Category: Brandpoint Health

2023-09-08T13:31:00

(BPT) – Sponsored by Intercept Pharmaceuticals

Primary biliary cholangitis (PBC) is a rare liver disease that causes the body to attack its own cells in the bile ducts of the liver. Bile ducts are tube-like structures that carry bile from the liver to the intestine to help digest food. However, when bile can’t flow through the bile ducts, it collects in the liver and causes damage.

The most common early symptoms of PBC are pruritis (itching) and fatigue, though some PBC patients do not show symptoms at the time of diagnosis. If PBC progresses, it can cause an increase in risk of liver cancer, the need for liver transplant and death.

There is no cure for PBC, however, there are treatment options that can help people manage their disease. In recognition of September’s PBC Awareness Month, let’s look at five key facts about this condition and hear from healthcare providers, advocates and people living with PBC:

Fact #1: PBC is progressive and chronic, which means it won’t just go away and can get worse over time

Damage from PBC can cause fibrosis (scarring) and, in its most severe form, lead to cirrhosis (severe scarring). In some cases, this can result in liver failure and the need for a liver transplant.

Dr. Kris Kowdley, Director of the Liver Institute Northwest and Professor of Medicine at Elson S. Floyd College of Medicine at Washington State University, explained, “PBC can progress slowly for some people, while others may advance to end-stage liver disease or liver failure much more rapidly. Therefore, it’s important to catch it as early as possible so that we can treat the disease to slow the rate of progression and minimize the amount of damage and scarring to the liver. With early detection, we can hopefully reduce the risk of the patient developing cirrhosis or other complications of liver disease.”

Fact #2: Because many people with PBC have no symptoms, the disease is often discovered from abnormal results on routine liver blood tests

Most people with PBC do not experience symptoms at the time of their diagnosis. Instead, it is detected during routine blood tests which assess damage to the liver by measuring different enzymes and proteins in the blood.

One of the key enzymes used to help diagnose PBC is alkaline phosphatase, or ALP, which can also monitor disease progression and track how well someone is responding to treatment. More recent studies have shown that other liver enzymes beyond ALP are also important in assessing total liver health. Treatment can help improve these enzymes and reduce liver damage.

Dr. Kim Brown, Division Chief of Gastroenterology and Hepatology and the Associate Medical Director of the Henry Ford Hospital Transplant Institute, stated, “We typically look at ALP levels when assessing PBC, though recent research shows that there are several biomarkers that should be measured and assessed. While still considered the cornerstone of PBC evaluations, we now look beyond ALP to include other liver enzymes as well as liver fibrosis when evaluating total liver health.”

Fact #3: While PBC is more common in females, it can affect anyone

People with PBC have historically been portrayed as middle-aged Caucasian women; however, it is widely recognized now that men and people of color are affected in higher numbers than once believed.

Wayne, a man living with PBC, was diagnosed in 1992, and before his diagnosis, the only person he knew with PBC was his father. He was shocked when he walked into his first PBC support group meeting and was surrounded by women. While more common in females, PBC can impact individuals from any background and may also be hereditary. A PBC diagnosis is often delayed among males because of the myth that PBC is rare in males, thus, the disease course in males tends to be more aggressive with worse outcomes.

Research also suggests that people of color living with PBC tend to have more severe disease when first diagnosed and experience worse long-term outcomes.

As Donna Cryer, a key advocacy leader and Founder, President and CEO of the Global Liver Institute, stated, “No matter who you are, you should be able to receive timely and thorough diagnosis and care for PBC. Equitable care for PBC patients requires us to move beyond harmful stereotypes and improve the system so that everyone has the same opportunity.”

Fact #4: PBC was once called primary biliary cirrhosis

For many years, PBC wasn’t diagnosed until it was late-stage and patients had already developed cirrhosis. Unfortunately, the negative stigma associated with cirrhosis led some people to incorrectly believe PBC was related to alcohol consumption.

Almost 10 years ago, a dedicated group of patient leaders and medical professionals, with the support of industry partners including Intercept Pharmaceuticals, teamed up and advocated to have the name changed to more accurately reflect the disease. Carol Roberts, President of the PBCers Organization who played a pivotal role in the movement, said, “Prior to the name change many patients did not share their diagnosis with others, even friends and family, because of the stigma. This prevented them from receiving the support they needed while dealing with the diagnosis. The name change helps them feel more comfortable sharing the diagnosis, allowing them to receive support and understanding, while increasing awareness of PBC.”

Fact #5: Even with initial treatment, up to 50% of people have uncontrolled disease

For many people, the first treatment their doctor prescribes is not enough to adequately control their PBC. Medical guidelines recommend that liver function tests are repeated every three to six months to monitor the disease and help determine if their initial treatment is working, or if additional therapy should be considered.

With this, it’s important for people with PBC to talk to their doctor about symptoms and test results to understand how they’re responding to treatment and if more can be done.

Visit LivingwithPBC.com for helpful resources, including discussion guides, tips for managing symptoms, patient videos and the PBC Living^® app that tracks test results.

2023-09-08T11:01:01

(BPT) – From record-breaking blizzards in upstate New York and devastating wildfires in California to powerful hurricanes off the coast of Florida, natural disasters are becoming increasingly common because of the ongoing climate crisis. While everyone is affected by severe weather, it poses a particular risk for people living with disabilities.

