Category: Brandpoint Health

2022-10-05T08:01:00

(BPT) – For millions of people around the world, hitting the snooze button in the morning offers a few more minutes of relaxation — a little quiet time before the day starts or some time to catch up on the news before breakfast. But for the millions of people like Lori who are living with plaque psoriasis, hitting the snooze button in the morning is often an act of desperation, following an exhausting night of tossing and turning and being unable to sleep due to the physical symptoms brought on by the condition.

“For me, the most difficult part of living with plaque psoriasis is the itching, the burning, the waking up in the middle of the night because of how uncomfortable it is,” says Lori, who has been living with plaque psoriasis for 15 years. “And then on top of that having to deal with how society sees me, the looks, and the questions… It’s a very difficult disease to live with. I’m embarrassed a lot of times when I go out because it’s so visible.”

Psoriasis is a complex and chronic inflammatory disease that impacts approximately 8 million Americans and 125 million people worldwide. Plaque psoriasis is the most common form of psoriasis, accounting for about 80% to 90% of cases.^[1],[2],[3]

Signs and symptoms of plaque psoriasis may vary from person to person but typically include raised patches of skin with silvery-white or gray scale that can be itchy, painful and disfiguring. It can appear on any part of the body, but is most common on the elbows, torso, scalp and legs. It can also appear in less common areas, such as the soles of a person’s feet, hands, and even sensitive areas like the eyelids or groin.^[1]

Beyond the outward symptoms of plaque psoriasis, the condition can take a significant toll on a person’s day-to-day life — impacting their psychological health and overall quality of life.^[4]

“As my plaque psoriasis progressed and my flare ups got worse, it affected what I wore, what I did and even my self-esteem,” says Lori. “I began avoiding clothes that didn’t cover up my plaques, and when my flares were at their worst with the constant itching and bleeding, I would avoid going out in public at all because the stares and questions were difficult to address.”

Because there is not a “one-size-fits all” treatment option, and because many treatment options may force people with plaque psoriasis to make compromises in treatment safety and tolerability, people like Lori who live with this chronic and debilitating disease may endure a frustrating trial-and-error process managing their condition. The journey to find a treatment that is right for them can be difficult.^[5],[6]

“The challenges of living with plaque psoriasis are more than skin deep. Typically, patients start with topical steroids which vary in their regimen instructions, are limited by where they can be used on the body and are limited in how long and how often they can be used overall,” says board-certified dermatologist Sandra M. Johnson, MD, FAAD, of Johnson Dermatology in Fort Smith, AR.

She adds, “Because of this, patients tend to cycle on and off steroid treatments, which can lead to reports of a lower quality of life, particularly when the condition interferes with their sleep, work, and social activities. Higher quality of life can be linked to treatment adherence, but treatment adherence can be difficult when patients may be unhappy with their plaque psoriasis treatment. This is why it’s critical to introduce novel topical therapies that are safe and effective that patients want to use and can use long term.”

Lori shares many of these common treatment experiences, noting that she tried different creams that were both prescribed and over the counter, in addition to biologics. Eventually she would find these topical treatments did not give her the results she was looking for and that biologics were not the right choice for her. A couple of years ago, she decided to join a clinical trial to see if a new type of topical treatment would help.

“I see a lot of patients living with plaque psoriasis, and finding the right treatment for each individual can take some trial and error,” says Jennifer Soung, MD, a board-certified dermatologist, and the director of clinical research at Southern California Dermatology in Santa Ana, CA. “Though the plaque psoriasis treatment landscape has evolved significantly to make room for oral treatments and biologics that treat more severe forms of plaque psoriasis, there is a large need for new topical treatments and particularly for non-steroids.”

Fortunately, there’s hope. On May 23, 2022, the Food and Drug Administration (FDA) approved VTAMA^® (tapinarof) cream, 1%, a once daily, cosmetically elegant, prescription topical treatment for adults living with mild, moderate, and severe plaque psoriasis. Thanks to clinical trial participants like Lori, this approval makes VTAMA cream the first and only steroid-free topical medication in its class in the U.S. following 25 years of minimal innovation in the topical psoriasis treatment landscape.^[7]

With this FDA approval, people like Lori living with plaque psoriasis have access to a steroid-free topical treatment, in the form of a convenient, once-daily cream, that is backed by extensive clinical trial data supporting its strong safety and efficacy profile — even with long-term use, as demonstrated in clinical trials over 52 weeks, and on sensitive areas, such as the face, groin and underarms.^[8]

For Lori, the FDA approval of VTAMA cream means that she can effectively treat her plaque psoriasis. With control over her psoriasis, she doesn’t always have to hide visible, itchy and painful plaques behind her clothes, and she is able to attend events without feeling ashamed.

Lori is sharing her story to encourage others going through a similar experience with plaque psoriasis to never give up hope. “While in the VTAMA cream clinical trials, my plaques started clearing. Knowing I have a plaque psoriasis treatment that works for me put a smile back on my face again.”

The most common side effects (incidence ≥1%) of VTAMA cream include red raised bumps around the hair pores (folliculitis), pain or swelling in the nose and throat (nasopharyngitis), skin rash or irritation including itching and redness, peeling, burning or stinging (contact dermatitis), headache, itching (pruritus), and flu (influenza).

