The Changing Landscape of Lung Cancer Treatment

2018-01-25T09:03:01

(BPT) – At age 64, Bob Carlson was diagnosed with non-small cell lung cancer, and he felt the diagnosis was like “an expiration date being stamped on his life, like a milk carton,” and the time he had left “wasn’t nearly enough.” Bob, his wife, Julia, and doctors chose chemotherapy to combat his illness—but according to Bob, his quality of life after taking the treatments was non-existent.

Bob became so sick from the chemotherapy that he felt the treatments were almost worse than the disease itself. He talked to his doctor, who said there was nothing else they could do. Bob was on the verge of giving up hope when his physician sent him to a different research center. There, Bob met with another physician who presented him with a new option and renewed his fight.

Understanding the changing lung cancer treatment landscape

Lung cancer is the most common cancer worldwide, representing approximately 13 percent of all cancer diagnoses. While a cure for lung cancer does not currently exist, cancer immunotherapy is changing the treatment landscape and improving the prognosis for many people with lung cancer. Several immunotherapy treatments are approved for lung cancer by the U.S. Food and Drug Administration (FDA), including some as a first-line treatment for advanced lung cancer patients.

Immunotherapy is widely considered to be the most promising new cancer treatment approach since the development of the first chemotherapies in the 1940s. Cancer immunotherapy treatments harness and enhance the innate powers of the immune system to fight cancer.

According to a report published in the Annals of Oncology by the Cancer Research Institute, a nonprofit organization dedicated to the advancement of cancer immunotherapy research, there are over 2,004 immunotherapy agents in development with over sixty clinical trials evaluating immunotherapy combinations in lung cancer. There are 26 immunotherapies approved by the FDA, including six immunotherapy agents for the treatment of lung cancer.

“Today, the lung cancer space has the largest number of combination clinical trials underway, evaluating how two or more medications can work better when taken together. These trials hold much promise for patients, but there are still a lot of misperceptions surrounding clinical trials, with many people thinking that these studies are only an option after other treatments have failed,” said Dr. Jill O’Donnell-Tormey, chief executive officer and director of scientific affairs at the Cancer Research Institute. “However, many of the clinical trials currently underway are evaluating immunotherapy treatments for front-line use.”

The Cancer Research Institute offers the Cancer Immunotherapy Clinical Trial Finder as a free resource to help patients match themselves with appropriate trials based on their specific cancer diagnosis, stage, and treatment history.

“We hope that the Clinical Trial Finder will help more people learn about potential clinical trial options earlier in their patient journey so that they might have better outcomes,” said Dr. O’Donnell-Tormey.

How a clinical trial made all the difference

In August 2013, Bob became the very last patient to enroll in a particular clinical trial for non-small cell lung cancer, evaluating a checkpoint inhibitor—a promising immunotherapy approach that works by “taking the brakes off” the immune system to allow it to mount a stronger and more effective attack against cancer.

Once he started the immunotherapy treatment in the clinical trial, Bob and his doctors realized in short order that the treatment was working. “We saw tumor reduction rather quickly—which was amazing. And to top it off, unlike chemotherapy, which involved lengthy infusions that took many hours and left me ill due to the side effects, the experience of having the immunotherapy treatment in this case only took about 30 minutes, and has very little impact on my quality of life. You take your medicine, and you go on with your life. I have had to make zero lifestyle changes,” said Bob.

Now, almost five years later, Bob and Julia are back pursuing their hobby of wildlife photography and travel. He is hopeful that more patients will benefit from emerging immunotherapy treatments—through new FDA-approved therapies and through clinical trial participation.

“My only wish is that I had known about the immunotherapy clinical trial sooner,” he continued. “And I hope that through continued research more immunotherapy treatments are discovered that work for all patients with all cancer types.”

There are many other cancer patients and survivors, like Bob, who have been given new hope thanks to cancer immunotherapy research and clinical trials. For more information on cancer immunotherapy and how to match with an open clinical trial, visit the Cancer Research Institute Cancer Immunotherapy Clinical Trial Finder at https://www.cancerresearch.org/patients/clinical-trials.