When a natural disaster hits, the routines and the infrastructures people with disabilities depend on can be dangerously disrupted. Also, state- and county-level disaster response protocols may pose a danger to people living with paralysis, as they may not have made those protocols with the disability community in mind. That’s why it’s crucial that people living with paralysis and their caregivers know how to prepare themselves.

With this in mind, the Christopher & Dana Reeve Foundation partnered with the Federal Emergency Management Agency (FEMA) to create the Emergency Preparedness for People with Paralysis Booklet. This comprehensive, crucial resource can aid national organizations, people living with paralysis and other disabilities and their caregivers to prepare for impending weather, including wildfires, hurricanes and tornadoes.

Below are some ways the booklet can help you identify your mobility needs, assess challenges and create tangible solutions in case of a power outage, hurricane, wildfire, tornado and extreme heat.

Power outage

Power outages are common during various natural disasters and storms. Because they are so common, it’s important that people who use power wheelchairs and/or ventilators know what they’ll need to do to prepare.

First, you’ll need to identify your frequently used electricity-dependent medical equipment. If you have extra batteries, know how long they’ll last and understand how to use a backup power supply.

Next, contact your local utility company and register as a power wheelchair user or dependent on a ventilator. This registration list is used to prioritize power restoration services.

Finally, contact emergency services to understand their protocols for those who require electricity to support medical equipment. This includes information on priority shelter placement or transportation to local EMS facilities.

Hurricane

Hurricanes are tropical storms with wind speeds of at least 74 miles per hour. While these storms pose a significant threat to coastal communities, they can also cause torrential rains and severe flooding hundreds of miles inland.

To prepare for a hurricane, look around the interior of your home and identify what items need to be secured. Securing these items will prevent injury from falling debris.

Know your evacuation routes and leave immediately if an evacuation order is issued. If you’re at home when a hurricane strikes, head to the highest level or shelter in a windowless room.

Wildfire

Although wildfires may begin in natural areas like forests and prairies, they can quickly threaten residential communities. Hazardous air conditions and emergency evacuation are likely, like those issued in the recent Canadian fires in the Northeast. If you live in an area where wildfire risks are possible, it’s critical that you identify a safe space in your home that can be closed off before a wildfire strikes.

Another thing to remember is that regional power grids may be shut off to lower the risk of igniting power lines. Contact your local utility company and government agencies to find out how residents will be notified of a public power shutdown.

During a wildfire, if possible, get out of your wheelchair and onto the floor. Smoke rises, and the best air for breathing will be down low. Wear an N95 mask to limit smoke inhalation, and call 911 if you are trapped.

After the wildfire has been contained, don’t touch fallen power lines and continue to wear masks. Make sure to wash service animals and/or pets to remove residual ash.

Tornado

Tornadoes are most common in the Great Plains but occur throughout the U.S. and can be triggered by thunderstorms, tropical storms or hurricanes. The funnel-shaped cloud, containing violently spinning air, can leave a path of devastation a mile wide and 50 miles long.

In case of a tornado, identify a safe space to take shelter in your home. If the basement is not accessible, plan to use a windowless room, such as a bathroom or closet, on the lowest possible level of the home. Don’t forget to lock your wheelchair wheels.

Extreme heat

As a result of climate change, extreme heat is increasingly becoming an issue throughout the country. It can pose a specific risk for people who have difficulty regulating body temperature due to spinal cord injury.

Get in touch with local emergency management officials to locate community cooling centers. Make sure to visit ahead of time to ensure they are accessible.

Pay attention to your wheelchair and mobility equipment, which can become extremely hot when left in the sun. Overheated equipment can burn the skin of individuals who brush up against hot armrests and seats or who place bare feet on a metal footrest.

Beyond preparation

In addition to ensuring the safety and livelihood of those living with disabilities and their caregivers, the Reeve Foundation’s Emergency Preparedness for People with Paralysis Booklet is a powerful reminder to local and government leaders that people living with disabilities should be top of mind and included in the conversations of natural disaster response protocols.

To learn more and download the Emergency Preparedness for People with Paralysis Booklet, please visit ChristopherReeve.org.

This publication is supported by the Administration for Community Living (ACL), U.S. Department of Health and Human Services (HHS) as part of a financial assistance award totaling $8,700,000 with 100 percent funding by ACL/HHS. The contents are those of the author(s) and do not necessarily represent the official views of, nor endorsement by, ACL/HHS, or the U.S. government.

2023-09-07T15:45:00

(BPT) – A few years ago, Kathy F. was at lunch when her heart suddenly began to race.

Her immediate thought: “I had too much caffeine in the tea I drank.”

But when her Apple Watch detected an unusually high heart rate, she knew it was time for an intervention. She left the eatery, went home, and immediately called her cardiologist.

After some testing, the 55-year-old Floridian became one of millions of Americans living with atrial fibrillation (AFib), the most common arrhythmia. This condition causes the heart to beat too slowly, quickly, or irregularly. While treatable, an AFib diagnosis and its treatment options often confuse and scare the newly diagnosed.

“It was kind of scary to think about having any kind of procedure, especially one having to do with your heart,” said Kathy, one of many AFib patients who have successfully undergone catheter ablation after drug therapy failed or was an ineffective treatment option.

