Category: Brandpoint Health

2018-03-16T12:01:01

(BPT) – As millennials become more conscious of how their diets affect their daily well-being, they’re driving demand across all generations for greater transparency in the food supply chain. They want to know how their foods were raised, sourced, processed and prepared.

“Sometimes, food is more than food,” report authors of a Nielsen study, indicating 75 percent of adults worldwide think they “are what they eat” and nearly 80 percent use foods to forestall health and medical issues.

Cargill recently conducted a Feed4Thought survey related to how these millennial-driven trends are shaping values related to food — and buying behaviors — for people of all ages.

1. Buying food based on how animals were raised

Consumers report being three times more likely to purchase protein if they know it was raised with natural health supplements. And 58 percent of U.S. consumers are more concerned about food animal welfare now than they were just a few years ago, according to a recent report by researcher Packaged Facts.

2. More emphasis on gut health

Nutritionists are increasingly learning about the role of the stomach and its microorganisms in maintaining our health. The foods we digest reportedly have a profound effect on our balance of “good and bad bacteria,” the soundness of our immune systems and our brain’s release of feel-good chemical serotonin, according to the NCBI. And supplements can be effective as well. In the Cargill survey, 80 percent of respondents report adjusting or supplementing their diets to achieve better gut health.

3. A desire for animals to use the same health supplements humans do

Millennials want to know the origins of their food, and that includes understanding what their meat sources have been fed. A December survey found 62 percent of millennials prefer their animal proteins to have been raised with the same supplements ingested by humans — like probiotics, plant extracts and essential oils. “People want natural, wholesome and sustainable ingredients,” notes Chuck Warta, president of Cargill Premix and Nutrition. “We’ve seen a rise in the popularity of digestive health supplements for humans, echoed in the demand for protein raised with natural supplements.”

4. Bigger emphasis on protein

Eighty-seven percent of U.S. millennials (and 99 percent of those who are college grads) consider protein important to their diets, says one study. And worldwide, a Nielsen report found 34 percent of millennials rate high amounts of protein a very important element in their decisions of which foods to buy. Nutritionists are finding new ways to meet the increased demand for proteins to address the growing world population and their desire for protein-rich diets.

While millennials have been the forerunners in driving new and healthier dietary trends in recent years, their initiatives have spread across all generations to improve awareness and make us all more conscious of exactly what we’re eating.

“It’s important for the animal agriculture community to remain in touch with food trends so we can continue to provide the choices consumers demand,” concludes Hannah Thompson-Weeman of the Animal Agriculture Alliance.

Cargill, a longtime leader in producing sustainable and wholesome foods, recently acquired two companies that specialize in natural, research-proven animal feed products. Read more about the company’s “Feed4Thought” survey at Cargill.com.

2018-03-13T16:07:01

(BPT) – Imagine your family carried the gene for a rare, life-threatening condition, but didn’t know it?

For generations, members of Angel’s family experienced fatigue, nerve pain, numbness in limbs, dizziness, shortness of breath and chest pain, but were unable to determine the cause. The answer was hereditary ATTR (hATTR) amyloidosis, a progressive, debilitating, life-threatening condition that typically runs in families.

“Early on, my family used to call hATTR amyloidosis ‘the curse’ because no one knew what it was and those who had it experienced a wide variety of symptoms and misdiagnoses,” Angel said. She witnessed firsthand how the condition, which affects approximately 50,000 people worldwide, can devastate a person’s quality of life.

“I watched my grandfather go from building houses and doing construction to being wheelchair bound and bedridden.”

Angel’s family’s experience was recently chronicled in “Living a Rare Life,” a new downloadable booklet sharing their personal account about how they’ve been living with this condition across generations. Like many rare conditions, hATTR amyloidosis varies from individual to individual and is often misdiagnosed because its wide array of symptoms, like shortness of breath, numbness of fingers and toes, constipation/diarrhea and headaches, resemble other, more common conditions.

While the degree and severity of symptoms vary from person to person, hATTR amyloidosis can lead to significant disability and a shortened life expectancy. Obtaining an early and accurate diagnosis is critical.

While Angel tested negative for the condition, she has taken an active role serving as an advocate and caregiver for her family. “The first step to managing a hereditary condition is knowing your family health history and identifying gaps in knowledge about genetic disorders,” said Angel. “Today my mom and many of her siblings are battling hATTR amyloidosis, but now we know how to recognize the symptoms and better manage them.”