More than 39,000 veterans are homeless each night: How you can help

2018-01-26T10:29:00

(BPT) – There are 18.8 million veterans in the U.S., according to the most recent U.S. Census. More than 9 million are seeking treatment at their local U.S. Department of Veteran Affairs medical center, and more than 39,000 are homeless on any given night, according to the U.S. Department of Housing and Urban Development.

There are many ways to help a veteran in need. Below are a few suggestions on how you can make a difference in a veteran’s life this year.

Tie your passion to your action.

We all have passions that bring us joy. There are many ways that suit your interests to give back while helping veterans in need. For example, do you like to spend time outdoors? Many organizations host volunteer activities like cleaning a veterans memorial in the community. Are you more of a people person? Give your time to a local veterans facility to connect with a resident in need of company.

Reach out to a veteran service organization to learn more.

The American Legion Auxiliary (ALA), The American Legion and Sons of The American Legion are actively involved in veteran causes with local units across the U.S. They offer community through memberships, organize and hold volunteer events throughout the year. As a first step, visit the websites of each organization and look for a unit close to you. Meeting with these organizations or others can kick-start your efforts to get involved with the veteran community.

Donate a day of service.

Everyday life can get messy with full-time jobs and commitments. One way to identify free time for charitable activities is to use a day off engaging in community service. “Donate” your Memorial Day to help the ALA distribute handmade poppies that support veterans in local hospitals, visit a veterans facility or deliver a meal or care package.

Give a gift.

Extend your thankfulness to the veteran community by making a gift. Mark your calendar for Nov. 27, 2018, when you can participate in #GivingTuesday, a global giving movement, by making a monetary donation to an organization that dedicates its efforts to helping veterans. Whether you come together as a family, a company, a community or by yourself, a donation can make a real difference.

Helping a veteran can be a year-long commitment or a one-day activity. To learn more about how to take the first step, visit www.ALAforVeterans.org.


Healthy half-time snacking tips from a pro

2018-01-17T14:33:00

(BPT) – Healthy snacking and making good food choices can be difficult any time of the year, but it can be especially tough during the big game. Business Insider reports that only 80 percent of people who start a New Year’s resolution keep that resolution through February. This happens to correspond with the biggest football game of the year and the common food temptations that go along with it — chicken wings, chips and salsa, pizza, not to mention beer.

Bryan Snyder, registered dietitian and nutrition director for the Denver Broncos, who is responsible for keeping the year-round nutrition strategies for the team’s players on track, also knows the pitfalls for the fans. “I advise people trying to eat healthier to follow a sustainable meal plan.”

Snyder describes a sustainable meal plan as one that allows some flexibility to have a meal here and there that might have a higher calorie intake.

“I often see people go from eating a poor diet and choosing unhealthy snacks, in combination with not exercising, to all of a sudden deciding to work out every day and eat perfectly every meal. The issue that can arise from that behavior is that it isn’t a sustainable plan, and it doesn’t allow any room for those big game snacks.”

Snyder’s recommendation is to find a nice middle ground. Allow yourself to sneak in some of those not-so-healthy calories on game day, but also give yourself some healthier options that you can have while keeping a guilt-free conscience.

Snyder’s snack of choice? Pistachios. “Pistachios are loaded with antioxidants and fiber, which will help you feel full and prevent you from overeating during the big game, and give you an immune system boost as well.”

Other healthy options are pita chips with hummus, vegetables with vegetable dip, bison or turkey burger sliders, popcorn, baked sweet potato fries, or a cup of turkey chili. For those who can’t imagine game day without wings, Snyder suggests baking the wings instead of deep-frying to replace some of the unwanted and unnecessary fats.

“Oftentimes we want to eat healthier, but we simply don’t know what to eat,” says Snyder. “All of these options are healthy swaps for satisfying game day enjoyment.”

Snyder recommends, too, having a backup plan if you’re going over to someone else’s house to watch the game, as this can be one of the biggest pitfalls to straying from a diet. “Don’t give yourself an excuse to eat poorly. Take along some portable healthy snacks — such as healthy bars, trail mix or pistachios — to be sure you have options and don’t indulge in hours of unhealthy snacking.”