But, she said, there are many resources available today to help AFib patients manage their physical and emotional well-being. In celebrating AFib Awareness Month, Kathy shares the advice to listen to your body, have a relationship with your cardiologist or primary care doctor, ask questions, and be open to learning about all potential treatment options.

Listen to your body. If something does not feel right, bring it up to your doctor.

Following her AFib diagnosis, Kathy’s cardiologist placed her on multiple blood thinners, but her symptoms persisted.

When a heart is in AFib, it may not be pumping enough oxygen-rich blood out to the body, leading to symptoms such as a racing heart, palpitations, shortness of breath, chest pain, and fatigue or weakness.

Kathy’s AFib episodes would last between two to 12 hours. They became so debilitating that she could not focus, especially at work, and they would occur at unforeseen times.

“Wherever I went, I was always thinking, ‘Am I going to have an episode?'” said Kathy, president of a non-profit that operates five special needs schools in North Florida.

Concerned, she returned to her cardiologist, who had treated her previously for a pulmonary aneurysm. Her cardiologist referred her to Dr. Saumil Oza.

“Some have described AFib as a sensation that feels like fish flopping around in the chest,’’ said Dr. Oza, an electrophysiologist in Jacksonville, Florida, who performed Kathy’s catheter ablation.

After another unsuccessful round of blood thinners, Dr. Oza recommended Kathy undergo catheter ablation.

“I didn’t look back,” she said. “It (catheter ablation) was an instant relief for me.”

Do not be afraid to talk to your doctor.

Because the diagnosis and treatment of AFib can be confusing and scary, Kathy recommends communicating with your cardiologist or electrophysiologist early and often.

Dr. Oza agrees.

As with any medical treatment, individual results may vary, so it is essential to communicate with your cardiologist or electrophysiologist, especially women. Women, he said, often ignore their symptoms and as a result often do not get treated as quickly. Their AFib symptoms are often dismissed as stress, lack of sleep, or panic attacks.

“Medications can help control the symptoms and keep the AFib at bay, however, when that doesn’t work, we have to move on to other treatments like catheter ablation,” said Dr. Oza. “Again, only a cardiologist or electrophysiologist can determine whether ablation is an appropriate course of treatment for you, which is why having discussions with your clinician is key.”

It is ok to seek out other credible resources for information.

Kathy underwent catheter ablation in 2020. Initially, and out of fear of the unknown, she hesitated about the procedure.

“I was scared,” said the mother of four adult children.

It was not until after some research and speaking with a trusted friend who had undergone the procedure that her thoughts changed.

“She (friend) confirmed it was not as scary as I thought it would be,” said Kathy. “My advice is to talk to your doctor, get as much information as possible, and seek the best option. But also talk to people and do your own research.”

To learn more about AFib and what resources are available to help you cope with the diagnosis and treatment options, visit GetSmartAboutAFib.com.

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THERMOCOOL^® Navigation Catheters are indicated for the treatment of drug refractory recurrent symptomatic paroxysmal atrial fibrillation, when used with CARTO^® 3 Systems (excluding NAVISTAR™ RMT THERMOCOOL™ Catheter).

As with any medical treatment, individual results may vary. Only a cardiologist or electrophysiologist can determine whether ablation is an appropriate course of treatment. There are potential risks including bleeding, swelling or bruising at the catheter insertion site, and infection. More serious complications are rare, which can include damage to the heart or blood vessels; blood clots (which may lead to stroke); heart attack, or death. These risks need to be discussed with your doctor and recovery takes time. The success of this procedure depends on many factors, including your physical condition and your body’s ability to tolerate the procedure. Use care in the selection of your doctors and hospital, based on their skill and experience.

256147-230810

© Biosense Webster, Inc. 2023. All Rights Reserved.

2023-09-07T10:23:00

(BPT) – Eating a well-balanced diet can positively impact your mood, energy levels and sleep, but did you know it can also impact your immune system function? The gastrointestinal (GI) tract is the body’s largest immune organ, so it’s important to prioritize gut health to support your overall well-being.

“Our bodies are interconnected in many ways, and supporting one function will in turn lead to improved function elsewhere,” said Olivia Robertson-Moe, Nutritional Therapy Practitioner (NTP). “For example, focusing on improving your digestive health can help support the immune system and your body’s response to toxins.”

According to Robertson-Moe, the foods we eat affect the composition of the bacteria in our gut, or the microbiome, which then affects our immune cell function and production. So, the phrase “you are what you eat” can be taken quite literally. However, it’s not always clear what foods we should and should not be eating. So, for more easy ways to support your digestive health, Robertson-Moe recommends the following tips:

1. Take a supplement with key prebiotics such as GI Stability™ from Standard Process, a leading whole food-based nutritional supplement company. It supports the GI tract by delivering 2’-FL, a prebiotic first identified in human milk, that is able to reach the lower GI tract where it is broken down to feed the growth of beneficial microbes.*^
2. Adding fermented foods to your diet can support the microbiome. Fermented foods contain live probiotic bacteria that can benefit the microbiome by supporting the diversity of your gut bacteria. The process of fermentation can also make foods easier to digest. If you want to support your gut and immune function, try incorporating fermented foods like sauerkraut, kimchi, yogurt and kefir.
3. Reducing stress is key to good gut health. Stress may negatively impact digestion, increase gut permeability, and alter the composition of the gut bacteria. A nutrient-rich diet combined with regular exercise, meditation and breathwork is a great way to reduce stress and support good gut health.