Here are a few of Angel’s tips to begin conversations with your loved ones about your health history:

1. Initiate a Dialogue. Having open and honest conversations about family health history may play a role in identifying symptoms sooner, reaching an accurate diagnosis sooner and allowing your loved ones to take control of their health.
2. Speak to a Genetic Counselor. Genetic counseling can help your family members understand their chances of inheriting a rare disease gene mutation and become familiar with the testing process. A counselor can help your family to understand potential issues related to genetic testing, like insurance, determine if genetic testing is appropriate and help make sense of results once they are obtained.
3. Become an Advocate. As an advocate, you can be your family’s most valuable resource for learning about a genetic condition. For some family members, it may be helpful for them to know that they have support throughout the journey of the condition. Building a support system can help the entire family continue to make educated decisions.

If you, or someone in your family, experience symptoms consistent with those of hATTR amyloidosis, talk to your doctor and visit hATTRBridge.com for information and resources like the “Living a Rare Life” booklet.

* Angel is partnering with Alnylam Pharmaceuticals to increase awareness of hATTR amyloidosis.

2018-03-15T14:01:00

(BPT) – Most of us who are aging hope to live comfortably and self-sufficiently at home well into our golden years. And, of course, we wish the same for our parents.

The good news is advancements in healthcare and other technology are increasingly allowing aging Americans to live longer at home. The bad news is many are unable to continue to do so once they take a serious fall at home, injuring their hips, heads or other body parts. That’s an all-too-common problem: One in four Americans age 65 and older fall each year, and falling once doubles their chances of falling again, according to the Centers for Disease Control and Prevention (CDC). Falls also are the number one cause of fatal and nonfatal injuries among older adults.

“We treat many older patients who lived happily and productively at home until they tripped and broke a hip,” notes orthopaedic trauma surgeon and American Academy of Orthopaedic Surgeons (AAOS) spokesperson Lisa Cannada, MD. “A broken hip or other fall-related injuries make it difficult for people to live at home again without assistance of some kind and loss of independence. With a little foresight and planning, many of these injuries could be prevented.”

Several steps can be taken to prevent debilitating falls from ever taking place. Consider how the following tips may help you or your loved ones hold on to the comforts of home for a longer period of time:

* Recognize your risk. A number of health issues can make you or your parents more prone to falling, ranging from arthritis to neurological conditions to vision or hearing loss. Various medications, the use of alcohol or simple dehydration may also affect your ability to safely navigate your surroundings. But the more you’re aware of such possible hindrances, the more you can plan for them.

* Optimize your health. Take responsibility for staying as healthy and fit as possible by remaining active, drinking enough water, limiting alcohol, avoiding smoking and eating a healthy diet with plenty of calcium and vitamin D. Annual physicals, eye exams and bone density tests are recommended. Make exercise a priority, and choose something that you enjoy to maintain your bone health and coordination.

* Fall-proof your home. Walk through your home and that of your parents to identify and fix possible hindrances such as slippery surfaces, inadequate lighting, cluttered pathways, unsecured rugs, electric cords, loose flooring, etc. Consider installing grab bars in the shower, securing loose rugs with slip-resistant backings and installing bright motion-detector lights. You also might move clothes, kitchenware and other everyday gear within easier reach. The AAOS and Orthopaedic Trauma Association offer additional tips in this Falls Awareness and Prevention Guide.

* Wear the right shoes. Limit footwear to well-fitting, low-heeled shoes or slippers with rubber or other non-skid soles. Also watch for untied shoelaces.

* Maintain an action plan. If you live alone, have someone check on you daily. If you do fall, you may avoid further injury by using your arms to protect your head instead of trying to break your fall. If possible, fall on your side or buttocks and roll slightly. If you can’t get up after bracing yourself on a wall or furniture, call a friend, relative or 911 for help. Finally, consider wearing a medical alert device 24-7; you never know where and when you’ll need emergency help, and your cell phone may not always be available.

Many aging Americans are able to enjoy long, productive lives in their own homes instead of turning to other accommodations. Increase your chances of making that happen for you and your parents by taking steps to plan for and avoid an injury-producing fall. Find more tips at orthoinfo.org/falls.

2018-03-07T11:31:00

(BPT) – The majority of Americans wouldn’t think that walking to their car after work is a difficult task, but that wasn’t the case for Michele Norris. Before her heart failure diagnosis and treatment, Michele found herself leaning on a co-worker while walking to her vehicle, taking frequent breaks along the short route.

She knew something wasn’t right. Michele, a 62-year-old budget director, noticed shortness of breath and swelling in her legs, limiting her daily routines. She decided to take action and talk to her doctor. After a few conversations, Michele was eventually diagnosed with heart failure with reduced ejection fraction, or HFrEF, a chronic and progressive condition affecting millions of Americans, though few know much about it. After discussions with her cardiologist, Michele was prescribed ENTRESTO^® (sacubitril/valsartan), a heart failure medicine that helps improve the heart’s ability to pump blood to the body.