If you’re struggling with plaque psoriasis, talk to your doctor to learn if VTAMA cream may be right for you. “Never stop advocating for your health — don’t accept that your disease controls you,” says Dr. Johnson.

Sandra M. Johnson, MD, FAAD and Jennifer Soung, MD are paid consultants of Dermavant Sciences, Inc.

For more information about VTAMA cream, speak to your dermatologist or visit www.VTAMA.com.

IMPORTANT SAFETY INFORMATION

Indication: VTAMA^® (tapinarof) cream, 1% is an aryl hydrocarbon receptor agonist indicated for the topical treatment of plaque psoriasis in adults. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in subjects treated with VTAMA cream were folliculitis (red raised bumps around the hair pores), nasopharyngitis (pain or swelling in the nose and throat), contact dermatitis (skin rash or irritation, including itching and redness, peeling, burning, or stinging), headache, pruritus (itching), and influenza (flu).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information here.

VTAMA is a registered trademark of Dermavant Sciences, GmbH.

2022-10-05T08:01:00

(BPT) – Michelle Trites, her husband and their 3-year-old daughter all have Type 1 diabetes. Diabetes is an ever-present part of their lives and ensuring that they have tools in their tool kits to handle low blood sugar emergencies is a top priority.

Ever since Michelle was diagnosed at 13 years old, the Glucagon Emergency Kit has been a constant presence — at school, at work, and on her person at all times. But not anymore. After learning about ready-to-use glucagon, Michelle made sure that everyone in her family replaced the old red kit with Gvoke HypoPen^®, a ready-to-use rescue pen for treatment of very low blood sugar in adults and kids ages 2 and older.

Michelle believes the emergency glucagon kit is cumbersome to use due to its 12-step administration process. “That was a lot to ask from non-medical professionals who could get squeamish just looking at a needle, much less completing so many steps in a high-stakes emergency,” Michelle said. In a usability study, only 31% of users could use the glucagon injection kit correctly.

Eli Lilly and Company, a producer of the GEK kit, recently announced that it is discontinuing distribution of the kit on December 31, 2022. The decision was reportedly made due to innovations in the glucagon market and highlights the importance of providing patients with products that enable simpler administration during critical moments of need.

As a result of this news, all patients that currently have a prescription for Eli Lilly’s GEK will need to be transitioned to another option.

The Trites recommend that people with diabetes and their caregivers ask their physician for Gvoke HypoPen^®. “Everyone should have Gvoke HypoPen in their tool kit,” said Michelle. “It can help you confidently manage a low blood sugar emergency.”

Gvoke HypoPen^®, the simple solution you can count on:

• Ready-to-use: Premixed and ready-to-go¹
• Simple to administer: Simple 2-step administration. Pull red. Push yellow
• Reliable method of delivery: 99% of people (trained and untrained) were able to give correctly in usability studies¹
• Proven to work: >99% of adults and pediatrics patients had their blood glucose raised to safe levels

Talk to your doctor about adding Gvoke HypoPen^® to your diabetes toolkit and visit GvokeGlucagon.com to learn more.

“We are focused on making our treatments simple for patients or caregivers to administer,” said Ken Johnson, senior vice president for Global Development and Medical Affairs at Xeris Pharmaceuticals. “Xeris is committed to offering historically hard-to-administer and potentially life-saving medications in innovative ready-to-use injectables.”

INDICATION AND SAFETY SUMMARY
GVOKE is a prescription medicine used to treat very low blood sugar (severe hypoglycemia) in adults and kids with diabetes ages 2 years and above. It is not known if GVOKE is safe and effective in children under 2 years of age.

WARNINGS

Do not use GVOKE if:

• you have a tumor in the gland on top of your kidneys (adrenal gland), called a pheochromocytoma.
• you have a tumor in your pancreas called an insulinoma.
• you are allergic to glucagon or any other inactive ingredient in GVOKE.

GVOKE MAY CAUSE SERIOUS SIDE EFFECTS, INCLUDING:

High blood pressure. GVOKE can cause high blood pressure in certain people with tumors in their adrenal glands.

Low blood sugar. GVOKE can cause low blood sugar in certain people with tumors in their pancreas called insulinomas by making too much insulin in their bodies.

Serious allergic reaction. Call your doctor or get medical help right away if you have a serious allergic reaction including:

• rash
• difficulty breathing
• low blood pressure

COMMON SIDE EFFECTS

The most common side effects of GVOKE in adults include:

• nausea
• vomiting
• swelling at the injection site
• headache

The most common side effects of GVOKE in children include:

• nausea
• low blood sugar
• high blood sugar
• vomiting
• abdominal pain
• headache
• pain or redness at the injection site
• itching

These are not all the possible side effects of GVOKE. For more information, ask your doctor.

Call your doctor for medical advice about side effects. You are encouraged to report side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

BEFORE USING

Before using GVOKE, tell your doctor about all your medical conditions, including if you:

• have adrenal gland problems
• have a tumor in your pancreas
• have not had food or water for a long time (prolonged fasting or starvation)
• have low blood sugar that does not go away (chronic hypoglycemia)
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

HOW TO USE

• Read the detailed Instructions for Use that come with GVOKE.
• Use GVOKE exactly how your healthcare provider tells you to use it
• Make sure your relatives, close friends, and caregivers know where you store GVOKE and how to use it the right way before you need their help.
• Act quickly. Having very low blood sugar for a period of time may be harmful.
• Your healthcare provider will tell you how and when to use GVOKE.
• After giving GVOKE, your caregiver should call for emergency medical help right away.
• If you do not respond after 15 minutes, your caregiver may give you another dose, if available. Tell your healthcare provider each time you use GVOKE. Low blood sugar may happen again after receiving an injection of GVOKE. Your diabetes medicine may need to be changed.