Our guts have the essential job of making sure any toxins or particles that aren’t supposed to pass through the intestinal lining don’t. These toxins may cause inflammation, pain and food sensitivities; that’s why it’s important to prioritize our digestive system health and promote a healthy gut microbiome, which in turn supports a healthy immune system response. So go with your gut if you’re looking to improve your overall health.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.

^To date, shown in multiple animal studies, infants, and one adult human study.

2023-09-07T07:01:01

(BPT) – Bryan, a dedicated father of three sons and a busy driver for a shipping company, was 52 years old when he underwent a quadruple bypass procedure following three heart attacks and was diagnosed with heart failure. Bryan saw his life change and, since then, he has found a new passion as a volunteer for The Mended Hearts Inc. (MHI), supporting others living with heart failure. Through his work with MHI, he shares his own journey with heart failure and how he finds joy in everyday activities, maintains a trusting relationship with his doctor, spreads awareness, and gives back to the community.

Heart failure is a common, serious condition in which the heart is unable to pump enough blood to meet the body’s needs for blood and oxygen. More than 1,000,000 new cases are diagnosed in Americans over the age of 55 each year. Currently, more than 6 million American adults have heart failure, and that number is expected to increase to nearly 8 million by 2030.

“When I was diagnosed with heart failure, I couldn’t believe it,” said Bryan. “But my cardiologist was able to explain the diagnosis in such a way that I could understand how it would impact my life.”

Since being diagnosed with heart failure, Bryan has enjoyed the support of his close friends and family. They help him stay on a healthy diet, accompany him on walks, and remind him to take his medications. Bryan’s children are among his biggest advocates, always looking out for him with the best of intentions. “My sons inspire me to continue looking forward to each day, even when some days are tougher than others,” said Bryan.

Bryan also maintains an open and trusting relationship with his doctor and continuously monitors his health, which has allowed for him to feel like a partner in his care.

“All the steps I am taking in my daily life allow me to find joy in the simplest activities,” said Bryan. “I want to be able to watch my two grandchildren, age two years and five months, grow. Family is everything to me.”

For people with heart failure, like Bryan, and their loved ones, At the Heart of the Matter: Moving Forward After Your Heart Failure Hospitalization is a program that provides support and educational information. Sponsored by Merck in collaboration with MHI, the program was created to help people living with heart failure better understand their condition and play a more proactive role in their care.

“I’ve learned that things can change in the blink of an eye, and it’s important to take life by the reins and enjoy it for all it’s worth. Living with heart failure is a wake-up call to start living your life and find your purpose,” explains Bryan. “I have had the humbling experience of giving back to my community and helping others through their own unique experiences with heart failure, which, in turn, helps me. Knowing that there are others in the community who have experienced similar challenges motivates me to keep going.”

For resources on living with heart failure and to see more stories from patients like Bryan, visit AtTheHeartOfTheMatter.com.

2023-09-06T15:31:01

(BPT) – Sponsored and developed by Pfizer

Vaccines have been an important tool in the fight against COVID-19. But it wasn’t just the traditional sort of vaccine that came to help — it was a different kind of vaccine made from messenger ribonucleic acid, or mRNA. While the vaccines for COVID-19 were the first to successfully use this technology, mRNA is not new. Scientists have been studying mRNA in medicine for decades, and this technology may serve as a valuable tool in the treatment toolbox in the coming years.

How Vaccines Work

To best appreciate how helpful mRNA technology can be in the fight against infection, it’s important to first understand how vaccines work. Ultimately, the goal is to build immunity — an immune response that helps protect us against disease. Vaccines build immunity by teaching our bodies how to fight off invading bacteria or viruses. Traditional vaccines do this by introducing a weakened form of the potential invader into the body, while mRNA vaccines make pieces of bacteria or viruses internally by taking advantage of how our cells work naturally. mRNA vaccines themselves do not contain any of the actual virus or bacteria.

Our cells are like a microscopic kitchen that cooks up an elaborate menu of thousands of different proteins, which form our entire bodies and help keep us alive. An mRNA vaccine delivers instructions that act like a special recipe, directing the kitchen to temporarily add your meal — or in this case, a small protein from part of the virus or bacteria — to the menu. The immune system then reacts to that new protein by creating a defense if and when the real invader comes along. mRNA vaccines do not alter a person’s DNA.

The Potential of mRNA

The instructions found in the mRNA vaccine’s recipe can be edited, meaning mRNA can be changed to help defend against different diseases. When creating a vaccine, the mRNA platform may offer advantages over traditional methods, including flexibility, speed, and timing.