While it is certainly understandable and sometimes difficult to eat healthy during the big game, it is something that can be done with the right planning and preparation, according to Snyder.

“One other common misconception about healthy snacking is that you have to sacrifice great taste,” warns Snyder. “Follow this game plan, and I guarantee you won’t.”


Do you know all of your psoriasis treatment options?

2018-01-25T08:01:00

(BPT) – Dru Riddle of Fort Worth, Texas, is one of the estimated 7.5 million people afflicted with psoriasis across the United States. A nurse anesthetist and university professor, Riddle understands first-hand the importance of receiving the proper treatment as quickly as possible and treating the condition with safe, effective medicine. Diagnosed with psoriasis in 2003 and psoriatic arthritis (PA) in 2010, Riddle underwent the treatment trials and errors common to many sufferers of PA before he was connected with a health care provider who prescribed a more aggressive plan that included biologics. Before doctors put him to a biologic therapy, Riddle suffered for several years with skin lesions and joint pain. “Finally I was switched to an injectable biologic medication,” Riddle says. “Those medications have really helped control my disease and the symptoms.”

A condition that is more than skin deep

Psoriasis often presents as patches of itchy, flaky skin, while PA — which affects about a third of psoriasis patients — results in joint swelling and pain, which may cause permanent damage. Both conditions are a product of the body’s immune system attacking itself instead of the foreign invader that should be its target.

PA can usually be identified by psoriasis-like skin inflammations. However, sometimes the joint pain and swelling appear first. This can make it difficult for doctors to properly diagnose the condition.

Initially, Riddle’s condition was treated topically with little to no effect. The relief he found with the right medicines was life-changing and he has vowed to help others with PA find the right care.

“I recommend anyone with PA be extremely aggressive with their treatment,” Riddle says. “The risks of not treating your PA are so much greater than treating it.”

Understanding biosimilars

In his quest for the right treatment regime, Riddle was diligent about his self-care and joined a number of clinical trials for the types of biologics that have been so integral to his treatment plan. It was thanks to his proactive approach to treating his condition that he started learning more about biosimilars.

Biosimilars are safe, effective and affordable alternatives to conventional biologic medicines, similar to generic offerings in other medicinal categories. Widely used in Europe, biosimilars have faced a biologics-dominated market in the United States that has so far been successful in limiting their availability. Expanding the biosimilars market in the United States will require manufacturers, the government and regulatory groups to work together to craft new policies, making access to these potentially life-changing treatments their top priority.

Riddle applauds the option of safe, effective and affordable biosimilars for patients.

“The expense of the biologic medication can be prohibitive — they’re very costly,” Riddle says. “So some people may benefit from a more affordable biosimilar medication. That medication has the same efficacy, meaning it works just as well as the biologic.”

Learning more about your options

“There’s no need to be afraid of the medicine,” says Christine Simmon, Executive Director of The Biosimilars Council, a group working to support the broad components of the biosimilar industry and enabling increased access to safe, effective and affordable biosimilar medicines. “Learn more about your options, talk to your doctor and make sure you’re receiving the medication that is the most effective treatment for your condition.”

If you have psoriasis and/or PA, you deserve to know all of your options, including biosimilars. Your doctor can provide you the information you need on these treatment options. To prepare for your next doctor’s visit and have your initial questions answered, visit http://biosimilarscouncil.org/ today.


Why probiotics should be part of your routine in 2018

2018-02-01T09:01:00

(BPT) – At the turn of the calendar, many people begin taking action on what they plan to accomplish in the new year. Some have resolved to take up a new hobby, to save more money, to travel and, of course, to improve their health.

New eating plans and gym memberships are common steps people take toward their health goals, but there are other effective ways to improve your health — like adding probiotics to your daily regimen. You’ve likely heard of probiotics before, but do you know how they benefit your health and how to select the right one for you? This article can help.*

What is a probiotic?