“Being diagnosed with heart failure was terrifying, but I learned how to trust my gut, and raise a flag when something feels off,” said Michele. “Taking steps to change my diet and stay active, and adding ENTRESTO to my regimen has helped me stay out of the hospital, although everyone’s experiences are different.”

Michele is passionate about helping others with HF and encourages them to keep all of their doctor appointments, and to be an active partner with their doctors when choosing a treatment plan – which includes medication and lifestyle changes.

Learn more at www.entresto.com

What is ENTRESTO?

ENTRESTO (sacubitril/valsartan) tablets 24/26 mg, 49/51 mg, 97/103 mg is a prescription medicine used to reduce the risk of death and hospitalization in people with certain types of long-lasting (chronic) heart failure. ENTRESTO is usually used with other heart failure therapies, in place of an ACE inhibitor or other ARB therapy.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENTRESTO?

ENTRESTO can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you plan to become pregnant. If you get pregnant while taking ENTRESTO, tell your doctor right away.

Who should not take ENTRESTO?

Do not take ENTRESTO if you

• are allergic to sacubitril or valsartan or any of the ingredients in ENTRESTO
• have had an allergic reaction including swelling of your face, lips, tongue, throat (angioedema) or trouble breathing while taking a type of medicine called an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB)
• take an ACE inhibitor medicine. Do not take ENTRESTO for at least 36 hours before or after you take an ACE inhibitor medicine. Talk with your doctor or pharmacist before taking ENTRESTO if you are not sure if you take an ACE inhibitor medicine
• have diabetes and take a medicine that contains aliskiren

What should I tell my doctor before taking ENTRESTO?

Before you take ENTRESTO, tell your doctor about all of your medical conditions, including if you have kidney or liver problems or a history of hereditary angioedema; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed. You should either take ENTRESTO or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take potassium supplements or a salt substitute; nonsteroidal anti-inflammatory drugs (NSAIDs); lithium; or other medicines for high blood pressure or heart problems such as an ACE inhibitor, ARB, or aliskiren.

What are the possible side effects of ENTRESTO?

ENTRESTO may cause serious side effects including:

• angioedema that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO. People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema
• low blood pressure (hypotension). Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue
• kidney problems
• increased amount of potassium in your blood

The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.

Please see full Prescribing Information, including Boxed WARNING, available at: https://www.pharma.us.novartis.com/sites/www.pharma.us.novartis.com/files/entresto.pdf.

Patients are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

2018-03-15T09:21:01

(BPT) – –

2018-03-14T14:17:00

(BPT) – One in every four people is affected by anemia, a condition that occurs when the body lacks enough healthy red blood cells.^1,2 Red blood cells carry hemoglobin, a protein that transports oxygen throughout the body, ensuring the body has energy and can function properly.³ Symptoms may vary in severity and can be acute or chronic. Further, many patients present with chronic anemia as a result of other health conditions — cancer, autoimmune and inflammatory diseases, or blood or bone marrow disorders — which each come with their own challenges.^2,4,5 For those with chronic anemia associated with other diseases, life after diagnosis often means adjusting to a new “normal.” Dizziness, trouble breathing and overall tiredness experienced by many with anemia may mean adjusting work schedules, changing exercise regimens, limiting social activities and generally slowing down.²

Kathleen Weis, chief executive officer of The Aplastic Anemia and MDS Awareness International Foundation, calls it the “elephant in the room.”⁶

“Chronic anemia impacts a person’s daily activities. For many, it means not being able to do the things they used to — like going to work or helping around the house. Symptoms, fatigue in particular, can be debilitating,” Weis explained.⁶

For patients, this may necessitate relinquishing aspects of independence. An increasing reliance on caregivers is one of the hardest transitions people living with chronic anemia face. It’s an entirely new learning process and is often coupled with the guilt of knowing there’s an added burden on family members and caregivers. Patients may even experience depression at one point or another.⁷

“It’s a double whammy in terms of emotions. Both patients and caregivers are learning how to deal with the changes,” Weis said. “We put a lot of focus on mindfulness and positivity to help patients and their families through these challenges, in addition to educating about treatment. We believe in treating the body and mind together.”⁶

This March marks the first ever Aplastic Anemia and MDS Awareness Month, an extension from the weeklong observance The Aplastic Anemia and MDS Awareness International Foundation has organized in previous years. Webinars and conferences throughout the month will offer learning opportunities on a wide variety of topics for patients, caregivers and healthcare providers.

Research is another core focus for the Foundation. Treatment options for patients with chronic anemia are limited, and the organization is trying to make sure researching new approaches is seen as a priority. One of the most common treatments is red blood cell transfusions; a process by which donated blood is infused into a patient’s bloodstream.² Frequency of transfusions depends on disease severity, but some patients may need to be transfused as often as every two weeks.^2,8 This is challenging as transfusions are cumbersome, costly and associated with risks.

