For love of family: How one woman persists throughout her breast cancer treatment journey

2024-10-03T13:01:00

(BPT) – Southern California native Lisa Shoemaker has been coping with breast cancer for a long time, and one thing keeps her going: her family. She married her high school sweetheart and had two boys before she was first diagnosed with stage 2 breast cancer at age 29. With this devastating diagnosis, Shoemaker feared she wouldn’t live to see her 2- and 4-year-old sons grow up.

That was 26 years ago.

Through all these years, Shoemaker has been motivated to keep going because of her love for her family — first her husband and sons, and now her three grandchildren, too.

While her initial treatment for the stage 2 breast cancer was intense and extensive, it provided stability for nearly a decade until a routine mammogram and subsequent MRI revealed that her cancer had returned. She went through treatment again, including surgery and hormone therapy, but after all she had endured, Shoemaker decided to undergo a preventative double mastectomy. With her cancer again stable, she was able to continue raising her children through their high school years and live life as she normally would.

But unfortunately, that was not the end of her cancer story. At age 45, and several years after her preventative double mastectomy, Shoemaker experienced pain in her shin, which she initially attributed to increased exercise. When her pain could no longer be ignored, she sought medical attention. An orthopedic doctor immediately sent her to the hospital after telling her that her cancer had likely metastasized to her bones.

After meeting with specialists, she had surgery to remove a tumor in her tibia which had caused it to fracture. Shoemaker was then diagnosed with metastatic breast cancer (mBC) and told she had about two years to live.

What is metastatic breast cancer?

When someone has mBC, that means the cancer is considered to be stage 4 and has spread to other parts of the body. While mBC has no cure, according to the National Breast Cancer Foundation, people with mBC have been able to live longer by managing it as a chronic illness with continuous treatment and monitoring.

For those living with ER+/HER2- metastatic breast cancer — the most common subtype of mBC — the first treatment is often a hormone therapy taken alone or in combination with a CDK4/6 inhibitor. But over time the cancer changes and mutates to try and “outsmart” the treatment, and these mutations can cause tumors to stop responding to certain therapies.

A specific mutation, called an ESR1 mutation, is an example of one mutation that may cause treatment to stop working, which can lead to disease progression and tumor growth. An ESR1 mutation develops as a result of previous exposure to endocrine, or hormone, therapy. Nearly 50% of people with ER+/HER2- metastatic breast cancer may develop an ESR1 mutation, which in turn can cause their disease to progress.

If you live with ER+/HER2- mBC, knowing whether this mutation is present can provide important information to help your health care team understand what other kinds of treatment options may be appropriate. This is why it is vital to ask your doctor about ESR1 mutation testing whenever mBC progresses.

ESR1 mutations are most likely to be found when:

  • A person’s metastatic breast cancer has progressed (spread, grown or worsened) while on hormone therapy
  • The current hormone therapy is no longer working
  • The person has taken a hormone therapy for a year or more
  • The person has taken multiple hormone therapies

“Unfortunately, for the majority of patients living with metastatic breast cancer, treatments eventually stop working,” said Dr. Aditya Bardia, Director, Breast Oncology Program, UCLA Health Jonsson Comprehensive Cancer Center, “which means, if possible, ESR1 mutation testing should be considered at every point of progression of the disease, as it might open doors for additional treatment options. We know that ESR1 mutations are acquired and serial testing might pick up mutations that are not present initially.”

This is exactly what happened to Lisa Shoemaker, as she had already been through several rounds of chemotherapy and hormone therapies after living with mBC for over 10 years. Shoemaker had regular scans and tests done to monitor her cancer. One of those was a blood test which found that the ESR1 mutation was present, and indicated a different treatment could potentially help manage the progression and spread of her cancer.

Thanks to this important information, Shoemaker’s health care team was able to adjust how they were treating her mBC. ESR1 mutation testing enabled her oncologist to tailor her treatment appropriately. Best yet, she can spend time with her grandchildren, which is one of the greatest joys in her life.

“I am so thankful that I’m able to help raise my grandchildren, not only to be alive to see them, but also to be present in their lives. I feel a sense of normalcy again,” said Shoemaker. “My grandchildren are the light of my life and motivate me. They are my reason to keep on keeping on.”

Because the ESR1 mutation can develop at any time during treatment, it’s essential to be retested for this mutation at every point of mBC disease progression throughout the treatment journey. If you or a loved one has ER+/HER2- metastatic breast cancer, ask your health care provider about being tested for the ESR1 mutation. Testing for an ESR1 mutation can be done via a blood test and does not require a tissue biopsy.

Learn more at mBCTesting.com.

What one man learned about the value of precise imaging for prostate cancer

2024-10-03T10:41:00

(BPT) – When retired aerospace engineer Steve Sakakini was diagnosed with prostate cancer at the age of 61, his doctor said he’d have to have his prostate removed. Caught off guard, Sakakini sought a second opinion. That was the beginning of his journey to learn about prostate cancer and the diagnostics available to determine the best treatment plan for him.

Sakakini’s new urologist recommended active monitoring of his cancer and treating it only when it showed signs of progression. This meant regular tests to determine the prostate-specific antigen (PSA) levels in his blood, plus MRIs to watch for signs the cancer might be spreading.