HOW TO STORE

• Keep GVOKE in the foil pouch until you are ready to use it.
• Store GVOKE at temperatures between 68°F and 77°F.
• Do not keep it in the refrigerator or let it freeze.

Keep GVOKE and all medicines out of the reach of children.

For more information, call 1-877-937-4737 or go to https://gvokeglucagon.com/

Please see the Full Prescribing Information for Gvoke: https://gvokeglucagon.com/pdf/gvoke-prescribing-information.pdf

2022-10-04T08:01:01

(BPT) – Falling temperatures don’t just mark the start of cold and flu season. There’s another virus that can have serious consequences for older adults.

Here are three things you need to know about RSV.

1. What is RSV?

Respiratory syncytial virus, or RSV, is a common and contagious virus that affects the lungs and breathing passages and typically circulates during the fall, winter and early spring.¹

“People tend to think of RSV as an illness primarily affecting infants, but this virus has the potential to impact the lungs and breathing passages of older adults as their immune systems decline with age, and adults with chronic heart and lung disease,” says Dr. Leonard Friedland, VP, Director of Scientific Affairs and Public Health, GSK Vaccines. “Being aware and taking preventative measures is especially important now as more people are gathering indoors and preparing to celebrate the holidays.”

Symptoms are typically mild and include:²

• Fever
• Runny nose
• Cough
• Congestion
• Sore throat
• Difficulty breathing

Each year approximately 177,000 older adults are hospitalized in the United States due to RSV and of those hospitalizations, an estimated 14,000 adults die because of the infection, according to the Centers for Disease Control and Prevention (CDC).³ There is no vaccine or specific treatment for RSV in adults, so learning about who is at risk of severe complications from RSV and taking preventative measures are essential, especially for those who are most vulnerable.

2. Which adults are most at risk?

According to Dr. Friedland, those at a higher risk for RSV infection, include:

• Older adults, especially those aged 65 years and older
• Adults with weakened immune systems
• Adults with chronic heart or lung disease (like asthma and heart failure)

The CDC states RSV can exacerbate underlying conditions and lead to severe outcomes for at-risk adults including pneumonia, hospitalization and death.^1,4

“Co-morbidities, which occur when someone has two or more chronic conditions or diseases, are additional factors that can lead to severe complications as a result of RSV,” says Dr. Friedland. “The chance of having co-morbid illnesses increases with age, so it’s important for older adults who are experiencing these issues to talk with a healthcare professional (HCP) about their risk.”

3. How can you prevent an RSV infection?

If you are at high risk for severe RSV infection, or if you interact with an older adult, there are important prevention steps you should take, according to the CDC.⁵

• Wash your hands often with soap and water for 20 seconds. If soap and water are not available, use an alcohol-based hand sanitizer. Washing your hands will help protect you from germs.
• Avoid touching your eyes, nose and mouth with unwashed hands. Germs spread this way.
• Avoid close contact, such as sharing cups or eating utensils with people who have cold-like symptoms.
• Cover your mouth and nose with a tissue when coughing or sneezing. Throw the tissue in the trash afterward.
• Clean and disinfect surfaces that people frequently touch, such as doorknobs. When people infected with RSV touch surfaces and objects, they can leave behind germs. Also, when they cough or sneeze, viral droplets can land on surfaces and objects.
• Stay at home if you are sick to help prevent spread to others.

The bottom line

Rest and fluids are important to relieve RSV symptoms and help the body heal. Speak with a healthcare professional about using over-the-counter fever reducers and pain relievers such as acetaminophen or ibuprofen to manage fever. ² If you are having trouble breathing or your symptoms get worse, call a healthcare provider immediately.

“Most RSV infections go away on their own in a week or two but for some older adults, it can lead to hospitalization,” explains Dr. Friedland. “By taking preventative measures, learning who is at risk of severe complications due to RSV and maintaining communication with a healthcare provider, you can help yourself or an older loved one in your life stay healthy.”

For more information, visit https://www.cdc.gov/rsv/high-risk/older-adults.html.

References

1. CDC. Respiratory Syncytial Virus Infection. Available at: https://www.cdc.gov/rsv/index.html
2. CDC. Symptoms and Care. Available at: https://www.cdc.gov/rsv/about/symptoms.html
3. CDC. RSV in Older Adults. Available at: https://www.cdc.gov/rsv/high-risk/older-adults.html
4. CDC. For Healthcare Providers. Available at: https://www.cdc.gov/rsv/clinical/index.html
5. CDC. RSV Prevention. Available at: https://www.cdc.gov/rsv/about/prevention.html

2022-10-04T05:01:01

(BPT) – Your digital accounts and online activities may make your life easier and perhaps even more enjoyable, but did you know every time you log in, it’s a chance for cybercriminals to hack your information and exploit it in numerous ways?