“Frequent blood transfusions require numerous visits to the doctors, which can be inconvenient for both patients and their caregivers. We would like to see new treatments that not only improve patient outcomes, but may also address current burdens,” said Weis.⁶

Despite the challenges they face, Weis notes that the patients she meets are resilient. “They want you to know they are still very much moving forward and this thing — this disease — is just something they are dealing with each day.”⁶

For more information about The Aplastic Anemia and MDS Awareness International Foundation or Aplastic Anemia and MDS Awareness Month, visit http://www.aamds.org/.

REFERENCES:

1. Pasricha, SR. Anemia: A Comprehensive Global Estimate. Blood. 2014;123(5).
2. American Cancer Society. Anemia in People With Cancer. Available at https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/low-blood-counts/anemia.html. Accessed March 2018.
3. American Cancer Society. Blood Transfusions for People with Cancer. Available at https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/blood-transfusion-and-donation/what-are-transfusions.html. Accessed March 2018.
4. Smith, Jr., R,E. The Clinical and Economic Burden of Anemia. Am J Manag Care. 2010; 16:S59-S66.
5. Gunnar Birgegård. Managing Anemia in Lymphoma and Multiple Myeloma. Therapeutics and Clinical Risk Management. 2008;4(2):527–539.
6. Interview with Kathleen Weis. Conducted by Marissa Vitha and Danielle Kroft for the Celgene Newsroom, January 2018.
7. Korkmaz S, Yildiz, S, et al. Frequency of anemia in chronic psychiatry patients. Neuropsychiatr Dis Treat. 2015;11:2737–2741. doi: 10.2147/NDT.S91581.
8. Langhi, Jr., D., et.al. Guidelines on Beta-thalassemia major – regular blood transfusion therapy: Associac¸ão Brasileira de Hematologia, Hemoterapia e Terapia Celular: project guidelines: Associac¸ão Médica Brasileira – 2016. Brazilian Journal of Hematology and Hemotherapy. 2016;3:8(4):341–345.

2018-03-19T08:01:00

(BPT) – Fitness is central to your well-being and ability to enjoy life to the fullest, however it’s easy to get stuck in a rut. How do you find new interest and motivation so you’re ready to maximize the warm weather months?

Dan Gaz, physical activity and assessment program manager at the Mayo Clinic Healthy Living Program, says there are many things people can do to get a jump-start on their health and wellness.

“Fitness doesn’t have to be complicated or boring,” says Gaz. “There are many creative ways to implement fitness activities into your life that are both fun and invigorating.”

Gaz suggests five simple ways to get a jump-start on summer fitness and energize your workout routine:

Try something new

Gaz says getting outside your comfort zone can be beneficial to your health. “Trying something new helps keep your fitness plan fresh. Plan a visit to the local farmers market to pick up produce. Sign up for a 5k run, or look at your local community education or rec center class catalog and sign up for activities. The social dynamics of these types of events benefit mental as well as physical health.”

Get outside

“Getting outdoors is rejuvenating,” Gaz says. “Taking a walk in nature is a nice change of pace that is good for the body and mind.” You can go for a walk, run or take a stroll around a local park. “Just being outdoors shakes things up and you may find higher levels of energy as you breathe in the fresh air. Plus, getting a daily dose of vitamin D from the sun does the body good.”

Bring friends

“It’s no secret when you work out with other people they tend to hold you accountable, but there’s also more benefit than just that,” says Gaz. “When you take an exercise class, join a running club or biking group, you may end up pushing yourself harder. The people next to you become your exercise advocates and suddenly, you’ll have the desire to keep up and do more. This can accelerate reaching your fitness goals.”

Rethink commuting

“Anything you can do to break up the monotony of sitting is a good thing.” Try being creative in commuting and how you travel throughout the day. “If possible, walk or bike to work or the grocery store. You can also take the bus, get off a couple blocks early and walk the rest of the way. A little planning ahead of time can help you accomplish multiple things at once: You’re getting exercise, completing an errand and reducing your carbon footprint.”

Be purposeful

“You may only have a few minutes a day to dedicate to exercise, but that doesn’t mean you can’t make a big impact,” says Gaz. “Being purposeful with your choices is important. For example, use intervals in your workout routine to maximize outcomes. If you enjoy walking, do a brisk 30 or 60 seconds, then walk slower for the same period of time before pushing yourself again. This type of interval training is simple, yet highly effective. It works similarly for other activities like swimming, biking and running.”

To find more tips about improving your health with creative approaches to exercise or to set up a visit with a wellness expert, visit healthyliving.mayoclinic.org.