For the next 11 years, Sakakini monitored his cancer, but at his annual physical in 2022, his PSA had risen to 160, and an MRI discovered his cancer had spread to surrounding bones. His doctor recommended PSMA PET imaging. PSMA stands for prostate-specific membrane antigen, a protein found mainly on prostate cancer cells. PET means positron emission tomography, a scan that uses a special dye with radioactive tracers that allow doctors to scan for cancer or other diseases. PSMA PET is an effective new body scan that helps doctors track hard-to-find prostate cancer potentially earlier and in smaller tumors, as opposed to standard imaging.

Sakakini was worried; he could not get an appointment with his urologist for several weeks. Fortunately, he was referred to an oncologist specializing in prostate cancer at a major cancer research center. Based on his test results, including PSMA PET imaging, Sakakini’s oncologist recommended an aggressive three-drug treatment regimen grounded in state-of-the-art research: a new oral hormone therapy drug and a new testosterone blocking drug, plus chemotherapy. After six chemotherapy sessions, his PSA dropped to zero.

Today Sakakini is doing well. He continues taking the two medicines to keep testosterone low. His PSA remains undetectable, and there is no evidence of prostate cancer on scans. Sakakini stays in touch with his care team to monitor his condition. He maintains a healthy diet, exercises and loves spending time with his family. His advice to others?

“I believe my treatment was successful because my doctor knew about the latest research on my type of prostate cancer and applied it to my care.” Sakakini said, “But it’s equally important to empower yourself with knowledge and be your own advocate too.”

How common is prostate cancer?

According to the American Cancer Society, 1 in 8 men in the U.S. will have prostate cancer at some point in their lives, and an estimated 3.3 million men are living with prostate cancer in the U.S. In addition, prostate cancer develops more often in Black men, and when it does develop in these men, they tend to be younger.

For your best health outcome, early detection is key. Talk to your doctor about your risk factors and screening. This is especially important as you age, because older men are at increased risk.

How PSMA PET helps doctors treat prostate cancer

Before doctors can treat your prostate cancer, they need to see it clearly. PSMA PET imaging can help diagnose better than conventional imaging and build a plan to treat prostate cancer for many patients with the disease.

Doctors performing a PSMA PET scan inject patients with a small radioactive molecule that is attracted to PSMA, which is specific to prostate cancer cells. The radioactive part lights up when a whole-body scan is done, giving doctors a clear image of exactly where the cancer is.

Ask your doctor if PSMA PET imaging is a good option for you and learn more about PSMA PET at Time2See.com.

If you or a loved one are impacted by prostate cancer, please visit The Prostate Cancer Foundation (PCF) to learn more or access patient resources. PCF funds the world’s most promising research on biology and treatment of prostate cancer, accelerating those discoveries into therapies and strategies designed to extend lives and improve quality of life for patients.

5 reasons coaches are key for weight loss and weight management

2024-10-03T08:01:00

(BPT) – Kristen Glass struggled with weight her entire life. She tried program after program, unable to uncover a solution that worked for her — then one night, she connected with a friend over dinner who had recently lost weight and “had a twinkle back in her eye.” Whatever had ignited that glow in her friend, Kristen wanted to experience it for herself. That night, Kristen called her friend’s independent OPTAVIA® coach — a stranger who would become her own coach and close friend.

OPTAVIA, the habit-based, coach-guided lifestyle solution, immediately clicked for Kristen — and she became a coach that same year. In the six years since, she has impacted 150,000 people across the OPTAVIA community, inspiring them to lose weight and helping them keep it off. Kristen believes coaches are the secret to weight loss and establishing a healthy lifestyle, and to celebrate National Coaches Day this October, she’s sharing why.

1. Coaches won’t let you do it alone

We all need a coach — someone to guide us through the ups and downs, join us in celebrating our wins and keep us committed to our goals. This is especially true along the weight-loss journey, as 96% of people recognize that lifestyle changes are needed for weight loss and weight management, yet only 17% are confident they can manage it on their own.*

2. Coaches keep it simple

Weight loss can be overwhelming with complicated, trendy diets and counting calories. Coaches like Kristen can provide guidance to streamline health and wellness. “People are craving someone to help simplify this process,” she said, noting this is especially true for the women and mothers that make up most of her client base.

Kristen focuses on an uncomplicated approach, especially in the critical early weeks of a health journey. She fosters straightforwardness, asking her clients pointed questions that get to the heart of their health choices.

3. Coaches keep it real

Accountability is crucial. As an OPTAVIA coach, Kristen challenges her clients to confront their lifestyle choices head on. Her coaching philosophy is to “get straight to the truth quickly and jump into discomfort fast and together.” Kristen emphasizes honesty and initial discomfort and encourages clients to take ownership of their choices to foster growth.

4. Coaches truly know what you’re going through

Empathy and shared experiences are powerful tools in a coach’s arsenal. This is particularly true at OPTAVIA, where over 90% of coaches were clients first. No matter where they are in their personal health journey, their coach has been in their shoes.