Hacking threats are constant. According to research from the University of Maryland, cyber attacks happen every 39 seconds on average. What’s more, hackers get more sophisticated every day. The good news is, there are steps you can take to greatly lower your chances of becoming a cybercrime victim.

1. Authorize multi-factor authentication

Multi-factor authentication (commonly known as MFA) is one of the best steps you can take to secure your accounts. And the good news is it’s already offered on many of your favorite applications and services today. MFA acts as an additional step to protect your accounts in addition to your username and password.

For example, if you sign into an account with two-factor authentication, the system may request you enter a one-time code sent to the phone number you have on file. You’ll confirm your identity by typing the number that was texted in the sign-on request. Often these codes are only activated for a short period of time for added protection.

2. Adopt physical authentication

Not all multi-factor authentication is created equal, and SMS or mobile authentication has been proven to be vulnerable to phishing. The modern and most effective approach to keeping you and your data protected is using phishing-resistant multi-factor authentication solutions such as a hardware security key. YubiKeys are small physical keys you tap on your phone or plug into your computer’s USB port to verify it’s you. Essentially, they’re like a key to your online accounts, similar to a house key or car key.

A single YubiKey has multiple functions for securing your login to email, online services, apps and computers. Because it’s something you carry with you, it’s far more secure than digital alternatives — so much so that there have been zero reported account takeovers. The YubiKey is used by thousands of businesses and is also available for individuals so you can add a higher level of online protection for yourself and your loved ones.

3. Use a password manager

Every password you use should be complex, with a mix of different letters, numbers and symbols. A password manager can create a unique, random password for each of your accounts. Better yet, it stores your passwords in an encrypted database to keep them safe while helping to ensure that you, and only you, will be able to access them easily when going online. And when you update your passwords — which you should do regularly — they are updated in the manager as well.

Additionally, don’t forget to protect your password manager with MFA. Pairing your hardware security key with it will give you the ultimate protection. That way, if someone gets your master password for your password manager, they won’t be able to log in without physically having your security key, too.

Finally, for your accounts or favorite sites that don’t offer MFA, reach out to them and encourage them to provide you the tools you need to protect yourself.

2022-10-03T10:01:00

(BPT) – Addiction is a disease that can be mentally and physically debilitating. If you or a loved one struggle with addiction, you know how dark it can be. Taking the next step and exploring rehab options can bring light into the darkness so you can fight — and ultimately win — the battle against addiction.

Millions of people in the United States have a substance use disorder and are addicted to alcohol and/or drugs. Even though you feel alone in your struggles, it’s important to know many people have walked in your shoes and found hope to overcome addiction.

“After finding the right rehab option, it’s time to prepare for the next steps. When a person first enters an addiction rehab center, they may be at risk of experiencing withdrawal from drugs or alcohol. Withdrawal can be an uncomfortable process, and the person may benefit from medical treatments in order to make the process less difficult,” said Debra Lloyd at California Behavioral Health. “This is why many people start their rehab experience in a detox center where medical treatments are available. Trained medical personnel may treat the individual with medications in order to decrease discomfort and reduce the risk of complications associated with substance withdrawal.”

Inpatient rehab

Inpatient rehab is one of the most effective treatment options for addicts because it separates the person from temptations and home stressors so they can focus 100% on recovery. Those struggling with addiction undergo the rehabilitation process with medical professionals, licensed alcohol and drug counselors, and their peers.

Inpatient rehab is a big step so it’s important to know what to expect. First, learn your options so you can choose the right rehab facility for you. Keep in mind, location, insurance acceptance, facility and personnel credentials, and staff-to-patient ratio are all important things to consider.

Better Addiction Care is a helpful resource when gathering rehab information, offering confidential, no-cost information via private phone calls through one or more of their treatment clients about addiction and rehabilitation treatment. The organization has a nationwide directory of substance abuse treatment facilities which includes some of the country’s top rehab centers.

After finding the right rehab option, it’s time to prepare for the next steps. When a person first enters an addiction rehab center, it’s likely that they have some drugs currently in their system. They must get all substances out of their body, but this can be a difficult and uncomfortable process.

This is why many people start their rehab experience in a detox center so they can go through a medically assisted detox. These centers are often located in the rehab facility and help patients safely through withdrawal, a process that may include prescription medication like anti-nausea medicine or anticonvulsants to treat symptoms.

“Professionals help patients flush addictive substances out of their system and manage withdrawal symptoms,” explained David Levin from Legacy Healing Center. “In particular, substances such as alcohol, benzodiazepines and opioids have life-threatening withdrawal symptoms, so medical monitoring is essential.”

Rehab schedules

After detox is complete you can begin full treatment. Your daily schedule at rehab may vary based on your needs and interests. A day at rehab may include:

• Group counseling
• Family therapy
• Individual therapy, such as cognitive-behavioral therapy
• 12-step meetings, such as Alcoholics Anonymous or Narcotics Anonymous
• Non-12-step meetings, such as SMART Recovery
• Scheduled mealtimes
• Free time to exercise, take walks, read, participate in creative arts therapy

Rehab length

Most people who enter an addiction treatment center for inpatient care stay 90 to 120 days. However, it’s important to remember that addiction is a lifelong struggle. Once you near the end of your inpatient rehab program, your treatment team will work with you to create an aftercare plan to help prevent relapse once you return home.