• Flexibility: Since you only need the genetic instructions to make an mRNA vaccine, it’s possible to swiftly adapt to match a new virus or mutation. As new strains of viruses like SARS-CoV-2 or seasonal flu continue to emerge or shift, scientists can potentially “plug” a new code into an mRNA vaccine to rapidly begin testing and development.¹

• Speed: When it comes to preventing life-threatening illness, speed is of the essence. Some traditional vaccines can take more than six months to make (or manufacture), because they have to be grown in living cells. That’s why the strains for flu vaccines rolled out each September are chosen in February. But mRNA vaccines can be made much more quickly, while maintaining the rigorous safety testing that comes with all new vaccines. In fact, it’s estimated that mRNA vaccines can be manufactured 10 times faster than traditional vaccines made from live, weakened, or killed viruses.²

• Timing: By requiring shorter manufacturing and development leads, the mRNA code may also better match the virus strain that you’re most likely to encounter in your everyday life, such as the particular strains of seasonal flu circulating in a given year. This could improve how well the vaccine works, or how effective it is.^3,4 Where traditional vaccines require a lead time of six months or more to mass produce, mRNA vaccines can be manufactured in as little as three months from the time the new strain is selected.

Ultimately, mRNA vaccine technology may help us better respond to future epidemics and pandemics as well as now-widespread diseases that may require regular strain updates, like the seasonal flu and COVID-19. Scientists and doctors around the world are excited about the potential future applications of mRNA.

2023-09-06T08:01:00

(BPT) – This content is sponsored by Sanofi

My name is David and I am a retiree living in Minneapolis after working 30+ years in sales.

Retirement has left me with what feels like a lot of time for my hobbies, like golf and traveling, and spending time with my wife, daughter, and our golden retriever.

I know this time is valuable, because I have a history of serious heart conditions among men in my family. Because of my family history, taking an active role in my health, including exercise and fitness, and eating healthy have always been a part of my life.

I’ve always done what I could to keep Mother Nature at bay, but about 14 years ago, my family history caught up with me.

It began with feeling winded and fatigued while on the golf course. I finished the front nine (in retrospect, not a good decision) and when I went home my wife took my pulse and it was absolutely racing.

Shortly after that I found myself in the ER, and an electrocardiogram (EKG) and other tests showed that I was in atrial fibrillation, also known as AFib. It’s estimated more than 5 million people in the U.S. have AFib, and I was formally diagnosed with paroxysmal AFib since my heart rhythm returned to normal on its own within a few hours.

AFib happens when there is a disruption in your heart’s normal rhythm and the symptoms of AFib itself can be highly debilitating, and if left untreated, can lead to serious and even life-threatening complications.

For me, when my heart came out of normal rhythm during an AFib episode, I felt discomfort and tightness in my chest, accompanied by extreme fatigue and weakness. I would find myself huffing and puffing and totally worn out. In some instances, my AFib episodes left me so weak I didn’t think I could get myself off the couch and to the hospital.

It can be difficult to predict when an AFib episode may occur. Some common symptoms of AFib include racing, fluttering or irregular heartbeat. It’s important to call your doctor right away to discuss how you’re feeling.

Unfortunately, I experienced additional AFib episodes after that first ER visit. Given my AFib episodes were becoming more frequent and lasting longer, I finally committed to finding a cardiologist who could help me manage my condition.

I went to my cardiologist ready to listen, but also brought questions that I wanted answers to as well.

After listening to my concerns and discussing potential side effects, my doctor suggested an antiarrhythmic medicine to help control the rhythm of my heart, called MULTAQ (dronedarone), a prescription medicine used to lower the chance that you will need to go into the hospital for an irregular heart rhythm called atrial fibrillation (AFib). It is meant for people with certain types of AFib (paroxysmal or persistent AFib) who have had AFib in the past but are now in normal rhythm. To learn more about MULTAQ, including the risk of serious side effects, visit Multaq.com.

Ever since then I’ve committed to managing my paroxysmal Afib with MULTAQ.

For people diagnosed with paroxysmal or persistent AFib – please understand that it is a serious condition that can progress over time if left untreated. Taking an active role in managing your AFib may reduce your risk of future AFib episodes. It is important to take action – and for me – the easiest step was scheduling an appointment with a cardiologist and listening to my options.

It’s also important to have a support system in place. My wife in particular is helpful with keeping me on track with doctor’s appointments and reminding me to take my MULTAQ as prescribed – if she still wants me to stick around then I guess I’ve done something right!

Every patient’s experience is unique and results may vary. Remember, your doctor is your best source of information and be sure to ask your doctor any questions you may have.

Important Safety Information

What is the most important safety information I should know about MULTAQ?

Do not take MULTAQ if you have symptoms of heart failure that recently worsened and you were hospitalized, or if you have severe heart failure. MULTAQ doubles your risk of dying if you have these conditions.

Do not take MULTAQ if you have a type of atrial fibrillation (AFIB) called permanent AFIB. You should not take MULTAQ if you are in AFIB and your doctor is not planning to change you back into normal rhythm. People with permanent AFIB who take MULTAQ have a higher risk of death, stroke, and needing to be treated in a hospital for heart failure.

MULTAQ may cause liver problems, including life-threatening liver failure. Call your doctor right away if you are taking MULTAQ and develop any of these signs and symptoms of liver problems: loss of appetite; nausea; vomiting; fever; feeling unwell; unusual tiredness; itching; yellowing of the skin or the whites of the eyes; unusual darkening of the urine; right upper stomach area pain or discomfort.

When should I call the doctor?

Call your doctor right away if you’re taking MULTAQ and have any signs and symptoms of heart failure. These may include shortness of breath or wheezing at rest; wheezing, chest tightness, or coughing up frothy sputum at rest, nighttime, or after minor exercise; trouble sleeping or waking up at night or using more pillows to prop yourself at night because of breathing problems; weight gain; or foot or leg swelling.

