Gvoke HypoPen (glucagon injection) is premixed and ready-to-use for low blood sugar emergencies

2022-10-05T08:01:00

(BPT) – Michelle Trites, her husband and their 3-year-old daughter all have Type 1 diabetes. Diabetes is an ever-present part of their lives and ensuring that they have tools in their tool kits to handle low blood sugar emergencies is a top priority.

Ever since Michelle was diagnosed at 13 years old, the Glucagon Emergency Kit has been a constant presence — at school, at work, and on her person at all times. But not anymore. After learning about ready-to-use glucagon, Michelle made sure that everyone in her family replaced the old red kit with Gvoke HypoPen®, a ready-to-use rescue pen for treatment of very low blood sugar in adults and kids ages 2 and older.

Michelle believes the emergency glucagon kit is cumbersome to use due to its 12-step administration process. “That was a lot to ask from non-medical professionals who could get squeamish just looking at a needle, much less completing so many steps in a high-stakes emergency,” Michelle said. In a usability study, only 31% of users could use the glucagon injection kit correctly.

Eli Lilly and Company, a producer of the GEK kit, recently announced that it is discontinuing distribution of the kit on December 31, 2022. The decision was reportedly made due to innovations in the glucagon market and highlights the importance of providing patients with products that enable simpler administration during critical moments of need.

As a result of this news, all patients that currently have a prescription for Eli Lilly’s GEK will need to be transitioned to another option.

The Trites recommend that people with diabetes and their caregivers ask their physician for Gvoke HypoPen®. “Everyone should have Gvoke HypoPen in their tool kit,” said Michelle. “It can help you confidently manage a low blood sugar emergency.”

Gvoke HypoPen®, the simple solution you can count on:

  • Ready-to-use: Premixed and ready-to-go1
  • Simple to administer: Simple 2-step administration. Pull red. Push yellow
  • Reliable method of delivery: 99% of people (trained and untrained) were able to give correctly in usability studies1
  • Proven to work: >99% of adults and pediatrics patients had their blood glucose raised to safe levels

Talk to your doctor about adding Gvoke HypoPen® to your diabetes toolkit and visit GvokeGlucagon.com to learn more.

“We are focused on making our treatments simple for patients or caregivers to administer,” said Ken Johnson, senior vice president for Global Development and Medical Affairs at Xeris Pharmaceuticals. “Xeris is committed to offering historically hard-to-administer and potentially life-saving medications in innovative ready-to-use injectables.”

INDICATION AND SAFETY SUMMARY
GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.

WARNINGS

Do not use GVOKE if:

  • you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
  • you have a tumor in your pancreas called an insulinoma.
  • you are allergic to glucagon or any other inactive ingredient in GVOKE.

GVOKE MAY CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

High blood pressure. GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar. GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction. Call your doctor or get medical help right away if you have a serious allergic reaction including:

  • rash
  • difficulty breathing
  • low blood pressure

COMMON SIDE EFFECTS

The most common side effects of GVOKE in adults include:

  • nausea
  • vomiting
  • swelling at the injection site
  • headache

The most common side effects of GVOKE in children include:

  • nausea
  • low blood sugar
  • high blood sugar
  • vomiting
  • abdominal pain
  • headache
  • pain or redness at the injection site
  • itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor.

Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

BEFORE USING

Before using GVOKE, tell your doctor about all your medical conditions, including if you:

  • have adrenal gland problems
  • have a tumor in your pancreas
  • have not had food or water for a long time (prolonged fasting or starvation)
  • have low blood sugar that does not go away (chronic hypoglycemia)
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

HOW TO USE

  • Read the detailed Instructions for Use that come with GVOKE.
  • Use GVOKE exactly how your healthcare provider tells you to use it
  • Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
  • Act quickly. Having very low blood sugar for a period of time may be harmful.
  • Your healthcare provider will tell you how and when to use GVOKE.
  • After giving GVOKE, your caregiver should call for emergency medical help right away.
  • If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.

HOW TO STORE

  • Keep GVOKE in the foil pouch until you are ready to use it.
  • Store GVOKE at temperatures between 68°F and 77°F.
  • Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to https://gvokeglucagon.com/

Please see the Full Prescribing Information for Gvoke: https://gvokeglucagon.com/pdf/gvoke-prescribing-information.pdf

The Truth about Living with Plaque Psoriasis

2022-10-05T08:01:00

(BPT) – For millions of people around the world, hitting the snooze button in the morning offers a few more minutes of relaxation — a little quiet time before the day starts or some time to catch up on the news before breakfast. But for the millions of people like Lori who are living with plaque psoriasis, hitting the snooze button in the morning is often an act of desperation, following an exhausting night of tossing and turning and being unable to sleep due to the physical symptoms brought on by the condition.

“For me, the most difficult part of living with plaque psoriasis is the itching, the burning, the waking up in the middle of the night because of how uncomfortable it is,” says Lori, who has been living with plaque psoriasis for 15 years. “And then on top of that having to deal with how society sees me, the looks, and the questions… It’s a very difficult disease to live with. I’m embarrassed a lot of times when I go out because it’s so visible.”