2018-03-13T16:01:00

(BPT) – An estimated 4.4 percent of adults have Attention Deficit Hyperactivity Disorder (ADHD) in the U.S. — which means that when applied to the full U.S. adult population aged 18 and over, approximately 10.5 million adults are estimated to have ADHD. Medication is not appropriate for all individuals diagnosed with ADHD. ADHD is a neurodevelopmental disorder that manifests as a persistent pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development. Many of these adults struggle with symptom management as they go through their day.

On June 20, 2017, the U.S. Food and Drug Administration (FDA) approved MYDAYIS^® (mixed salts of a single-entity amphetamine product), an extended-release treatment for ADHD in patients 13 years and older. Mydayis is not for use in children 12 years and younger. In clinical studies, Mydayis demonstrated improved attention up to 16 hours after dosing, beginning at 2 to 4 hours, compared to placebo. Attention was measured using the Permanent Product Measure of Performances (PERMP), a skill-adjusted math test that measures attention in ADHD. Mydayis is now available for appropriate patients by prescription.

Mydayis, other amphetamine containing medicines, and methylphenidate have a high chance for abuse and can cause physical and psychological dependence. Your healthcare provider should check you or your child for signs of abuse and dependence before and during treatment with Mydayis. Tell your healthcare provider if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs. Your healthcare provider can tell you more about the differences between physical and psychological dependence and drug addiction.

Mydayis is a federally controlled substance (CII) because it contains amphetamine that can be a target for people who abuse prescription medicines or street drugs. Keep Mydayis in a safe place to protect it from theft. Never give Mydayis to anyone else, because it may cause death or harm them. Selling or giving away Mydayis may harm others and is against the law.

“The recognition and treatment of ADHD have gone through significant developments in the past 20 years as we’ve come to understand more about how symptoms may impact a patient’s day,” said Dr. Theresa Cerulli, Clinical Instructor at Harvard Medical School. “The availability of multiple, different ADHD treatments, including Mydayis, provides healthcare professionals with different tools they can consider using as part of their patients’ management plans.”

As the understanding of ADHD and the ways it impacts people continues to evolve, it is also important for healthcare professionals to have a range of treatment options to help address the needs of their individual patients. Mydayis provides healthcare professionals with another option for their appropriate patients who may seek an extended-release treatment that helps address their individual needs. People living with ADHD should work with a healthcare professional to determine whether a pharmacological treatment is appropriate for them, and if so, which one helps meet their individual needs.

For more information about Mydayis, talk to your healthcare provider and visit www.MYDAYIS.com.

What is MYDAYIS^®?

Mydayis is a prescription medicine for ADHD in patients 13 years and older. Mydayis is not for children 12 years and younger.

IMPORTANT SAFETY INFORMATION

Abuse and dependence. Mydayis, other amphetamine containing medicines, and methylphenidate have a high chance for abuse and can cause physical and psychological dependence. Your healthcare provider should check you or your child for signs of abuse and dependence before and during treatment with Mydayis.

Tell your healthcare provider (HCP) if you or your child have ever abused or been dependent on alcohol, prescription medicines, or street drugs. Your HCP can tell you how physical and psychological dependence and drug addiction are different.

Mydayis is a federally controlled substance (CII) because it contains amphetamine that can be a target for people who abuse prescription medicines or street drugs. Keep Mydayis in a safe place to protect it from theft. Never give Mydayis to anyone else, because it may cause death or harm them. Selling or giving away Mydayis may harm others and is against the law.

Who should not take Mydayis?

Do not take Mydayis if you or your child is:

• allergic to amphetamine or any of the ingredients in Mydayis. See Medication Guide for a list of ingredients.
• taking or have taken a medicine for depression (monoamine oxidase inhibitor [MAOI]) within the past 14 days.

Serious problems can occur while taking Mydayis. Tell your HCP:

• if you or your child have heart problems, heart defects, high blood pressure, or a family history of these problems. Sudden death has occurred in people with heart problems or defects taking stimulant medicines. Sudden death, stroke and heart attack have happened in adults taking stimulant medicines. Your HCP should check you or your child carefully for heart problems before starting Mydayis. Since increases in blood pressure and heart rate may occur, your HCP should regularly check these during treatment. Call your HCP or go to the ER right away if you or your child has any signs of heart problems such as chest pain, shortness of breath, or fainting while taking Mydayis.

• if you or your child have mental (psychiatric) problems, or a family history of suicide, bipolar illness, or depression. New or worse behavior and thought problems or new or worse bipolar illness may occur. New psychotic symptoms (such as hearing voices, or seeing or believing things that are not real) or new manic symptoms may occur. Call your HCP right away if you or your child have any new or worsening mental symptoms or problems during treatment, especially hearing voices, seeing or believing things that are not real, or new manic symptoms.