Call your doctor right away if you notice that your heartbeat or pulse is irregular. This is a sign that you are in AFIB.

Call your doctor if you develop shortness of breath or a dry cough during treatment with MULTAQ.

Call your doctor if you experience an allergic reaction, such as itchy rash, low blood pressure, or rapid swelling of the throat or skin, especially around the lips or eyes.

Who else shouldn’t take MULTAQ?

You should not take MULTAQ if you are allergic to dronedarone or any of the other ingredients in MULTAQ.

You should not take MULTAQ if you have severe liver problems or if you had liver or lung problems after using amiodarone.

You should not take MULTAQ if you have a certain type of heart problem called heart block, and you do not have an implanted pacemaker.

You should not take MULTAQ if you are breastfeeding, pregnant, or plan to become pregnant as it is not known if it may pass to or harm your baby. Women who may become pregnant should use effective birth control while taking MULTAQ. Talk to your doctor about the best birth control methods for you.

Are there any medications I should avoid while taking MULTAQ?

MULTAQ can interact with certain medications. Do not use the following medications with MULTAQ:

• Nefazodone
• Ketoconazole
• Voriconazole
• Clarithromycin
• Ritonavir
• Itraconazole
• Telithromycin
• Cyclosporine

Are there other medicines that would be harmful when taken with MULTAQ?

The following medicines can lead to a dangerous abnormal heart rhythm if taken with MULTAQ:

• Phenothiazines
• Tricyclic antidepressant
• Certain antibiotics
• Certain medicines used to treat an abnormal heart rhythm or fast heartbeat

What are possible serious side effects from taking MULTAQ?

MULTAQ may cause serious side effects including slowed heartbeat, inflammation of the lungs (including scarring and thickening), low potassium and magnesium levels in your blood, and changes in kidney function blood tests.

What are the most common side effects?

The most common side effects when taking MULTAQ include stomach problems such as diarrhea, nausea, vomiting, stomach area pain, and indigestion; feeling tired and weak; skin problems such as redness, rash, and itching. Tell your doctor about any side effect that bothers you or that does not go away.

Are there other things I should avoid while taking MULTAQ?

Do not drink grapefruit juice while taking MULTAQ, as this can increase the likelihood that you will have a side effect of MULTAQ.

What else should I tell my doctor?

Tell your doctor about all medications, vitamins, and herbal remedies (including St. John’s Wort) you take to help avoid serious drug interactions.

Is it OK to take a diuretic (“water pill”) while on MULTAQ?

Your potassium levels should be within the normal range prior to and while taking MULTAQ. Tell your doctor about any diuretic medications (“water pills”) you are taking as some can lower the level of potassium or magnesium in your blood.

Will I need any tests while I’m on MULTAQ?

Your doctor will monitor your heart rhythm regularly to make sure your heartbeat keeps a normal rhythm. Your doctor may perform certain tests, such as heart exams and blood tests, while you’re taking MULTAQ.

Click here for full Prescribing Information, including SERIOUS SIDE EFFECTS.

Click here for the MULTAQ Medication Guide (English).

Click here to learn more about Sanofi’s commitment to fighting counterfeit drugs.

Remember, your doctor is the single best source of information regarding your health. Please consult your doctor if you have any questions about your health or your medicine.

If you are a patient experiencing problems with a Sanofi U.S. product, please contact Sanofi U.S. at 1-800-633-1610.

The health information contained herein is provided for general educational purposes only. Your healthcare professional is the single best source of information regarding your health. Please consult your healthcare professional if you have any questions about your health or treatment.

2023-09-06T06:01:00

(BPT) – Most men living with prostate cancer are familiar with their PSA, or prostate-specific antigen, level. Often, they have been getting PSA tests as part of regular health screenings since even before their diagnosis.¹

Now, there is another important biomarker to know about: PSMA, meaning prostate-specific membrane antigen. PSMA is a biomarker that is located on the outside of prostate cancer cells and found in more than 80% of men with prostate cancer. Both PSA and PSMA can help doctors diagnose and track the progression of prostate cancer.^2,3

Unlike PSA tests, doctors use PET (positron emission tomography) scans to test for PSMA. The PET scan works by using a tracer that attaches to PSMA and enables your doctor to detect precisely where PSMA-positive tumors reside in the body. Importantly, a PSMA scan can also provide valuable information for evaluating available treatment options with your doctor.^2,4

When prostate cancer advances and spreads to other parts of the body, and remains unresponsive to hormone treatment, it is called metastatic castration-resistant prostate cancer (mCRPC).⁵ PLUVICTO^® (lutetium Lu 177 vipivotide tetraxetan) is a type of precision medicine that targets PSMA-positive cancer cells. PLUVICTO attaches to PSMA and releases radiation treatment that can damage and kill PSMA-positive tumor cells.⁶

PLUVICTO is a radioligand therapy (RLT) and the first and only RLT approved for the treatment of adult patients with PSMA-positive mCRPC who have already been treated with other anticancer treatments (ie, androgen receptor pathway inhibition and taxane-based chemotherapy).⁶

To learn more about PLUVICTO, go to www.Pluvicto.com and see below for Important Safety Information.

