she meditates, works out with a trainer and eats healthfully. “I’ve been focusing on me,” she says. “As much as I want to be a great mom and wife, if I’m not OK, my family’s not OK.” She has started writing about her experiences with the disease, “talking about things that people don’t talk about.” Bilingual in Spanish, she engages daily with people living with NMOSD all over the globe.

Aldelly says, “living with a demyelinating disease is not a death sentence, more like a constant reinvention of an adaptive lifestyle.”