Psoriasis is a complex and chronic inflammatory disease that impacts approximately 8 million Americans and 125 million people worldwide. Plaque psoriasis is the most common form of psoriasis, accounting for about 80% to 90% of cases.[1],[2],[3]

Signs and symptoms of plaque psoriasis may vary from person to person but typically include raised patches of skin with silvery-white or gray scale that can be itchy, painful and disfiguring. It can appear on any part of the body, but is most common on the elbows, torso, scalp and legs. It can also appear in less common areas, such as the soles of a person’s feet, hands, and even sensitive areas like the eyelids or groin.[1]

Beyond the outward symptoms of plaque psoriasis, the condition can take a significant toll on a person’s day-to-day life — impacting their psychological health and overall quality of life.[4]

“As my plaque psoriasis progressed and my flare ups got worse, it affected what I wore, what I did and even my self-esteem,” says Lori. “I began avoiding clothes that didn’t cover up my plaques, and when my flares were at their worst with the constant itching and bleeding, I would avoid going out in public at all because the stares and questions were difficult to address.”

Because there is not a “one-size-fits all” treatment option, and because many treatment options may force people with plaque psoriasis to make compromises in treatment safety and tolerability, people like Lori who live with this chronic and debilitating disease may endure a frustrating trial-and-error process managing their condition. The journey to find a treatment that is right for them can be difficult.[5],[6]

“The challenges of living with plaque psoriasis are more than skin deep. Typically, patients start with topical steroids which vary in their regimen instructions, are limited by where they can be used on the body and are limited in how long and how often they can be used overall,” says board-certified dermatologist Sandra M. Johnson, MD, FAAD, of Johnson Dermatology in Fort Smith, AR.

She adds, “Because of this, patients tend to cycle on and off steroid treatments, which can lead to reports of a lower quality of life, particularly when the condition interferes with their sleep, work, and social activities. Higher quality of life can be linked to treatment adherence, but treatment adherence can be difficult when patients may be unhappy with their plaque psoriasis treatment. This is why it’s critical to introduce novel topical therapies that are safe and effective that patients want to use and can use long term.”

Lori shares many of these common treatment experiences, noting that she tried different creams that were both prescribed and over the counter, in addition to biologics. Eventually she would find these topical treatments did not give her the results she was looking for and that biologics were not the right choice for her. A couple of years ago, she decided to join a clinical trial to see if a new type of topical treatment would help.

“I see a lot of patients living with plaque psoriasis, and finding the right treatment for each individual can take some trial and error,” says Jennifer Soung, MD, a board-certified dermatologist, and the director of clinical research at Southern California Dermatology in Santa Ana, CA. “Though the plaque psoriasis treatment landscape has evolved significantly to make room for oral treatments and biologics that treat more severe forms of plaque psoriasis, there is a large need for new topical treatments and particularly for non-steroids.”

Fortunately, there’s hope. On May 23, 2022, the Food and Drug Administration (FDA) approved VTAMA® (tapinarof) cream, 1%, a once daily, cosmetically elegant, prescription topical treatment for adults living with mild, moderate, and severe plaque psoriasis. Thanks to clinical trial participants like Lori, this approval makes VTAMA cream the first and only steroid-free topical medication in its class in the U.S. following 25 years of minimal innovation in the topical psoriasis treatment landscape.[7]

With this FDA approval, people like Lori living with plaque psoriasis have access to a steroid-free topical treatment, in the form of a convenient, once-daily cream, that is backed by extensive clinical trial data supporting its strong safety and efficacy profile — even with long-term use, as demonstrated in clinical trials over 52 weeks, and on sensitive areas, such as the face, groin and underarms.[8]

For Lori, the FDA approval of VTAMA cream means that she can effectively treat her plaque psoriasis. With control over her psoriasis, she doesn’t always have to hide visible, itchy and painful plaques behind her clothes, and she is able to attend events without feeling ashamed.

Lori is sharing her story to encourage others going through a similar experience with plaque psoriasis to never give up hope. “While in the VTAMA cream clinical trials, my plaques started clearing. Knowing I have a plaque psoriasis treatment that works for me put a smile back on my face again.”

The most common side effects (incidence ≥1%) of VTAMA cream include red raised bumps around the hair pores (folliculitis), pain or swelling in the nose and throat (nasopharyngitis), skin rash or irritation including itching and redness, peeling, burning or stinging (contact dermatitis), headache, itching (pruritus), and flu (influenza).

If you’re struggling with plaque psoriasis, talk to your doctor to learn if VTAMA cream may be right for you. “Never stop advocating for your health — don’t accept that your disease controls you,” says Dr. Johnson.

Sandra M. Johnson, MD, FAAD and Jennifer Soung, MD are paid consultants of Dermavant Sciences, Inc.

For more information about VTAMA cream, speak to your dermatologist or visit www.VTAMA.com.