Kristen knows that thousands of women like her have struggled to uncover a solution to weight loss and weight management. In her own journey, Kristen has also learned the role mental health plays in physical health. This breakthrough prompted her to help her clients reflect on the mental and emotional reasons for their health decisions so they can make better choices going forward.

5. Coaches celebrate your successes and milestones

A coach is there beside you every step of the way to celebrate the wins, both big and small. Whether you hit a new weight loss milestone or made a healthy choice at dinner, your coach is there to reinforce positive behaviors and motivate you to keep going. They become your cheerleader, your mentor and your guide — providing the encouragement and support you need to stay committed to your goals.

Learn more at Optavia.com/results.

*IPSOS commissioned by Medifast, June 2023.

5 Things Everyone Should Know About Falls and Concussions

2024-10-02T15:01:00

(BPT) – Five million people go to the emergency department for a traumatic brain injury (TBI) in the U.S. each year, but more than half of people who suspect they have a concussion never get it checked.[1],[2] A main reason for this is that people aren’t familiar with the common causes and symptoms of concussions, and unfortunately, there are a lot of myths out there. One especially dangerous myth is that concussions only happen to athletes. Most concussions occur when people fall while doing everyday activities — such as falling while taking a shower or tripping on a toy at home. These types of falls account for nearly half of all concussions in the U.S.[3] And while concussions can happen to anyone, rates of concussions increase significantly in older adults.

Abbott, the developer of a rapid test for the assessment of concussions, and the National Council on Aging (NCOA) want to share five things everyone should know about concussions and falls prevention.

1. Concussions can happen to anyone, anywhere, anytime.

Concussions can result from almost anything when the brain moves in ways it shouldn’t. While falls are the most common cause, concussions can also be caused by a hit to the head or jolts (think: a car crash or whiplash).

Dr. Beth McQuiston is a neuroscientist, licensed physician, registered dietitian and medical director for Abbott’s diagnostics business. She wants everyone to know the importance of getting your head checked if you think you’ve sustained a concussion.

“The brain is literally everything that makes you, you. It holds memories of the people we love, the songs we can’t stop listening to, and the information we need for work and life, so we should treat it with the utmost respect. Concussions may be an invisible injury, but it’s just as important to immediately seek care for a concussion as you would for a broken bone,” said McQuiston.

2. Older adults are at an increased risk for falls and concussions.

Falls are the leading cause of injuries for older Americans and can have serious, life-threatening consequences, including concussions.[4] The latest data from the Centers for Disease Control and Prevention (CDC) show that people age 75+ have the highest numbers and rates of TBI-related hospitalizations and deaths compared to other age groups.[5] Furthermore, older adults have a higher risk for severe outcomes following a concussion, including strokes.[6],[7]

Many people think falls are a normal part of aging, but most falls can be prevented, and everyone has the power to reduce the risk.

NCOA leads the National Falls Prevention Resource Center, which supports awareness and educational efforts about falls, and promotes evidence-based falls prevention programs and strategies across the nation. Kathleen Cameron is senior director of NCOA’s Center for Healthy Aging, and she wants to increase awareness of fall risks and how to prevent them.

“Every 11 seconds in the U.S., an older adult is treated in the emergency room due to a fall. Falls and concussions threaten the safety and independence of older Americans. But practical lifestyle adjustments such as regular exercise, making sure your vision and hearing are checked annually and keeping your home safe from tripping hazards can substantially reduce falls,” said Cameron.

Visit NCOA’s website for more tips on falls prevention and healthy aging.

3. Recognize the symptoms of concussions.

Despite the widespread prevalence of concussions, most adults can’t identify the common signs. A common myth about concussions is that all concussions result in a loss of consciousness, but that isn’t the case.[8]

It’s important to recognize the following symptoms if you experience a head injury:

  • Changes in emotions
  • Changes to sleep patterns
  • Clumsiness
  • Dizziness or feeling off-balance
  • Exhaustion
  • Headaches
  • Memory Loss
  • Mental fog or concentration problems
  • Nausea or vomiting
  • Numbness or tingling
  • Personality changes or irritability
  • Sensitivity to noise or light
  • Loss of consciousness
  • Slowed reaction time
  • Vision issues
  • Vomiting

For more symptoms and information, visit Concussion Awareness Now.

4. You should never just “walk it off.”

When it comes to concussion, it’s never best to “wait and see.” For your best chance at a full recovery, seek professional medical help immediately.

If you hit your head, remember these steps:

  • Stop: Slow down, take a breath. Then, take a moment to assess.
  • Look for symptoms: Some symptoms like headaches or nausea or vomiting might not show up immediately, and other warning signs like dizziness or feeling off-balance may not appear for hours or even days after an injury.
  • Get it checked: It’s important to be cautious. If you have even the slightest suspicion of a concussion, seek medical attention.

5. Concussion evaluation is evolving and doesn’t always require a CT scan.

Concussions can be evaluated in several ways, most often including a physical evaluation and a series of questions. A physician will look for physical symptoms, such as balance and vision issues, and then ask questions that might help uncover other potential symptoms, such as memory loss and slowed reaction time.

