Category: Brandpoint

2025-02-21T08:31:00

(BPT) – Imagine you haven’t slept in 72 hours and every step you take feels like you’re walking through wet cement. Then imagine you experience this feeling every day. This is how excessive daytime sleepiness can feel for people living with narcolepsy, a rare neurological disorder that can affect all aspects of a person’s daily life. Approximately 170,000 people in the United States are thought to be living with narcolepsy.

All people living with narcolepsy experience excessive daytime sleepiness, which means they struggle to stay awake and alert during the day, or they constantly feel sleepy. This can impact their daily lives at work or at home in many ways. They may have trouble staying awake while being sedentary or inactive, such as during meetings or while reading. Some may also experience difficulty with memory, concentration, and attention due to excessive daytime sleepiness. Their sleepiness may affect interactions and relationships with family and friends. Excessive daytime sleepiness can be mistaken for symptoms of other disorders, making a narcolepsy diagnosis challenging.

Many people living with narcolepsy struggle with symptoms for years before getting the right diagnosis, often taking 8 to 15 years. For Lindsay and Matt, it was no different.

The road to a diagnosis

Lindsay was just 16 years old when she began experiencing excessive daytime sleepiness. “When I go back through my memory, some days are perfectly clear. Then there are other days, months, seasons, and even years that feel like looking through a diary with blank pages. That reflects how sleepy I was at that time,” Lindsay described. “I was going through life feeling like I was moving underneath a weighted blanket.”

For nearly two decades, Lindsay pursued an explanation for her excessive daytime sleepiness with different healthcare providers, but to no avail. It wasn’t until she was 35 years old that she found a sleep specialist and was ultimately diagnosed with narcolepsy.

Matt’s excessive daytime sleepiness became very disruptive when he was 12 years old, long before his diagnosis of narcolepsy. He tried to sneak in what he called “mini-sleeps,” or 15-minute naps, whenever possible to make it through the different activities in his day, often taking two such naps between waking up in the morning and arriving at school. “I would find myself waking up, taking a shower, eating breakfast, taking a nap on the couch. Going to school, while my mom drove, I would be taking a nap,” Matt recalled. His sleepiness led to feelings of depression, which impacted his life and may have delayed his eventual diagnosis of narcolepsy.

By the time he was in his mid-twenties, Matt had seen various healthcare providers but still had no answers. Then he found a sleep specialist. “I went into his office, and he gave me a very exhaustive questionnaire. It asked questions about clumsiness and about slumping over — things that I thought were actually normal,” he said. After hearing Matt’s history, how he was feeling, and evaluating his sleep study results, the sleep specialist diagnosed Matt with narcolepsy with cataplexy. Cataplexy is the sudden and brief loss of muscle strength often brought on by strong emotions or certain situations.

“When assessing someone for narcolepsy, healthcare providers often use questionnaires such as the Epworth Sleepiness Scale (commonly called ESS) along with a diagnostic test such as the MSLT (Multiple Sleep Latency Test) to aid in their diagnosis,” explained, Dr. Alcibiades Rodriguez, MD, a board-certified neurologist and sleep specialist at New York University Langone Medical Center. “While sleep tests are an important part of confirming a diagnosis, it is important for me to ask how sleepiness impacts someone’s daily life. Questions like, what are some things you would like to be doing that you can’t do because of your excessive daytime sleepiness?”

The impact of a narcolepsy diagnosis

Receiving an official diagnosis can bring a sense of relief since it provides validation and an official name for what people are experiencing, but it’s just the first step to living with narcolepsy. Narcolepsy is a lifelong disorder and is often portrayed inaccurately in the media. This can add to the burden and stigma people living with narcolepsy often feel because others often aren’t familiar with the disorder or only know what they’ve seen portrayed in the media.