IMPORTANT SAFETY INFORMATION

Indication: VTAMA® (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in subjects treated with VTAMA cream were folliculitis (red raised bumps around the hair pores), nasopharyngitis (pain or swelling in the nose and throat), contact dermatitis (skin rash or irritation, including itching and redness, peeling, burning, or stinging), headache, pruritus (itching), and influenza (flu).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information here.

VTAMA is a registered trademark of Dermavant Sciences, GmbH.


[1] National Psoriasis Foundation. About psoriasis. Available at: https://www.psoriasis.org/about-psoriasis/. Accessed August 2022.

[2] National Psoriasis Foundation. Psoriasis statistics. Available at: https://www.psoriasis.org/psoriasis-statistics/. Accessed August 2022.

[3] Menter A, Gottlieb A, Feldman SR, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis. J Am Acad Dermatol. 2008;58(5), pp.826-850.

[4] National Psoriasis Foundation. Psoriatic disease affects more than skin and joints. Available at: https://www.psoriasis.org/advance/psoriatic-disease-affects-more-than-skin-and-joints/. Accessed August 2022.

[5] Schaarschmidt M, Schmieder A, Umar N, et al. Patient preferences for psoriasis treatments: process characteristics can outweigh outcome attributes. Arch Dermatol. 2011;147(11):1285-1294.

[6] National Psoriasis Foundation. Treatments for psoriatic disease. Available at: https://www.psoriasis.org/treatments-for-psoriatic-disease/. Accessed August 2022.

[7] FDA approves Dermavant’s VTAMA® (tapinarof) cream, 1% for the treatment of plaque psoriasis in adults: first topical novel chemical entity launched for psoriasis in the U.S. in 25 years. Available at: https://www.dermavant.com/u-s-fda-approves-our-novel-topical-treatment-for-adults-with-plaque-psoriasis/. Accessed August 2022.

[8] VTAMA Cream. Prescribing Information. Long Beach, CA. Dermavant Sciences.

3 proactive steps to ensure the health and happiness of your cat

2022-10-05T10:01:00

(BPT) – If you’re a cat owner, you know your furry family members enhance your life in many ways with their curiosity, cuddles and unique personalities. Being a pet parent, you want to return the love by doing everything you can to ensure their health and happiness, but it’s not always clear how you can make the biggest impact.

While pet parents know that properly caring for their cat includes love, affection, regular vet visits, lots of play and providing essentials like complete and balanced food and clean litterboxes, experts agree that going beyond the basics can truly help your feline friend thrive.

Here are three proactive steps you can take to help your cat stay healthy and happy so they can live their best life with you:

Learn litterbox patterns

Did you know your cats’ litterbox habits provide important insight into their overall wellness? That’s why a team of Purina behaviorists, veterinarians and data scientists, developed the Petivity Smart Litterbox System, which uses artificial intelligence to learn a cat’s unique litterbox patterns and identify subtle but meaningful changes in weight, frequency, waste type and elimination schedule.

Often unseen by cat owners, these patterns identify changes that may be associated with health conditions like diabetes, kidney disease, hyperthyroidism, urinary tract infections and obesity. While the Petivity Smart Litterbox System is not intended to diagnose, treat, mitigate or cure any conditions, it alerts you through the Petivity app when a change may require attention or a visit to your veterinarian. Seeking veterinary advice early in identifying potential issues can help unlock better outcomes for your cat.

How does it work? You place the monitor under each litterbox in the household, and the sensors gather precise data on each cat’s weight and important litterbox habits. In addition to receiving alerts through the app, you’ll receive frequent insight reports with helpful explanations and tips for managing your cat’s overall well-being.

The smart system can be used in households with up to three cats and with most standard litter and litterbox sizes.

Spot health problems early

Just like your own health, if you can catch a pet’s health issue early, you increase the chances of a better outcome. One big step is annual wellness checkups that allow professionals to examine your cat and conduct tests. This is also an important time to update vaccines to protect them and the humans they’re around.

With the rich data that the Petivity Smart Litterbox System provides, veterinary professionals can get a holistic view of your cat’s needs so they can evaluate potential issues early, see the bigger picture of what might be occurring internally and provide proper guidance and advice.

Additionally, pet parents should always be alert for any changes in their cat’s behavior, health or physical appearance and call their vet for advice.

Provide mental stimulation and engagement

Don’t forget to support your cat’s mental health and provide your cat with ample mental stimulation and engagement.

It’s important to support your cat while you’re not available to provide dedicated attention. For example, if you work out of the house, place an interactive toy in a favorite hangout spot for them to find. Another idea is to use a puzzle feeder as a fun, engaging way for your cat to enjoy a few treats while you’re away.

Remember, you don’t need to spend a lot of money to pique your cat’s curiosity. Add a soft blanket or shirt that smells like you to a favorite lounge spot for nesting before napping. Also, don’t forget how much fun empty cardboard boxes can be to explore, so leave those out for a day or two after deliveries.

With these tips and more, cat lovers can play a proactive role in the lifelong health of their pet through smart care.