Before delving into how probiotics can help your body, let’s first explain what they actually are. In the simplest terms, probiotics are the good bacteria (live microorganisms) that live inside your digestive tract and help your body to function properly. There are many different types of probiotics, and each one performs a different function in your digestive system.*

The billions of bacteria that live inside your digestive tract are often called “microflora,” or more correctly, “microbiota,” and the environment that they work together to create inside the body is called the microbiome. Maintaining proper balance within your microbiome is crucial for overall health.*

How do probiotics help?

The beneficial bacteria in the digestive tract are influenced by a variety of factors such as stress, medication use, traveling and poor diet. Therefore, it is important to prioritize diet and lifestyle to maintain proper gut ecology. Probiotics are also effective for maintaining healthy populations of beneficial bacteria. Numerous clinical studies have shown probiotics have positive effects on health, including assisting in the digestion of food and the absorption of nutrients and contributing to immune system health. Some studies have suggested that certain beneficial strains may also support brain function.*

Probiotics in your diet

Probiotics are found in many foods you may enjoy every day including yogurt, kefir and sauerkraut. However, due to food processing and packaging, maintaining the stability and potency of the live beneficial bacteria in these foods can be a challenge. Including probiotic supplements in your routine ensures a consistent dose to help you and your family maintain optimal health.*

Finding the right probiotic supplement for you

Probiotic supplements can help support health at any age — from infancy to adulthood. When it comes to selecting the probiotics for you and your family, the best options are those that are formulated based on clinical research. Genestra Brands offers a comprehensive line of clinically studied, effective probiotic strains that have been recommended by doctors for more than 20 years. With more than 25 gluten-free, non-GMO formulas, Genestra Brands’ probiotics offer personalized support to help make your New Year’s resolution of becoming a healthier you that much easier.*

Before you begin taking any type of probiotic, speak with your doctor and/or pharmacist about whether they are safe and right for you.

To learn more about probiotics designed with you in mind, visit genestrahmf.com.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


An underutilized retirement strategy

2018-02-14T14:41:00

(BPT) – Across the nation, thousands of seniors have used a Home Equity Conversion Mortgage (HECM), commonly called a reverse mortgage loan, as a savvy way to access the equity in their homes as part of their retirement strategy.

Those who are interested in a reverse mortgage loan should know that there are six main phases to the process: 1) educating and qualifying, 2) counseling, 3) approval, 4) funding, 5) using and 6) settling.

1. Educating and qualifying

The HECM process begins by contacting an FHA-approved lender who will review the borrower’s situation, educate them on the HECM program, and determine if they would likely qualify for a reverse mortgage loan.

“Once the lender has determined that the borrower is eligible, they work closely with them to shape the loan so it fits their needs,” says Paul Fiore, Chief Sales Officer for American Advisors Group, the leading reverse mortgage lender in the nation. “At AAG, this is a highly personalized process designed to give the borrower the best outcome for their financial situation.”

2. Counseling

Once qualified, borrowers are referred to reverse mortgage counseling, an important consumer safeguard mandated by the government. During counseling, a HUD-approved HECM counselor reviews the borrower’s needs and circumstances. They consider how the funds might best be distributed, the financial and tax implications, and whether a HECM is right for them. If so, an application is submitted to the lender.

3. Approval

Next, the property will be appraised, and after that the approval process will begin. Before closing on the loan, borrowers will choose between several loan disbursement options, from taking it all out in a lump sum, receiving fixed monthly payments, opening a line of credit or any combination.

4. Funding

After the closing papers are signed, the homeowner has three business days to change their mind and cancel the loan (except if the loan is being used to purchase a new home). After the rescission period has passed, the funds are ready to be paid out through the payment option selected, subject to an initial disbursement limit that is determined by HUD.

5. Using your loan

The loan servicer will generally disburse funds via direct deposit or mail on the first business day of the month, following the funding of the loan. The borrower can live in the home as long as they like without making monthly mortgage payments, as long as they continue to pay property taxes and insurance on the home, maintain it in good condition and comply with any other loan terms.

6. Settling your loan

If the last surviving borrower sells or transfers the property, passes away, or does not use the property as a principal residence for more than 12 months, the loan has reached a “maturity event,” meaning that the loan comes due and no further funds can be disbursed. Borrowers also have the option of paying off their loan in full at any time without penalty.