Matt found comfort in his diagnosis and was open about his disorder with others, but he struggled to find information about what he was experiencing. When he was diagnosed in 2007 at age 25, there wasn’t a lot of support and resources available, so he did his own research through university websites and textbooks. Matt had trouble understanding his diagnosis because the excessive daytime sleepiness and cataplexy he’d experienced differed from the way narcolepsy was shown in the media. “I was trying to project my own experiences onto what I was seeing, and that wasn’t what the reality was,” he shared.

For Lindsay, receiving a narcolepsy diagnosis made her feel grief for who she once was. “When I first got diagnosed, I really did not want anybody to know,” Lindsay recounted. “I did not talk about it, which is very counter to who I am. The idea of people knowing that I had narcolepsy felt really scary to me.”

The importance of sharing lived experiences and community support

Connecting with the narcolepsy community helped give Lindsay a new perspective on living with her disorder. “Getting involved was an opportunity to not just be surrounded by other people living with narcolepsy, but to be surrounded by people with narcolepsy who were using their voices to make positive change,” Lindsay said. Now, Lindsay regularly writes and speaks publicly about her diagnosis and sleep health to help others on their journey.

Matt also found inspiration within the community. Recalling the lack of resources available to him after diagnosis, he wanted to share his story, his lived experience to help raise awareness for others. On social media and other online platforms, he was able to support others in the narcolepsy community and feel more supported himself.

“Getting the right diagnosis is just the first step in a person living with narcolepsy’s journey. Even though life after diagnosis can be challenging, the right resources, support system, and the narcolepsy community are there to help,” shared Dr. Rodriguez. “Organizations like Narcolepsy Network, Project Sleep, and Wake Up Narcolepsy host events, offer programs and have different ways for people living with narcolepsy to connect with each other, share experiences, and help to drive broader awareness,” he said. “Access to resources can help people with narcolepsy stay informed and feel supported in their journey.”

In addition to these organizations, Know Narcolepsy is another resource. Visit KnowNarcolepsy.com to learn more.

Harmony Biosciences and logo are trademarks of Harmony Biosciences Management, Inc. and are used herein by permission.
© 2025 Harmony Biosciences. All rights reserved.
US-NAR-2400154/Feb 2025

2025-02-21T08:01:00

(BPT) – After overcoming multiple health challenges, Kasey was eager to embrace a new chapter in her life with her husband and young children, filled with hope and excitement. Having celebrated four years of sobriety from injection drug use at the time, she was passionate about working with other women in her community to help them achieve the same. When her own health-related concerns led her to a doctor’s visit, her doctor asked Kasey about other areas of her health, including her hepatitis C (HCV) status.

HCV is a viral infection that attacks the liver and is spread through blood-to-blood contact, which is why people who inject drugs are more likely to acquire the condition.¹ “My doctor explained to me that HCV testing is not part of a routine check-up and needs to be requested, and I realized that I was never tested for the condition in previous wellness check-ups or during my pregnancies,” Kasey recounts.

After testing, Kasey’s doctor delivered the news that she was living with HCV. “The result was not surprising to me, but it brought a lot of shame and guilt around wishing I had known to get tested for HCV earlier. I was nervous, sad and scared, not only for myself, but for my partner and kids who would need to be tested as well,” Kasey explains.

HCV is often spread through injection drug use, and as such, the opioid epidemic has exacerbated transmission rates over the past decade.² Data show that this has led to a resurgence of new cases as injection drug use accounts for a majority (approximately 70%) of new HCV cases.³

Kasey’s experience is more common than you’d think. Coined the ‘silent disease,’ HCV symptoms can go unnoticed, and if left untreated, can progress to liver fibrosis, cirrhosis and/or liver cancer.^1,4 Of the nearly 4 million people living with HCV in the U.S., an estimated 40% are unaware they have it.⁵

Getting tested is the only way to know if someone is living with HCV and is the first step toward curing their disease.⁶ In fact, the Centers for Disease Control and Prevention (CDC) recommends that all adults are tested at least once in their life and encourages more regular testing for individuals who meet additional criteria, such as a history of injection drug use.⁷