To learn more about the Petivity Smart Litterbox System, including how and where to purchase, visit Petivity.com.

Free online resource helps small businesses achieve success and prepare for the digital world

2022-10-03T07:01:00

(BPT) – With the fall and holiday seasons fast approaching, small business owners might consider leveraging the power of digital tools to ensure that sales, marketing, operations and other key function areas are ready to help drive business outcomes.

One free online digital resource that thousands of small business owners across the U.S. are using is Verizon Small Business Digital Ready.

As a technology company, Verizon has a longstanding commitment to supporting small businesses, especially those owned by women and people of color in under-resourced areas. It’s part of Verizon’s overall goal to provide digital support for 1 million small businesses by 2030.

Verizon partnered with a diverse set of experts and small business owners to design, develop and produce Small Business Digital Ready. Overall, the in-depth digital resource provides an integrated and customized learning plan, including:

  • Courses: Curated and self-paced courses are presented by small business owners and feature brief, information-packed lessons that can be used right away and provide essential resources necessary to help you build and grow.
  • Expert Coaching: Mentorship, 1:1 coaching and advice from experts are available to help small businesses leverage their knowledge and learnings to create a plan of action.
  • Incentives: A marketplace of tools, solutions, products and services to help propel a small business forward. Small Business Digital Ready users also have exclusive access to apply for grant funding.
  • Peer Networking: Opportunities to make connections, share and receive information, and participate in business development activities.

Verizon is currently supporting a series of $10,000 grants to small businesses. To be eligible to apply, users of Small Business Digital Ready must complete any combination of two courses, coaching events and community events now through November 14, 2022 and applications must be received by November 14, 2022.

To register for Small Business Digital Ready, please click on this link or visit verizon.com/digitalready.

Whatever your small business needs, please take a moment to consider how Small Business Digital Ready can help your business be more successful.

Maintaining a viable tool box: The benefits of atrazine for weed control

2022-10-05T07:01:00

(BPT) – A valuable weed control product could come under tighter use restrictions if the Environmental Protection Agency (EPA) moves forward with a new aquatic ecosystem concentration regulation for atrazine, decreasing the equivalent level of concern (LOC) from 15 parts per billion (ppb) to 3.4 ppb.

The agency is accepting comments for the proposed rule for atrazine until Oct. 7. This proposed restriction could mean reducing rates of an important and often irreplaceable option in farmers’ weed-control toolbox.

The importance of atrazine

Farmers need multiple tools to tackle pests and environmental conditions, especially if they come up against herbicide-resistant weeds. For over 60 years, atrazine has been hailed as a safe and effective herbicide that has helped farmers stay in business and may be a key to maintaining a strong domestic food supply.

In Arkansas, where at least one population of Palmer amaranth has resistance to six different herbicide modes of action, keeping atrazine is critical, said Tom Barber, Ph.D., a University of Arkansas Extension weed scientist.

“We’ve got a lot of five-way resistant populations in the state that are pretty widespread, and atrazine is still one of the only herbicides that is highly effective on those populations,” said Barber.

However, over the years, EPA has made several label changes to the herbicide, including designating it as a restricted use material, which has left farmers with fewer weed-control options.

The proposed rule further restricts those options and doesn’t align with previously submitted material regarding atrazine. Chris Tutino, senior communications manager for Syngenta, says scientific data and regulatory records completely and categorically refute the proposed LOC.

A potentially costly loss

According to Bill Johnson, Ph.D., a Purdue University Extension weed specialist, further restricting access to atrazine would make weed control more costly and difficult for Indiana corn and sorghum producers without guaranteeing environmental benefits.

“I think we would really struggle with control of some weeds, like morning glory, waterhemp, giant ragweed and newly germinated annual grasses that are common in cornfields,” said Johnson. “We’d have to pick up those weeds with other herbicides that aren’t as effective and are more expensive. And we would be replacing one product with another product that may not put us at a better place environmentally.”

Johnson says that fewer weed-control options could also increase resistance selection pressure on the remaining herbicides. Already, Indiana has waterhemp populations resistant to five different modes of action, and testing is underway on suspected resistance to a sixth mode. Other weeds, including Palmer amaranth, marestail and giant ragweed, have confirmed resistance to multiple modes of action.

Benefits for sustainable farming

Sustainability is more than just a buzzword, but it’s also not as complicated a concept as it may seem. According to Genevieve O’Sullivan, vice president of communications and marketing for Crop Life America, sustainability is “simply using technology to produce more using less.” Restricting the use of atrazine could make it more difficult for growers to use sustainable practices and negatively impact the planet.

Atrazine is critical to no-till farming, a sustainable practice where growers keep plant residue on the surface to minimize soil disturbance and erosion. In recent years, no-till production has been praised for helping store carbon in the soil — benefiting soil health and global warming.

In Indiana, about half the acres that receive atrazine are farmed conventionally, and half are in some form of no-till or conservation tillage. However, according to Mark White, Syngenta’s senior stewardship and regulatory portfolio manager, further restricting use of atrazine could prompt some growers to return to tillage, potentially increasing soil carbon releases.