What is PLUVICTO^® (lutetium Lu 177 vipivotide tetraxetan)?

PLUVICTO is a radiopharmaceutical used to treat adults with an advanced cancer called prostate-specific membrane antigen­–­positive metastatic castration-resistant prostate cancer (PSMA-positive mCRPC) that:

• has spread to other parts of the body (metastatic), and
• has already been treated with other anticancer treatments

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about PLUVICTO?

Use of PLUVICTO involves exposure to radioactivity. Long-term, accruing radiation exposure is associated with an increased risk for cancer.

To minimize radiation exposure to others following administration of PLUVICTO, limit close contact (less than 3 feet) with household contacts for 2 days or with children and pregnant women for 7 days, refrain from sexual activity for 7 days, and sleep in a separate bedroom from household contacts for 3 days, from children for 7 days, or from pregnant women for 15 days.

PLUVICTO may cause serious side effects, including:

• Low level of blood cell counts. Tell your doctor right away if you develop any new or worsening symptoms, including:
  • Tiredness or weakness
  • Pale skin
  • Shortness of breath
  • Bleeding or bruising more easily than normal or difficulty stopping bleeding
  • Frequent infections with signs such as fever, chills, sore throat, or mouth ulcers

• Kidney problems. Tell your doctor right away if you develop any new or worsening symptoms, including passing urine less often or passing much smaller amounts of urine than usual

Before you receive PLUVICTO, tell your doctor if any of these apply to you:

• You have low level of blood cell counts (hemoglobin, white blood cell count, absolute neutrophil count, platelet count)
• You have or have had tiredness, weakness, pale skin, shortness of breath, bleeding or bruising more easily than normal or difficulty stopping bleeding, or frequent infections with signs such as fever, chills, sore throat, or mouth ulcers (possible signs of myelosuppression)
• You have or have had kidney problems
• You have or have had any other type of cancer or treatment for cancer, as PLUVICTO contributes to your long-term cumulative radiation exposure
• You are sexually active as:
  • All radiopharmaceuticals, including PLUVICTO, have the potential to cause harm to an unborn baby
  • You should use effective contraception for intercourse during treatment with PLUVICTO and for 14 weeks after your last dose
  • PLUVICTO may cause temporary or permanent infertility

Before administration of PLUVICTO, you should drink plenty of water in order to urinate as often as possible during the first hours after administration.

The most common side effects of PLUVICTO include:

• Tiredness
• Dry mouth
• Nausea
• Low red blood cell count
• Loss of appetite
• Changes in bowel movements (constipation or diarrhea)
• Vomiting
• Low blood platelet count
• Urinary tract infection
• Weight loss
• Abdominal pain

These are not all of the possible side effects of PLUVICTO. Call your doctor for advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information.

References:

1. National Cancer Institute. Prostate-specific antigen (PSA) test. Accessed July 25, 2023. https://www.cancer.gov/types/prostate/psa-fact-sheet
2. Hope TA, Aggarwal R, Chee B, et al. Impact of ⁶⁸Ga-PSMA-11 PET on management in patients with biochemically recurrent prostate cancer. J Nucl Med. 2017;58(12):1956-1961.
3. Sonni I, Eiber M, Fendler WP, et al. Impact of ⁶⁸Ga-PSMA-11 PET/CT on staging and management of prostate cancer patients in various clinical settings: a prospective single-center study. J Nucl Med. 2020;61:1153-1160. doi:10.2967/jnumed.119.237602
4. Hofman MS, Lawrentschuk N, Francis RJ, et al. Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective randomised, multi-centre study. Lancet. 2020;395:1208-1216.
5. Society of Nuclear Medicine and Molecular Imaging. Radiopharmaceutical therapy and prostate cancer. Accessed July 24, 2023. https://www.snmmi.org/AboutSNMMI/Content.aspx?ItemNumber=12772
6. Pluvicto. Prescribing information. Advanced Accelerator Applications USA, Inc.

2023-09-05T06:01:00

(BPT) – If you’ve been thinking about making improvements to your home and dreaming of the possibilities, you may be imagining expensive renovations or a complete design overhaul. But the truth is, you can start with smaller projects that offer a big impact. For example, one simple but effective and budget-friendly project that’s frequently overlooked is updating your window coverings. This easy upgrade can have a significant effect on the aesthetics, energy savings and even safety of your living spaces.

Here are four compelling reasons why you should consider updating your window coverings first.

1. Enhanced aesthetics. Window coverings serve as both functional and decorative elements, and they are highly visible both indoors and from the outside. You’ve probably already observed how outdated or worn-out curtains, blinds or shades can bring down the overall appearance of a room. By updating your window treatments, you can instantly infuse a fresh look that will complement your interior design style.

The good news is that your window treatments don’t have to match the walls or trim. You can choose contrasting colors from your existing walls or trim, or select a neutral color like off-white that will complement any decor. Especially if you’re envisioning making renovations like painting or wallpapering a room fairly soon, you’ll know that more neutral colors will likely go with any interior design choices you make in the future.

2. Improved energy efficiency. With energy costs on the rise, it’s important to consider how your window coverings may be affecting the energy efficiency of your home.