“Inpatient rehab helps you overcome addiction and provides you the skills needed to live a sober life,” Dr. Christian Small of California Behavioral Health said. “Keep in mind, people who have been free of drugs or alcohol for years still say they are in recovery. Even if they aren’t using they know addiction is a disease that requires them to be aware of temptations and use the skills they’ve learned at rehab and through therapy to maintain sobriety.”

2022-10-03T08:01:00

(BPT) – This article was sponsored and developed by Neurocrine Biosciences.

Each year, millions of Americans are impacted by mental health conditions. Recognized during the first week of October, Mental Illness Awareness Week aims to raise awareness of the 1 in 5 Americans experiencing mental illness each year, dispel common misperceptions, and provide support to all impacted, including people with experience with a mental health condition, care partners, and advocates.

Marilyn, who hails from a small town in Colorado, was diagnosed with postpartum depression after the birth of her daughter nearly 40 years ago. As her condition worsened, she was also diagnosed with anxiety and bipolar disorder.

“I have been to so many primary healthcare providers, neurologists, and psychiatrists for my mental health conditions, and we’ve tried many different medications,” said Marilyn. After taking antipsychotics for six years, Marilyn experienced involuntary movements such as pronounced lip smacking.

Unfortunately, these involuntary movements did not go away and continued to be disruptive nearly two years later. What Marilyn did not know was that the involuntary movements are a condition called tardive dyskinesia (TD).

TD is a real, chronic condition that affects approximately 600,000 people in the U.S. It’s a condition where people taking certain mental health medicines (antipsychotics) experience mild, moderate, or severe uncontrollable movements in different parts of their bodies.

“I was constantly moving uncontrollably and could never keep still. It was especially bad in my face, fingers, and feet,” said Marilyn. “I didn’t want to socialize anymore because I was so self-conscious of my movements.”

Everyday activities like sitting in a car or watching football games with her family were difficult due to her uncontrollable movements in her legs and hands. After speaking with her psychiatrist and then her neurologist about these movements, she was diagnosed with TD.

Marilyn’s doctor shared information with her about INGREZZA^® (valbenazine) capsules, a prescription medicine to treat adults with the uncontrollable movements of TD. After reviewing the benefits and side effects, including the most common side effect of sleepiness, together they decided that INGREZZA, a simple one capsule, once-daily treatment, was the choice for her.

Please see additional Important Safety Information below.

After starting INGREZZA, Marilyn saw a reduction in her movements, and therefore was able to return to the activities she enjoyed. “I can now sit in my chair and cheer on my teams,” she said. “It feels good to be able to engage in one of my favorite pastimes again with my family.”

This Mental Illness Awareness Week, Marilyn wants to share her story to help others and encourage those experiencing involuntary movements to talk to their doctor.

“Stories like Marilyn’s highlight how living with a mental health condition and TD is not only debilitating but can have a significant emotional and social impact as well,” said Dr. Leslie Lundt, Executive Medical Director at Neurocrine Biosciences. “Mental Illness Awareness Week is an important time to broaden the conversation around mental health and associated challenges and help those who may be experiencing TD understand there are treatment options to help.”

To learn more about TD and INGREZZA, talk to your doctor or visit INGREZZA.com for more safety information.

Important Information

Approved Use

INGREZZA^® (valbenazine) capsules is a prescription medicine used to treat adults with movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia).

It is not known if INGREZZA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

Do not take INGREZZA if you:

• are allergic to valbenazine, or any of the ingredients in INGREZZA.

INGREZZA may cause serious side effects, including:

• Sleepiness (somnolence). Do not drive, operate heavy machinery, or do other dangerous activities until you know how INGREZZA affects you.
• Heart rhythm problems (QT prolongation). INGREZZA may cause a heart problem known as QT prolongation.

Symptoms of QT prolongation may include:

fast, slow, or irregular heartbeat	shortness of breath
dizziness or fainting

Tell your healthcare provider right away if you have a change in your heartbeat (a fast or irregular heartbeat), or if you faint.

• Abnormal movements (Parkinson-like). Symptoms include: shaking, body stiffness, trouble moving or walking, or keeping your balance.

Before taking INGREZZA, tell your healthcare provider about all of your medical conditions including if you: have liver or heart problems, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effect of INGREZZA is sleepiness (somnolence). Other side effects include changes in balance (balance problems, dizziness) or an increased risk of falls, headache, feelings of restlessness, dry mouth, constipation, and blurred vision.

These are not all of the possible side effects of INGREZZA. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see accompanying INGREZZA full Product Information.

This article was sponsored and developed by Neurocrine Biosciences, Inc. Marilyn was compensated by Neurocrine Biosciences to share her story.

©2022 Neurocrine Biosciences, Inc. All Rights Reserved. CP-VBZ-US-2126 10/2022

2022-09-27T12:05:00

(BPT) – Over the last two years, Americans’ resolve was tested by an onslaught of stressful events that changed how people navigate risks and what they are doing to protect their finances and health. However, not everyone reacted the same.

According to a new survey on risk, sponsored by Aflac, nearly half of Americans identified themselves as “risk-takers,” with a much higher inclination than everyone else to act now on opportunities to improve their state in life.