Industry support

Despite government regulations of atrazine, the herbicide has strong industry support. Barber and Johnson were among eight Weed Science Society of America (WSSA) members who submitted letters to the EPA in 2021 supporting the current uses and rates of atrazine. Their comments were in response to EPA’s draft Endangered Species Act biological evaluations for triazine herbicides, which include atrazine, simazine and propazine.

Companies are also taking a stand. Syngenta, for example, continues to support pesticides like atrazine because they are highly effective and because it’s a sound business decision for both the farmer and the registrant.

“We know that the public is interested in the safety of their food,” says Chris Tutino, Syngenta’s senior communications manager. “So, we redesigned the atrazine site to help people understand and share the science behind atrazine’s safety that ultimately leads to higher crop production in an increasingly food-insecure world.”

To learn more about the importance of growers having access to a safe, effective weed-control toolbox, visit Atrazine.com or www.SyngentaThrive.com.

© 2022 Syngenta. Important: Always read and follow label instructions. Some products may not be registered for sale or use in all states or counties. Please check with your local extension service to ensure registration status. The trademarks or service marks displayed or otherwise used herein are the property of a Syngenta Group Company.

Managing Mental Health and Tardive Dyskinesia (TD): One Woman Shares her Story

2022-10-03T08:01:00

(BPT) – This article was sponsored and developed by Neurocrine Biosciences.

Each year, millions of Americans are impacted by mental health conditions. Recognized during the first week of October, Mental Illness Awareness Week aims to raise awareness of the 1 in 5 Americans experiencing mental illness each year, dispel common misperceptions, and provide support to all impacted, including people with experience with a mental health condition, care partners, and advocates.

Marilyn, who hails from a small town in Colorado, was diagnosed with postpartum depression after the birth of her daughter nearly 40 years ago. As her condition worsened, she was also diagnosed with anxiety and bipolar disorder.

“I have been to so many primary healthcare providers, neurologists, and psychiatrists for my mental health conditions, and we’ve tried many different medications,” said Marilyn. After taking antipsychotics for six years, Marilyn experienced involuntary movements such as pronounced lip smacking.

Unfortunately, these involuntary movements did not go away and continued to be disruptive nearly two years later. What Marilyn did not know was that the involuntary movements are a condition called tardive dyskinesia (TD).

TD is a real, chronic condition that affects approximately 600,000 people in the U.S. It’s a condition where people taking certain mental health medicines (antipsychotics) experience mild, moderate, or severe uncontrollable movements in different parts of their bodies.

“I was constantly moving uncontrollably and could never keep still. It was especially bad in my face, fingers, and feet,” said Marilyn. “I didn’t want to socialize anymore because I was so self-conscious of my movements.”

Everyday activities like sitting in a car or watching football games with her family were difficult due to her uncontrollable movements in her legs and hands. After speaking with her psychiatrist and then her neurologist about these movements, she was diagnosed with TD.

Marilyn’s doctor shared information with her about INGREZZA® (valbenazine) capsules, a prescription medicine to treat adults with the uncontrollable movements of TD. After reviewing the benefits and side effects, including the most common side effect of sleepiness, together they decided that INGREZZA, a simple one capsule, once-daily treatment, was the choice for her.

Please see additional Important Safety Information below.

After starting INGREZZA, Marilyn saw a reduction in her movements, and therefore was able to return to the activities she enjoyed. “I can now sit in my chair and cheer on my teams,” she said. “It feels good to be able to engage in one of my favorite pastimes again with my family.”

This Mental Illness Awareness Week, Marilyn wants to share her story to help others and encourage those experiencing involuntary movements to talk to their doctor.

“Stories like Marilyn’s highlight how living with a mental health condition and TD is not only debilitating but can have a significant emotional and social impact as well,” said Dr. Leslie Lundt, Executive Medical Director at Neurocrine Biosciences. “Mental Illness Awareness Week is an important time to broaden the conversation around mental health and associated challenges and help those who may be experiencing TD understand there are treatment options to help.”

To learn more about TD and INGREZZA, talk to your doctor or visit INGREZZA.com for more safety information.

Important Information

Approved Use

INGREZZA® (valbenazine) capsules is a prescription medicine used to treat adults with movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if INGREZZA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take INGREZZA if you:

  • are allergic to valbenazine, or any of the ingredients in INGREZZA.

INGREZZA may cause serious side effects, including:

  • Sleepiness (somnolence). Do not drive, operate heavy machinery, or do other dangerous activities until you know how INGREZZA affects you.
  • Heart rhythm problems (QT prolongation). INGREZZA may cause a heart problem known as QT prolongation.

Symptoms of QT prolongation may include:

  • fast, slow, or irregular heartbeat
  • shortness of breath
  • dizziness or fainting

Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you faint.

  • Abnormal movements (Parkinson-like). Symptoms include: shaking, body stiffness, trouble moving or walking, or keeping your balance.