The good news is that curative options are available. With guidance from her doctor, Kasey started treatment with the direct acting antiviral (DAA), EPCLUSA^® (sofosbuvir/velpatasvir) 400mg/100mg, a prescription medicine to treat adults with chronic HCV genotype 1-6 infection with or without cirrhosis (compensated). She was also happy to learn that there was an average cure rate of 98% in clinical studies*, and that her treatment only required one pill a day for 12 weeks. EPCLUSA can also be taken during addiction recovery and with other common medications.⁸

“As a mother, I was worried treatment would interrupt my daily life, but the once-daily pill was easy for me,” Kasey says. “I developed my own, unique system to track my pills, so I didn’t forget to take my medication.” Throughout Kasey’s HCV treatment, she experienced side effects like nausea and fatigue.⁹ Three months after completing treatment, she received the news that the virus was undetectable in her latest blood test and that she was cured of HCV.

A lack of knowledge of the disease, fear of side effects from medication and the potential of stigma for seeking treatment may further prevent people from getting tested.¹⁰ Additionally, advances in medicine are further undermined by complex factors like the opioid epidemic and COVID-19 pandemic, which have limited access to care for many.^{11, 12} To date, acute HCV cases in the U.S. have doubled in the past ten years, with 70% of those acute cases becoming chronic HCV.¹

Vulnerable populations, like people who inject drugs, often experience gaps in care or may not be prioritized for treatment.¹³ However, there is strong evidence to support that treating these individuals may be critical in achieving HCV elimination efforts, emphasizing the importance of expanding screening and treatment public health initiatives.¹⁴ On average, each person who injects drugs and is living with HCV is likely to transmit the disease to about 20 others.¹⁵ As such, curing HCV in one individual who injects drugs may therefore help reduce further transmission. “I knew that seeking a cure was the best choice for me and my family. There will always be good and bad days, but it is important to focus on the positives as a way to move forward,” Kasey states.

Following her own HCV and addiction recovery story, Kasey understands firsthand how stigma can often make it harder to seek out help and support. “While everyone’s experience is unique, it’s important to remember that you don’t have to face this journey by yourself,” Kasey remarks. Approaching HCV treatment holistically with the help of doctors, community organizers and public health officials can help people get on the path to cure. “At a minimum, I hope sharing my personal experience helps people feel empowered to get tested.”

Today, Kasey is nearly seven years sober, working with women in the addiction recovery community, and applying to masters programs to expand her substance use counseling credentials. “I’m now back living in the town [where] I was in active addiction, so it’s motivation to continue being the healthiest version of myself and encouraging others in the community to do the same,” she says proudly.

“Going through my own recovery and liver health journey, I want to inspire others who may be experiencing something similar,” Kasey adds. Her advice for others who are undergoing HCV treatment or think they should get tested? “No one has to ever feel alone in HCV. There is a supportive community of safety and love for people across the spectrum of care, including those who may be at risk for HCV, are undergoing treatment, or are in recovery, offering a space of understanding and empowerment for everyone in their journey.”

Learn more at www.epclusa.com or talk to your healthcare provider to see if EPCLUSA may be right for you or a loved one.

*98% cure rate is an average from studies of genotype 1-6 patients without cirrhosis or with compensated cirrhosis

Please see Important Facts about EPCLUSA including Important Warnings for hepatitis B reactivation.

What is EPCLUSA?

EPCLUSA is a prescription medicine used to treat adults with chronic (lasting a long time) hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about EPCLUSA?

EPCLUSA can cause serious side effects, including:

• Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. This may cause serious liver problems including liver failure and death. If you are at risk, your healthcare provider will monitor you during and after taking EPCLUSA.

What should I tell my healthcare provider before taking EPCLUSA?