Following a maturity event, an appraisal will be ordered by the loan servicer to determine the property’s current market value. The heirs can sell the property to repay the loan, or purchase the property for 95 percent of its appraised value. Since HECMs are non-recourse loans, the proceeds from the sale of the home are the only asset that can be taken to pay the loan’s balance, even if the loan amount exceeds the value of the home.

A home equity conversion mortgage can be shaped to fit an individual’s needs. With new consumer safeguards in place, many seniors are discovering that it is an important part of their retirement strategy.


Navigating Medicare: 5 allies who can help

2018-02-16T12:01:00

(BPT) – Enrolling in Medicare for the first time or starting coverage under a new plan? It might bring you back to that first day starting a new job. You knew some of the basics, but you also knew there was a lot more to learn. More than likely, you got help from colleagues who have been around for a while and helped show you the ropes.

Don’t worry. With Medicare, you have the same kind of knowledgeable support. You’ve got a team on your side that can help make navigating the health care system easier. Goodbye hassles, hello helpers.

Here are five allies in your corner:

1. Your Primary Care Physician. This physician is the “go-to” doctor who provides guidance on your health care needs, taking the time to really get to know you, your medical history and your health goals. Think of your Primary Care Physician as the “quarterback” of your medical team — someone who can take charge of knowing the ins and outs of your health status and help drive decisions to get you on the right track and keep you there.

2. A caregiver. Perhaps the “unsung hero” of your health care team, caregivers are the ones you know you can count on — the ones you know are there to offer support and care for you, whenever you need it. Whether a family member, neighbor, friend or professional assistant, these are the people in your life who help you along the way. Their assistance can span everything from bringing you to appointments or getting prescriptions filled to making meals or offering emotional support.

3. Your pharmacist. This team member keeps an eye on the medications you take — prescription and over-the-counter — to make sure they work safely together. Your pharmacist is a great person to talk with about how medications are making you feel and answer any questions you have on topics including what side effects to expect, what to do if you miss a dose, or how to store your meds.

4. An insurance agent. Original Medicare. Medicare Supplement. Part D. Medicare Advantage. There are many options and decisions to make when it comes to your Medicare coverage, and a licensed insurance agent can help you find the right plan, or plans, for you. Once you’ve selected a plan, you can also always call your agent to ask questions if your health or coverage needs change or if your plan changes from year to year.

5. Your insurance company. Within your insurance company, there are more people than you likely realize who are working hard on your behalf to ensure you get the medical care and support you need. Insurers can offer tools, resources and support that can help you live a healthier life.

For more information to help you navigate Medicare, visit MedicareMadeClear.com.


New Treatment Option for People With Cystic Fibrosis

2018-02-20T12:01:00

(BPT) – For patients with cystic fibrosis (CF) 12 years and older with certain mutations

At 17 years old, Taylor Brown is a straight-A student balancing a 10-hour work week and competitive dancing. She is also one of approximately 30,000 Americans living with cystic fibrosis (CF), a progressive genetic disease that makes it difficult to breathei.

Taylor has been taking a combination of medicines to treat and manage her disease since her diagnosis when she was six days old. In the U.S., approximately 1,000 people are diagnosed with CF each yeari. CF is a disease you are born with.

“Cystic fibrosis has always been a part of my life, but I don’t let it define me,” said Taylor. “I’m still able to do the things I love, like competitive dancing and advocating for other people with cystic fibrosis.”

There is no cure for the life-shortening disease, but therapies are available for some people that target the underlying cause of CFii. CF is caused by a reduction in the quantity and/or function of cystic fibrosis transmembrane conductance regulator (CFTR) proteins resulting from gene mutations that leads to the buildup of mucus in organs, such as the lungsi.

After talking with her treatment team and family, Taylor participated in a clinical trial for SYMDEKO™ (tezacaftor/ivacaftor and ivacaftor). SYMDEKO was recently approved by the Food and Drug Administration (FDA) for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have two copies of the F508del mutation or who have at least one mutation in the CF gene that is responsive to SYMDEKO.