Before taking INGREZZA, tell your healthcare provider about all of your medical conditions including if you: have liver or heart problems, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effect of INGREZZA is sleepiness (somnolence). Other side effects include changes in balance (balance problems, dizziness) or an increased risk of falls, headache, feelings of restlessness, dry mouth, constipation, and blurred vision.

These are not all of the possible side effects of INGREZZA. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see accompanying INGREZZA full Product Information.

This article was sponsored and developed by Neurocrine Biosciences, Inc. Marilyn was compensated by Neurocrine Biosciences to share her story.

©2022 Neurocrine Biosciences, Inc. All Rights Reserved. CP-VBZ-US-2126 10/2022

Overcoming addiction: What to expect when you go through inpatient rehab

2022-10-03T10:01:00

(BPT) – Addiction is a disease that can be mentally and physically debilitating. If you or a loved one struggle with addiction, you know how dark it can be. Taking the next step and exploring rehab options can bring light into the darkness so you can fight — and ultimately win — the battle against addiction.

Millions of people in the United States have a substance use disorder and are addicted to alcohol and/or drugs. Even though you feel alone in your struggles, it’s important to know many people have walked in your shoes and found hope to overcome addiction.

“After finding the right rehab option, it’s time to prepare for the next steps. When a person first enters an addiction rehab center, they may be at risk of experiencing withdrawal from drugs or alcohol. Withdrawal can be an uncomfortable process, and the person may benefit from medical treatments in order to make the process less difficult,” said Debra Lloyd at California Behavioral Health. “This is why many people start their rehab experience in a detox center where medical treatments are available. Trained medical personnel may treat the individual with medications in order to decrease discomfort and reduce the risk of complications associated with substance withdrawal.”

Inpatient rehab

Inpatient rehab is one of the most effective treatment options for addicts because it separates the person from temptations and home stressors so they can focus 100% on recovery. Those struggling with addiction undergo the rehabilitation process with medical professionals, licensed alcohol and drug counselors, and their peers.

Inpatient rehab is a big step so it’s important to know what to expect. First, learn your options so you can choose the right rehab facility for you. Keep in mind, location, insurance acceptance, facility and personnel credentials, and staff-to-patient ratio are all important things to consider.

Better Addiction Care is a helpful resource when gathering rehab information, offering confidential, no-cost information via private phone calls through one or more of their treatment clients about addiction and rehabilitation treatment. The organization has a nationwide directory of substance abuse treatment facilities which includes some of the country’s top rehab centers.

After finding the right rehab option, it’s time to prepare for the next steps. When a person first enters an addiction rehab center, it’s likely that they have some drugs currently in their system. They must get all substances out of their body, but this can be a difficult and uncomfortable process.

This is why many people start their rehab experience in a detox center so they can go through a medically assisted detox. These centers are often located in the rehab facility and help patients safely through withdrawal, a process that may include prescription medication like anti-nausea medicine or anticonvulsants to treat symptoms.

“Professionals help patients flush addictive substances out of their system and manage withdrawal symptoms,” explained David Levin from Legacy Healing Center. “In particular, substances such as alcohol, benzodiazepines and opioids have life-threatening withdrawal symptoms, so medical monitoring is essential.”

Rehab schedules

After detox is complete you can begin full treatment. Your daily schedule at rehab may vary based on your needs and interests. A day at rehab may include:

  • Group counseling
  • Family therapy
  • Individual therapy, such as cognitive-behavioral therapy
  • 12-step meetings, such as Alcoholics Anonymous or Narcotics Anonymous
  • Non-12-step meetings, such as SMART Recovery
  • Scheduled mealtimes
  • Free time to exercise, take walks, read, participate in creative arts therapy

Rehab length

Most people who enter an addiction treatment center for inpatient care stay 90 to 120 days. However, it’s important to remember that addiction is a lifelong struggle. Once you near the end of your inpatient rehab program, your treatment team will work with you to create an aftercare plan to help prevent relapse once you return home.

“Inpatient rehab helps you overcome addiction and provides you the skills needed to live a sober life,” Dr. Christian Small of California Behavioral Health said. “Keep in mind, people who have been free of drugs or alcohol for years still say they are in recovery. Even if they aren’t using they know addiction is a disease that requires them to be aware of temptations and use the skills they’ve learned at rehab and through therapy to maintain sobriety.”

What the hack: 3 tips to keep you safe online

2022-10-04T05:01:01

(BPT) – Your digital accounts and online activities may make your life easier and perhaps even more enjoyable, but did you know every time you log in, it’s a chance for cybercriminals to hack your information and exploit it in numerous ways?

Hacking threats are constant. According to research from the University of Maryland, cyber attacks happen every 39 seconds on average. What’s more, hackers get more sophisticated every day. The good news is, there are steps you can take to greatly lower your chances of becoming a cybercrime victim.

1. Authorize multi-factor authentication

Multi-factor authentication (commonly known as MFA) is one of the best steps you can take to secure your accounts. And the good news is it’s already offered on many of your favorite applications and services today. MFA acts as an additional step to protect your accounts in addition to your username and password.