• Tell your healthcare provider about all of your medical conditions, including if you have ever had hepatitis B infection, liver problems other than hepatitis C infection, or a liver transplant; if you have kidney problems or are on dialysis; if you have HIV; or if you are pregnant or breastfeeding, or plan to become pregnant or breastfeed. It is not known if EPCLUSA will harm your unborn baby or pass into your breast milk.
• Tell your healthcare provider and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. EPCLUSA and certain other medicines may affect each other, or may cause side effects.

What are the possible side effects of EPCLUSA?

Serious side effects may also include:

• Slow heart rate (bradycardia): EPCLUSA, when taken with amiodarone (Cordarone^®, Nexterone^®, Pacerone^®), a medicine used to treat certain heart problems, may cause slow heart rate. In some cases slow heart rate has led to death or the need for a pacemaker when amiodarone is taken with medicines containing sofosbuvir. Get medical help right away if you take amiodarone with EPCLUSA and get any of the following symptoms: fainting or near-fainting, dizziness or lightheadedness, not feeling well, weakness, extreme tiredness, shortness of breath, chest pains, confusion, or memory problems.
• The most common side effects of EPCLUSA in adults include headache and tiredness.

These are not all the possible side effects of EPCLUSA. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescriptions drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Important Facts about EPCLUSA including Important Warnings.

A message from Gilead Sciences, Inc.

EPCLUSA and GILEAD are trademarks of Gilead Sciences, Inc. or its related companies. All other marks are the property of their respective owners.

©2025 Gilead Sciences, Inc. All rights reserved. US-EPCC-0271 02/25

References

1. CDC. Hepatitis C Surveillance 2022. April 2024. (2022 Hepatitis C | Viral Hepatitis Surveillance Report | CDC)
2. Mateu-Gelabert P, Sabounchi NS, Guarino H, et al. Hepatitis C virus risk among young people who inject drugs. Front Public Health. 2022;10:835836. Published 2022 Jul 29. doi:10.3389/fpubh.2022.835836
3. Key Populations: Identification and management of HCV in people who inject drugs | HCV Guidance (n.d.). (https://www.hcvguidelines.org/unique-populations/pwid)
4. CDC. Transcript: Hepatitis C Briefing. Jun 2023. (https://www.cdc.gov/media/releases/2023/t0629-hepc-briefing.html)
5. CDC. New CDC Data Reveal Less Than a Third of People Diagnosed with Hepatitis C Receive Timely Treatment for the Deadly, yet Curable, Infection. Aug 2022. (https://www.cdc.gov/nchhstp/newsroom/releases/2022/2022-Hep-C-Vital-Signs.html)
6. CDC. Viral Hepatitis Basics. Jul 2024 (https://www.cdc.gov/hepatitis/about/index.html)
7. CDC. Clinical Screening and Diagnosis for Hepatitis C. Dec 2023. (https://www.cdc.gov/hepatitis-c/hcp/diagnosis-testing/index.html)
8. EPCLUSA [prescribing information]. Foster City, CA: Gilead Sciences, Inc; April 2022
9. Hayes KN, Burkard T, Weiler S, Tadrous M, Burden AM. Global adverse events reported for direct-acting antiviral therapies for the treatment of hepatitis C: an analysis of the World Health Organization VigiBase. Eur J Gastroenterol Hepatol. 2021;33(1S Suppl 1):e1017-e1021. doi:10.1097/MEG.0000000000002173
10. McGowan CE, Fried MW. Barriers to hepatitis C treatment. Liver Int. 2012;32 Suppl 1(0 1):151-156. doi:10.1111/j.1478-3231.2011.02706.x
11. Perlman DC, Jordan AE. The Syndemic of Opioid Misuse, Overdose, HCV, and HIV: Structural-Level Causes and Interventions. Curr HIV/AIDS Rep. 2018;15(2):96-112. doi:10.1007/s11904-018-0390-3
12. CDC. National Profile of Viral Hepatitis. Aug 2022. (https://www.cdc.gov/hepatitis/statistics/2020surveillance/introduction/national-profile.htm)
13. Arain A, Robaeys G. Eligibility of persons who inject drugs for treatment of hepatitis C virus infection. World J Gastroenterol. 2014;20(36):12722-12733. doi:10.3748/wjg.v20.i36.12722
14. Day E, Hellard M, Treloar C, et al. Hepatitis C elimination among people who inject drugs: Challenges and recommendations for action within a health systems framework. Liver Int. 2019;39(1):20-30. doi:10.1111/liv.13949
15. NIH. Viral Hepatitis. (https://nida.nih.gov/research-topics/viral-hepatitis)