Unfortunately, this process is subjective, as a physician must make a diagnosis decision based on their evaluation of the situation. In patients where symptoms aren’t obvious (think: a patient with memory loss being asked if they’ve forgotten anything), this approach to diagnosis isn’t always effective. CT scans and MRIs are often conducted when a concussion is suspected, but these scans are used to detect brain bleeds and can’t identify other concussion symptoms.[9]

The good news is that major advancements are happening in evaluating mild traumatic brain injury (mTBI). Abbott’s i-STAT TBI cartridge — a simple blood test — received clearance from the U.S. Food and Drug Administration (FDA) as a prescription use only test to help physicians assess patients with suspected mTBI at the patient’s bedside.[10] The test can share lab-quality results in just 15 minutes and is cleared for use in anyone 18 years and older. The test measures the level of two biomarkers associated with brain injury in the blood stream to assist in determining the need for a CT scan of the head within 24 hours of head trauma. Based on the test results and an overall patient evaluation, a physician may be able to quickly rule out the need for a CT scan of the head, allowing patients to be sent home sooner without unnecessary exposure to radiation or delays. Find more information about the test and brain health here.

Abbott is working with hospitals around the globe and the Concussion Awareness Now braintrust of partners to make concussion testing widely available to ensure everyone can get the best possible care. Because concussions can happen to anyone, it is vital that everyone knows the risks, what symptoms to watch out for, and how to respond if you may have experienced a concussion. Remember these five things to ensure you and your loved ones are protecting your heads and, ultimately, your health:

  • Concussions can happen to anyone, anywhere, anytime.
  • Older adults are at an increased risk for falls and concussions.
  • It’s important to recognize the symptoms of concussions.
  • You should never just “walk it off.”
  • Concussion evaluation is evolving and doesn’t always require a CT scan.

[1] Korley, et al. Emergency Department Evaluation of Traumatic Brain Injury in the United States, 2009-2010. J Head Trauma Rehabil. 2016 Nov/Dec;31(6):379-387

[2] Concussion Awareness Now. Thank you know about concussions? Think again. Accessed September 2024.

[3] Centers for Disease Control and Prevention. Facts about TBI. Accessed September 2024.

[4] Centers for Disease Control and Prevention. Older Adult Falls Data. Accessed September 2024.

[5] Centers for Disease Control and Prevention. Health Disparities in TBI. Accessed September 2024.

[6] June, et al. Lasting consequences of concussion on the aging brain: Findings from the Baltimore Longitudinal Study of Aging. Neuroimage. 2020 Nov 1; 221: 117182.

[7] Concussions in Older Adults. Concussion Alliance. Accessed September 2024. https://www.concussionalliance.org/concussions-in-older-adults

[8] Levin, et al. Association of Sex and Age With Mild Traumatic Brain Injury–Related Symptoms: A TRACK-TBI Study. JAMA Netw Open. 2021;4(4):e213046.

[9] Brain Injury Association of America. True or False? Seven Common Myths About Brain Injury. Accessed September 2024.

Do you or a loved one have advanced multiple myeloma?

2024-10-02T08:01:00

(BPT) – Two clinical trials are seeking adults for research on an investigational medicine for relapsed and/or refractory multiple myeloma.

Multiple myeloma is a rare bone marrow cancer, and about 35,000 people in the United States will be diagnosed this year.[1],[2] Most people will be diagnosed over the age of 65, and African Americans are more than twice as likely to be diagnosed compared to Caucasian patients.[3] Multiple myeloma can cause a range of difficult symptoms, from bone pain and infections, to weakness, nerve damage, or impaired kidney function.[4]

While there are treatments approved for multiple myeloma, most people will have their cancer return after treatment (what doctors call “relapse”) or they may no longer respond to a certain medicine (called “refractory” disease).[5],[6] Doctors may determine suitable treatments for each patient based on a range of factors, including the stage of the disease and previous therapies, as different treatments may be combined or used one after another.[7]

Bristol Myers Squibb is currently investigating the potential of an investigational therapy for patients living with relapsed or refractory multiple myeloma.

Evaluating an investigational treatment option for multiple myeloma:

Medical research built on existing scientific knowledge and proven mechanisms of disease have the potential to improve anti-myeloma activity and overcome treatment resistance.

Clinical trials are controlled studies of potential new medicines, procedures or other treatments, and doctors use information they learn from these studies to help figure out new or improved ways to treat diseases like multiple myeloma. While clinical trials offer the possibility of accessing cutting-edge treatments and contributing to medical advancements, they also come with potential risks, including side effects and uncertainties about the effectiveness of the treatment being studied.

Two clinical trials are underway evaluating an oral therapy called mezigdomide, which is part of a group of novel therapies known as CELMoDs™. CELMoDs, like mezigdomide, have been designed to help remove harmful proteins from cells, potentially killing cancerous myeloma cells and helping the body’s immune system to attack these cells as well.

“Despite continued scientific progress, multiple myeloma is still incurable, and many people have periods of remission followed by relapse, making the long-term management of this cancer incredibly important,” said Anne Kerber, M.D., Senior Vice President and Head of Late Clinical Development, Hematology, Oncology and Cell Therapy for Bristol Myers Squibb. “Having many different medicines available for people as they live with this cancer is necessary for the future of myeloma therapy and clinical trials are critical in helping us find the next wave of potential treatment approaches. People who take part in clinical trials play a vital role in how we advance research for this disease and, ultimately, improve outcomes.”