One smart move is upgrading to energy-efficient window attachment products, such as those certified by the Attachments Energy Rating Council (AERC) for improved energy savings. The products will help with regulating your home’s indoor temperatures, as well as improving comfort for you and your family — while also helping to reduce your utility bills.

3. Ease of use. With today’s advanced technology, you can get even more out of your window coverings. Motorized and automated options with remote or smart home integration make adjusting your window treatments easier than ever, and you can even make adjustments right from your smartphone. As an added bonus, you can even close your blinds remotely while you’re away from your home, for additional security and privacy.

4. Safety improvements. Kids in the home? If you have corded window coverings, you may not realize that you have what the Consumer Product Safety Commission (CPSC) calls one of the “top hidden hazards in the home” as they may pose a strangulation risk to infants and young children. Some homes may also have older window coverings which may not be recognized as a danger by new homeowners. It’s important to take notice of the window coverings wherever children live or visit, and make necessary safety updates.

It’s easier than ever to “go cordless.” Just look for products marked with the Best For Kids™ logo. Products with this logo either have no cords, no operating cords or inner cords that are not accessible and are also unable to create a hazardous loop. You can find Best for Kids™ labeled products at all major U.S. retailers. Learn more at WindowCoverings.org/best-for-kids.

As you can see, window coverings can be an important component of your home’s overall look, as well as contributing to its energy efficiency, comfort, safety and security. Refreshing your window coverings can be a straightforward, quick and impactful first step in renovating any of the rooms in your home.

2023-09-05T06:01:00

(BPT) – With heat waves, wildfires, droughts, hurricanes and more breaking records seemingly year after year — it’s impossible to ignore the impact of severe weather and natural disasters across the United States. Without proper planning and preparation, you may be leaving yourself, your family and your property susceptible to damage or harm.

Consider the massive damage storms can cause to communities. The National Oceanic and Atmospheric Administration (NOAA) reported more than $165 billion in damages from weather-related disasters in 2022 alone, a $20 billion increase from the 2021 estimates.

The National Fire Protection Association also reported that roughly 343,100 home fires occur per year, resulting in $7.6 billion in total property damage — most often started by simple everyday activities like cooking.

Knowing homes can be vulnerable to weather incidents and other accidents, it’s more important than ever to plan and invest in dependable solutions that can help keep your family and property safe.

In recognition of National Preparedness Month this September, The Master Lock Company, a trusted name in security for over 100 years, is spotlighting common mistakes people make when it comes to home emergency planning to help provide peace of mind and safeguard everything worth protecting.

Mistake #1: Misunderstanding disaster risk in your area

Different types of severe weather require different preparation, making it imperative to identify which disasters your community is most at-risk for and plan accordingly. Some weather patterns have also changed over the years, meaning you may be vulnerable to new climate events you haven’t considered in the past. A little research can go a long way when it comes to the safety of you and your home.

Mistake #2: Not having a family fire plan

Be fire smart by verifying your home contains the right number of smoke alarms and make sure to check them annually. Everyone in the household should rehearse your fire escape plan at least once to get familiar with the sound of the alarm, exit routes from each room and the agreed-upon family meeting spot, located outside the home at a safe distance.

Mistake #3: Forgetting to safely store important documents and valuables

When evacuating during a fire or other immediate emergency, every second counts and no time should be wasted grabbing items like passports, birth certificates, jewelry or family mementos. By investing in a dependable, high-quality safe that can withstand fire and water damage, such as the SentrySafe Next Generation Fire Safe, you can leave with peace of mind that your valuables are safe and sound. However, if your community is prone to more gradual disasters like wildfires that are forecasted days in advance and allow time for evacuation, consider the SentrySafe Fire Bag for portable fire protection. Designed to hold small items like passports, birth certificates and extra cash, the fire bag provides lightweight, convenient fire-resistant storage so you can easily grab your valuables and go.

Mistake #4: Ignoring storm warnings

If you know a storm is coming, don’t make the mistake of ignoring the alert until your area is affected. Store lawn furniture, pots and other loose items in a secure location. Close and lock windows and shutters. For disasters like hurricanes that are monitored in advance, check if nearby trees should be trimmed to prevent property damage and reduce post-storm debris. Storm warnings also present an opportunity to plan whether it’s safer to stay home or evacuate, and gather necessary items as needed.

Mistake #5: Not preparing an emergency “go kit” ahead of time

Being proactive is essential when preparing for unexpected emergencies, and the earlier you can prepare, the better. Though taking initiative to gather necessities before storm seasons begin is ideal, there are also situations when local officials provide advance notice in the days leading up to severe weather like hurricanes. Either way, have an emergency “go kit” in case you need to evacuate your home in a hurry. This “go kit” should contain medical supplies, food, water and other essentials to ensure your household’s basic needs are met.

Mistake #6: Overlooking physical home security

Some severe weather may require you to evacuate your home at the drop of a hat. Convenient, seamless security solutions like the Master Lock Bluetooth^® Portable Lock Box manages access even if you’re not there, allowing you to let in safety personnel and protect your property from unwanted visitors. Simply use your smartphone to manage your lock with the Master Lock Vault Home iOS and Android apps.

No matter the crisis, you can depend on The Master Lock Company for durable, reliable solutions to protect the people and the belongings that mean the most to you. For more information, visit insights.masterlock.com.