2025-02-19T09:01:00

(BPT) – Is strength training a regular part of your gym workout? If not, it’s time to add a few sets in to your fitness routine.

Cardio is great, but it’s better when paired with strength training. Each type of exercise has its own role to play. Cardio — as the name implies — supports your cardiovascular health and can improve your endurance and lung capacity. Strength training helps you build muscle mass, which plays a significant part in maintaining your overall health and wellness.

Why is building muscle important?

As you age, you naturally lose lean muscle mass. Regular strength training can help you gain and maintain lean muscle mass, which can also help improve your balance.

According to the Mayo Clinic, strength training is a key component of overall health and fitness and can help you:

• Develop strong bones
• Manage weight
• Improve your quality of life
• Manage chronic conditions
• Enhance your thinking skills

Strength training can also help you meet your fitness goals more efficiently than cardio alone.

If you’re new to strength training, it can be intimidating to start. A good goal is to aim for 2-3 days of strength training workouts per week in a comfortable environment. Below, you’ll find three strength machine exercises that can help you get started on your journey of getting stronger.

1. Supine bench press

A supine bench press can be used to work your chest, shoulders and triceps using a natural, strength-building motion.

To perform this exercise on a machine, lie on your back on the bench with your feet flat on the ground. Add your choice of weighted plates, starting small, and grip the handles to raise the weight over your chest. Keep your arms slightly wider than your shoulders. Lower the machine to your chest, elbows out, pause for a moment, and then press them back up.

2. Hack squats

Squats help strengthen your body’s base and improve your stability and posture. When you do squats, you’re targeting your quads and glutes, providing a complete lower body workout.

A variation on the traditional squat is a hack squat. A hack squat is performed on a special piece of equipment that may remind you of a reverse leg press machine.

Performing a hack squat is fairly simple. Stand in the hack squat machine with your feet on the platform, about shoulder width apart, and rest your shoulders and hips on the back rest. Grab the handlebars, inhale, and bend your knees until you’re parallel to the ground. Then, exhale and press through your feet to straighten your legs and stand.

3. Seated calf raises

How often do you think about your calf strength? Every day, your calves help you walk, run, jump and perform other daily activities. Strong calves also support your ankles, improving stability. The perfect exercise to target your calves (and also work out your hamstrings!) is a seated calf raise.

Using a plate-loaded seated calf machine, make sure you’re seated with your feet positioned slightly narrower than your hips. With a comfortable amount of weighted plates, press through your toes and lift your heels. You should feel your calf muscles squeeze. Hold for a moment, then slowly relax down. Remember to keep your knees aligned.

One place with all the equipment you need

One surefire way to safely and easily perform these three strength training exercises and more is to join a gym that has all the right equipment in a supporting community.

For example, Planet Fitness is dedicated to providing its members with best-in-class strength (and cardio) equipment. Industry trends have continued to show consumers looking for more strength equipment. To meet these demands, Planet Fitness is offering new plate-loaded equipment including Magnum Supine Bench Presses, Magnum Hack Squats and Seated Calf machines. The equipment is now in 1,700 clubs and expected to be available in nearly all clubs by the end of 2025.

New members can sign up for a high value membership with thousands of convenient locations (many open 24 hours) starting at $15 a month. To learn more and find a gym near you, visit PlanetFitness.com.