For example, if you sign into an account with two-factor authentication, the system may request you enter a one-time code sent to the phone number you have on file. You’ll confirm your identity by typing the number that was texted in the sign-on request. Often these codes are only activated for a short period of time for added protection.

2. Adopt physical authentication

Not all multi-factor authentication is created equal, and SMS or mobile authentication has been proven to be vulnerable to phishing. The modern and most effective approach to keeping you and your data protected is using phishing-resistant multi-factor authentication solutions such as a hardware security key. YubiKeys are small physical keys you tap on your phone or plug into your computer’s USB port to verify it’s you. Essentially, they’re like a key to your online accounts, similar to a house key or car key.

A single YubiKey has multiple functions for securing your login to email, online services, apps and computers. Because it’s something you carry with you, it’s far more secure than digital alternatives — so much so that there have been zero reported account takeovers. The YubiKey is used by thousands of businesses and is also available for individuals so you can add a higher level of online protection for yourself and your loved ones.

3. Use a password manager

Every password you use should be complex, with a mix of different letters, numbers and symbols. A password manager can create a unique, random password for each of your accounts. Better yet, it stores your passwords in an encrypted database to keep them safe while helping to ensure that you, and only you, will be able to access them easily when going online. And when you update your passwords — which you should do regularly — they are updated in the manager as well.

Additionally, don’t forget to protect your password manager with MFA. Pairing your hardware security key with it will give you the ultimate protection. That way, if someone gets your master password for your password manager, they won’t be able to log in without physically having your security key, too.

Finally, for your accounts or favorite sites that don’t offer MFA, reach out to them and encourage them to provide you the tools you need to protect yourself.

This respiratory disease you probably haven’t heard of can impact adults 60+ (hint: it’s not COVID or the flu!)

2022-10-04T08:01:01

(BPT) – Falling temperatures don’t just mark the start of cold and flu season. There’s another virus that can have serious consequences for older adults.

Here are three things you need to know about RSV.

1. What is RSV?

Respiratory syncytial virus, or RSV, is a common and contagious virus that affects the lungs and breathing passages and typically circulates during the fall, winter and early spring.1

“People tend to think of RSV as an illness primarily affecting infants, but this virus has the potential to impact the lungs and breathing passages of older adults as their immune systems decline with age, and adults with chronic heart and lung disease,” says Dr. Leonard Friedland, VP, Director of Scientific Affairs and Public Health, GSK Vaccines. “Being aware and taking preventative measures is especially important now as more people are gathering indoors and preparing to celebrate the holidays.”

Symptoms are typically mild and include:2

  • Fever
  • Runny nose
  • Cough
  • Congestion
  • Sore throat
  • Difficulty breathing

Each year approximately 177,000 older adults are hospitalized in the United States due to RSV and of those hospitalizations, an estimated 14,000 adults die because of the infection, according to the Centers for Disease Control and Prevention (CDC).3 There is no vaccine or specific treatment for RSV in adults, so learning about who is at risk of severe complications from RSV and taking preventative measures are essential, especially for those who are most vulnerable.

2. Which adults are most at risk?

According to Dr. Friedland, those at a higher risk for RSV infection, include:

  • Older adults, especially those aged 65 years and older
  • Adults with weakened immune systems
  • Adults with chronic heart or lung disease (like asthma and heart failure)

The CDC states RSV can exacerbate underlying conditions and lead to severe outcomes for at-risk adults including pneumonia, hospitalization and death.1,4

“Co-morbidities, which occur when someone has two or more chronic conditions or diseases, are additional factors that can lead to severe complications as a result of RSV,” says Dr. Friedland. “The chance of having co-morbid illnesses increases with age, so it’s important for older adults who are experiencing these issues to talk with a healthcare professional (HCP) about their risk.”

3. How can you prevent an RSV infection?

If you are at high risk for severe RSV infection, or if you interact with an older adult, there are important prevention steps you should take, according to the CDC.5

  • Wash your hands often with soap and water for 20 seconds. If soap and water are not available, use an alcohol-based hand sanitizer. Washing your hands will help protect you from germs.
  • Avoid touching your eyes, nose and mouth with unwashed hands. Germs spread this way.
  • Avoid close contact, such as sharing cups or eating utensils with people who have cold-like symptoms.
  • Cover your mouth and nose with a tissue when coughing or sneezing. Throw the tissue in the trash afterward.
  • Clean and disinfect surfaces that people frequently touch, such as doorknobs. When people infected with RSV touch surfaces and objects, they can leave behind germs. Also, when they cough or sneeze, viral droplets can land on surfaces and objects.
  • Stay at home if you are sick to help prevent spread to others.

The bottom line

Rest and fluids are important to relieve RSV symptoms and help the body heal. Speak with a healthcare professional about using over-the-counter fever reducers and pain relievers such as acetaminophen or ibuprofen to manage fever. 2 If you are having trouble breathing or your symptoms get worse, call a healthcare provider immediately.