“SYMDEKO is a new treatment option that helps the body’s CFTR proteins work better,” said Patrick Flume, M.D., Director of the Cystic Fibrosis Program at the Medical University of South Carolina. “Scientific innovations have enabled medicines to target cystic fibrosis at its root. I encourage patients and their families to work with their doctors to understand how these developments may help them.”

SYMDEKO is made up of two medicines that work to help increase the quantity and function of CFTR protein in certain people with CF. The FDA approval of SYMDEKO was based on results from two global Phase 3 trials in approximately 750 patients, which demonstrated the safety and efficacy of SYMDEKO in people with CF ages 12 and older who had certain mutations in the CFTR gene.

“I’m excited about new discoveries and research in cystic fibrosis, because they have a very real impact on my life and the lives of others with cystic fibrosis,” said Taylor.

Indication and Important Safety Information for SYMDEKO tablets (tezacaftor 100 mg/ivacaftor 150 mg and ivacaftor 150 mg)

What is SYMDEKO (tezacaftor/ivacaftor and ivacaftor)?
  • SYMDEKO is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with SYMDEKO.
  • Talk to your doctor to learn if you have an indicated CF gene mutation.

It is not known if SYMDEKO is safe and effective in children under 12 years of age.

Important Safety Information

Do not take SYMDEKO if you take certain medicines or herbal supplements such as:
  • antibiotics such as rifampin (Rifamate®, Rifater®) or rifabutin (Mycobutin®)
  • seizure medicines such as phenobarbital, carbamazepine (Tegretol®, Carbatrol®, Equetro®) or phenytoin (Dilantin®, Phenytek®)
  • St. John’s wort

Talk to your doctor before taking SYMDEKO if you take any of the medicines or herbal supplements listed above.

Before taking SYMDEKO, tell your doctor about all of your medical conditions, including if you:
  • have or have had liver problems
  • have kidney problems
  • are pregnant or plan to become pregnant. It is not known if SYMDEKO will harm your unborn baby. You and your doctor should decide if you will take SYMDEKO while you are pregnant
  • are breastfeeding or planning to breastfeed. It is not known if SYMDEKO passes into your breast milk. You and your doctor should decide if you will take SYMDEKO while you are breastfeeding

SYMDEKO may affect the way other medicines work, and other medicines may affect how SYMDEKO works.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, because the dose of SYMDEKO may need to be adjusted when taken with certain medicines.

Especially tell your doctor if you take:
  • antifungal medicines such as ketoconazole (e.g., Nizoral®), itraconazole (e.g., Sporanox®), posaconazole (e.g., Noxafil®), voriconazole (e.g., Vfend®), or fluconazole (e.g., Diflucan®)
  • antibiotics such as telithromycin (e.g., Ketek®), clarithromycin (e.g., Biaxin®), or erythromycin (e.g., Ery-Tab®)
What should I avoid while taking SYMDEKO?
  • SYMDEKO can cause dizziness in some people who take it. Do not drive a car, use machinery, or do anything that needs you to be alert until you know how SYMDEKO affects you.
  • Avoid food or drink that contains grapefruit or Seville oranges while you are taking SYMDEKO.
What are the possible side effects of SYMDEKO?
SYMDEKO can cause serious side effects, including:
  • High liver enzymes in the blood have been reported in people treated with SYMDEKO or treated with ivacaftor alone. Your doctor will do blood tests to check your liver:
    • before you start SYMDEKO
    • every 3 months during your first year of taking SYMDEKO
    • every year while you are taking SYMDEKO
  • Your doctor may do blood tests to check the liver more often if you have had high liver enzymes in your blood in the past.
  • Call your doctor right away if you have any of the following symptoms of liver problems:
    • pain or discomfort in the upper right stomach (abdominal) area
    • yellowing of your skin or the white part of your eyes
    • loss of appetite
    • nausea or vomiting
    • dark, amber-colored urine
  • Abnormality of the eye lens (cataract) in some children and adolescents treated with SYMDEKO or with ivacaftor alone. If you are a child or adolescent, your doctor should perform eye examinations before and during treatment with SYMDEKO to look for cataracts.
The most common side effects of SYMDEKO include headache, nausea, sinus congestion, and dizziness.