About the SUCCESSOR-1 and SUCCESOR-2 studies:

The SUCCESSOR-1 and SUCCESSOR-2 studies are studying the safety, tolerability, and effectiveness of mezigdomide in combination with other myeloma treatments, compared to standard medicines for multiple myeloma without mezigdomide in adults with relapsed and/or refractory multiple myeloma.[8],[9],[10],[11]

Before joining a SUCCESSOR trial, patients sign their consent, then take part in a screening period, during which a doctor performs several tests and assessments to see if they are eligible to participate in the study. For both SUCCESSOR studies, eligible participants must be at least 18 years of age, have a diagnosis of progressive multiple myeloma, and have received prior treatment for multiple myeloma with certain medicines. After all necessary tests and assessments have been completed, and if patients are eligible to take part, they may enter the study assigned and will be randomized to receive standard multiple myeloma treatment or standard multiple myeloma treatment with mezigdomide. Participation in a clinical trial is voluntary. Once study treatment begins, it will continue until the disease returns or the treatment is stopped for another reason, such as issues with tolerability. There are also follow-up visits to assess the long-term effectiveness and safety of the therapy.

During the study, patients would not be responsible for study-related costs, such as doctor visits, lab tests and procedures. Those costs are all covered by Bristol Myers Squibb. Patients and caregivers may also be able to receive reimbursement for some costs like time, travel, or transportation.

If interested in learning more about the SUCCESSOR trial program, patients should talk to their doctor to decide if taking part is right for them. Visit the BMS Clinical Trials website for more information.


[1] Hansen JD, Correa M, Nagy MA, et al. Discovery of CRBN E3 ligase modulator CC-92480 for the treatment of relapsed and refractory multiple myeloma. J Med Chem. 2020;63(13):6648-6676. doi:10.1021/acs.jmedchem.9b01928. Accessed September 2024.

[2] American Cancer Society. Cancer Facts & Figures 2024. American Cancer Society. https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2024-cancer-facts-figures.html. Published January 2024. Accessed September 2024.

[3] American Cancer Society. Multiple Myeloma Causes, Risk Factors and Prevention. American Cancer Society. https://www.cancer.org/cancer/types/multiple-myeloma/causes-risks-prevention/risk-factors.html. Published January 2024. Accessed September 2024.

[4] American Cancer Society. Signs and Symptoms of Multiple Myeloma. Available at: https://www.cancer.org/cancer/types/multiple-myeloma/detection-diagnosis-staging/signs-symptoms.html. Published February 2018. Accessed September 2024.

[5] Cancer Treatment Centers of America. Multiple myeloma relapse. Cancer Treatment Centers of America. https://www.cancercenter.com/cancer-types/multiple-myeloma/types/relapsed-multiple-myeloma. Published June 2023. Accessed September 2024.

[6] Yang WC, Lin SF. Mechanisms of Drug Resistance in Relapse and Refractory Multiple Myeloma. Biomed Res Int. National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/26649299/. doi:10.1155/2015/341430. Published November 2015. Accessed September 2024.

[7] Multiple Myeloma Treatments | Drugs & Treatment by Stage. MMRF. https://themmrf.org/diagnosis-and-treatment/treatment-options/#:~:text=The%20choice%20of%20initial%20treatment Accessed September 2024.

[8] Richardson PG, Badelita S, Besemer B, et al. A phase 3, two-stage, randomized study of mezigdomide, bortezomib, and dexamethasone versus pomalidomide, bortezomib, and dexamethasone in relapsed/refractory multiple myeloma: SUCCESSOR-1. Poster presented at: 11th Annual Meeting of the Society for Hematologic Oncology (SOHO); September 6-9, 2023; Houston, TX.

[9] A phase 3, two-stage, randomized, multicenter, open-label study comparing mezigdomide (CC-92480), bortezomib and dexamethasone (MeziVd) versus pomalidomide, bortezomib and dexamethasone (PVd) in subjects with relapsed or refractory multiple myeloma (RRMM): SUCCESSOR-1. ClinicalTrials.gov identifier: NCT05519085. Updated October 27, 2023. Accessed September 2024. https://clinicaltrials.gov/study/NCT05519085

[10] Richardson PG, Amatangelo M, Berenson JR, et al. A phase 3, two-stage, randomized study of mezigdomide, carfilzomib, and dexamethasone versus carfilzomib and dexamethasone in relapsed/refractory multiple myeloma: SUCCESSOR-2. Poster presented at: Annual Meeting of the American Society of Clinical Oncology (ASCO); June 2-6, 2023; Chicago, IL.