• if your child is having slowing of growth (height or weight). The HCP should check your child’s height and weight often while on Mydayis, and may stop treatment if a problem is found. Mydayis is not for children 12 years and younger.

• if you or your child have circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud’s phenomenon). Fingers or toes may feel numb, cool, painful, sensitive to temperature and/or change color. Call your HCP if you or your child have any of these symptoms or any signs of unexplained wounds appearing on fingers or toes while taking Mydayis.

• if you or your child have a seizure. Your HCP will stop treatment.

• if you or your child have symptoms of serotonin syndrome: agitation, hallucinations, coma, or changes in mental status; problems controlling movements or muscle twitching, stiffness, or tightness; fast heartbeat; sweating or fever; nausea, vomiting or diarrhea. Call your HCP or go to the ER if symptoms occur. Serotonin syndrome may occur if Mydayis is taken with certain medicines and may be life-threatening.

• if you or your child are or become pregnant or plan to become pregnant. It is not known if Mydayis may harm your unborn baby.

• if you or your child are breastfeeding or plan to breastfeed. You should not breastfeed while taking Mydayis. Mydayis passes into breast milk.

What should I avoid during Mydayis treatment?

• Avoid drinking alcohol during treatment with Mydayis.

What are possible side effects of Mydayis?

The most common side effects of Mydayis include:

• trouble sleeping
• decreased appetite
• dry mouth
• increased heart rate
• anxiety
• nausea
• irritability
• weight loss

For additional safety information, click for Medication Guide and discuss with your healthcare provider.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Mydayis is a registered trademark of Shire LLC.

2018-03-23T08:00:00

(BPT) – When you’re shopping for something, it’s good to have options to help you decide on the best choice for you.

This remains true when shopping for health care providers. However, determining which of the numerous health care options is right for you can be difficult. Like what’s the difference between a doctor of osteopathic medicine (D.O.) and a medical doctor (M.D.), or the difference between a physician assistant and a nurse practitioner?

If such questions have you confused, this article is a handy guide to help you understand your options and choose the right health care professional for you.

Doctor of osteopathic medicine

As mentioned above, D.O. stands for doctor of osteopathic medicine, and while D.O.s receive equivalent training to a medical doctor (M.D.), they also receive 200 hours of training in osteopathic manipulative medicine, which is used to diagnose and treat structural and functional issues in the bones, joints, tissues and muscles of the body.

D.O.s, like M.D.s, are found in all medical specialties, such as emergency medicine, neurology and pediatrics. The difference that sets D.O.s apart is mainly philosophical. D.O.s are trained to take a whole-person approach to patient care, not just focus on treatment of a disease. They also focus on wellness and prevention, while considering the patient’s mental, physical and emotional status, which contribute to overall health.

Medical doctor

M.D.s and D.O.s are the most highly trained health care professionals. This training teaches them to not only treat symptoms but to view the body as a system and link those symptoms to an underlying condition. Both M.D.s and D.O.s prescribe medication and can perform surgery, something others on this list cannot do.

The current market has seen a shortage of doctors in some areas and in some cases people who believe they are being treated by a doctor are actually seeing a person in another role like one of the next three professions.

Physician assistant

P.A.s are able to perform many of the same functions as M.D.s and D.O.s, including ordering X-rays, conducting physical exams and even prescribing medication. However, a P.A.’s training is limited and these professionals work under the supervision of a licensed M.D. or D.O.

Nurse practitioner

Perhaps the least widely known of the five on this list, a nurse practitioner is a registered nurse who has advanced their education and training — via a master’s or doctorate degree — to specialize in a given area, such as women’s health or pediatrics.

In addition to diagnosing conditions, nurse practitioners also prioritize counseling and health education in their work. N.P.s can practice independently in some states while others require them to work under an M.D. or D.O.

Registered nurse

The most common medical professional on this list, R.N.s generally have a Bachelor of Science degree in nursing. They have experience assessing symptoms, offering patient support and recording medical histories. As with nurse practitioners, patient education is a vital component of an R.N.’s role.

Yet, while R.N.s are skilled medical professionals, they are not allowed to work independently and cannot write prescriptions. In all cases an R.N. must work under the supervision of a D.O. or M.D.

Finding the best solution for you

So, which health care professional is right for you? Start by matching your needs to the qualifications of the professionals above and from there, search based on what is most important to you. Be diligent in your search, because finding the perfect solution for your medical needs will make it worth the time spent considering all those options.

To find a practicing D.O. in your area, visit doctorsthatdo.org.

2018-03-21T18:01:01

(BPT) – This article is sponsored advertising content from Amgen, Inc.