These are not all the possible side effects of SYMDEKO. Call your doctor for medical advice about side effects. You are encouraged to report side effects to FDA at 1-800-FDA-1088.

Please click here to see the full US Prescribing Information for SYMDEKO.

To learn more about SYMDEKO, visit www.SYMDEKO.com.

i Cystic Fibrosis Foundation. About Cystic Fibrosis. Available at https://www.cff.org/What-is-CF/About-Cystic-Fibrosis/. Accessed February, 2018.
ii Pettit, RS and Fellner C. CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 July; 39(7): 500-511. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103577/.

© 2018 Vertex Pharmaceuticals Incorporated | VXR-US-23-00149 | 02/2018


Visit Durban for an unforgettable South African experience

2018-02-08T10:32:00

(BPT) – Think of South Africa, and images of majestic savannas and roaming wildlife come to mind. A South African safari is an unforgettable experience, but no visit to the country is truly complete without a cultural immersion. The vibrant city of Durban combines the best of both worlds. Located along the Indian Ocean coast an hour from Johannesburg by air, Durban offers an eclectic array of activities where you can explore the city’s significant role in world history, the rich heritage of its Zulu people, and innumerable natural wonders — from the beach to the bush.

Experience authentic Zulu culture

Named for its dramatic surrounding landscape, the Valley of 1,000 Hills has been home to the Zulu people, South Africa’s largest ethnic group, for centuries.

Visitors can take an organized tour deep into tribal lands to experience Zulu culture with its exuberant ceremonies, traditional music and dancing. You’ll learn about Zulu beliefs and healing practices, break bread with local families and learn the hidden meanings behind their colorful beadwork. You can even arrange one-on-one sessions with the village healer or spend the night with a Zulu family in their home.

Walk in Gandhi’s and Mandela’s footsteps

Not everyone is aware that Mahatma Gandhi’s life work was inspired by his experiences in Durban. In 1893, he arrived as a young lawyer, and the discrimination he witnessed personally and against his fellow Indians drove him to start his worldwide movement of passive resistance fighting for the rights of the Indian population. At the Phoenix Settlement, you will see Gandhi’s house and the printing press he used to publish his newspaper, The Indian Opinion. Many of the more than one million Indians living in the city make the pilgrimage to this historical site alongside visitors from around the world.

Five years after his death, Nelson Mandela remains South Africa’s most revered public figure. 2018 marks a year-long celebration of his life and what would have been his 100th birthday on July 18. Honor his work when you’re in Durban by visiting the Nelson Mandela Capture Site, at the exact spot where he began his “Long Walk to Freedom” after being arrested for anti-Apartheid activism in 1952. Visit the striking monument and educational exhibition walking you through Mandela’s life and role in establishing a democratic South Africa.

Hit the beach at Umhlanga Rocks

Umhlanga Rocks, Durban’s laidback beach village, is on a picturesque stretch of the Indian Ocean. It beckons visitors with a scenic promenade passing by local landmarks including Umhlanga Lighthouse and Whale Bone Pier. A walkable downtown makes dining and nightlife easily accessible from the area’s many boutique hotels and guesthouses, and opportunities to get on the water abound — from surfing to deep sea fishing, scuba diving, whale watching and kiteboarding.

Discover an underwater wonderland

Consistently rated one of the top warm water diving and snorkeling sites in the world, Aliwal Shoal is also the spot to get up close and personal with blacktip reef sharks. Those brave enough can swim or dive alongside these mysterious creatures in the open ocean, but viewing from inside a cage is always an option.

Experience a Big Five safari

Back on land, the South African bush is less than four hours away by car. Private game reserves offer high-end safari lodge accommodations, minimal crowds and optimal chances for getting the perfect photos of the “Big Five” — elephants, rhinos, water buffalo, lions and leopards. In iSimangaliso Wetland Park, a UNESCO World Heritage Site, hippos, crocodiles, pelicans and flamingos roam Lake St. Lucia, while elephants, giraffes and leopards inhabit the adjacent grasslands.