[11] A phase 3, two-stage, randomized, multicenter, open-label study comparing mezigdomide (CC-92480/BMS-986348), carfilzomib and dexamethasone (MeziKD) versus carfilzomib and dexamethasone (Kd) in participants with relapsed or refractory multiple myeloma (RRMM): SUCCESSOR-2. ClinicalTrials.gov identifier: NCT05552976. Updated October 31, 2023. Accessed September 2024. https://clinicaltrials.gov/study/NCT05552976

Skip the waiting room: How professional online second opinions services simplify healthcare

2024-10-02T07:01:00

(BPT) – Getting a second opinion after a medical diagnosis has been a routine part of healthcare for nearly as long as doctors have been diagnosing patients. However, the process of getting a second opinion can be complicated and time consuming. That’s because it requires finding another physician or specialist, perhaps scheduling another appointment, transferring records and other information, and waiting for a diagnosis.

Wouldn’t it be nice if it could be done at home?

Second Opinions, an online medical consultation service, has been at the forefront of virtual second opinions since 2012. The process is simple: a patient creates an account with Second Opinions, plugs in information about their diagnosis, and uploads scans and other health records. All of that information is reviewed by expert clinicians who then deliver a second opinion diagnosis via a phone call, video chat or email.

No second appointment, no travel, no hunting on your own for specialists. It’s a fast, easy and convenient way to up the quality of your healthcare, and ultimately help give you peace of mind before making a critical medical decision.

Second Opinions, owned by USARAD Holdings Inc, a subsidiary of medical imaging company Nanox, was founded with the notion of using the internet to help increase the standard of care and provide virtual second opinions to people everywhere. Patients have the opportunity to connect with physicians from a wide variety of medical specialties, including radiology, neurology, oncology and cardiology. Multiple areas of surgery are also covered, such as orthopedic, vascular and bariatric.

“Healthcare today is more complicated than ever, and getting a second opinion can be crucial for patients facing an important medical decision,” says Erez Meltzer, Nanox Chief Executive Officer. “Through Second Opinions, we have expanded on USARAD’s extensive network of radiologists and offer patients access to top specialists across many areas of medicine. We want to give patients the information they need to make confident healthcare choices, with the convenience and speed of an online platform.”

AI assists in diagnoses

Virtual second opinions were made possible by advances in technology. And now, as we’re learning more about artificial intelligence, it’s possible to harness this powerful tool to enhance the process of second opinions even more.

In June 2024, Nanox announced the integration of advanced AI to further enhance the Second Opinions offerings in radiology and imaging. Patients upload their chest and abdominal scans, which are evaluated by AI. Those evaluations are reviewed by real, human doctors, before delivering the diagnosis to patients, ensuring a balance of technological precision and human expertise.

A team of medial professionals reviewing a patient's x-ray.

It’s all about early detection of chronic conditions on existing scans, often before symptoms appear. As the medical publication STAT recently noted, AI-based second opinion services can also improve clinical decision making by helping eliminate bias.

Creating more opportunity for a higher standard of care

Another positive aspect of online second opinions is the opportunity it brings to people in rural areas or other parts of the country where it’s not easy or even possible to get a second opinion, Meltzer noted. In many rural locations, getting quality healthcare can mean a long car trip, staying overnight and other costly factors; oftentimes one hospital, with one team of specialists, serves entire communities. There simply isn’t the option to find a second opinion locally. Second Opinions simplifies the process of accessing and obtaining a second opinion — anyone with an internet connection can request this service from home. And now AI can level up that care even more.

For more information about getting a second opinion, visit https://www.secondopinions.com/ and enter coupon code CSO10OFF at signup for a 10% discount.

6 tips to help keep your pets healthy this National Pet Wellness Month

2024-10-02T08:07:00

(BPT) – A staggering 86.9 million U.S. homes share their lives with a beloved pet, according to MarketWatch. From playful personalities to curious instincts, pets enrich our lives by providing companionship, emotional support and a sense of security. In honor of National Pet Wellness Month this October, Royal Canin, a division of Mars, Incorporated and leader in pet health nutrition, invites pet owners to explore essential tips to help keep their pets healthy and happy.

“National Pet Wellness Month is a crucial reminder that our pets’ health is in our hands,” said Dr. Todd East, DVM, veterinary affairs director, Royal Canin North America. “As a veterinarian, I see how preventive care can dramatically improve and extend the lives of our pets. I encourage all pet owners to be proactive about their pets’ health to help them remain happy, active members of your lives for years to come.”

Navigating all the online resources for pet care can feel overwhelming and it can be tough to know which is best for your pets’ specific needs. To make that journey easier, try these simple yet effective tips so you can help your pet thrive:

  • Make sure they are getting the right nutrients from their food based on their stage of life, breed and specific nutritional needs: From a German Shepherd to Yorkshire Terrier or French Bulldog to Labrador Retriever, every pet is unique, and so are their nutritional needs. That means each one requires a specific balance of nutrients to ensure they are maintaining a healthy lifestyle depending on their specific needs and stage of life. Be sure to consult your veterinarian for their recommendation on proper nutrition that’s specific to your pet, like Royal Canin’s tailored nutrition lines.
  • Annual visits to the veterinarian are important: Taking your pet to the veterinarian is a great preventive measure to help them stay as healthy as possible. While going to the veterinarian may be a stressful experience for both pets and pet owners, it is essential to ensure no health issues go unnoticed.
  • Exercise is key to staying happy and healthy: Let your pets get their energy out! Whether it’s taking them for a walk or letting them run around in the backyard, fresh air and movement can help maintain a healthy weight for your pet, which can reduce the risk of serious conditions associated with obesity.
  • Hydration, hydration, hydration: Water is fundamental to your pet’s survival. It is essential for their everyday functions, and many body processes rely on water to work properly. Always take your portable water bowl wherever you go and make sure clean and fresh water is available to your pet every day!
  • Don’t forget grooming: Grooming your kitten or puppy is an important part of ownership, and if done gently and patiently, will help you build a bond with your pet. Frequent grooming allows you to recognize any changes to your pet’s body condition, protect them against fleas or ticks, and maintain healthy skin and coat.
  • Enhance their overall health with social stimulation and play: In order for your pet to gain independence, it is important to socialize them at a young age. Both kittens and puppies benefit from socialization, as it teaches them how to react in various situations and enhance their brain development.

“I always make sure I am giving my dog, Max, the care he needs in return for all the love and support he provides me,” said Racquel White, vice president of corporate affairs, Royal Canin North America. “In order to do so, I stay on top of his health to ensure he has what he needs to help him thrive. From the day I brought him home, I made sure he was eating the right foods with tailored nutrients for his unique needs. I also make annual veterinarian visits a priority, focus on preventive care, and never miss our daily walks outside to enjoy the sunshine. And of course, I make sure he gets plenty of playtime in. All these things are important for Max to be the best he can be, day in and day out.”

To continue on your journey of helping your pet with their overall wellness, check out Royal Canin’s pet food finder so you can ensure you are feeding them the right diet based on their specific needs and stage of life.

See Doja Cat like never before at her exclusive living room session

2024-10-02T02:01:00

(BPT) – Fresh from her European tour, Doja Cat is inviting fans to see her like never before with an immersive living room performance you won’t want to miss. For one night only, guests will step into the world of Doja and experience her live artistry in an intimate setting.

Doja’s creative vision has been brought to life in this personal, otherworldly space complete with her grandmother’s hand-painted art, an elegant feast, and playlist to set the tone before Doja takes the living room stage for an unplugged performance.

“I’ve spent the last year performing on the world’s biggest stages, and now I’m ready to share my art with fans in a more intimate setting,” said Doja Cat. “This will be a first for both me and my fans, and I’m excited to share this moment with them.”

About the experience

Doja Cat is inviting fans to connect with her on a new level at this one-night experience in Los Angeles. The experience will occur Saturday, October 26 for 15 guests for $77 per person.

Here’s what you can expect:

  • You’ll be transported to an undisclosed location where you’ll enter into Doja’s personal gallery featuring her grandmother’s hand-painted artwork and listen to a playlist curated by Doja herself
  • Doja has prepared a spread of only the finest bites for you to devour — fancy fruits, cheeses, and her favorite, caviar
  • Reveal your inner artist in the vanity room where you’ll answer a question Doja left for you
  • Sign the guestbook with your name and a message for Doja to read later
  • Settle in for a private, personal performance of Doja’s recent hits and some of her all-time faves
  • Maybe even capture a group selfie to end the evening

How to request to book

Fans ready to experience Doja’s latest artistic rebirth can request to book1 and learn more about all Icons at airbnb.com/dojacat.

The booking request period opens on Tuesday, October 8 at 6:00 AM PT and closes on Friday, October 11 at 11:59 PM PT for a single, one-night experience for 15 people each occurring Saturday, October 26 for $77.

Guests must be 21+ and able to provide a government-issued ID.

Filling up an electric vehicle? It’s easier than you think

2024-10-01T12:01:00

(BPT) – What’s holding you back from buying an electric vehicle? You’ve likely heard a lot of myths and misconceptions about electric vehicle ownership, especially when it comes to how you fill it up. However, the truth is that charging an electric vehicle can be simple, convenient and cost-effective.

If you’re on the fence about making the switch, check out these three fueling myths. With this knowledge, you can separate fact from fiction and make an informed decision about your next vehicle.

Myth #1: You can only charge an electric vehicle at a public charging station.

Depending on where you live, you may be concerned about finding public charging stations. However, the reality is that the majority of electric vehicle owners fill up at home. According to a new Ford survey, 88% of electric vehicle owners across the country prefer the convenience and savings of filling up at home with electricity and rarely charge publicly.

If you’re concerned that filling up at home will be complicated, don’t sweat it. The survey also found that 92% of current electric vehicle owners find filling up at home as easy as plugging in their phone. Once you have a charging station installed in your garage, you can plug in your car at night and wake up to a full tank!

Myth #2: A single charge won’t get you where you need to go.

Early electric vehicles were limited by range, but newer models have more than enough fuel to get you to and from work, school, the grocery store and more. For example, Ford offers electric trucks and SUVs with over 300 miles of range.

If you’re skeptical whether that’s enough to get you around town, consider this: According to Ford, the average vehicle in America travels more than 150 miles in a day just four times per year. So, if you are planning a longer trip, you might have to stop at a public charging station, but you’ll have more than enough for your daily drive on a single charge.

Myth #3: Charging an electric vehicle is expensive.