Patients living with multiple myeloma and physicians who treat them are realizing the importance of not only treating the underlying disease, but also treating or preventing disease complications. One important area that sometimes gets overlooked is how multiple myeloma can impact the bones. Multiple myeloma is typically characterized by bone lesions, which often result in serious bone problems, defined as broken bones, the need for surgery (to prevent or repair broken bones), the need for radiation treatments to the bone, and pressure on the spinal cord (spinal cord compression).^1,2

While still incurable, availability of new multiple myeloma treatment regimens have been shown to improve survival compared to recent standards-of-care. With these gains in survival, doctors and patients should be considering the importance of setting additional treatment goals to try to prevent some of the problems having multiple myeloma can bring, like fractures and other serious bone problems.³

March is Multiple Myeloma Awareness Month, which recognizes patients like Joshua Fine who are living with this life-threatening, incurable blood cancer that, as of 2014, affected an estimated 118,539 people in the U.S.^4,5

Bone lesions were present at the time of Joshua’s diagnosis and, in his case, were an indication of the underlying disease.⁶

“After I was diagnosed with multiple myeloma, I experienced significant damage to my hip and had to begin using crutches. My doctor wanted to avoid surgery,” recalled Joshua. “We immediately discussed the importance of getting on a bone targeting agent to help protect my bones from further damage.”

Until recently, treatment options to prevent serious bone problems in patients with multiple myeloma were limited to bisphosphonates, most commonly given as an intravenous infusion.⁷ These are cleared by the body through the kidneys. Renal impairment (which means your kidneys are not working normally) is a common problem for patients with multiple myeloma.⁷ In fact, approximately 60 percent of all multiple myeloma patients have or will develop renal impairment over the course of the disease.⁸

There is a new bone targeting medicine available, called XGEVA^® (denosumab), that is not cleared through the kidneys and can help prevent serious bone problems in patients with multiple myeloma.⁹ XGEVA^®‎, a prescription medicine given as a shot once every four weeks in your doctor’s office, is used to prevent fracture, spinal cord compression, or the need for radiation or surgery to bone in patients with multiple myeloma and in patients with bone metastases from solid tumors.¹⁰

XGEVA^® should not be used by women who are pregnant because it could harm the unborn baby. XGEVA^® should not be used by people with low blood calcium levels (hypocalcemia). XGEVA^® can cause low blood calcium levels, which in some cases could be life threatening. Patients with renal impairment are more likely to have problems with low calcium levels in their blood while taking XGEVA. Your doctor should check your blood calcium levels before you start and while on XGEVA^®. Take calcium and vitamin D supplements as directed by your doctor while you are on XGEVA^®. Please see the additional Important Safety Information at the end of this article to learn about risks to consider when talking to your doctor about starting XGEVA^®.

In the largest international multiple myeloma clinical trial ever conducted, which enrolled 1,718 newly diagnosed patients, XGEVA^® was no worse at reducing the risk of having a serious bone problem than another drug called zoledronic acid, based on the time to first on-study serious bone problem (median 22.8 months vs. 24 months, respectively).^10,11

Despite the risk of experiencing a serious bone problem, 36 percent of myeloma patients remain untreated for the prevention of bone problems.¹² XGEVA^® offers multiple myeloma patients protection from serious bone problems, with a convenient shot under the skin, instead of an intravenous infusion, providing patients with an alternative treatment option. Your doctor will check your blood before you start XGEVA^® to make sure you do not have low calcium levels in your blood.¹⁰

“Since my diagnosis I have learned a lot about the effect multiple myeloma has on the body, especially the bones,” Joshua said. “I’m excited about the approval of XGEVA in multiple myeloma as it provides patients like me a new option that can help prevent serious bone problems.”

For more information about how XGEVA^® can prevent serious bone problems in patients with multiple myeloma, and for support tools such as a list of questions for your doctor, visit http://www.xgeva.com/.

Important Safety Information

Do not take XGEVA^® if you have low blood calcium (hypocalcemia). Your low blood calcium must be treated before you receive XGEVA^®. XGEVA^® can significantly lower the calcium levels in your blood and some deaths have been reported. Take calcium and vitamin D as your doctor tells you to. Tell your doctor right away if you experience spasms, twitches, cramps, or stiffness in your muscles or numbness or tingling in your fingers, toes, or around your mouth.

Do not take XGEVA^® if you are allergic to denosumab or any of the ingredients of XGEVA^®. Serious allergic reactions have happened in people who take XGEVA^®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of the face, lips, or tongue, rash; itching; or hives.

What is the most important information you should know about XGEVA^®?

Do not take XGEVA^® if you take Prolia. XGEVA^® contains the same medicine as Prolia^® (denosumab).

Severe jaw bone problems (osteonecrosis)

Severe jaw bone problems may happen when you take XGEVA^®. Your doctor should examine your mouth before you start, and while you are taking XGEVA^®. Tell your dentist that you are taking XGEVA^®. It is important for you to practice good mouth care during treatment with XGEVA^®. In studies of patients with bone involvement, the rate of severe jaw problems was higher the longer they were being treated with XGEVA^®.