“Most RSV infections go away on their own in a week or two but for some older adults, it can lead to hospitalization,” explains Dr. Friedland. “By taking preventative measures, learning who is at risk of severe complications due to RSV and maintaining communication with a healthcare provider, you can help yourself or an older loved one in your life stay healthy.”

For more information, visit https://www.cdc.gov/rsv/high-risk/older-adults.html.

References

  1. CDC. Respiratory Syncytial Virus Infection. Available at: https://www.cdc.gov/rsv/index.html
  2. CDC. Symptoms and Care. Available at: https://www.cdc.gov/rsv/about/symptoms.html
  3. CDC. RSV in Older Adults. Available at: https://www.cdc.gov/rsv/high-risk/older-adults.html
  4. CDC. For Healthcare Providers. Available at: https://www.cdc.gov/rsv/clinical/index.html
  5. CDC. RSV Prevention. Available at: https://www.cdc.gov/rsv/about/prevention.html

Presenting: America’s Top 10 Shelter Dog Makeovers

2022-10-04T10:01:00

(BPT) – October is Adopt a Shelter Dog Month, and it’s the perfect time to shine a spotlight on some amazing shelter dogs, who have gone through amazing transformations. The sad truth is fewer than half of dogs entering shelters are getting the grooming they need due to a lack of resources. The effects of neglect, or a life on the street, can often overshadow these sweet dogs and far too often they are overlooked by adoptive families. That’s why pet industry leader Wahl and Greater Good Charities, a global nonprofit, have partnered again for the 11th annual Dirty Dogs Contest (dirtydogscontest.com). Wahl donated grooming supplies to rescues and shelters nationwide, and they in turn shared amazing Before and After grooming photos — including the Top 10 Shelter Dog Makeovers of 2022. Vote for your favorite pup and help the organization affiliated with the dog win $10,000.

1) Flynn was found outside a shelter in a box. He was so matted in dirt and debris that his rescuers could hardly tell his head from his tail. Besides being underweight, Flynn was also suffering from a broken leg and corneal ulcers. Fortunately, after a few surgeries and a lot of grooming, Flynn recovered and was adopted by one of the volunteers at his shelter.

2) Gracie was brought to the shelter as a stray, and it was apparent she had never been groomed. She was understandably nervous about being groomed for the first time, but the groomer was gentle with Gracie and patiently finished the job in three visits. It was worth the wait because a playful pup was revealed, and from there Gracie soon found her forever family.

3) Ottie was spotted at midnight walking down a busy road. He was in deplorable condition and even had a chain intertwined into his matted fur. After several grooming sessions and losing nearly half his body weight in shaved fur, the sweetest little dog appeared. Ottie is now living a great life at a rescue, but he’s still in search of a family.

4) Luna was rescued from a puppy mill. She was covered in mats, dirt and sores from years of neglect. After the groomer shaved her painful fur, a little beauty queen emerged, and she immediately began to enjoy her newfound life. Luna now loves to run around the yard and play with her adoptive family. They say she brightens the lives of everyone she meets.

5) Louie was found as a stray. He was underweight, covered in fleas and severely matted. Despite clearly having gone through some tough times, Louie was the sweetest little boy. After his grooming his appearance finally matched his personality, and he won even more hearts — including the love of a forever family.

6) Ziggy was found lying next to another dog on a busy country road. Unfortunately, Ziggy’s companion had been hit by a car and died. It was crucial Ziggy be rescued so she didn’t face the same fate. Her rescue wasn’t an easy one though, as it took 12 hours to lure Ziggy away from her friend. Once Ziggy was safe, the next step was freeing her from the rope and burrs that were stuck in her matted fur. Then after some time to heal, Ziggy found a new home and a new furry best friend named Batman, who helped bring joy to Ziggy’s life again.

7) JD had suffered many years of neglect before he was finally brought into his shelter. He had layers of matted fur covering his whole body, including both of his eyes. After a garbage bag of fur was removed from JD, he could finally see the faces of the caring staff who rescued him. He also got a whole new outlook on life. This sweet pup has lots of love to give, and he’s looking forward to getting adopted.

8) Lucy was underweight and covered in matted fur when she arrived at the shelter. After being rescued, she was matched with a foster home to recover from her neglect and she soon flourished. Lucy finally found her happily ever after in a loving home, and she spreads joy wherever she goes.

9) Bentley had been noticed several times hanging out by a bridge, before being brought into the shelter. A volunteer groomer worked her magic and completely transformed him into a handsome gentleman. Bentley was soon adopted into a loving home, and now his hangouts are on a comfy couch.

10) Zen was rescued from a horrendous hoarding case. She arrived at the shelter with mange that required regular medicated baths. The 6-month-old pup went from sick, to healthy, to spunky in no time. As her name implies, she is a happy and relaxed girl ready for her forever home.

For more information on Wahl’s complete line of grooming products, including tips on how to pamper your own pooch, visit WahlUSA.com, or follow @WahlPets on Facebook, Instagram and Twitter.