Visit www.durbanexperience.co.za to learn more.


7 things you didn’t know about adult vaccination in the U.S.

2018-02-08T10:31:00

(BPT) – Even though vaccines are one of the greatest health innovations of the last century, a new survey shows that among some adults in America there is a lack of awareness about the immunizations they need as adults.

According to an online survey of 1,000 American adults aged 18 years and older, there is a critical gap between awareness and action when it comes to vaccination.1

Adults should talk to their healthcare providers about the Centers for Disease Control and Prevention’s list of recommended adult vaccines. The best way to protect yourself and those closest to you is to vaccinate for life. So, ask your doctor if you are up to date on all your vaccines. It’s a simple step that can help protect you, your family and your community.

1. Adults may think they know, but they have no idea

Nearly half of adults consider themselves to be “very” or “quite” knowledgeable about vaccines,2 yet fewer than three in ten Americans are aware of the vaccines recommended for adults their age.1

2. Vaccines are not just for kids

Most of us are familiar with the importance of vaccination during childhood; however, vaccination is equally important throughout adulthood, as the immune system begins to decline with age.3 Immunosenescence, also known as age-related decline in immunity, significantly contributes to the susceptibility of older adults to serious, yet preventable conditions including: influenza, pneumonia and shingles.3 Despite this, 65 percent of adults are not fully up to date on their vaccines.1

3. Vaccines may help save your life

Six million deaths are prevented globally each year as a result of vaccination. If global vaccination rates increased, even more deaths could be prevented.4

4. Vaccination may prevent unnecessary death

Vaccine-preventable diseases can cause long-term illness and even death. In fact, 99 percent of the more than 50,000 deaths from vaccine-preventable diseases that occur every year in the U.S. are in adults.5

5. Vaccination may protect against more than just vaccine-preventable diseases

Vaccination can also protect against other health problems. In fact, vaccinating against the flu can also help protect people against heart attacks and stroke.6

6. Vaccine knowledge may supersede action

Despite longstanding recommendations for the use of many vaccines, adult vaccination rates remain low. In 2015, the flu vaccination rate for adults aged 19 and older was less than 45 percent, Tdap (Tetanus/diphtheria/pertussis) vaccination rate for adults was only about 23 percent, and shingles vaccination rate for adults 60 and older was just about 31 percent.7

7. Vaccination may impact all of us in unexpected ways

Medical costs related to vaccine-preventable diseases in older adults are high and are expected to grow substantially in the coming years. One study forecasts U.S. medical costs for Americans 65 and older in the Medicare population to be $4.74 billion annually by 2030 for just one vaccine-preventable disease.8


1 Vaccinate for Life consumer survey. Exploration based on Q9. Which of the following statements best describes how up-to-date you consider yourself to be on vaccinations. I am aware of the vaccines recommended to adults of my age and have received all of these recommended vaccinations. Total base all respondents n=1000.

2 Vaccinate for Life consumer survey. Exploration based Q4A. How knowledgeable do you consider yourself to be on adult vaccinations, also referred to as immunizations? Are you … very knowledgeable, quite knowledgeable, not quite knowledgeable, not at all knowledgeable. Total base all respondents n=1000.

3 American College of Physicians et al. Aging and Immunity: The Important Role of Vaccines, 2017. Available at https://www.acponline.org/system/files/documents/clinical_information/resources/adult_immunization/aging_and_immunity_guide.pdf.

4 Ehreth J. The global value of vaccination. Vaccine. 2003;21:596-600.

5 Rice HR, Varkey P. What immunizations should I offer to my patients? A primer on adult immunizations. J Assoc Physicians India. 2011; 59:568-72.

6 Hung IFN et al. Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study. Clin Infect Dis. 2010; 51:1007–1016.

7 U.S. Centers for Disease Control and Prevention. Surveillance of Vaccination Coverage Among Adult Populations — United States, 2015. MMWR Surveill Summ. 2017; 66(11):1–28.

8 Varghese L et al. The temporal impact of aging on the burden of herpes zoster. BMC Geriatrics. 2017;17:30.