Unusual thigh bone fracture

Unusual thigh bone fracture has been reported. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Risk of high calcium levels in patients who are still growing

Patients with bones that are not fully matured are at a greater risk to develop high blood calcium levels after they stop taking XGEVA^®, that can be serious.

Increased risk of broken bones in the spine after discontinuing XGEVA^®

After your treatment with XGEVA^® is stopped, your risk for breaking bones in your spine can increase, especially if you have a history of risk factors such as osteoporosis or prior fractures.

Possible harm to your unborn baby

You should not become pregnant while taking XGEVA^®. Tell your doctor right away if you are pregnant, plan to become pregnant, or suspect you are pregnant. XGEVA^® can harm your unborn baby.

Tell your doctor if you:

• Are taking a medicine called Prolia^® (denosumab) because it contains the same medicine as XGEVA^®
• Have symptoms of low blood calcium such as muscle stiffness or cramps
• Have symptoms of severe jaw bone problems such as pain or numbness
• Have ongoing pain or slow healing after dental surgery
• Have symptoms of high blood calcium such as nausea, vomiting, headache, and decreased alertness
• Are pregnant, plan to become pregnant, suspect you are pregnant, or breastfeeding

While taking XGEVA^®, you should:

• Take good care of your teeth and gums and visit a dentist as recommended
• Tell your dentist that you are taking XGEVA^®
• Tell your doctor if you plan to have dental surgery or teeth removed
• Talk to your doctor before you stop taking XGEVA^® about your risk for broken bones in your spine.
• Women of child bearing age should use highly effective contraception while taking XGEVA^® and for at least 5 months after the last dose of XGEVA^®

What are the possible side effects of XGEVA^®?

In patients with bone metastases from solid tumors using XGEVA^®, the most common side effects were tiredness/weakness, low phosphate levels in your blood, and nausea. The most common serious side effect of XGEVA^® was shortness of breath.

In multiple myeloma patients receiving XGEVA^®, the most common side effects were diarrhea, nausea, low red blood cells, low blood platelets and calcium levels, back pain, swelling of the lower legs or hands, upper respiratory tract infection, rash, and headache. The most common serious adverse reaction in multiple myeloma patients was pneumonia.

These are not all the possible side effects of XGEVA^®. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1–800–FDA1088.

Please see Full Prescribing Information.

*BPT: Brandpoint

References

1. Roodman GD. Pathogenesis of myeloma bone disease. Leukemia. 2009;23(3):435–441.
2. Drake MT. Bone disease in multiple myeloma. Oncology (Williston Park). 2009;23 (14 Suppl 5):28-32.
3. Rajkumar, SV, Moreau, P. Advances in biology and therapy. Nat Rev Clin Oncol. 2014; 11.
4. Jakubowiak A. Management Strategies for Relapsed/Refractory Multiple Myeloma: Current Clinical Perspectives. Semin in Hematol. 2012; 49(3)(1),S16-S32.
5. NCI SEER Cancer Stat Facts: Myeloma. www.seer.cancer.gov/statfacts/html/mulmy.html. Accessed August 28, 2017.
6. International Myeloma Working Group. International Myeloma Working Group (IMWG) Criteria for the Diagnosis of Multiple Myeloma. http://imwg.myeloma.org/international-myeloma-working-group-imwg-criteria-for-the-diagnosis-of-multiple-myeloma/. Accessed January 24, 2018.
7. Terpos E, et al. International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol. 2013;31(18):2347-57.
8. Qian Y et al. Renal impairment and use of nephrotoxic agents in patients with multiple myeloma in the clinical practice setting in the United States. Cancer Med. 2017;6:1523-1530XGEVA^® (denosumab) prescribing information, Amgen.
9. Lewiecki EM. Denosumab: an investigational drug for the management of postmenopausal osteoporosis. Biologics: Targets & Therapy. 2008;2:645-653, 638-A-2.
10. XGEVA^® (denosumab) Prescribing information, Amgen.
11. Raje et al. Denosumab versus zoledronic acid in bone disease treatment of newly diagnosed multiple myeloma: an international, double-blind, double-dummy, randomised, controlled, phase 3 study [published online ahead of print February 8, 2018]. Lancet Oncol. https://doi.org/10.1016/S1470-2045(18)30072-X.
12. Kim, C., Hernandez, R. K., Cheng, P. C., Smith, J., Cyprien, L., & Liede, A. (2016). Bone Targeting Agent Treatment Patterns Among Patients with Multiple Myeloma Treated at Oncology Clinics Across the United States: Observations from Real-World Data. Blood. 128(22), 2364.