In fact, more than half of self-identified “risk-takers” said they are now somewhat or very likely to quit their jobs and start a business. Surprisingly, risk-takers are also willing to take steps to mitigate risk. For example, 56% of risk-takers see the cost of an unexpected medical emergency as a high risk to their financial well-being, and compared to those who call themselves “absolutely not risk-takers,” “absolute risk-takers” are nearly five times more likely to increase their health coverage due to the economy.

“The last two years have awakened an entrepreneurial spirit among Americans, particularly those who self-identify as ‘risk-takers,’” said Jeramy Tipton, Aflac Senior Vice President of Distribution Expansion and Consumer Markets. “But with this new spirit comes new challenges, including how these independent people will gain access to health insurance. That’s why companies like Aflac are advancing their consumer direct programs providing online purchasing power.”

With healthcare costs rising and the economy uncertain, almost half of Americans are concerned that the cost of future healthcare is a significant risk. One of the biggest concerns today is mental health. Unfortunately, mental healthcare services appear to be a luxury not everyone can afford yet.

Overall, 57% of Americans with annual incomes over $150,000 indicated that “proactively managing risks to your and your family’s mental health” has grown in importance over the last couple of years. Comparatively, only 40% of Americans who make $35,000 or less each year feel the importance of managing their mental health has grown in that span.

While 82% of Americans feel mental health is as important as physical health¹, one in four Americans still has to choose between getting mental health treatment and paying for daily necessities.²

For some, a greater focus on mental health has come along with a reassessment of career goals and job satisfaction.

“After a major pandemic, economic challenges, social justice anxieties and political unrest, Americans are reassessing their approach to mental health, seeing it as a greater risk to themselves and their families than it was prior to just two years ago,” said Bob Ruff, Aflac Senior Vice President of Group Voluntary Benefits. Aflac has a long history of supporting healthcare research and a culture of care to help ease financial burdens on patients and their families when unexpected medical costs arise and has recently introduced new products that address mental health issues. “How people manage these risks has a lot to do with their income and education, showcasing the real likelihood of a healthcare gap for mental illness that must be addressed,” Ruff added.

According to the National Alliance on Mental Health, 21%, or nearly 53 million U.S. adults, experienced mental illness in 2020, and 46% of adults with mental illness received treatment. Serious mental illness causes $193.2 billion in lost earnings each year.³

When it comes to managing financial risks, nearly all Americans (91%) are reducing household spending in the face of high inflation, according to the survey. However, some also see this as a moment of opportunity. In fact, 27% of those surveyed are actually increasing investments. Their top choices? 1) The stock market, 2) retirement accounts and 3) cryptocurrency. One thing remains clear, however, and that is perceptions of risk have changed and will likely continue to change.

See complete survey results at https://surveyresults.aflac.com/.

¹ Source: Cleveland Clinic study, 2021.

² Cohen Veterans Network and National Council for Behavior Health study, 2018.

³ Source: National Alliance on Mental Health (2022). Mental Health Stats. Accessed July 20, 2022, from https://www.nami.org/mhstats.

Z2200882 Exp. 8/23

2022-09-26T08:01:00

(BPT) – People go to great lengths to reduce their odds of getting cancer. Many of us wear sunscreen, avoid processed foods, have regular checkups and eat organic produce, but what if your risk is hereditary rather than environmental? Read on to learn more about hereditary cancer and what you can do to learn about and manage your risk.

1. More than 10% of cancers are caused by inherited mutations in specific genes.

News stories about Angelina Jolie and other celebrities have made people aware that mutations in one of the BRCA genes can cause breast and ovarian cancer, but that’s not the whole story. Mutations in other genes can cause a condition known as Lynch syndrome which leads to a very high risk for colorectal, endometrial and other cancers. Although fewer people are aware of Lynch syndrome mutations, they are actually even more common than BRCA mutations. Inherited mutations in many other genes are also linked to an increased risk for breast, colorectal, endometrial, pancreatic, prostate, skin and other cancers.

2. Up to 90% of people are unaware that they have a genetic mutation that increases their cancer risk.

Most people have no idea that they are predisposed to cancer until they — or a close family member — receive a cancer diagnosis that leads them to have genetic testing. People who know about their mutation before a cancer diagnosis can take steps to protect their health, reduce their odds of developing certain cancers or increase their chance of catching cancer at an early, more treatable stage. If you’re wondering whether you should be tested for an inherited predisposition to cancer, this quiz is a good place to start.

3. Being aware of your cancer risk can save your life.

Some people shrug off the idea of genetic testing, believing if they test positive for a mutation there’s nothing they can do about it — but that’s not the case. A number of prevention and screening options are available to reduce the risk of getting cancer or increase the odds of catching it early before it spreads. Those who know they’re at high risk can also schedule more frequent cancer screenings.

4. Hereditary cancer affects men, too.

Men are just as likely as women to inherit (or pass on) a genetic mutation that increases cancer risk. Depending on the gene, mutations can increase the risk for a variety of male cancers, including prostate, pancreatic, breast and colorectal.

5. Hereditary cancer can affect people of any ethnicity. Disparities exist in access to care.

While white celebrities including Angelina Jolie, Christina Applegate, Kelly Osbourne and Chris Evert have received significant media attention about their BRCA mutations, people of all backgrounds can inherit genetic mutations that predispose them to cancer. For example, studies have shown that Black and white women inherit genetic mutations associated with breast cancer at the same rates, yet Black women are much less likely to receive genetic counseling and testing, due in part to differences in physician recommendations and access to care. Later-stage diagnoses and higher mortality rates are also common among Black women, who are 40% more likely to die of breast cancer than white women.