2025-02-19T10:21:26

(BPT) – After starting boot camp at just 17 years old, Heather embarked on a 13-year journey in the U.S. Army as a staff sergeant, truck driver, and trainer of new recruits. While she began her military career at a healthy weight, maintaining it became a constant battle. Despite the challenges that came with trying to maintain her weight, Heather persevered, meeting the Army’s uncompromising standards and proving her resilience time and time again.

Today, around 40% of adults in the U.S. struggle with obesity—up from about 30% compared to about two decades ago.

Growing up, Heather was always larger than her peers, which hindered her from participating in certain activities—even those she enjoyed. Despite her passion for dance, the outfits often made her the subject of ridicule. Any time Heather exposed her skin or wore tight clothes, her peers would call attention to her weight. Stigma made dancing or going to the pool a particularly dreadful experience.

As the years went on, Heather became more committed to losing weight. From crash diets and supplements to weightlifting and high-intensity cardio, she tried any and every intervention that promised results, but the results never lasted.

“I tried walking, weightlifting, dieting, but nothing seemed to keep the weight off.”

After her military career ended, Heather’s weight problems only intensified. Within a year, she had gained over 80 pounds. Public spaces became hotbeds of judgment and stigma. Negative attention was commonplace. In an airplane, a person in the neighboring seat would flash her a look that said, Oh no, I have to sit next to her?

“I was constantly getting that icky energy from people who just didn’t know any better,” Heather recalls.

Obesity impacted her to a point where she could no longer be as involved with her kids.

She struggled with how she felt about herself, and despite being a lifelong extrovert, Heather retreated inward, avoiding social events as her weight increased.

“I felt trapped and did not feel good about myself. I didn’t want my kids to only see me that way.”

As Heather searched for weight loss solutions, she came to learn that obesity is a chronic disease, which can be influenced by many things such as genetic, environmental, and physiologic factors. She realized that managing excess weight is not simply a matter of willpower or personal responsibility, and often requires comprehensive care, treatment and support. Finally, Heather spoke to her doctor.

After discussing multiple treatment options, they decided that Zepbound^® (tirzepatide) along with diet and exercise was the best fit for her.

Zepbound is an injectable prescription medicine that may help adults with obesity, or some adults with overweight who also have weight-related medical problems, to lose excess body weight and keep the weight off. Zepbound should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

Please see below Select Safety Information

Warning: Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, Zepbound and medicines that work like Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Do not take Zepbound if you or any of your family have ever had MTC or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Please see below Indications and Safety Summary with Warnings for Zepbound

Along with Zepbound, Heather’s exercise routine includes hikes in the park near her house, jogs around the block, and activities with her kids. Heather loves grilling fresh veggies and lean proteins. She feels good and has a fresh outlook on life. “Zepbound was one of the important missing puzzle pieces for me,” says Heather. “Obesity was holding me back, as it does for so many others, but you don’t have to face it alone. Talking to my doctor about Zepbound, along with diet and exercise, really helped me lose weight and keep it off.”

Watch Heather’s patient testimonial to learn more about Heather and her weight journey.

If you’re an adult struggling with obesity, ask your doctor about Zepbound. Zepbound may be able to help you reach your weight loss goals, along with a reduced calorie diet and increased physical activity. Visit Zepbound.com to learn more.

INDICATIONS AND SAFETY SUMMARY WITH WARNINGS

Zepbound^® (ZEHP-bownd) is an injectable prescription medicine that may help adults with:

• obesity, or some adults with overweight who also have weight-related medical problems to lose excess body weight and keep the weight off.

• moderate-to-severe obstructive sleep apnea (OSA) and obesity to improve their OSA.

It should be used with a reduced-calorie diet and increased physical activity.

Zepbound contains tirzepatide and should not be used with other tirzepatide-containing products or any GLP-1 receptor agonist medicines. It is not known if Zepbound is safe and effective for use in children.

Warnings – Zepbound may cause tumors in the thyroid, including thyroid cancer. Watch for possible symptoms, such as a lump or swelling in the neck, hoarseness, trouble swallowing, or shortness of breath. If you have any of these symptoms, tell your healthcare provider.

• Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC).

• Do not use Zepbound if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

• Do not use Zepbound if you have had a serious allergic reaction to tirzepatide or any of the ingredients in Zepbound.

Zepbound may cause serious side effects, including:

Severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use Zepbound. Tell your healthcare provider if you have stomach problems that are severe or will not go away.

Kidney problems (kidney failure). Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.

Gallbladder problems. Gallbladder problems have happened in some people who use Zepbound. Tell your healthcare provider right away if you get symptoms of gallbladder problems, which may include pain in your upper stomach (abdomen), fever, yellowing of skin or eyes (jaundice), or clay-colored stools.

Inflammation of the pancreas (pancreatitis). Stop using Zepbound and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back.

Serious allergic reactions. Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue or throat, problems breathing or swallowing, severe rash or itching, fainting or feeling dizzy, or very rapid heartbeat.

Low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use Zepbound with medicines that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include dizziness or light-headedness, sweating, confusion or drowsiness, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability, mood changes, hunger, weakness or feeling jittery.

Changes in vision in patients with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with Zepbound.

Depression or thoughts of suicide. You should pay attention to changes in your mood, behaviors, feelings or thoughts. Call your healthcare provider right away if you have any mental changes that are new, worse, or worry you.

Food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). Zepbound may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking Zepbound before you are scheduled to have surgery or other procedures.

Common side effects

The most common side effects of Zepbound include nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, indigestion, injection site reactions, feeling tired, allergic reactions, belching, hair loss, and heartburn. These are not all the possible side effects of Zepbound. Talk to your healthcare provider about any side effect that bothers you or doesn’t go away.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using Zepbound

• Your healthcare provider should show you how to use Zepbound before you use it for the first time.

• Tell your healthcare provider if you are taking medicines to treat diabetes including an insulin or sulfonylurea which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar levels and how to manage them.

• If you take birth control pills by mouth, talk to your healthcare provider before you use Zepbound. Birth control pills may not work as well while using Zepbound. Your healthcare provider may recommend another type of birth control for 4 weeks after you start Zepbound and for 4 weeks after each increase in your dose of Zepbound.

Review these questions with your healthcare provider:

• Do you have other medical conditions, including problems with your pancreas or kidneys, or severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems digesting food?
• Do you take diabetes medicines, such as insulin or sulfonylureas?
• Do you have a history of diabetic retinopathy?
• Are you scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation)?
• Do you take any other prescription medicines or over-the-counter drugs, vitamins, or herbal supplements?
• Are you pregnant, plan to become pregnant, breastfeeding, or plan to breastfeed? Zepbound may harm your unborn baby. Tell your healthcare provider if you become pregnant while using Zepbound. It is not known if Zepbound passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using Zepbound.

• Pregnancy Exposure Registry: There will be a pregnancy exposure registry for women who have taken Zepbound during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry, or you may contact Lilly at 1-800-LillyRx (1-800-545-5979).

How to take

• Read the Instructions for Use that come with Zepbound.
• Use Zepbound exactly as your healthcare provider says.
• Use Zepbound with a reduced-calorie diet and increased physical activity.
• Zepbound is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm.
• Use Zepbound 1 time each week, at any time of the day.
• Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection.
• If you take too much Zepbound, call your healthcare provider, seek medical advice promptly, or contact a Poison Center expert right away at 1-800-222-1222.

Zepbound injection is approved as a 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg per 0.5 mL in single-dose pen or single-dose vial.

Learn more
Zepbound is a prescription medicine. For more information, call 1-800-LillyRx (1-800-545-5979) or go to www.zepbound.lilly.com.

This summary provides basic information about Zepbound but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your healthcare provider. Be sure to talk to your healthcare provider about Zepbound and how to take it. Your healthcare provider is the best person to help you decide if Zepbound is right for you.

ZP CON BS 20DEC2024
Zepbound^® and its delivery device base are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.