Filling up with electricity is often more cost-effective than filling up with a tank of gas. In fact, Consumer Reports found that electric vehicle owners spend 60% less to fill up compared to traditional gas-powered cars.

Why? Electricity prices are typically lower than gas prices. Also, electricity prices are more stable than gas prices. As an electric vehicle owner, not only will you avoid weekly or monthly trips to the gas station, but you’ll also avoid the sticker shock of fluctuating gas prices.

Go electric with confidence

Are you ready to go electric? If so, check out the new Ford Power Promise.

Ford wants to make electric vehicle ownership easier by directly supporting owners and car shoppers in the areas that matter most, starting with the most important — charging. For a limited time, Ford is offering a complimentary home charger and standard installation, so you can switch to an electric vehicle with confidence. Simply plug in at night, just like you do with your phone, and wake up with a full tank.

The Ford Power Promise also includes:

  • Ongoing support and guidance: With 24/7 electric vehicle support and roadside assistance with proactive charging support, Ford has your back.
  • On-the-road charging: Ford makes charging on the road easy, now with access to more than 15,000 designated Tesla Superchargers with the available Fast Charging Adapter.
  • Battery confidence: Ford offers an 8-year, 100,000-mile warranty on its electric vehicle batteries.

To learn more about Ford electric vehicles and the Ford Power Promise, visit FordPowerPromise.com.

Ultimate guide to finding the most reliable home appliances

2024-10-01T14:21:00

(BPT) – When you’re in the market for a new appliance for your home, the choices can seem overwhelming. How do you know which features to look for, and what brands will be the most reliable? The last thing you want is to make a big purchase, only to end up with an appliance that doesn’t work well or that needs that needs constant repairs costing an average of $300-$500.1

LG, who is known for their reliability, was recently named the #1 appliance brand in the U.S. according to OpenBrand2 and offers top-of-the-line appliances that you can count on. Here’s a look at some of the most recommended appliances from LG to help you make more informed decisions for your home.

LG LSEL6331F Range

This high-performance range has a cooktop that features two high-power elements and two low-power ones — so it can not only bring water to a near-boil quickly but also simmer your tomato sauce steadily without scalding it. Its spacious oven excels at baking and delivers an even broil, too. The range can connect to the Wi-Fi in your home, so you can access smart controls via LG’s ThinQ® app on your phone.

LG LDE4413ST Range

This Wi-Fi-enabled range costs nearly $1,000 less than some of its competitors, but it still has strong marks across the board. The cooktop has two high-powered elements and two low-powered elements, plus a warming element. The roomy oven earns a solid rating for baking, and it offers convection mode. It also does a great job with self-cleaning.

LG WM5500HWA Washer and LG DLGX5501W Dryer

LG consistently stands out for providing the most well-liked full-sized washers and electric dryers, like this pair offered in white or graphite steel. For both the washer and dryer, built-in intelligence thanks to AI technology selects the optimal wash or dry settings for you, taking the guesswork out of doing your laundry. You’ll also be able to access smart functions of both appliances through their ThinQ® app.

The LG WM5500HWA 4.5 cubic foot Ultra Large Capacity washer lets you clean larger loads, with TurboWash® 360° Technology to power clean big loads in under 30 minutes — which helps explain why this model is ENERGY STAR® certified for an efficient clean that saves on water and energy. Even better, it’s Allergy and Asthma Friendly certified by the AAFA with its Allergiene® Cycle, using the power of steam to deep clean your wash.

You can dry your clothes smarter, too. With the LGDLGX5501W 7.4 cubic foot Ultra Large Capacity dryer, you’ll be able to clean larger loads, as well as refresh clothes in between washes thanks to TurboSteam.™ You can rest easy knowing your dryer is clean, efficient and safe due to the FlowSense® Duct Clogging and Lint Filter Indicators, and the LCD Digital Dial Control with LED Display provides helpful information with each turn of the dial.

For budget-conscious consumers, you might also consider their DLEX4000W or DLEX4200W, two similar but more affordable 7.4-cubic-foot capacity electric dryers.

LG WM3900HWA Washing Machine and LG WM3400CW Washing Machine

Front load washers from LG provide reliability, performance and efficiency. The WM3900HWA model has a cycle time of 85 minutes, while the WM3400CW’s cycle time is 105 minutes. Both models offer excellent water efficiency, gentler cycles and reduced noise and vibrations. They both come with a one-year warranty.

LG LRDCS2603S Refrigerator

This top-notch 33-inch-wide bottom-freezer refrigerator excels in thermostat control and temperature uniformity. It also boasts very good scores for ease of use, energy efficiency and low noise output, making it a strong contender in its category. The fridge is equipped with an icemaker, built-in water filter and digital controls. This model is a reliable, high-performing choice for those in the market for a bottom-freezer refrigerator.

Are you ready to find the next reliable appliance for your home? You can feel confident in your purchase with LG home appliances. Learn more at LG.com/us/reliable-home-appliances.

1) Based on cost of LG’s out of warranty repair services in 2023

2) #1 Appliance Brand in the U.S. | Source: OpenBrand Durable IQ, Major Appliances (AHAM Core 6) Q2 2024