6. New medications can target hereditary cancer.

If someone’s cancer stems from a genetic mutation, they may have better odds of beating it thanks to drugs called PARP inhibitors, which were recently approved by the FDA. Initially developed to treat cancers in people with inherited BRCA mutations, PARP inhibitors are currently approved to treat select cases of breast, ovarian, pancreatic and prostate cancer. A type of immunotherapy known as immune checkpoint inhibitors is used to treat cancers in people with Lynch syndrome.

7. Support is available for people diagnosed with hereditary cancer and those at high risk.

No one wants to discover that they’re at increased risk for hereditary cancer, but it’s not something you need to face alone. Organizations like Facing Our Risk of Cancer Empowered (FORCE) have annual conferences, local support groups, peer-to-peer networks and many other resources to help people learn about their specific mutation and its cancer risks.

Want to learn more about hereditary cancer? Visit FORCE’s website or grab a copy of Living with Hereditary Cancer Risk, a comprehensive guide on hereditary cancers that covers risk, prevention, genetic counseling and testing, treatment, quality of life and more. You can also stay up to date on the latest research and what it means for you by reading FORCE’s XRAY reviews. XRAY looks behind the cancer headlines to deliver balanced information in plain language.

2022-09-22T15:31:00

(BPT) – The beach is an ideal place to make memories with friends and family, the perfect way to unwind, relax and soak in the sun. But for those living with uncontrolled moderate-to-severe atopic dermatitis (AD), the most common form of eczema, going to the beach can get complicated when the heat, saltwater and sand can worsen the persistent itch and lesions.

The Now Me: Beach Mode, a program by Sanofi and Regeneron, aims to help empower those living with moderate-to-severe eczema to feel comfortable with their own skin. As part of the program, two teams of patients and caregivers took on common beach day challenges inspired by their own experiences living with eczema. Working together, they activated their “Beach Mode” and found comfort in connecting with each other to have a successful beach day.

If you or your loved one are living with moderate-to-severe eczema, here are some tips to help you enjoy a day at the beach.

1. Set Up Shade and Cool Off

Too much heat exposure can exacerbate eczema symptoms – making dry skin, itching and irritation worse. Setting up a shady area to stay protected from the heat is an important part of a day at the beach for many living with moderate-to-severe eczema.

Take it from Adante, one of the participants in the Now Me: Beach Mode challenge. “Beach umbrellas can be key to helping me feel comfortable if it’s too hot,” he noted. “It can be hard to avoid the sun unless you find or create your own shade.”

2. Pack the Right Items for You

Preparation is key when headed to the beach. In addition to the typical supplies like towels and sunscreen, people with moderate-to-severe eczema may also need to bring things like moisturizer to help with dryness, and fresh water to gently rinse off sand and cool off.

Arsalan, who has moderate-to-severe eczema, got packing down to a science during The Now Me: Beach Mode challenges: “You have to pack a very large amount of sunscreen, and make sure it’s the right kind of sunscreen for the sake of sensitivity,” he said. “I always try to bring a lot of lotion to prevent my skin from drying out, and I bring towels to make sure that the sand doesn’t aggravate my skin.”

3. Wear Protective Clothing

Some people may find it beneficial to bring extra clothing made of breathable fabric to the beach to help prevent sunburn and protect skin. Long-sleeved rash guards, hats, extra towels and sunglasses are a must have for many beachgoers with eczema.

Arsalan knows from personal experience how wearing clothing that helps protect your skin can help make your day at the beach. “Bringing sunglasses, hats and extra clothing to the beach can make the experience more comfortable for you,” he explained. “Find what works for you and stick with it!”

4. Finding the Right Treatment Plan for You

If you or your loved one are experiencing symptoms of uncontrolled moderate-to-severe eczema, it’s important to talk to your doctor to find the right treatment plan for you. Treatments for people with uncontrolled moderate-to-severe eczema range from over-the-counter and prescription topical therapies to systemic therapies, including prescription oral steroids, immunosuppressants and biologic treatments such as Dupixent, also known as dupilumab.

Dupixent is a biologic treatment for people ages 6 months and older with moderate-to-severe atopic dermatitis that is not well-controlled with topical prescription therapies, or for those who cannot use topical therapies.

Dupixent helps block a key source of inflammation deep beneath the skin to help heal the skin from within, leading to noticeably less itch and clearer skin. It is the only biologic medicine for uncontrolled moderate-to-severe atopic dermatitis approved by the FDA for children as young as six months to adulthood.

In two clinical trials, almost four times more adult patients taking Dupixent saw clear or almost clear skin at 16 weeks compared with those not taking Dupixent (37% taking Dupixent vs 9% not taking Dupixent). Adult patients also experienced significant reduction in itch at 16 weeks when treated with Dupixent (38% vs 11% in those not taking Dupixent).

People shouldn’t use Dupixent if they are allergic to it or its ingredients. The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia). Serious side effects include allergic reactions that can sometimes be severe, eye problems and joint aches and pain. Please see full indication and Important Safety Information below along with links to the full Prescribing Information and Patient Information.

Visit Dupixent.com to learn more about Dupixent.

As Arsalan says, if you or your loved ones are struggling with uncontrolled moderate-to-severe eczema, “please don’t lose hope.” Do your own research, talk to your doctor, and empower yourself with strategies that work for you or your loved one, so you can activate your “Beach Mode” this summer.

Visit TheNowMe.com to learn about the program and watch inspiring stories of people living with moderate-to-severe eczema and their “Beach Mode.”

IMPORTANT SAFETY INFORMATION & INDICATION

Do not use if you are allergic to dupilumab or to any of the ingredients in DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical conditions, including if you:

• have eye problems.
• have a parasitic (helminth) infection.
• are scheduled to receive any vaccinations. You should not receive a “live vaccine” right before and during treatment with DUPIXENT.
• are pregnant or plan to become pregnant. It is not known whether DUPIXENT will harm your unborn baby.
  • A pregnancy registry for women who take DUPIXENT during pregnancy collects information about the health of you and your baby. To enroll or get more information call 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/dupixent/.
• are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including prescription and over-the- counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical or inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and use an asthma medicine. Do not change or stop your corticosteroid medicine or other asthma medicine without talking to your healthcare provider. This may cause other symptoms that were controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes be severe. Stop using DUPIXENT and tell your healthcare provider or get emergency help right away if you get any of the following signs or symptoms: breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives, joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea or vomiting, or cramps in your stomach-area.
• Eye problems. Tell your healthcare provider if you have any new or worsening eye problems, including eye pain or changes in vision, such as blurred vision. Your healthcare provider may send you to an ophthalmologist for an eye exam if needed.
• Joint aches and pain. Some people who use DUPIXENT have had trouble walking or moving due to their joint symptoms, and in some cases needed to be hospitalized. Tell your healthcare provider about any new or worsening joint symptoms. Your healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with atopic dermatitis include injection site reactions, eye and eyelid inflammation, including redness, swelling, and itching, sometimes with blurred vision, cold sores in your mouth or on your lips, and high count of a certain white blood cell (eosinophilia).

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of DUPIXENT. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an injection given under the skin (subcutaneous injection). Your healthcare provider will decide if you or your caregiver can inject DUPIXENT. Do not try to prepare and inject DUPIXENT until you or your caregiver have been trained by your healthcare provider. In children 12 years of age and older, it’s recommended DUPIXENT be administered by or under supervision of an adult. In children under 12 years of age, DUPIXENT should be given by a caregiver.

Please see full Prescribing Information including Patient Information.

INDICATION

DUPIXENT is a prescription medicine used to treat adults and children 6 months of age and older with moderate-to-severe atopic dermatitis (eczema) that is not well controlled with prescription therapies used on the skin (topical), or who cannot use topical therapies. DUPIXENT can be used with or without topical corticosteroids. It is not known if DUPIXENT is safe and effective in children with atopic dermatitis under 6 months of age.

© 2022 Sanofi and Regeneron Pharmaceuticals, Inc.

All Rights Reserved. DUPIXENT^® is a registered trademark of Sanofi Biotechnology.

DUP.22.07.0249

2022-09-21T06:31:00

(BPT) – Young adults between the ages of 18 and 39 are often embarking on new journeys or pursuing personal and professional goals. A cancer diagnosis can bring their plans to a screeching halt. The experience can cause physical side effects as well as psychological and psychosocial effects that can be detrimental. Treatment can be isolating and might cause long-term health complications such as an increased risk of developing a secondary cancer later in life, compromised organ function, and fertility issues. It’s important for young adults to have an adequate support system during their cancer experience.

The Leukemia & Lymphoma Society (LLS) understands the unique concerns and needs specific to young adults who have been diagnosed with or have survived leukemia, lymphoma, or other types of blood cancer and has resources to help them. Perhaps it’s their first time experiencing a serious illness and they might feel uncomfortable talking about their diagnosis with others. Or they might have questions about what to expect during and after treatment. No matter their questions or concerns, LLS has a wide array of free programs, resources and support services available for all those affected by blood cancers, including family members and caregivers. The following list highlights some of LLS’s programs with resources and groups dedicated exclusively to young adults with or who have survived blood cancer.

In addition to programs listed, LLS also has a host of free informational and educational resources including The Bloodline podcast, webcasts and videos, downloadable booklets and more. Visit LLS.org for more information

LLS Information Specialists are trained oncology professionals who offer one-on-one support throughout the entire cancer journey into survivorship. They provide personalized, accurate and up-to-date information about blood cancers, clinical trials, nutrition resources, and more as well as help navigate financial and social challenges young adults might encounter. They are available by phone at (800) 955-4572, email and chat. Information Specialists can communicate in up to 350 languages.

LLS’s Weekly Online Chat is an open forum for young adults dealing with cancer and cancer survivorship moderated by oncology social workers.

LLS Community, A Project of the Michael J. Garil Data Collective, is an online community that features a group specifically devoted to the young adult cancer community.

LLS’s Patti Robinson Kaufmann First Connection Program^® connects blood cancer patients and their loved ones with trained peer volunteers who have shared similar experiences. Young adults can receive or volunteer to provide peer support.

LLS Support Groups are local, in-person groups that provide mutual support and education to members who may feel a little less alone by meeting with others whose situations are similar to their own.